Research in Cell Biology

Research in Cell Biology is an international peer-reviewed journal that provides a forum of experimental cell investigation, publishes reviews, original articles and short communications on the structure, function and macromolecular organization of cells and cell components. Contributions addressing cell biological problems in prokaryotes and plants are welcome.

Anna Ivana Scovassi

Editorial Board Member of Research in Cell Biology

Research Scientist, Istituto di Genetica Molecolare IGM-CNR, Italy

Research Areas

Cell Biology

Education

1984Ph.DGenetics, University of Pavia, Italy
1979Ph.DBiochemistry, University of Paris VI, Paris, France

Experience

2010-2012National Coordinator of the group "I processi di ADP-ribosilazione"
2005Visiting Professor, Université Paris VII, Paris, France
2001-presentResearch Director, Istituto di Genetica Molecolare of CNR, Pavia, Italy
1997-2001Senior Researcher, Istituto di Genetica Molecolare of CNR, Pavia, Italy
1996-present"Professore a contratto", University of Pavia (Faculty of Medicine), Italy
1995NATO-CNR Fellow, Université Laval, Québec, Canada
1994-2001Member of the Scientific Committee of the Istituto di Genetica Molecolare of CNR
1988Maître de Conférence Associé, Université Paris VI, France
1986EMBO Fellow, University of Sussex, Brighton, UK
1984-1997CNR Researcher, Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Pavia, Italy
1979-1983Fellow of Accademia Nazionale di Agricoltura, IGBE-CNR, Pavia, Italy
1977-1979CEE Fellow, Institut Curie, Paris

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Bertazzoni U., Scovassi A.I., Brun G. Chick embryo DNA polymerase γ: identity of γ-polymerase purified from nuclei and mitochondria. Eur. J. Biochem. 81: 237-248 (1977).
[2]  Bertazzoni U., Scovassi A.I., Stefanini M., Giulotto E., Spadari S., Pedrini A.M. DNA polymerases α, β and γ in inherited diseases affecting DNA repair. Nucleic Acids Res. 5: 2189-2196 (1978).
[3]  Scovassi A.I., Wicker R. and Bertazzoni U. A phylogenetic study on vertebrate mitochondrial DNA polymerase γ. Eur. J. Biochem. 110: 491-496 (1979).
[4]  Scovassi A.I., Wicker R., Nocentini S. DNA polymerase activities α, β and γ in UV irradiated monkey cells. Nucleic Acids Res. 6: 1591-1606 (1979).
[5]  Scovassi A.I., Plevani P., Bertazzoni U. Eukaryotic DNA polymerases. Trends Biochem. Sci. 5: 335-337 (1980).
[6]  Brun G., Vannier P., Scovassi A.I., Callen J.C. DNA topoisomerase I from mitochondria of Xenopus laevis oocytes. Eur. J. Biochem. 118: 407-415 (1981).
[7]  Brusamolino E., Bertazzoni U., Isernia P., Ginelli E., Scovassi A.I., Zurlo M.G., Plevani P., Sacchi N., Bernasconi C. Clinical relevance of terminal transferase and adenosine deaminase in leukemia. Adv. Exp. Med. Biol. 145: 279-303 (1982).
[8]  Damiani G., Palla E., Sgaramella V., Scovassi A.I., Bertazzoni U. Restriction analysis of cloned heteropolymeric DNA synthesized in vitro by TdT. Adv. Exp. Med. Biol. 145: 75-80 (1982).
[9]  Bertazzoni U., Ciarrocchi G., Cobianchi F., Giulotto E., Nuzzo F., Pedrali Noy G., Pedrini M.A., Riva S., Scovassi A.I., Spadari S., Stefanini M., Falaschi A. Enzymes of DNA metabolism in animal cells. Mutation Res. 96: 120-121 (1982).
[10]  Bertazzoni U., Brusamolino E., Isernia P., Scovassi A.I., Torsello S., Lazzarino M. Bernasconi C. Prognostic significance of terminal transferase and adenosine deaminase in acute and chronic myeloid leukemia. Blood 60: 685-692 (1982).
[11]  Scovassi A.I., Torsello S., Plevani P., Badaracco G.F., Bertazzoni U. Active polypeptide fragments common to prokaryotic, eukaryotic and mitochondrial DNA polymerases. EMBO J. 1: 1161-1165 (1982).
