Journal of Health Science

Journal of Health Sciences is a peer-reviewed journal that disseminates information, scholarship and experience in education, practice and investigation between medicine, nursing and all the sciences involved in health care. Aim of journal is to supply scientists of health with resources in order to provide the scientific knowledge, intellection and research and especially to improve health status and qualification of care for individuals, families and communities.

Jin-Rong Zhou

Editor-in-Chief of Journal of Health Science

Associate Professor, Harvard Medical School, Beth Israel Deaconess Medical Center, USA

Research Areas

Cancer Prevention, Metabolic Syndrome, Nutrition, Bioactive Components, Complementary and Alternative Medicine, Nutraceuticals, Dietary Supplement, Cancer Stem Cell


1994Ph.DNutritional Sciences, University of Illinois, Urbana, IL, USA
1987M.S.Environmental Sciences, Nanjing University, Nanjing, China
1984B.S.Chemistry, Nanjing University, Nanjing, China


1998-present "Director, Nutrition/Metabolism Laboratory, Beth Israel Deaconess Medical Center
2010-presentAssociate Professor Surgery (Nutrition) Harvard Medical School
2000-2010Assistant Professor Surgery (Nutrition), Harvard Medical School
1996-1999Instructor, Surgery (Nutrition) Harvard Medical School
1987-1989 Instructor, Science and Nanjing University of Traditional, Technology Chinese Medicine, Nanjing, China

