Research In Cancer and Tumor

International Journal of Cancer and Tumor is a peer-reviewed international journal which provides a forum for prompt communication of original and innovative research findings that have relevance to understanding the etiology of cancer and to improving the treatment and survival of patients.

Valdemar Máximo

Editorial Board Member of Research In Cancer and Tumor

Associate Professor, Institute of Molecular Pathology and Immunology of the University of Porto, Portugal

Research Areas



1997-2001Ph.DFaculty of Medicine, University of Porto, Portugal & Pathologisches Institut, Ludwig-Maximilians Universitat, Munich, Germany
1995-1997M.ScFaculty of Science and Technology, University of Coimbra, Portugal
1990-1994Degree in BiologyFaculty of Science and Technology, University of Coimbra, Portugal


2007-PresentSenior Researcher, Institute of Molecular Pathology and Immunology of the University of Porto&Invited Associated Professor-Faculty of Medicine, University of Porto, Portugal
2002-2006Post-Doc, Institute of Molecular Pathology and Immunology of the University of Porto

Publications: Journals

[1]  Máximo V, Sores P, Rocha AS, Sobrinho-Simões M. The common deletion of mitochondrial DNA is found in goiters and thyroid tumors with and without oxyphil cell change. Ultrastruct Pathol 1998;22:271-273.
[2]  Máximo V, Soares P, Seruca R, Sobrinho-Simões M. Comments on: mutations in mitochondrial control region DNA in gastric tumours of Japanese patients, Tamura, et al. Eur J Cancer 1999, 35, 316-319. Eur J Cancer 1999;35:1407-1408.
[3]  Manco L, Ribeiro ML, Máximo V, Almeida H, Costa A, Freitas O, Barbot J, Abade A, Tamagnini G. A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency. Br J Haematol 2000;110:993-997.
[4]  Máximo V, Soares P, Machado JC, Seruca R, Sobrinho-Simões M. Mitochondrial DNA alteration in gastric cancer. (Letter to the editor) Gastroenterology 2000;119:1808-1809.
[5]  Máximo V, Sobrinho-Simões M. Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance. Virchows Arch 2000;437:107-115.
[6]  Máximo V, Sobrinho-Simões M. Mitochondrial DNA ´common´ deletion in Hürthle cell lesions of the thyroid. (Letter to the editor) J Pathol 2000;192:561-562.
[7]  Rocha AS, Soares P, Seruca R, Máximo V, Matias-Guiu X, Cameselle-Teijeiro J, Sobrinho-Simões M. Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant. J Pathol 2001;194:358-366.
[8]  Máximo V, Soares P, Seruca R, Rocha AS, Castro P, Sobrinho-Simões M. Microsatellite Instability, Mitochondrial DNA Large Deletions, and Mitochondrial DNA Mutations in Gastric Carcinoma. Genes Chromosomes Cancer 2001;32:136-143.
[9]  Máximo V, Soares P, Cameselle-Teijeiro J, Sobrinho-Simões M. Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology. A study with emphasis in Hürthle cell tumours. Am J Pathol 2002;160:1857-1865.
[10]  Rocha AS, Soares P, Machado JC, Máximo V, Fonseca E, Franssila K, Sobrinho-Simões M. Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex. Virchows Arch 2002;440:498-504.
[11]  Lima J, Máximo V, Sobrinho-Simões M. Phenotype versus genotype in thyroid tumours. Histopathology 2002;41:184-187.
[12]  Lima J, Máximo V, Soares P, Sobrinho-Simões M. Alterations of the SDHD gene locus in midgut carcinoids. (Letter to the editor) Genes Chromosomes Cancer 2003;36:424.
[13]  Soares P, Trovisco V, Rocha AS, Lima J, Castro P, Preto A, Máximo V, Botelho T, Seruca R, Sobrinho-Simões M. BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene 2003;22:4578-4580.
[14]  Lima J, Teixeira-Gomes J, Soares P, Máximo V, Honavar M, Williams D, Sobrinho-Simões M. Germline SDHD mutation segregating with familial non-RET C-cell hyperplasia. J Clin Endocrinol Metab 2003;88:4932-4937.
[15]  Lima J, Máximo V, Soares P, Williams D, Bogdanova T, Thomas GA, Sobrinho-Simões M. Comment on: Differential mutation frequency in mitochondrial DNA from thyroid tumours. Carcinogenesis 2003;24:1155.
[16]  Soares P, Máximo V, Sobrinho-Simões M. Molecular pathology of papillary, follicular and Hürthle cell carcinomas of the thyroid. Arkh Patol 2003;65:45-47.
[17]  Trovisco V, Vieira De Castro I, Soares P, Máximo V, Silva P, Magalhães J, Abrosimov A, Guiu XM, Sobrinho-Simões M. BRAF mutations are associated with some histological types of papillary thyroid carcinoma. J Pathol 2004;202:247-251.
[18]  Máximo V, Preto A, Crespo A, Rocha AS, Machado JC, Soares P, Sobrinho-Simões M. Core I gene is overexpressed in Hürthle and non-Hürthle cell microfollicular adenomas and follicular carcinomas of the thyroid. BMC Cancer 2004;4:12
[19]  Sobrinho-Simões M, Máximo V, de Castro IV, Fonseca E, Soares P, Garcia-Rostan G, de Oliveira MC. Hürthle (oncocytic) cell tumours of thyroid: Etiopathogenesis, diagnosis and clinical significance. Int J Surg Pathol 2005;13:29-35