[12]  Damiani G., Scovassi A.I., Romagnoli S., Palla E., Bertazzoni U., Sgaramella V. Sequence analysis of heteropolymeric DNA synthesized in vitro by the enzyme terminal deoxynucleotidyl transferase and cloned in E. coli. Nucleic Acids Res. 10: 6401-6410 (1982).
[13]  Bertazzoni U., Scovassi A.I., Torsello S., Badaracco G.F., Plevani P. Structural study of DNA polymerases of eukaryotes and lower organisms. Prog. Clin. Biol. Res. 102 Pt C: 99-108 (1982).
[14]  Scovassi A.I., Cavalloro R., Bertazzoni U. A DNA polymerase α partially resistant to aphidicolin in cells and embryos of Med-fly (Ceratitis capitata Wied). Biochem. Int. 7: 481-491 (1983).
[15]  Scovassi A.I., Stefanini M., Bonelli F., Bertazzoni U. Catalytic activities of human poly(ADP-ribose)polymerase after SDS-PAGE. Adv. Exp. Med. Biol. 179: 519-522 (1984).
[16]  Brusamolino E., Isernia P., Lazzarino M., Scovassi A.I., Bertazzoni U., Bernasconi C. Clinical utility of terminal transferase and adenosine deaminase determinations in adult leukemia with a lymphoid phenotype. J. Clin. Oncol. 2: 871-880 (1984).
[17]  Scovassi A.I., Stefanini M., Bertazzoni U. Catalytic activities of human poly(ADP-ribose)polymerase from normal and mutagenized cells detected after SDS-polyacrylamide gel electrophoresis. J. Biol. Chem. 259: 10973-10977 (1984).
[18]  Brusamolino E., Isernia P., Alessandrino E.P., Scovassi A.I., Bertazzoni U., Bernasconi C. Terminal deoxynucleotidyl transferase-positive acute leukemias evolving from a myelodysplastic syndrome. Am. J. Hematol. 20: 187-190 (1985).
[19]  Cavalloro R., Bertazzoni U., Pozzi G., Scovassi A.I. Effect of γ-irradiation and aphidicolin of the growth and DNA polymerases of eukaryotic invertebrate cells (Ceratitis capitata Wied). Redia 68: 229-238 (1985).
[20]  Scovassi A.I., Stefanini M., Bertazzoni U. Variations of poly(ADP-ribose)polymerase in different cell systems. Mutation Res. 147: 319-320 (1985).
[21]  Bertazzoni U., Scovassi A.I., Mezzina M., Sarasin A., Franchi E., Izzo R. Activity gels for analyzing DNA processing enzymes. Trends Genet. 2: 67-72 (1986).
[22]  Scovassi A.I., Izzo R., Franchi E., Bertazzoni U. Structural analysis of poly(ADP-ribose)polymerase in higher and lower eukaryotes. Eur. J. Biochem. 159: 77-84 (1986).
[23]  Scovassi A.I., Stefanini M., Lagomarsini P., Izzo R., Bertazzoni U. Response of mammalian ADPRT to lymphocyte stimulation, mutagen treatment and cell cycling. Carcinogenesis 8: 1295-1300 (1987).
[24]  Casoli C., Tremolada F., Lori F., Scovassi A.I., Bertazzoni U., Starcich R., Alberti A. Reverse transcriptase activity in post-transfusion non-A, non-B hepatitis: characterization and association with retrovirus-like particles in serum. Serodiagnosis and Immunotheraphy 1: 339-346 (1987).
[25]  Casoli C., Magnani G., Scovassi A.I., Bertazzoni U., Starcich R. Prognostic significance of ADA determinations in subjects with lymphoadenopathy syndrome. J. Med. Virol. 24: 413-422 (1988).
[26]  Lori F., Scovassi A.I., Brusamolino E., Casoli C., Starcich R. Different distribution of DNA polymerases α and β in bone marrow and peripheral blood from human leukemia. Med. Oncol. Tumor Pharmacother. 5: 181-186 (1988).
[27]  Cesarone C.F., Scovassi A.I., Scarabelli L., Izzo R., Orunesu M., Bertazzoni U. Depletion of ADP-ribosyl transferase activity in rat liver during exposure to N-2 acetylaminofluorene; effect of thiols. Cancer Res. 48: 3581-3585 (1988).
[28]  Lori F., Scovassi A.I., Zella D., Achilli G., Cattaneo E., Casoli C., Bertazzoni U. Enzymological active forms of reverse trascriptase of Human Immunodeficiency Virus. AIDS Research Human Retroviruses 4: 393-398 (1988).