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Zhang, Z, Zhou J. A method for the determination of copper in superoxide dismutase by anodic stripping voltammetry. J Nanjing Univ (Natural Sciences Edition) 1988;24:713-716.
[2]  Zhou J, Chen X-Y. Study of the relationship between trace element vanadium and cardiovascular diseases. J Nanjing Univ (Trace Element Special) 1990;20-27.
[3]  Zhou J, Chen X-Y. Study of catalytic spectrophotometric analysis of vanadium in human hair. J Nanjing Univ (Trace Element Special) 1990;1-6.
[4]  Zhou J-R, Fordyce EJ, Raboy V, Dickinson DB, Song M-S, Burns RA, Erdman JW Jr. Reduction of phytic acid in soybean products improves zinc bioavailability in rats. J Nutr 1992;122:2466-2473.
[5]  Zhou J-R, Canar MM, Erdman JW Jr. Bone zinc is poorly released in young, growing rats fed marginal zinc restricted diet. J Nutr 1993;123:1383-1388.
[6]  Zhou J-R, Erdman JW Jr. Phytic acid: Nutritional and biochemical implications. Newsletter, The University of Illinois Functional Foods for Health Program 1993;1(1):8-13.
[7]  Zhou J-R, Gugger ET, Erdman JW Jr. Isolation and partial characterization of an 18 kDa carotenoid-protein complex from carrot roots. J Agri Food Chem 1994;42:2386-2390.
[8]  Zhou J-R, Erdman JW Jr. Phytic acid in health and disease. Crit Rev Food Sci Nutr 1995;35(6):495-508.
[9]  Zhou J-R, Gugger ET, Erdman JW Jr. The crystalline form of carotenes and the food matrix in carrot root decrease the bioavailability of beta-and alpha-carotene in the ferret model. J Am Coll Nutr 1996;15(1):84-91.
[10]  Zhou J-R, Blackburn GL. Bridging animal and human studies: What are the missing segments in dietary fat and prostate cancer? Am J Clin Nutr 1997;66:1572S-1580S.
[11]  Zhou J-R, Erdman JW Jr. Chemical effects of processing and food preparation on carotenoids and soy and garlic phytochemicals. In: Lachance PA, editor. Nutraeuticals: Designer Food III. Trumbull; Food and Nutrition Press Inc.; 1997. p 23-37.
[12]  Zhou J-R, Blackburn GL. Dietary lipid modulation of immune response in tumorigenesis. In: Heber D, Blackburn GL, Go VLW, editors. Nutritional Oncology. San Diego: Academic Press Inc.; 1998. p. 195-213.
[13]  Zhou J-R, Mukherjee P, Gugger ET, Tanaka T, Blackburn GL, Clinton SK. The inhibition of murine bladder tumorigenesis by soy isoflavones in association with changes in cell cycle control, apoptosis, and angiogenesis. Cancer Res 1998;58:5231-5238.
[14]  Mukherjee P, Sotnikov AV, Mangian HJ, Zhou J-R, Visek WJ, Clinton SK. Energy intake and prostate tumor growth, angiogenesis, and vascular endothelial growth factor expression. J Natl Cancer Inst 1999;91:512-523.
[15]  Mukherjee P, Zhou J-R, Sotnikov A, Clinton SK. Dietary and nutritional modulation of tumor angiogenesis. In: Teicher BA, editor. Antiangiogenic Agents in Cancer Therapy. Totowa: Humana Press Inc.; 1999. p.237-262.
[16]  Zhou J-R, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 1999;129:1628-1635.
[17]  Williams AW, Boileau TW-M, Zhou J-R, Clinton SK, Erdman JW Jr. Beta-carotene modulates human prostate cancer cell growth and may undergo intracellular metabolism to retinol. J Nutr 2000;130:728-732.
[18]  Jones JL, Daley BJ, Enderson BL, Zhou J-R, Karlstad MD. Genistein inhibits tamoxifen effects on cell proliferation and cell cycle arrest in T47D breast cancer cells. Am Surg 2002;68(6):575-577.
[19]  Zhou J-R, Yu L, Zhong Y, Nassr RL, Franke AA, Gaston SM, Blackburn GL. Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean components. Prostate 2002;53:143-153.
[20]  Zhou J-R, Yu L, Zhong Y, Blackburn GL. Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice. J Nutr 2003;133:516-521.
[21]  Yu L, Blackburn GL, Zhou J-R. Genistein and daidzein down-regulate androgen-regulated transcript-1 (PART-1) gene expression induced by 5a-dihydrotestosterone in human prostate LNCaP cancer cells. J Nutr 2003;133:389-392.
