Research in Neuroscience

Research in Neuroscience is a peer-reviewed journal aims to advance our understanding of the nervous system in health and disease, thereby improving the diagnosis and treatment of neuropsychiatric and neurodegenerative disorders. It presents novel results that can be of interest to a broad spectrum of neuroscientists and that were generated by experiments guided by clearly defined aims or hypotheses.


Yong Chen

Editorial Board Member of Research in Neuroscience

Staff Scientist, Division of Neurology, Duke University, USA

Research Areas

Neuroscience, Neurology

Education

1998-2003DoctorLanzhou University, Lanzhou, China

Experience

2008-presentSenior Research Associate, Duke University, Durham, USA
2006-2008Postdoctoral Fellow, University of North Carolina, Chapel Hill, USA
2003-2006Postdoctoral Fellow, University of Wuerzburg, Wuerzburg, Germany

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Chen Y*, Palm P, Lesch KP, Gerlach M, Moessner R, Sommer C. 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice. Mol Pain. 2011; 7:21
[2]  Willcockson HH, Chen Y, Han JE, Valtschanoff JG. Effect of genetic deletion of the vanilloid receptor TRPV1 on the expression of Substance P in sensory neurons of mice with adjuvant-induced arthritis. Neuropeptides. 2010; 44:293-7.
[3]  Chen Y*, Boettger K, Reif A, Schmitt A, Üceyler A, Sommer C. Inhibition of nitric oxide synthase modulates CFA-induced thermal hyperalgesia by cytokine regulation in mice. Mol Pain. 2010; 6:13.
[4]  Chen Y, Willcockson HH, Valtschanoff JG. Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain. Exp Neurol. 2009; 220:383-90.
[5]  Chen Y, Willcockson HH, Valtschanoff JG. Vanilloid receptor TRPV1–mediated phosphorylation of ERK in murine adjuvant arthritis. Osteoarthr Cartilage. 2009; 17:244-51.
[6]  Chen Y*, Sommer C. The role of mitogen-activated protein kinase (MAPK) in morphine tolerance and dependence. Mol Neurobiol. 2009, 40:101-7.
[7]  Chen Y, Willcockson HH, Valtschanoff JG. Increased expression of CGRP in sensory afferents of arthritic mice – effect of genetic deletion of the vanilloid receptor TRPV1. Neuropeptides. 2008; 42:551-6.
[8]  Chen Y*, Geis C, Sommer C. Activation of TRPV1 contributes to morphine tolerance: involvement of the MAPK signaling pathway. J Neurosci. 2008; 28:5836-45.
[9]  Palm F, Mössner R, Chen Y, He L, Gerlach M, Bischofs S, Riederer P, Lesch KP, Sommer C. Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter. Eur J Pain. 2008; 12:790-7.
[10]  Boettger MK, Uceyler N, Zelenka M, Schmitt A, Reif A, Chen Y, Sommer C. Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice. Eur J Pain. 2007; 11:810-8.
[11]  Chen Y*, Sommer C. Activation of the nociceptin opioid system in rat sensory neurons produces antinociceptive effects in inflammatory pain: involvement of inflammatory mediators. J Neurosci Res. 2007; 85:1478-88.
[12]  Chen Y*, Sommer C. Nociceptin and its receptor in rat dorsal root ganglion neurons in neuropathic and inflammatory pain models: implications on pain processing. J Peripher Nerv Syst. 2006; 11:232-40.
[13]  Yang Q, Chen Y, Fu CY, Chang M, Peng YL, Wang R. Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1-13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus. Protein Pept Lett. 2006; 13:185-8.
[14]  Chen Y, Chang M, Wang R. Progress in the studies of nociceptin related peptides. Prog Biochem Biophy. 2004; 31:106-11.
[15]  Chen LX, Fang Q, Chen, Q, Guo J, Wang, ZZ, Chen Y, Wang R. Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3. Peptides. 2004; 25:1349-54.
[16]  Chen LX, Chen Y, Peng YL, Wang ZZ, Chen Q, Wang R. Effects of nocistatin or nocistatin (10~17) on nociceptin in antagonizing endomorphin-1 and endomorphin-2 analgesia in mice. Acta Pharm Sin. 2002; 37: 837-40.
[17]  Chen Y, Chang M, Wang ZZ, Chen LX, Yang Q, Qi YM, Wang R. [Nphe1]nociceptin(1-13)NH2 antagonizes nociceptin-induced hypotension, bradycardia and hindquarters vasodilation in the anesthetized rat. Can J Physiol Pharmacol. 2002; 80:31-5.
[18]  Chen LX, Wang ZZ, Wu H, Fang Q, Chen Y, Wang R. Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice. Neurosci Lett. 2002; 331:95-8.
[19]  Chen Q, Chen Y, Chen LX, Yang DJ, Dong SL, Wang R. The effects of the synthetic nocistatin on blood vessel activities. Chin Sci Bull. 2001; 46:675-8.
[20]  Chen Y, Chen LX, Chen Q, Yang DJ, Peng YL, Yang Q, Wang R. Reversal by nocistatin of the effect of nociceptin in antagonizing morphine analgesia in mice. Chin Pharmacol Bull. 2001; 17:383-5.
[21]  Wang R, Dong SL, Chen Q, Chen Y, Wang T. Synthesis and opioid activity of [Tyr1]NC(1-13)NH2. Peptides. Jean Martinez and Jean Fehrentz (Eds.) EDK, Paris, France. 2001; 773-4.
[22]  Wang R, Dong SL, Wang T, Chen Y, Wang XL. Synthesis, structure-activity relationship of nociceptin and its fragments. J Peptide Sci. 2000; 6: s18.