[29]  Scovassi A.I., Stefanini M., Izzo R., Lagomarsini P., Bertazzoni U., Moustacchi E. The basal and mutagen-induced levels of ADP-ribosyl transferase activity are not modified in Fanconi's anemia cells. Mutation Res. 255: 65-69 (1989).
[30]  Bertazzoni U., Scovassi A.I., Shall S. Meeting report: Fourth European Meeting on ADP-ribosylation of Proteins. Mutation Res. 219: 303-307 (1989).
[31]  Negri C., Scovassi A.I., Cerino A., Negroni M., Borzì R.M., Meliconi R., Facchini A., Montecucco C.M., Astaldi Ricotti G.C.B. Autoantibodies to poly(ADP-ribose)polymerase in autoimmune diseases. Autoimmunity 6: 203-209 (1990).
[32]  Sestili P., Spadoni G., Balsamini C., Scovassi A.I., Cattabeni F., Duranti E., Cantoni O., Higgins D., Thomson C. Structure requirements for inhibitors of poly(ADP-ribose)polymerase. J. Cancer Res. Clin. Oncol. 116: 1-8 (1990).
[33]  Cesarone C.F., Scarabelli L., Scovassi A.I., Izzo R., Menegazzi M., Carcereri De Prati A., Orunesu M., Bertazzoni U. Changes in activity and mRNA levels of poly(ADP-ribose)polymerase during rat liver regeneration. Biochim. Biophys. Acta 1087: 241-246 (1990).
[34]  Cesarone C.F., Suzuki H., Scovassi A.I., Scarabelli L., Izzo R., Giannoni P., Mariani C., Miwa M., Orunesu M., Bertazzoni U. Influence of poly(ADP-ribose)polymerase depletion on promotion of liver carcinogenesis. Mol. Carcin. 5: 111-117 (1992).
[35]  Astaldi Ricotti G.C.B., Facchini A., Montecucco C.M., Negri C., Scovassi A.I. New targets of autoantibodies. Adv. Allergy Immunol. 1: 187-194 (1992).
[36]  Scovassi A.I., Negri C., Negroni M., Dal V., Borzì R.M., Meliconi R., Facchini A., Montecucco C.M., Astaldi RIcotti G.C.B. Detection of circulating autoantibodies to poly (ADP-ribose)polymerase in autoimmune diseases. Ann. N Y Acad. Sci. 663: 508-509 (1992).
[37]  Bertazzoni U. and Scovassi A.I. Correlation of poly(ADP-ribose)polymerase activity with cellular defense mechanism. Ann. N Y Acad. Sci. 663: 215-217 (1992).
[38]  Scovassi A.I., Mariani C., Negroni M., Negri C., Bertazzoni U. ADP-ribosylation of non-histone proteins in HeLa cells: modification of DNA topoisomerase II. Exp. Cell Res. 206: 177-181 (1993).
[39]  Prosperi E., Stivala L.A., Sala E., Scovassi A.I., Bianchi L. Proliferating cell nuclear antigen (PCNA) complex formation induced by UV irradiation in human quiescent fibroblasts as detected by immunostaining and flow cytometry. Exp. Cell Res. 205: 320-325 (1993).
[40]  Negri C., Scovassi A.I., Braghetti A., Guano F., Astaldi Ricotti G.C.B. DNA topoisomerase II β: stability and distribution in different animal cells in comparison to DNA topoisomerase I and II α. Exp. Cell Res. 206: 128-133 (1993).
[41]  Negri C., Bernardi R., Braghetti A., Astaldi Ricotti G.C.B., Scovassi A.I. Effect of chemotherapeutic drug VP-16 on poly(ADP-ribosylation) in apoptotic HeLa cells. Carcinogenesis 14: 2559-2564 (1993).
[42]  Guano F., Bernardi R., Negri C., Donzelli M., Prosperi E., Astaldi Ricotti G.C.B., Scovassi A.I. Dose-dependent zinc inhibition of DNA ladder in apoptotic HeLa cells regulates the activity of poly(ADP-ribose)polymerase and does not protect from death induced by VP-16. Cell Death Differ. 1: 101-107 (1994).
[43]  Prosperi E., Scovassi A.I., Stivala L.A., Bianchi L. Proliferating cell nuclear antigen bound to DNA synthesis sites: phosphorylation and association with cyclin D1 and cyclin A. Exp. Cell Res. 215: 257-262 (1994).
[44]  Bernardi R., Negri C., Donzelli M., Guano F., Torti M., Prosperi E., Scovassi A.I. Activation of poly(ADP-ribose)polymerase in apoptotic human cells. Biochimie 77: 378-384 (1995).