[22]  Zhou J-R, Yu L, Mai Z, Blackburn GL. Combined inhibition of estrogen-dependent human breast carcinoma by soy and tea bioactive components in mice. Int J Cancer 204;108:8-14.
[23]  Zhou J-R, Yu L, Zerbini L, Libermann TA, Blackburn GL. Progression to androgen-independent LNCaP human prostate tumors: Cellular and molecular alterations. Int J Cancer 2004;110:800-806.
[24]  Zerbini L, Wang Y, Czibere A, Correa R, Cho J-Y, Ijiri K, Wei W, Joseph M, Gu X, Grall F, Goldring M, Zhou J-R, Libermann T. NF-kappaB mediated repression of GADD45 alpha and gamma is essential for cancer cell survival. Proc Natl Acad Sci USA 2004;101:13618-13623.
[25]  Zhou J-R, Erdman JW Jr. Soy consumption and cancer prevention: a critical review. In: Bendich A, Deckelbaum R, editors. Preventive Nutrition (3rd Edition). Totowa: Humana Press Inc.; 2004. p. 123-155.
[26]  Zhou J-R. Soy and the prevention of lifestyle-related disease. Clin Exp Pharmacol Physiol 2004;31(Suppl 2):S14-S19.
[27]  Zhou J-R. Flavonoids as inhibitors of tumor metastasis. In: Awad AB, Bradford PG, editors. Nutrition and Cancer Prevention. Marcel Dekker Inc.; 2005. p. 325-349.
[28]  Zhou J-R. Soy-food and soy-drug interactions in prevention and treatment of cancer. In: Thompson LU, Ward WE, editors. Food Drug Synergy and Safety. CRC Press; 2005. p. 125-146.
[29]  Singh AV, Franke AA, Blackburn GL, Zhou J-R. Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer by alteration of cancer cell apoptosis and tumor angiogenesis in a mouse model. Cancer Res 2006;66(3):1851-1858.
[30]  Zerbini LF, Czibere A, Wang Y, Correa RG, Out H, Joseph M, Takayasu Y, Silver M, Gu X, Ruchusatsawat K, Li L, Sarkar D, Zhou J-R, Fisher PB, Libermann TA. A novel pathway involving melanoma differentiation associated gene-7/IL-24 mediates nonsteroidal anti-inflammatory drug-induced apoptosis and growth arrest of cancer cells. Cancer Res 2006;66:11922-11931.
[31]  Zhou J-R. Animal models in nutritional oncology. In: Heber D, Blackburn GL, Go VLW, Milner J, editors. Nutritional Oncology (2nd Edition). San Diego: Academic Press Inc.; 2006. p. 333-347.
[32]  Zhou J-R, Blackburn GL, Walker WA. Symposium introduction: Metabolic syndrome and the onset of cancer. Am J Clin Nutr 2007;86:817S-819S.
[33]  Mai Z, Blackburn GL, Zhou J-R. Genistein synergistically increases inhibitory effect of tamoxifen on the growth of HER2-overexpressing human breast cancer cells. Mol Carcinogenesis 2007;46:534-542.
[34]  Mai Z, Blackburn GL, Zhou J-R. Soy phytochemicals synergistically enhance the inhibitory effect of tamoxifen on the growth of estrogen-dependent MCF-7 human breast tumors in mice. Carcinogenesis 2007;28:1217-1223.
[35]  Welty FK, Lee SK, Lew NS, Nasca M, Zhou J-R. The association between soy nut consumption and decreased menopausal symptoms. J Women's Health 2007;16:361-369.
[36]  Jiang R-W, Zhou J-R, Hon P-M, Li S-L, Zhou Y, Li L, Ye W-C, Zu H-X, Shaw P-C, But PP-H. Lignans from Dysosma versipellis with inhibitory effects on prostate cancer cell lines. J Nat Prod 2007;70:283-286.
[37]  Pan W, Blackburn GL, Zhou J-R. Effects of a daidzein-rich isoflavone aglycone extract on diet-induced obesity in an ovariectomized mouse model. Clin Exp Pharmacol Physiol 2007;34:S55-S57.
[38]  Zhou J-R, Li L, Pan W. Dietary soy and tea combinations for prevention of breast and prostate cancers by targeting on metabolic syndrome elements in mice. Am J Clin Nutr 2007;86:882S-888S.
[39]  Welty FK, Lee KS, Lew NS, Zhou J-R. Effect of soy nuts on blood pressure and lipid levels in hypertensive, prehypertensive, and normotensive postmenopausal women. Arch Intern Med 2007;167:1060-1067.
[40]  Beresneva JV, Kireev GV, Gildieva MS, Abduvaliev AA, Jusupova AA, Kuznetsova NN, Ibragimov FA, Bokov AF, Zhou J-R. Antineoplastic activity of sp-2 soy protein at experimental carcinogenesis on transplanted Melanoma B-16 tumor culture. Theoretical and Clinical Medicine (Russian journal) 2007;3:17-23.
