Research in Cell Biology

Research in Cell Biology is an international peer-reviewed journal that provides a forum of experimental cell investigation, publishes reviews, original articles and short communications on the structure, function and macromolecular organization of cells and cell components. Contributions addressing cell biological problems in prokaryotes and plants are welcome.

Manisha Sharma

Editorial Board Member of Research in Cell Biology

Post-doctoral Fellow, University of Sydney, Australia

Research Areas

Cancer research, molecular biology, nuclear transport

Education

2002Doctorate of Philosophy (PhD)Biotechnology, University of New South Wales
1997Bachelor of Advanced Science (Honours)Biotechnology, University of New South Wales
1993-1996Bachelor of Science (Honours)Botany, University of Delhi, India

Experience

2007-CurrentSenior Post Doctoral Fellow and Wnt Signalling team leader at Westmead Millennium Institute, University of Sydney
2003-2006Post-Doctoral Fellow, Gene Expression Unit, Westmead Millennium Institute, University of Sydney

Academic Achievement

Awarded Westmead Millennium Institute Science Prize for excellence in research, 2011 (Paper: Jamieson, C. etal, 2011, Traffic 2011 Aug: 12(8):983-99)
Awarded Best Poster Presentation prize at Westmead Association Research Symposium, 2009
Awarded Best Poster Presentation prize at Westmead Association Research Symposium, 2004
Australian Postgraduate Research Award, UNSW, March-98 to Sept.-01 for study towards the PhD degree

Membership

2009-Current, Member of the Westmead Millennium Institute Cell Imaging committee
2006-2008, Member of Westmead Millennium Institute Tissue culture committee

Publications: Journals

[1]  Sharma M, Jamieson C, Johnson M, Molloy, MP. and Henderson, B.R.: Specific armadillo repeat sequences facilitate -catenin nuclear transport in live cells via direct binding to nucleoporins Nup62, Nup153 and RanBP2/Nup358. J. Biol. Chem., 2012, 287(2): 819-831
[2]  Jamieson C, Sharma M and Henderson, B.R.: Regulation of beta-catenin nuclear export and retention by GSK-3beta in live cells involves a LEF-1-dependent positive feedback loop. Traffic, 2011, 12:983-99
[3]  Johnson M, Sharma M, Brocardo MG, Henderson BR.: IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Int J Biochem Cell Biol. 2011;43(1):65-73.
[4]  Flegg CP, Sharma M, Medina-Palazon C, Jamieson C, Galea M, Brocardo MG, Mills K, Henderson BR.: Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear export of the catalytic subunit. J Biol Chem., 2010, 285(24):18144-54.
[5]  Johnson M*, Sharma M*, Jamieson C, Henderson JM, Mok MT, Bendall L, Henderson BR.: Regulation of beta-catenin trafficking to the membrane in living cells. Cell Signal. 2009, 21(2):339-48.
[6]  Sharma, M and Henderson, B. R.(2007): IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli. J Biol Chem. 2007, 282(11):8545-56.
[7]  Sharma M*, Leung L*, Brocardo M, Henderson J, Flegg C, Henderson BR.: Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J Biol Chem. 2006, 281(25):17140-9.
[8]  Sharma M, Barrow KD, Smith GM. Flow cytometric isolation of a cDNA clone encoding an intracellular protein. Biotechniques., 2005, 39(1):46-50
[9]  Jamieson, C., Sharma, M and Henderson BR.: Wnt Signaling from membrane to nucleus: β-catenin caught in a loop. Int. J. Biochem. Cell Biol., 2012, 44(6): 847-50.
[10]  Lui, C., Mills, K., Brocardo, M,G, Sharma, M, Henderson, B.R.: APC as a mobile scaffold: Rgulation and Function at the nucleus, centrosome and mitochondria. IUBMB Life., 2012, 64(3): 209-214.
[11]  Johnson, M, Sharma, M, Henderson, BR.: IQGAP1 regulation and roles in cancer. Cell Signal, 2009, 21:1471-478

Publications: Books/Book Chapters

[1]  Sharma M, Henderson BR.: Methods to measure nuclear export of beta-catenin using fixed and live cell assays. Methods Mol Biol.,2010, 647:187-97 editor: Paul Higgins, Humana Press