[45]  Bernardi R., Negri C., Donzelli M., Guano F., Scovassi A.I. Analysis of phosphorylation level of DNA topoisomerase II α and β in human HeLa cells. Int. J. Oncol. 6: 203-208 (1995).
[46]  Negri C., Bernardi R., Donzelli M., Scovassi A.I. Induction of cell death by DNA topoisomerase II inhibitors. Biochimie 77: 893-899 (1995).
[47]  Stivala L.A., Scovassi A.I., Bianchi L., Prosperi E. Nuclear binding of cell cycle-related proteins: cyclin A versus proliferating cell nuclear antigen (PCNA). Biochimie 77: 888-892 (1995).
[48]  Negri C., Bernardi R., Donzelli M., Prosperi E., Scovassi A.I. Sequence of events leading to apoptosis in growth-arrested HeLa cells. Cell Death Differ. 3: 425-429 (1996).
[49]  Savio M., Stivala M., Scovassi A.I., Bianchi L., Prosperi E. p21waf1/cip1 protein associates with the detergent-insoluble form of PCNA concomitantly with disassembly of PCNA at nucleotide excision repair sites. Oncogene 13: 1591-1598 (1996).
[50]  Bernardi R., Rossi L., Poirier G.G., Scovassi A.I. Analysis of poly(ADP-ribose) glycohydrolase activity in nuclear extracts from mammalian cells. Biochim. Biophys. Acta 1338: 60-68 (1997).
[51]  Negri C., Donzelli M., Bernardi R., Rossi L., Bürkle A., Scovassi A.I. Multiparametric staining to identify apoptotic human cells. Exp. Cell Res. 234: 174-177 (1997).
[52]  Prosperi E., Stivala L.A., Scovassi A.I., Bianchi L. Cyclins: relevance of subcellular localizations in cell cycle control. Eur. J. Histochem. 41: 161-168 (1997).
[53]  Scovassi A.I., Stivala L.A., Rossi L., Bianchi L., Prosperi E. Nuclear association of cyclin D1 in human fibroblasts: tight binding to nuclear structures and modulation by protein kinase inhibitors. Exp. Cell Res. 237: 127-134 (1997).
[54]  Barni S., Lambiase S., Grigolo A., Sacchi L., Corona S., Scovassi A.I., Laudani U. Occurrence of apoptosis in serosa of Periplaneta americana L. (Blattaria: Blattidae): ultrastructural and biochemical features. J. Insect Physiol. 43: 999-1008 (1997).
[55]  Donzelli M., Negri C., Mandarino A., Rossi L., Prosperi E., Frouin I., Bernardi R., Bürkle A., Scovassi A.I. Poly(ADP-ribose) synthesis: a useful parameter to identify apoptotic cells. Histochem. J. 29: 831-837 (1997).
[56]  Codegoni A.M., Castagna S., Mangioni C., Scovassi A.I., Broggini M., D'Incalci M. DNA topoisomerase I activity and content in epithelial ovarian cancer. Annals Oncol. 9: 313-320 (1998).
[57]  Alessi F., Quarta S., Savio M., Riva F., Rossi L., Stivala L.A., Scovassi A.I., Meijer L., Prosperi E. The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. Exp. Cell Res. 244: 8-18 (1998).
[58]  Pagano G., Korkina L.G., Brunk U.T., Chessa L., Degan P., Del Principe D., Kelly F.J., Malorni W., Pallardò F., Pasquier C., Scovassi I., Zatterale A., Franceschi C. Congenital disorders sharing oxidative stress and cancer proneness as phenotypic hallmarks: prospects for joint research in pharmacology. Medical Hypotheses 51: 253-266 (1998).
[59]  Scovassi A.I., Denegri M., Donzelli M., Rossi L., Bernardi R., Mandarino A., Frouin I., Negri C. Poly(ADP-ribose) synthesis in cells undergoing apoptosis: an attempt to face death before PARP degradation. Eur. J. Histochem. 4: 251-258 (1998).
[60]  Donzelli M., Bernardi R., Negri C., Prosperi E., Padovan L., Lavialle C., Brison O., Scovassi A.I. Apoptosis-prone phenotype of human colon carcinoma cells with a high level amplification of the c-myc gene. Oncogene 18: 439-448 (1999).
[61]  Winstall E., Affar E. B., Shah R., Bourassa S., Scovassi A.I., Poirier G.G. Poly(ADP-ribose) glycohydrolase is present and active in mammalian cells as a 110 kDa protein. Exp. Cell Res. 246: 395-398 (1999).