[41]  Beresneva JV, Kireev GV, Gildieva MS, Abduvaliev AA, Jusupova AA, Ibragimov FA, Bokov AF, Zhou J-R. Antineoplastic activity of sp-2 soy protein at experimental carcinogenesis on transplanted tumor culture of adenocarcinoma of large intestines (AKATOL). Theoretical and Clinical Medicine (Russian journal) 2007;4:32-37.
[42]  Khaodhiar L, Ricciotti HA, Li L, Pan W, Schickel M, Zhou J-R, Blackburn GL. Daidzein-rich isoflavone aglycones for the treatment of hot flashes in menopausal women. Menopause 2008;15:125-134.
[43]  Nasca MM, Zhou J-R, Welty FK. Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women. Am J Cardiol 2008;102:84-86.
[44]  Abdolmaleky HM, Zhou J-R, Thiagalingam S, Smith CL. Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics. Pharmacogenomics 2008;9:1809-1823.
[45]  Abdolmaleky HM, Smith CL, Zhou J-R, Thiagalingam S. Epigenetic modulation of reelin function in schizophrenia and bipolar disorder. In: Fatemi SH, editor. Reelin Glycoprotein Biology, Structure and Roles in Health and Disease. Springer; 2008. p. 366-384.
[46]  Abdolmaleky HM, Smith CL, Zhou J-R, Thiagalingam S. Epigenetic alterations of the dopaminergic system in major psychiatric disorders. Pharmacogenomics in drug discovery and development. In: Walker J, Yan W, editors. Methods in Molecular Biology. Totowa: Humana Press Inc.; 2008;448:187-212.
[47]  Hagen S, Ohtani M, Zhou J-R, Taylor NS, Rickman B, Blackburn GL, Fox JG. Dietary glutamine reduces inflammation and foveolar hyperplasia during Helicobacter pylori infection in the mouse stomach. J Nutrition 2009;139:1-7.
[48]  Feng J-F, Wu J-Z, Hu S-N, Gao C-M, Shi M-Q, Lu Z-H, Sun X-C, Zhou J-R, Chen B-A. Polymorphisms of the ribonucleotide reductase MI gene and sensitivity to platin-based chemotherapy in non-small cell lung cancer. Lung Cancer 2009; 66:344-349 (in press). PMID: 19304340.
[49]  Li M, Jiang R-W, Hon P-M, Cheng L, Li L-L, Zhou J-R, Shaw P-C, But P-H. Authentication of the anti-tumor herb Baihuasheshecao with bioactive marker compounds and molecular sequences. Food Chem 2010; 119:1239-124509 (in press). doi: 10.1016/j.foodchem.2009.09.013.
[50]  Mai Z, Zhou J-R. Identification of genes responsible for synergistic effects between genistein and tamoxifen on the growth of HER-2-overexpressing human breast cancer cells by cDNA microarray and RNA-interference techniques. Front Biosci (in press).
[51]  Singh AV, Li L, Out HH, Kaplan H, Libermann T, Zhou J-R. Gene expression profiling of responses to sulforaphane in human bladder cancer cells by cDNA microarray assay. Front Biosci (in press).
[52]  P. Papageorgis, K. Cheng, S. Ozturk, Y. Gong, A.W. Lambert, H.M. Abdolmaleky, J.-R. Zhou, S. Thiagalingam. Smad4 inactivation promotes malignancy and drug resistance of colon cancer. Cancer Res. 71(3):998-1008, 2011.
[53]  Abdolmaleky HM, Zhou J-R. Dietary and environmental influences on the genomic and epigenomic code in cancer. In: Thiagalingam S, editor. Systems Biology of Cancer. Cambridge University Press; (in press).
[54]  Y. Gong, Y. Li, Y. Lu, L. Li, H. M. Abdolmaleky, G.L. Blackburn, J.-R. Zhou: Bioactive tanshinones in Salvia Miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice. Int. J. Cancer, 129:1042-52, 2011.
[55]  JM Nagel, M Brinkoetter, F Magkos, X Liu, JP Chamberland, S Shah, J Zhou, G Blackburn, C Mantzoros. Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition. In press, PMID: 21795022, 2011.
[56]  LF Zerbini, JF de Vasconcellos, A Czibere, Y Wang, JD Paccez, X Gu, J Zhou, TA Libermann: JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer. Cell Cycle, 10:1-9, 2011.
[57]  LF Zerbini, RE Tamura, RG Correa, A Czibere, J Cordeiro, F Simabuco, Y Wang, X Gu, L Li, D Sarkar, J Zhou, PB Fisher, TA Libermann: Combinatorial effect of Non-Steroidal Anti-inflammatory Drugs and NF-kB inhibitors in ovarian cancer therapy. In press, PLoS ONE.