Basic Sciences of Medicine

Basic Sciences of Medicine is a peer reviewed international basic medical sciences journal, which is aimed to promote research and information in basic medical sciences. It can improve health, health care and health education, internationally by elevating the quality of medical care, disease prevention, and research.

Hai Zhang

Post-doctoral Fellow, Stanford University, USA

Research Areas

Cancer, Diabetes, Obesity, Transcription regulation, Aging, Neuroendocrinology

Publications: Journals

[1]  Yan J*, Zhang H*, Yin Y, Li J, Tang Y, Purkayastha S, Li L, Cai D.Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response.Nat Med.2014 Aug 3.doi: 10.1038/nm.3616. *Co-first authors
[2]  Zhang H*, Wu C*, Chen Q, Xu Z, Wu J, Cai D.Treatment of Obesity and Diabetes Using Oxytocin or Analogs in Patients and Mouse Models.PLoS ONE.2013 May 20; 8(5):e61477.*Co-first authors.
[3]  Zhang G*, Li J*, Purkayastha S*, Tang Y*, Zhang H*, Yin Y, Li B, Liu G, Cai D.Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH.Nature.2013 May 9;497(7448):211-6.*Co-first authors.
[4]  He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS.Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals.Mol Cell Biol.2012 May;32(10):1867-78.
[5]  Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D.Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation.PLoS Biol.2011 Jul;9(7)
[6]  Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, Guariglia S, Meng Q, Cai D.Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance.Neuron.2011 Feb 10;69(3):523-35.
[7]  Purkayastha S, Zhang H, Zhang G, Ahmed Z, Wang Y, Cai D.Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress.Proc Natl Acad Sci U S A.2011 Feb 15;108(7):2939-44.
[8]  Zhang X*, Zhang G*, Zhang H*, Karin M, Bai H, Cai D.Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.Cell.2008 Oct 3;135(1):61-73.*Co-first authors.
[9]  Huang J, Gan Q, Han L, Li J, Zhang H, Sun Y, Zhang Z, Tong T.SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts.PLoS One.2008 Mar 5;3(3)
[10]  Sun YC, Li Y, Zhang H, Yan HQ, Dowling DN, Wang YP.Reconstitution of the enzyme AroA and its glyphosate tolerance by fragment complementation.FEBS Lett.2006 Feb 20;580(5):1521-7.