[62]  Torriglia A., Negri C., Chaudun E., Prosperi E., Courtois Y, Counis M.F., Scovassi A.I. Differential involvement of DNase II in HeLa cell apoptosis induced by etoposide and long term culture. Cell Death Differ. 6: 234-244 (1999).
[63]  Scovassi A.I. and Poirier G.G. Poly(ADP-ribosylation) and apoptosis. Mol. Cell. Biochem. 199:125-137 (1999).
[64]  Winstall E., Affar E. B., Shah R., Bourassa S., Scovassi A.I., Poirier G.G. Preferential perinuclear localization of poly(ADP-ribose) glycohydrolase. Exp. Cell Res. 251: 372-378 (1999).
[65]  Rossi R., Villa A., Negri C., Scovassi I., Ciarrocchi G., Biamonti G., Montecucco A. The replication factory targeting sequence/PCNA binding site is required in G1 to control the phosphorylation status of DNA ligase I. EMBO J. 18: 5745-5754 (1999).
[66]  Ghibelli L., Coppola S., Fanelli C., Rotilio G., Civitareale P., Scovassi A.I., Ciriolo M.R. Glutathione depletion causes cytochrome C release in apoptotic and viable cells. FASEB J. 13: 2031-2036 (1999).
[67]  Stivala L.A., Savio M., Quarta S., Scotti C., Cazzalini O., Rossi L., Scovassi I.A., Pizzala R., Melli R., Bianchi L., Vannini V., Prosperi E. The antiproliferative effect of β-carotene requires p21waf1/cip1 in normal human fibroblasts. Eur. J. Biochem. 267: 2290-2296 (2000).
[68]  Reale A., Malanga M., Zardo G., Strom R., Scovassi A.I., Farina B., Caiafa P. In vitro induction of H1-H1 histone cross-linking by adenosine diphosphate-ribose polymers. Biochemistry 39: 10413-10418 (2000).
[69]  Denegri M., Lambiase S., Donadoni C., Rossi L., Scovassi A.I. Evidence of poly(ADP-ribosylation) in the cockroach Periplaneta americana. Insect Biochem Mol. Biol. 30: 1045-1050 (2000).
[70]  Pellicciari C., Bottone M.G., Scovassi A.I., Martin T.E., Biggiogera M. Rearrangement of nuclear ribonucleoproteins and extrusion of nucleolus-like bodies during apoptosis induced by hypertonic stress. Eur. J. Histochem. 44: 247-254 (2000).
[71]  Frouin I., Prosperi E., Denegri M., Negri C., Donzelli M., Rossi L., Riva F., Stefanini M., Scovassi A.I. Different effects of methotrexate on DNA mismatch repair proficient and deficient cells. Eur. J. Cancer 37: 1173-1180 (2001).
[72]  Montecucco A., Rossi R., Ferrari G., Scovassi A.I., Prosperi E., Biamonti G. Etoposide induces the dispersal of DNA ligase I from replication factories. Mol. Biol. Cell 12: 2109-2118 (2001).
[73]  Soldani C., Lazzè M.C., Bottone M.G., Tognon G., Biggiogera M., Pellicciari C., Scovassi A.I. Poly(ADP-ribose) polymerase cleavage during apoptosis: when and where? Exp. Cell Res. 269: 193-201 (2001).
[74]  Palomba L., Guidarelli A., Scovassi A.I., Cantoni O. Different effects of tert-buthylhydroperoxide-induced peroxynitrite-dependent and-independent DNA single strand breakage on PC12 cell poly(ADP-ribose) polymerase. Eur. J. Biochem. 268: 5223-5228 (2001).
[75]  Scovassi A.I., Pellegata N.S., Di Stefano L., Padovan L., Negri C., Prosperi E., Riva F., Ciomei M., Ranzani G.N. Effects of topoisomerase II inhibitors on gastric cancer cells characterized by different genetic lesions. Anticancer Res. 21: 2803-2808 (2001).
[76]  Soldani C., Bottone M.G., Pellicciari C., Scovassi A.I. Two-color fluorescence detection of Poly(ADP-Ribose) Polymerase-1 (PARP-1) cleavage and DNA strand breaks in etoposide-induced apoptotic cells. Eur. J. Histochem. 45: 389-392 (2001).
[77]  Rossi R., Montecucco A., Donzelli M., Denegri M., Biamonti G., Scovassi A.I. DNA ligase I is dephosphorylated during the execution step of etoposide-induced apoptosis. Cell Death Differ. 9: 89-90 (2002).
