Research In Cancer and Tumor

International Journal of Cancer and Tumor is a peer-reviewed international journal which provides a forum for prompt communication of original and innovative research findings that have relevance to understanding the etiology of cancer and to improving the treatment and survival of patients.

Subrata Haldar

Editorial Board Member of Research In Cancer and Tumor

Associate Professor, MetroHealth Campus, Case Western Reserve University, Dept Pharmacology, Case Comprehensive Cancer Center, USA

Research Areas

Cancer Cell Signaling, Preclinical Experimental Therapeutics, Micrornas, Mouse Models of Human Cancer


1983Ph.DBiochemistry, University of Calcutta, India
1975M.ScBiochemistry, University of Calcutta, India
1973B.ScChemistry, University of Calcutta, India


2004-presentAssociate Professor, Department of Pharmacology, Case Western Reserve University, Cleveland, OH
1997-presentStaff Scientist, Center for Biomedical Sciences, Rammelkamp, Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland, OH
1997-2004Assistant Professor, Department of Pharmacology, Case Western Reserve University, Cleveland, OH
1997-presentMember, Regulation of Cell Death-Apoptosis and Autophagy Focus Group, Case Comprehensive Cancer Center, Cleveland, OH
2007-presentMember, Drug Discovery Focus Group, Case Comprehensive Cancer Center, Cleveland, OH.
1993-1997Instructor, Departnebt of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
1991-1992Post-Doctoral Research Fellow, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
1988-1991Post-Doctoral Research Fellow, Fels Institute for Cancer Research, Temple University, Philadelphia, PA
1988Post-Doctoral Research Fellow, The Wistar Institute, University of Pennsylvania, Philadelphia, PA
1985-1988Post-Doctoral Research Fellow, Department of Pathology, University of Pennsylvania, Philadelphia
1983-1985Research Associate, Department of Biochemistry, University of Calcutta, India

Academic Achievement

Special recognition from Ohio Cancer Research Associates for outstanding grant (2002)
CDF-5 Study Section, to review grant applications (02-1999 to 06/2000)
Invited by National Cancer Institute, Bethesda, MD, to review RFA grant applications (03/1995)
24-month Post-Doctoral Fellowship from Dept. of Environment, Govt. of India. (1983-1985)
48-month Pre-Doctoral Fellowship from Indian Council for Medical Research.(1979-1982)
Graduated with honors from University of Calcutta, India (1973)
Awarded National Scholarship from Dept. of Education, Government of India on the basis of Merit List (1969)


American Association for Cancer Research
Minorities in Cancer Research (MICR)