[20]  Lima J, Trovisco V, Soares P, Máximo V, Magalhães J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simões M. BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas. J Clin Endocrinol Metab 2004;89:4267-4271
[21]  Lima J, Trovisco V, Soares P, Máximo V, Magalhães J, Salvatore G, Santoro M, Bogdanova T, Tronko M, Abrosimov A, Jeremiah S, Thomas G, Williams D, Sobrinho-Simões M. Reply to: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas. Cancer Lett 2005;230:149-150.
[22]  Máximo V, Lima J, Soares P, Botelho T, Gomes L, Sobrinho-Simões M.Mitochondrial D-Loop instability in thyroid tumours is not a marker of malignancy. Mitochondrion 2005;5:333-340.
[23]  Trovisco V, Soares P, Preto A, de Castro IV, Lima J, Castro P, Máximo V, Botelho T, Moreira S, Meireles AM, Magalhaes J, Abrosimov A, Cameselle-Teijeiro J, Sobrinho-Simões M. Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients\' age but not with tumour aggressiveness. Virchows Arch 2005;446:589-595.
[24]  Sobrinho-Simões M, Preto A, Rocha AS, Castro P, Máximo V, Fonseca E, Soares P. Molecular pathology of well-differentiated thyroid carcinomas. Virchows Arch. 2005;447:787-793.
[25]  Máximo V, Botelho T, Capela J, Soares P, Lima J, Taveira A, Amaro T, Barbosa AP, Preto A, Harach HR, Williams D, Sobrinho-Simões M.Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. Br J Cancer 2005;92:1892-1898.
[26]  Sobrinho-Simões M, Máximo V. Warthin's tumour. Virchows Arch 2006;448:877-878
[27]  Trovisco V, Soares P, Preto A, Castro P, Máximo V, Sobrinho-Simões M. Molecular Genetics of Papillary Thyroid Carcinoma-Great Expectations… Arq Bras Endocrinol Metab 2007;51:643-653.
[28]  Meireles AM, Preto A, Rocha AS, Rebocho AP, Máximo V, Pereira-Castro I, Moreira S, Feijao T, Botelho T, Marques R, Trovisco V, Cirnes L, Alves C, Velho S, Soares P, Sobrinho-Simões M. Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines. Thyroid 2007;17:707-715.
[29]  Lima J, Feijao T, da Silva AF, Pereira-Castro I, Fernandez-Ballester G, Máximo V, Herrero A, Serrano L, Sobrinho-Simões M, Garcia-Rostan G. High Frequency of Germline Succinate Dehydrogenase Mutations in Sporadic Cervical Paragangliomas in Northern Spain: Mitochondrial Succinate Dehydrogenase Structure-Function Relationships and Clinical-Pathological Correlations. J Clin Endocrinol Metab 2007;92:4853-4864.
[30]  Máximo V, Lima J, Soares P, Silva A, Bento I, Sobrinho-Simões M. GRIM-19 in health and disease. Adv Anat Pathol 2008;15:46-53
[31]  Ferreira AC, Gomes L, Máximo V, Amil J, Carneiro F, Machado JC, Tavarela-Veloso F. GRIM-19 mutations are not associated with Crohn´s disease. Inflamm Bowel Dis 2008;14:434-435.
[32]  Bertagnolli AC, Soares P, van Asch B, Amorim A, Cirnes L, Máximo V, Cassali GD. An assessment of the clonality of the components of canine mixed mammary tumours by mitochondrial DNA analysis. Vet J. 2008 Aug 25. [Epub ahead of print].
[33]  Pereira L, Freitas F, Fernandes V, Pereira JB, Costa MD, Costa S, Máximo V, Macaulay V, Rocha R, Samuels DC. The diversity present in 5140 human mitochondrial genomes. Am J Hum Genet 2009;84:628-640.
[34]  Machado AM, Figueiredo C, Touati E, Máximo V, Sousa S, Michel V, Carneiro F, Nielsen FC, Seruca R, Rasmussen LJ. Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. Clin Cancer Res 2009;15:2995-3002.
[35]  Máximo V, Lima J, Soares P, Sobrinho-Simões M. Mitochondria and cancer. Virchows Arch 2009;454:481-495.
[36]  Couto JP, Prazeres H, Castro P, Lima J, Máximo V, Soares P, Sobrinho-Simões M. How molecular pathology is changing and will change the therapeutics of patients with follicular cell-derived thyroid cancer. J Clin Pathol 2009;62:414-421
[37]  Gonçalves AP, Videira A, Máximo V, Soares. Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death. J Biosci 2011;36:639-648
[38]  Gonçalves AP, Máximo V, Lima J, Singh KK, Soares P, Videira A. Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone. Biochim Biophys Acta 2011;1813:492-499
[39]  Moreira S, Correia M, Soares P, Máximo V. GRIM-19 function in cancer development. Mitochondrion 2011;11:693-699
[40]  Gonçalves AP, Videira A, Soares P, Máximo V. Orthovanadate-induced cell death in RET/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K/Akt/mTOR. Life Sci 2011;89:371-377.

Publications: Books/Book Chapters

[1]  Sobrinho-Simões M, Máximo V, Rocha AS, Trovisco V, Castro P, Preto A, Lima J, Soares P. Intragenic Mutations in Thyroid Cancer. In: Endocrinology Metabolism Clinics of North America 2008;37:333-362, viii.
[2]  Lima J, Máximo V, Soares P, Portugal R, Guimarães S, Sobrinho-Simões M. Mitochondria and Oncocytomas. In: Singh KK (ed) Mitochondria and Cancer 2009. Springer, New York
[3]  Máximo V, Soares P, Seruca R, David L, Carneiro F, Sobrinho-Simões M. A célula neoplásica. In: Azevedo C, Sunkel CE (ed) Biologia Celular e Molecular (5.ª Edição) 2011. LIDEL-Edições Técnicas Lda., Porto.