[78]  Soldani C. and Scovassi A.I. Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update. Apoptosis, 7: 321-328 (2002).
[79]  Scovassi A.I. Multiple roles of poly(ADP-ribosylation). Recent Res. Devel. Prot. 1: 345-360 (2002).
[80]  Soldani C., Bottone M.G., Biggiogera M., Alpini C., Scovassi A.I, Martin T., Pellicciari C. Nuclear localization of phosphorylated c-Myc protein in human tumor cells. Eur. J. Histochem. 46: 377-380 (2002).
[81]  Rossi L., Denegri M., Torti M., Poirier G.G., Scovassi A.I. Poly(ADP-ribose) degradation by post-nuclear extracts from human cells. Biochimie 84: 1227-1233 (2002).
[82]  Gorrini G., Donzelli M., TorrigliaA., Supino R., Brison O., Bernardi R., Negri C., Denegri M., Counis M.F., Ranzani G.N., Scovassi A.I. Effect of apoptogenic stimuli on colon carcinoma cell lines with a different c-myc expression level. Int. J. Mol. Med. 11: 737-742 (2003).
[83]  Di Meglio S., Denegri M., Vallefuoco S., Tramontano F., Scovassi A.I., Quesada P. Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells. Mol. Cell Biochem. 248: 85-91 (2003).
[84]  Scovassi A.I. and Torriglia A. Activation of DNA-degrading enzymes during apoptosis. Eur. J. Histochem. 47: 185-194 (2003).
[85]  Bottone M.G., Soldani C., Tognon, G.L., Gorrini, C., Lazzè M.C., Brison O., Ciomei M., Pellicciari C., Scovassi A.I. Multiple effects of paclitaxel are modulated by a high c-myc amplification level. Exp. Cell Res. 290: 49-59 (2003).
[86]  Frouin I., Maga G., Denegri M., Riva F., Savio M., Spadari S., Prosperi E., Scovassi A.I. Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1 and p21waf1/cip1: a dynamic exchange of partners. J. Biol. Chem. 278: 39265-39268 (2003).
[87]  Riva F., Savio M., Cazzalini O., Stivala L.A., Scovassi A.I., Cox L.S., Ducommun B., Prosperi E. Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with p125 subunit DNA of polymerase δ or DNA ligase I. Exp. Cell Res. 293: 357-367 (2004).
[88]  Mondello C. and Scovassi A.I. Telomeres, telomerase and apoptosis. Biochem. Cell Biol. 82: 498-507 (2004).
[89]  Lazzè M.C., Savio M., Pizzala R., Cazzalini O., Perucca P., Scovassi A.I., Stivala L.A., Bianchi L. Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Carcinogenesis 25: 1427-1433 (2004).
[90]  Scovassi A.I. and Diederich M. Modulation of poly(ADP-ribosylation) in apoptotic cells. Biochem. Pharmacol. 68: 1041-1047 (2004).
[91]  Cassinelli G., Zuco V., Supino R., Lanzi C., Scovassi A.I., Semple S.C., Zunino F. Role of c-myc protein in hormone refractory prostate carcinoma: cellular response to paclitaxel. Biochem. Pharmacol. 68: 923-931 (2004).
[92]  Scovassi A.I. (2004) Mitochondrial poly(ADP-ribosylation): from old data to new perspectives. FASEB J. 18: 1487-1488 (2004).
[93]  Supino S. and Scovassi A.I. c-myc: a double-headed Janus that regulates cell survival and death. Gene Ther. Mol. Biol. 8: 385-394 (2004).
[94]  Biggiogera M., Bottone M.G., Scovassi A.I., Soldani C., Vecchio L., Pellicciari C. Rearrangement of nuclear RNP-containing structures during apoptosis and transcriptional arrest. Biol. Cell 96: 603-615 (2004).
[95]  Fraschini A., Bottone M.G., Scovassi A.I., Denegri M., Risueno M.C., Testillano P.S., Martin T.E., Biggiogera M., Pellicciari C. Changes in extranucleolar transcription during actinomycin D-induced apoptosis. Histol. Histopathol. 20:107-117 (2005).
[96]  Soldani C., Scovassi A.I., Canosi U., Bramucci E., Ardissino D., Arbustini E. Multicolor fluorescence technique to detect apoptotic cells in advanced coronary atherosclerotic plaques. Eur. J. Histochem. 49: 383-388 (2005).