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Basu A, Jiang X, Negrini M and Haldar S. MicroRNA mediated regulation of pancreatic cancer cell proliferation. Oncology Letters 2010; 1:565-8.
[2]  Basu A and Haldar S. Antiproliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down modulation. Int J Oncol. 2009; 35(3):593-9.
[3]  Basu A and Haldar S. 2-Methoxyestradiol mediated signaling network in pancreatic cancer. Front Biosci. 2009; 14: 2170-78.
[4]  Basu A and Haldar S. Combinatorial Effect of Epigallocatechin-3-gallate and TRAIL on Pancreatic Cancer Cell Death. Int J Oncol. 2009; 34(1):281-6.
[5]  Basu A and Haldar S. Dietary isothiocyanate mediated apoptosis of human cancer cells is associated with Bcl-xL phosphorylation. Int J Oncol. 2008; 33(4):657-63.
[6]  Basu A, Castle VP, Bouziane M, Bhalla K and Haldar S. Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family. Cancer Res. 2006; 66(8):4309-18.
[7]  Basu A, DuBois G and Haldar S. Posttranslational modifications of Bcl2 family members--a potential therapeutic target for human malignancy. Front Biosci. 2006; 11:1508-21.
[8]  Qanungo S, Das M, Haldar S and Basu A. Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells. Carcinogenesis. 2005; 26(5):958-67.
[9]  Qanungo, S., Haldar, S. and Basu, A. Restoration of silenced Peutz-Jeghers syndrome gene, LKB1, induces apoptosis in pancreatic carcinoma cells. Neoplasia. 2003; 5(4):367-74.
[10]  Basu, A. and Haldar, S. Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol-or 2-methoxyestradiol-induced apoptosis. FEBS Lett. 2003;538(1-3):41-7.
[11]  Basu A and Haldar, S. Signal-induced site specific phosphorylation targets Bcl2 to the proteasome pathway. Int J Oncol. 2002; 21(3):597-601.
[12]  Qanungo S, Basu A, Das M and Haldar, S. 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells. Oncogene. 2002;21(26):4149-57.
[13]  Basu, A., Das, M., Qanungo, S., Fan, X-U, Dubois, G and Haldar, S. Proteasomal degradation of human peptidyl prolyl isomerase pin1-pointing phospho Bcl2 toward dephosphorylation. Neoplasia. 2002;4(3):218-27.
[14]  Wible, BA., Liming L., Kuryshev, Y., Basu, A., Haldar, S. and Brown AM. Increased K+ efflux and apoptosis induced by the potassium channel modulatory protein KChAP/PIAS3beta in prostate cancer cells. J Biol Chem. 2002; 277(20):17852-62.
[15]  Pathan, N, Aime-Sempe, C, Kitada, S, Basu, A., Haldar, S, and Reed, JC. Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1. Neoplasia. 2001; 3(6):550-9.
[16]  Basu, A., You, S-A and Haldar, S. Regulation of Bcl2 phosphorylation by stress response kinase pathway. Int J Oncol. 2000; 16(3):497-500.
[17]  Basu, A. and Haldar, S. The relationship between BcI2, Bax and p53: consequences for cell cycle progression and cell death. Mol Hum Reprod. 1998; 4(12):1099-109. Review.
[18]  You, S-A, Basu, A. and Haldar, S. Potent antitumor agent proteasome inhibitors: a novel trigger for Bcl2 phosphorylation to induce apoptosis. Int J Oncol. 1999; 15(4):625-8.
[19]  Basu, A. and Haldar, S. Microtubule-damaging drugs triggered bcl2 phosphorylation-requirement of phosphorylation on both serine-70 and serine-87 residues of bcl2 protein. Int J Oncol. 1998;13(4):659-64.
[20]  Haldar, S., Basu, A. and Croce, C.M. Serine-70 is one of the critical sites for drug-induced Bcl2 phosphorylation in cancer cells. Cancer Res. 1998;58(8):1609-15.
[21]  Carson, W., Fehniger, T.A., Haldar, S., Eckhert, K., Lindemann, M.J., Lai, C.F., Croce, C.M., Baumann H. and Caliguiri, M.A. A potential role for interleukin-15 in the regulation of human natural killer cell survival. J Clin Invest. 1997; 99(5):937-43.
[22]  Haldar, S., Basu, A. and Croce, C.M. Bcl2 is the guardian of microtubule integrity. Cancer Res. 1997; 57(2):229-33.
[23]  Haldar, S., Chintapalli, J. and Croce, C.M. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res. 1996;56(6):1253-5.
[24]  Haldar, S., Jena, N. and Croce, C.M. Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci USA. 1995; 92(10):4507-11..
[25]  Rinaudo MS, Su K, Falk LA, Haldar S and Mufson RA. Human Interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells. Blood 1995; 86(1): 80-8.
[26]  Haldar, S, Jena, N, Coss, RA, Sedar, AW, Waschsberger, PR, Beatty, C and Croce, CM. Cellular localization of the bcl-2 protein and response to glucocorticoid stress. Cell Death Differ. 1994; 1(2):109-15.
[27]  Carson, W, Haldar, S., Baiocchi, RA, Croce, CM and Caliguiri, M. The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2. Proc Natl Acad Sci USA. 1994; 91(16):7553-7.
[28]  Reed JC, Stein C, Subasinghe C, Haldar S., Croce CM, Yum S and Cohen J. Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides. Cancer Res.1990; 50(20):6565-70.
[29]  Haldar, S., Jena, N and Croce, CM. Anti-apoptosis potential of BCL2 oncogene by dephosphorylation. Biochemistry & Cell Biology 1994; 72: 455-61.
[30]  Haldar, S., Jena, N, Dubois, G, Reed, JC, Fu, S. and Croce, CM. Purification and characterization ofthe Bcl2 protein. Arch. Biochem. Biophys. 1994; 315: 483-8.
[31]  Haldar, S., Jena, N, Coss, RA, Sedar, AW, Waschsberger, PR, Beatty, C and Croce, CM Cellular localization of the Bcl2 protein and response to glucocorticoid stress. Cell Death & Differentiation 1994; 1: 109-115.
[32]  Haldar, S., Negrini, M, Monne, M, Sabbioni, S and Croce, CM. Down regulation of Bcl2 by p53 in breast cancer cells. Cancer Res. 1994; 54:2095-7.
[33]  Negrini, M, Sabbioni, S, Haldar, S., Possati, L, Costaggnoli, A, Corallini, A, Barbanti-Brodano, G and Croce, CM. Tumor and growth suppression of breast cancer cells by chromosome 17 associated functions. Cancer Res. 1994; 54:1818-24.
[34]  Alnemri, ES, Fernandes TF, Haldar, S., Croce, CM and Litwack, G Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias. Cancer Res. 1992; 52(2):491-5.
[35]  Reed JC, Cuddy M, Haldar S, Croce C, Nowell P, Makover D and Bradley K. BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense. Proc Natl Acad Sci USA. 1990; 87: 3660-4.
[36]  Reed JC, Stein C, Subasinghe C, Haldar S, Croce CM, Yum S and Cohen J. Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides. Cancer Res. 1990; 50:6565-70.
[37]  Reed JC, Haldar S, Croce CM and Cuddy MP. Complementation by BCL2 and C-HA-RAS oncogenes in malignant transformation of rat embryo fibroblasts. Mol Cell Biol. 1990;10:4370-4.
[38]  Haldar, S., Reed,J.C., Beatty,C. and Croce, C.M. Role of bcl-2 in growth factor triggered signal transduction. Cancer Res. 1990; 50, 7399-7401.
[39]  Reed, JC, Haldar, S, Cuddy, MP, Croce, CM and Makover, D. Deregulated Bcl2 expression enhances growth of a human B cell line. Oncogene 1989; 4:1123-7.
[40]  Monroe,J.G. and Haldar, S. Involvement of a specific guanine nucleotide binding protein in receptor immunoglobulin stimulated inositol phospholipid hydrolysis. Biochim.Biophys.Acta, 1989; 1013, 273-8.
[41]  Marino,T.A., Haldar, S., Williamson,E.C., Beaverson,K., Walter,R.A., Marino,D.R., Beatty,C., and Lipson,K.E. (1991) Proliferating cell nuclear antigen in developing and adult rat cardiac muscle cells. Circ Res 1990; 69, 1353-60.