Research in Cell Biology

Research in Cell Biology is an international peer-reviewed journal that provides a forum of experimental cell investigation, publishes reviews, original articles and short communications on the structure, function and macromolecular organization of cells and cell components. Contributions addressing cell biological problems in prokaryotes and plants are welcome.

Yulong Liang

Editorial Board Member of Research in Cell Biology

Lecturer, Baylor College of Medicine, USA

Research Areas

Cancer Cell Biology, DNA Damage Response and DNA Repair, Genomic Instability

Education

2003Ph.D.Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China
2000MasterDepartment of Pathology Tongji Medical College, Huazhong Univ. of Sci & Tech, Wuhan, China

Experience

2011-presentInstructor, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China
2006-2011Post-doctoral Associate, Department of Surgery, Baylor College of Medicine, Houston, TX
2004-2005Lecturer, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China
2002-2003Research Assistant/Teaching Assistant, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China
2000-2002Research Assistant, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China

Academic Achievement

2008, Molecular Surgeon Young Investigator Award, Michael E. DeBakey Dept. of Surgery, Baylor College of Medicine, Houston, Texas
2007, Molecular Surgeon Young Investigator Award, Michael E. DeBakey Dept. of Surgery, Baylor College of Medicine, Houston, Texas
2006, Molecular Surgeon Young Investigator Award, Michael E. DeBakey Dept. of Surgery, Baylor College of Medicine, Houston, Texas
2006, Award for Best Scientific Articles in the journals of China Association for Science and Technology (CAST), Beijing, China
2005, Award for Best Scientific Articles in Dr. Zheng Ji's Foundation, Beijing, China
2004, National Natural Science Foundation of China (NSFC) Award, Beijing, China
2002, Gu Tianjue Scholarship, Shanghai Medical College, Fudan University, Shanghai, China
1998, All-round Developed Student Award, Tongji Medical College, Huazhong Univ. of Sci & Tech, Wuhan, China
1996, Excellent Graduate Student Award, Medical College of Henan Univ. of Sci & Tech, Luoyang, China

Membership

2009-present, Member, American Association for Cancer Research (AACR)
2011-present, Member, American Society for Cell Biology (ASCB)
2011-present, Member, American Association for the Advancement of Science (AAAS)