[97]  Scovassi A.I. and Prosperi E. Analysis of proliferating cell nuclear antigen (PCNA) associated with DNA excision repair sites in mammalian cells. Methods Mol Biol. 314: 457-475 (2006).
[98]  Scovassi A.I., Gorrini C., Pastori W., Ciomei M. Analysis of brostallicin effect on different human gastrointestinal cancer cell lines. Lett. Drug Design Discov. 3: 524-527 (2006).
[99]  Mondello C., Bottone M.G., Noriki S., Soldani C., Pellicciari C., Scovassi A.I. Oxidative stress response in telomerase immortalized fibroblasts from a centenarian. Annals N.Y. Acad. Sci. 1091: 94-101 (2006).
[100]  Soldani C., Bottone M.G., Pellicciari C., Scovassi A.I. Nucleolus disassembly in mitosis and apoptosis: dynamic redistribution of phosphorylated-c-Myc, fibrillarin and Ki-67. Eur J Histochem. 50: 257-264 (2006).
[101]  Cattaneo F., Venesio T., Molatore S., Russo A., Fiocca R., Frattini M., Scovassi A.I., Ottini L., Bertario L., Ranzani G.N. Functional analysis and case-control study of-160C/A polymorphism in the E-cadherin gene promoter: association with cancer risk. Anticancer Res. 26: 4627-4632 (2006).
[102]  Supino R., Favini E., Cuccuru G., Zunino F., Scovassi A.I. Effect of paclitaxel on intracellular localization of c-Myc and P-c-Myc in prostate carcinoma cell lines. Annals N.Y. Acad. Sci. 1095: 175-181 (2007).
[103]  La Regina G., Edler M.C., Brancale A., Kandil S., Coluccia A., Piscitelli F., Hamel E., Martino G.D., Matesanz R., Diaz J.F., Scovassi A.I., Prosperi E., Lavecchia A., Novellino E., Artico M., Silvestri R. Arylthioindole Inhibitors of Tubulin Polymerization. 3. Biological Evaluation, Structure-Activity Relationships and Molecular Modeling Studies. J. Med. Chem. 50: 2865-2874 (2007).
[104]  Ross C.R., Ricevuti G., Scovassi A.I. The antimicrobial peptide PR-39 has a protective effect against HeLa cell apoptosis. Chem. Biol. Drug Des. 70: 154-157 (2007).
[105]  Scovassi A.I. The poly(ADP-ribosylation) story: A long route from Cinderella to Princess. Biology Forum, 100: 351-360 (2007).
[106]  Donà F., Mondello C., Scovassi A.I. Poly(ADP-ribosylation) at telomeres. Trends Cell Mol. Biol. 2: 77-88 (2007).
[107]  Cazzalini O., Perucca P., Savio M., Necchi D., Bianchi L., Stivala L., Ducommun B., Scovassi A.I., Prosperi E. Interaction of p21CDKN1A with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair. Nucl. Acids Res. 36: 1713-22 (2008).
[108]  Scovassi A.I., Bottone M.G., Biggiogera M., Pellicciari C. (2008) Dynamic relocation of nuclear proteins during the execution phase of apoptosis. Biochem. Pharmacol. 76: 1440-1450 (2008).
[109]  Donà F., Prosperi E., Savio M., Coppa T., Scovassi A.I., Mondello C. Loss of histone H2AX increases sensitivity of immortalized mouse fibroblasts to the topoisomerase II inhibitor etoposide. Int. J. Oncol. 33: 613-622 (2008).
[110]  Giansanti V. and Scovassi A.I. Cell death: a one-way journey to the graveyard. Open Biol. J. 1: 27-34 (2008).
[111]  Cristofanon C., Morceau F., Scovassi A.I., Dicato M., Ghibelli L., Diederich M. Oxidative, multistep activation of the noncanonical NF-kB pathway via disulfide Bcl-3/p50 complex. FASEB J. 23: 45-57 (2009).
[112]  Leprêtre C., Scovassi A.I., Shah G.M., Torriglia A. Regulation of Poly(ADP-Ribose) polymerase-1 functions by Leukocyte Elastase Inhibitor/LEI-derived-DNase II during caspase-independent apoptosis. Int. J. Biochem. Cell Biol. 41: 1046-1054 (2009).
[113]  Bottone M.G., Soldani C., Fraschini A., Croce A.C., Bottiroli G., Camboni T., Scovassi A.I., Pellicciari C. Enzyme-assisted photosensitization activates different apoptotic pathways in Rose Bengal acetate treated HeLa cells. Histochem. Cell Biol. 131: 391-399 (2009).
