International Journal of Stroke Research

International Journal of Stroke Research concentrates on the clinical aspects of stroke with basic science contributions in areas of clinical interest. Reviews of current topics are broadly based to encompass not only recent advances of global interest but also those which may be more significant in certain regions and the journal regularly features items of news interest from all parts of the world.

Claire Gibson

Editorial Board Member of International Journal of Stroke Research

Lecturer, University of Leicester, UK

Research Areas

Cerebral Ischemia, Neuroprotection, Basic Stroke Research (In Vivo and In Vitro Models), Translational Stroke Research, Steroid Hormones and Neuroprotection, Cognitive Ageing.

Education

2000Ph.DPhD, University of Newcastle upon Tyne
1996B.ScBSc, Neuroscience, University of Sheffield

Experience

2005-presentLecturer in Behavioural Neuroscience, School of Psychology, University of Leicester, September
2001-2005Research Fellow, Institute of Neuroscience, University of Nottingham
1999-2001Research Associate, Developmental Neuroscience Group, University of Newcastle

Academic Achievement

2011 Nuffield Foundation Undergraduate Bursary
2011 Wellcome Trust Vacation Scholarship
2010-13 College PhD Studentship (joint with Cell Physiology & Pharmacology)
2008-09 New Investigator Award, Research Into Ageing
2005 Value In People Award, Wellcome Trust

Membership

Ms Asha Akram (PhD student, joint with Cell Physiology & Pharmacology)
Ms Melissa Trotman (PhD student, joint with Cell Physiology & Pharmacology)
Mr Raymond Wong (visiting PhD student)