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Liang Y, Gao H, Lin SY, Peng G, Huang X, Zhang P, Goss JA, Brunicardi FC, Multani AS, Chang S, Li K. BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice. PLoS Genet. 2010, 6: e1000826.
[2]  Liang Y, Gao H, Lin SY, Goss JA, Brunicardi FC, Li K. siRNA-based targeting of cyclin E over expression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model. PLoS ONE. 2010, 5: e12860.
[3]  Lin SY, Liang Y, Li K. Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression. Yonsei Med J. 2010, 51:295-301.
[4]  Liang Y, Lin SY, Brunicardi FC, Goss J, Li K. DNA Damage Response Pathways in Tumor Suppression and Cancer Treatment. World J Surg. 2009, 33: 661-666.
[5]  Liang Y, Lin SY, Li K. MCPH1 (microcephalin 1). Atlas Genet Cytogenet Oncol Haematol. March 2009. URL: http://AtlasGeneticsOncology.org/Genes/MCPH1ID44370ch8p23.html
[6]  Wood JL, Liang Y, Li K, Chen J. Microcephalin/MCPH1 Associates with the Condensin II Complex to Function in Homologous Recombination Repair. J Biol Chem. 2008, 283: 29586-29592.
[7]  Zhao H, Liang Y, Xu Z, Wang L, Zhou F, Li Z, Jin J, Yang Y, Fang Z, Hu Y, Zhang L, Su J, Zha X. N-glycosylation affects the adhesive function of E-Cadherin through modifying the composition of adherens junctions (AJs) in human breast carcinoma cell line MDA-MB-435. J Cell Biochem. 2008, 104: 162-175.
[8]  Fang Z, Fu Y, Liang Y#, Li Z, Zhang W, Jin J, Yang Y, Zha X#. Increased expression of integrin beta1 subunit enhances p21WAF1/Cip1 transcription through the Sp1 sites and p300-mediated histone acetylation in human hepatocellular carcinoma cells. J Cell Biochem. 2007, 10: 654-664. (#Co-corresponding author)
[9]  Sun L, Zhao H, Xu Z, Liu Q, Liang Y, Wang L, Cai X, Zhang L, Hu L, Wang G, Zha X. Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation. Cell Signal. 2007, 19: 2255-2263.
[10]  Xu Z, Zhou X, Lu H, Wu N, Zhao H, Zhang L, Zhang W, Liang YL, Wang L, Liu Y, Yang P, Zha X. Comparative glycoproteomics based on lectins affinity capture of N-linked glycoproteins from human Chang liver cells and MHCC97-H cells. Proteomics 2007, 7: 2358-2370.
[11]  Wang L, Liang Y, Li Z, Cai X, Zhang W, Wu G, Jin J, Fang Z, Yang Y, Zha X. Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721. J Cell Biochem. 2007, 100: 230-241.
[12]  Fu Y, Fang Z, Liang Y, Zhu X, Prins P, Li Z, Wang L, Sun L, Jin J, Yang Y, Zha X. Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. J Cell Biochem. 2007, 102: 704-718.
[13]  Fu Y, Wang LY, Liang YL, Jin JW, Fang ZY, Zha XL. Integrin beta(1A) upregulates p27 protein amount at the post-translational level in human hepatocellular carcinoma cell line SMMC-7721. Acta Biochim Biophys Sin (Shanghai). 2006, 38:523-530.
[14]  Wu N, Zhang W, Yang Y, Liang YL, Wang LY, Jin JW, Cai XM, Zha XL. Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinoma cell lines is involved in inhibition of cell proliferation and migration. Proteomics 2006, 6: 6095-6106.
[15]  Wu H, Liang YL, Li Z, Jin J, Zhang W, Duan L, Zha X. Positive expression of E-cadherin suppresses cell adhesion to fibronectin via reduction of alpha5beta1 integrin in human breast carcinoma cells. J Cancer Res Clin Oncol. 2006, 132: 795-803.
[16]  Cai XM, Tao BB, Wang LY, Liang YL, Jin JW, Yang Y, Hu YL, Zha XL. Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression. Int J Cancer, 2005, 117: 905-912.
[17]  Ma DZ, Xu Z, Liang YL, Su JM, Li ZX, Zhang W, Wang LY, Zha XL. Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines. World J Gastroenterol. 2005, 11: 4472-4477.
[18]  Su JM, Wang LY, Liang YL, Zha XL. Role of cell adhesion signal molecules in hepatocellular carcinoma cell apoptosis. World J Gastroenterol. 2005,11: 4667-4673.
[19]  Liang YL, Fu Y, Chen SG, Cai XM, Su JM, Jin JW, Ma DZ, Li ZX, Zhang W, Zha X. Integrin beta1 subunit overexpressed in the SMMC-7721 cells regulates the promoter activity of p21(CIP1) and enhances its transcription. FEBS Lett. 2004, 558: 107-113.
[20]  Liang YL, Lei TW, Wu H, Su JM, Wang LY, Lei QY, Zha XL. S-phase delay in human hepatocellular carcinoma cells induced by overexpression of integrin β1. World J Gastroenterol. 2003, 9: 1689-1696.
[21]  Liang YL, Wang LY, Wu H, Ma DZ, Xu Z, Zha XL. PKB phosphorylation and survivin expression are cooperatively regulated by disruption of microfilament cytoskeleton. Mol Cell Biochem. 2003, 254: 257-263.
[22]  Lei TW, Liang YL, Zha XL. Overexpression of integrin β1 induces anoikis in human hepatocellular carcinoma cells SMMC-7721. Chin J Biochem Mol Biol, 2004, 20(1): 112-118. (Chinese)