[114]  Lisa A., Monti D., Franceschi C., Scovassi A.I. Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis. Gerontology 55: 427-429 (2009).
[115]  Giansanti V., Donà F. and Scovassi A.I. Poly(ADP-ribosylation): Beneficial effects of its inhibition. Curr. Enzyme Inhib. 5, 99-109 (2009).
[116]  Giansanti V., Camboni T., Piscitelli F., Prosperi E., La Regina G., Lazzè M.C., Santin G., Silvestri R., Scovassi A.I. Study of the effects of a new pyrazolecarboxamide: Changes in mitochondria and induction of apoptosis. Int. J. Biochem. Cell Biol. 41: 1890-1898 (2009).
[117]  Leprêtre C., Sidoli G., Scovassi A.I., Torriglia A. Leukocyte Elastase Inhibitor: a new regulator of PARP-1. Annals N.Y. Acad. Sci. 1171: 25-31 (2009).
[118]  Supino R, Scovassi A.I., Croce A.C., Dal Bo L., Favini, E. Corbelli A., Farina C., Misiano P., Zunino F. Biological effects of a new v-H-ATPase inhibitor in colon carcinoma cell lines. Annals N.Y. Acad. Sci. 1171: 606-616 (2009).
[119]  Perdoni F., Bottone M.G., Soldati C., Veneroni P., Alpini C., Pellicciari C., Scovassi A.I. Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis. Annals N.Y. Acad. Sci. 1171: 32-37 (2009).
[120]  Scovassi A.I., Soldani C., Veneroni P., Bottone M.G., Pellicciari C. Changes of mitochondria and relocation of the Apoptosis Inducing Factor (AIF) during apoptosis. Annals N.Y. Acad. Sci. 1171: 12-17 (2009).
[121]  La Regina G., Sarkar T., Bai R., Edler M.C., Saletti R., Coluccia A., Piscitelli F., Minelli L., Gatti V., Mazzoccoli C., Palermo V., Mazzoni C., Falcone C., Scovassi A.I., Giansanti V., Campiglia P., Porta A., Maresca B., Hamel E., Brancale A., Novellino E., Silvestri S. New Arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modelling studies. J. Med. Chem. 52: 7512-7527 (2009).
[122]  Giansanti V., Piscitelli F., Camboni T., Prosperi E., La Regina G., Parks M., Silvestri S., Scovassi A.I. Arylthioindoles: promising compounds against cancer cell proliferation. Oncol. Lett. 1: 109-112 (2010).
[123]  Cazzalini O., Scovassi A.I., Savio M., Stivala L.A., Prosperi E. Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response. Mutation Res. 704: 12-20 (2010).
[124]  Cazzalini O., Donà F. Savio M., Tillhon M., Maccario C., Perucca P., Stivala L.A., Scovassi A.I. Prosperi E. p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1. DNA Repair 9: 627-635 (2010).
[125]  Giansanti V., Donà F., Tillhon M., Scovassi A.I. PARP inhibitors: new tools to protect from inflammation. Biochem. Pharmacol. 80: 1869-1877 (2010).
[126]  Donà F., Scovassi A.I. Poly(ADP-ribose) synthesis: A marker of cellular stress. Microscopie VII: 38-42 (2010).
[127]  Parks M., Tillhon M., Donà F., Prosperi E., Scovassi A.I. 2-methoxyestradiol: New perspectives in colon carcinoma treatment. Mol. Cell. Endocrinol. 331: 119-128 (2011).
[128]  Chiodi I., Belgiovine C., Donà F., Scovassi A.I., Mondello C. Drug treatment of cancer cell lines: a way to select for cancer stem cells? Cancers 3: 111-1128 (2011).
[129]  Giansanti V., Torriglia A., Scovassi A.I. Conversation between apoptosis and autophagy: "Is it your turn or mine?" Apoptosis 16: 321-333 (2011).
[130]  Scarabelli L., Lanza C., Demori I., Accomando R., Giansanti V. Scovassi A.I., Palmero S. Expression of antioxidant defense and poly(ADP-ribose) polymerase-1 in rat developing Sertoli cells. Cell Biol. Int. 9: 883-889 (2011).
[131]  Donà F., Belgiovine C., Chiodi I., Raineri T., Ricotti R., Mondello C., Scovassi A.I. Poly(ADP-ribosylation) and neoplastic transformation: Effects of PARP inhibitors. Current Pharmaceut. Biotechnol. in press (2011).