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Gibson CL, Coomber B, Murphy SP (2011) Progesterone is neuroprotective following cerebral ischemia in reproductively ageing female mice. Brain 134: 2125-2133.
[2]  Davidson C, Coomber B, Gibson CL, Young AMJ (2011) Effect of pre-ischaemic conditioning on hypoxic depolarization of dopamine efflux in the rat caudate brain slice measured in real-time with fast cyclic voltammetry. Neurochemistry International (In Press).
[3]  Davidson C, Prados J, Gibson CL, Young AMJ, Barnes D, Sherlock R, Hutchinson CV (2011) Shedding light on photosensitive behaviour in brown planaria (Dugesia Tigrina). Perception (In Press).
[4]  Davidson C, Chauhan NK, Knight S, Gibson CL, Young AMJ (2011) Modelling ischaemia in vitro: effects of temperature and glucose concentration on dopamine release evoked by oxygen and glucose depletion in a mouse brain slice model of ischaemic brain damage. Journal of Neuroscience Methods (In Press).
[5]  Coomber B, Gibson CL (2010) Sustained levels of progesterone prior to the onset of cerebral ischemia are not beneficial to female mice. Brain Research 1361: 124-132.
[6]  Gibson CL, Murphy SP (2010) Benefits of histone deacetylase inhibitors for acute brain injury: a systematic review of animal studies. Journal of Neurochemistry 115: 806-813.
[7]  Gibson CL, Bath PMW, Murphy SP (2010) G-CSF administration is neuroprotective following transient cerebral ischemia even in the absence of a functional NOS-2 gene. Journal of Cerebral Blood Flow and Metabolism, 30: 739-743.
[8]  England TJ, Gibson CL, Bath PMW (2009) Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review. Brain Research Reviews, 62: 71-82.
[9]  Gibson CL, Coomber B, Rathbone J (2009) Is progesterone a candidate neuroprotective treatment following ischemic stroke? The Neuroscientist, 15:324-332.
[10]  Coughlan T, Gibson C, Murphy S (2009) Progesterone, BDNF and neuroprotection in the injured CNS. International Journal of Neuroscience, 119: 1718-1740.
[11]  Gibson CL, Gray LJ, Bath PMW, Murphy SP (2008) Progesterone for the treatment of experimental brain injury: a systematic review. Brain, 131: 318-328
[12]  Murphy S & Gibson CL (2007) Nitric oxide, ischaemia and brain inflammation. Biochemical Society Transactions, 35, 1133-1137.
[13]  Sun Y, Alexander SPH, Garle MJ, Gibson CL, Hewitt K, Murphy SP, Kendall DA & Bennett AJ (2007) Cannabinoid activation of PPARalpha; a novel neuroprotective mechanism. British Journal of Pharmacology, 152, 734-743.
[14]  Gibson, CL, Gray, L, Murphy, SP, Bath, PMW (2006) Estrogen for experimental ischemic stroke; a systematic review. J Cereb Blood Flow Metab. 26: 1103-1113.
[15]  Gibson, CL, Jones, NC, Prior, MJW, Bath, PMW & Murphy SP (2005) G-CSF suppresses edema formation and reduced interleukin-1 beta expression following cerebral ischemia in mice. J Neuropath Exp Neurol. 64: 763-769.
[16]  Gibson, CL, Constantin, DC, Prior, MJW, Bath, PMW & Murphy SP (2005) Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp Neurol. 193: 522-530.
[17]  Gibson, CL, Coughlan, TC, & Murphy, SP (2005) Glial Nitric Oxide and Ischemia. Glia 50: 417-426 (Invited review).
[18]  Gibson, CL, Bath, PMW & Murphy, SP (2005) G-CSF promotes functional recovery following middle cerebral artery occlusion in male mice. J Cereb Blood Flow Metab 25: 431-439.
[19]  Coughlan, T, Gibson, CL & Murphy, SP (2005) Modulatory effects of progesterone on NOS-2 expression in vivo and in vitro. J. Neurochem. 93: 932-942.
[20]  Willmot, M, Gibson, CL, Gray, L, Murphy, SP, Bath, PMW (2005) Nitric oxide synthase inhibitors in experimental stroke and their effects on infarct size and cerebral blood flow; a systematic review. Free Radical Biology and Medicine. 39: 412-435.
[21]  Willmot, M, Gray, L, Gibson, CL, Murphy, SP & Bath, PMW (2005) Systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow. Nitric Oxide 12: 141-149.
[22]  Gibson, CL & Murphy, SP (2004) Progesterone enhances functional recovery following middle cerebral artery occlusion in male mice. J Cereb Blood Flow Metab 24 (7): 805-813.
[23]  Jones, NC, Constantin, DC, Gibson, CL, Prior, MJ, Morris, PG, Marsden, CA & Murphy, SP (2004) A detrimental role for nitric oxide synthase-2 in the pathology resulting from acute cerebral injury. J Neuropath Exp Neurol. 63(7): 708-720.
[24]  Clowry, GJ, Davies, BM, Upile, NS, Gibson, CL & Bradley, PM (2004) Spinal cord plasticity in response to unilateral inhibition of the rat motor cortex during development: changes to gene expression, muscle afferents and the ipsilateral corticospinal projection. Eur J Neurosci 20:2555-2566.
[25]  Gibson, CL & Clowry, GJ (2003) The effect on motor cortical neuronal development of focal lesions to the sub-cortical white matter in the neonatal rat. Int J Dev Neurosci 21(4): 171-182.
[26]  Gibson, CL & Clowry, GJ (2001) N-methyl-D-aspartate receptor blockade during development induces short-term but not long-term changes in cJun and parvalbumin expression in the rat cervical spinal cord. Exp Neurol, 170(2): 380-384.
[27]  Gibson, CL, Arnott, GA, & Clowry, GJ (2000) Plasticity in the rat spinal cord seen in response to lesions to the motor cortex during development but not to lesions in maturity. Exp Neurol 166: 422-434.
[28]  Gibson, CL & Clowry, GJ (1999) Transient expression of calcitonin gene-related peptide immunoreactivity in the ventral horn of the post-natal rat cervical spinal cord. Dev Brain Res 155: 93-96.
[29]  Gibson, CL & Clowry, GJ (1999) Retraction of muscle afferents from the rat ventral horn during development. Neuroreport 10: 231-235.