Basic Sciences of Medicine

Basic Sciences of Medicine is a peer reviewed international basic medical sciences journal, which is aimed to promote research and information in basic medical sciences. It can improve health, health care and health education, internationally by elevating the quality of medical care, disease prevention, and research.

Mengyao Jin

Post-doctoral Fellow, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, USA

Research Areas

Inflammation, atherosclerosis, drug-drug interaction, metabolism and obesity, substance abuse, HIV and AIDS, oxidative stress and cell signaling cascades

Education

2008-2012Ph.D.University of Missouri-Kansas City
2004-2008B.S.Soochow University

Publications: Journals

[1]  Jin, M., Ande, A., Kumar, A., and Kumar, S., Ethanol mediated regulation of cytochrome P450 2E1: Role of oxidative stress-mediated PKC/JNK/SP1 pathway, Cell Death and Disease. 2013;4: e554. (Impact factor: 5.33)
[2]  Jin, M., Kumar, A., and Kumar, S., Ethanol mediated induction of cytochrome P450 2A6: Role of oxidative stress-mediated PKC/Erk-Nrf2 pathway, PLoS ONE. 7, e35505, 2012. (Impact factor: 4.09)
[3]  Jin, M., Earla, R. Shah, A., Earla, R.L., Gupte, R., Mitra, A. K., Kumar, A., and Kumar, S., A LC-MS/MS method for concurrent determination of CYP2A6-mediated nicotine metabolites and analysis of nicotine-mediated oxidative stress in U937 macrophages, J. NeuroImmune Pharmacol., 7,289-299, 2012. (Impact factor: 3.53)
[4]  Jin, M., Arya, P. Patel, K., Singh, B., Silverstein, P., Bhat, H., Kumar, A., and Kumar, S., Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages, Alcohol Clin. Exp. Res., 35, 1-8, 2011. (Impact factor: 3.34)
[5]  Ande, A., Earla, R., Jin M., Silverstein, P.S., Mitra, A.L., Kumar, A., and Kumar S., An LC-MS/MS Method for Concurrent Determination of Nicotine Metabolites and the Role of CYP2A6 in Nicotine Metabolite-mediated Oxidative Stress in SVGA Astrocytes, Drug and Alcohol dependence. 125, 49-59, 2012. (Impact factor: 3.38)
[6]  Kumar, S., Earla, R., Jin, M., Mitra, A. K., and Kumar, A., Effect of ethanol on spectral binding, inhibition, and activity of CYP3A4 with an antiretroviral drug nelfinavir, Biochem. Biophys. Res. Commun., 402, 163-167, 2010. (Impact factor: 2.48)
[7]  Kumar S., Jin M., A need for the improvement of cytochrome P450 based transgenic plants for bioremediation. Petrol. Envir. Biotechnol. 3, 1-5, 2012. (Impact factor: 3.14*)
[8]  Kumar S., Jin M., Ande A., Silverstein P.S., Kumar A. Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: Role of cytochrome P450 isozymes. Expert Opinion on Drug Metabolism and Toxicology. 8, 1363-1375, 2012. (Impact factor: 3.12)
[9]  Liu, C., Jin, M., Zhang X., Studies on Preparation of Diclofenac Sodium Silk Fibroin-Chitosan Sustained-Release Microsphere and Its Characteristics in Vivo and in Vitro. Chinese Pharmaceutical Journal. 21, 1642-1647, 2009.
[10]  Zhang, Y, Jin, M., Zhu, J., Lu, Z., Zhang G., A clinical comparative study of venlafaxine and fluxetine in treatment of obsessive-compulsive disorder. Journal of Clinical Psychological Medicine. 4, 2008.

Publications: Conferences/Workshops/Symposiums

[1]  Jin, M., Kumar, A., and Kumar, S.. CYP2E1-mediated alcohol metabolism induces expressions of CYP2A6 and CYP2E1 through oxidative stress-induced PKC signaling cascades in monocytes and astrocytes. 18th SNIP Conference, Honolulu, HI, April 25-28, 2012
[2]  Jin, M., Earla, R. Shah, A., Rajya L. Earla, Gupte, R., Mitra, A. K., Kumar, A., and Kumar, S., A LC-MS/MS method for concurrent determination of CYP2A6-mediated nicotine metabolites and analysis of nicotine-mediated oxidative stress in U937 macrophages, American Society of Mass Spectrometry, Denver, CO, June 5-9, 2011
[3]  Jin, M., Earla, R., Shah, A., Gupte, R., Mitra, A.K., Kumar, A., and Kumar, S., The role of cytochrome P450 on alcohol/nicotine-mediated oxidative stress in U937 macrophages,17th SNIP Conference, Clearwater Beach, FL, April 6-10, 2011.
[4]  Jin, M., Silverstein, P., Kumar, A., Kumar, S., Cytochrome P450-mediated drug interactions and adverse effects, International Conference on Integrative & Personalized Medicine and 42nd Annual Conference of Indian Pharmacological Society, Kolkata, India, 2009.