This special issue initiated with an aim of promoting the progress and upholding the cause of Science and Technology using the concept of Open Access with the best system ever available along with retaining its "Quality"-the main element.

It promotes the publication of inventive and advanced research work in the field of biotechnology and biomedical science. It aims to maintain a media for the researchers to submit and exchange the knowledge gained over the world wide.

Recent advances in biomedical imagining techniques have allowed us to investigate both structural and functional properties of biological systems from the molecular level to the system level. Furthermore, imaging techniques also allow us to visualize the data in multi-dimensions. The findings of these imaging results can provide insights on disorders as well as normal physiological functions both theoretically and experimentally.

The purpose of this special issue is to bring researchers together to focus on the advances using biomedical imaging techniques to explore the physiological functions ranging from cellular imagining to brain imaging, and visualize the results dynamically.

Earlier cancer cell detection is very important in both research and clinic applications. Many physical cell properties have been utilized to separate cancer cells from blood sample, such as size, flexibility, biomarkers, and external assistance such as magnetic field, electrical field and acoustic waves. Meanwhile, computational models are also used to help understanding the cell separation study. In this special issue, we would like to bring the latest development in both experiments and simulation in cancer cell detection.

Viable bone tissue supplementation is required in surgical treatment of bone fractures’ non-union, spine stabilization and for implantation of hardware for restoring limb and joint mobility. Therefore there is a great need for development of effective methods for closing gaps in bone by scaffolds with osteoinductive and osteoconductive properties for the success of ex vivo and in vivo generated bone tissue local incorporation. In this special issue we would like to bring the latest developments as well as classical methods in this aspect of tissue engineering.

The remarkable progress of Medical Imaging during the twentieth century has become essential in clinical practice and allowing the development and use in new areas of great importance, such as molecular biology, biomedical research and therapeutic noninvasive intervention radiology. With improved health care programs and increasing of the availability of the medical equipment, the number of radiological medical procedures increased considerably, and therefore the diagnostic radiology is invaluable for the health care. Effective and of good quality imaging is important for further medical decision and can reduce unnecessary procedures and risks; furthermore, concerning ionizing imaging modalities the radiation protection of the patient becomes an important issue must be consider.

In this special issue, we intend to invite front-line researchers and authors to submit original research and review articles on exploring Image Quality and analysis in Diagnostic Radiology.

Lipid membranes are fundamental to wide range of cellular functions. The key is to understand the biophysical mechanisms that underlie the function of lipid membranes in cells and to create bio-inspired materials and systems that borrow these mechanisms. Theme of this issue is to study lipid-lipid, proteins-lipid and protein-protein interactions in model membranes to understand organization, dynamics and structure of membranes and using this knowledge to build functional systems such as targeted drug delivery vehicles, biosensors, light harvesting platforms and imaging tools.

Microfluidic technologies have advanced the design and development of point-of-care assays through low consumption of sample and reagent, fast reaction/detection, low cost, high portability and disposability. Versatile microfluidic platforms have been initiated for creative and efficient solutions for medical testing, diagnostics and disease treatment. It has proven to be a breakthrough analytical tool that has rendered analysis of proteins a biomedical routine. The high parallelization and integration facilitate identification of biomembrane proteins as new biomarkers for applications in biosensors. The sensitivity limits of assays have been significantly enhanced using new labeling techniques, label-free detection methods, and on-chip circuit boards for signal transduction and acquisition. Additionally, microfluidics initiated new cell culture methods and realistic microenvironment that enable simultaneous stimuli and intercellular communication, response to infection, evolution of disease, and response to medications.

The aim of this special issue is to foster state-of-the-art research in the area of microfluidic technologies for biomedical applications. This special issue focuses on the interface between microfluidics, biomechanics, molecular and cellular biology with applications for diagnostics, treatment, and medicine applications.