Research In Cancer and Tumor

International Journal of Cancer and Tumor is a peer-reviewed international journal which provides a forum for prompt communication of original and innovative research findings that have relevance to understanding the etiology of cancer and to improving the treatment and survival of patients.

Ki-Hyuk Shin

Editorial Board Member of Research In Cancer and Tumor

Associate Professor, University of California Los Angeles, USA

Research Areas

Cancer and Aging Biology

Education

1995Ph.DUniversity of California, Los Angeles
1992M.ScUniversity of California, Los Angeles
1990B.ScKorea University, Seoul, Korea

Experience

2006-presentAssociate Professor,Division of Oral Biology & Medicine,School of Dentistry,University of California, Los Angeles
2005-presentJonsson Comprehensive Cancer Center
2001-2006Assistant Professor,Division of Oral Biology & Medicine,School of Dentistry,University of California, Los Angeles
2001Assistant Professor,Research Division of Human Life Science,Department of Oral Biochemistry,College of Dentistry,Seoul National University
1996-2001Senior Research Scientist,Cancer Research Institute,School of Medicine,Seoul National University

Membership

Member, Special Emphasis Panel (SEP-ZRG1 OBT [Oncology Basic Translational] A 58) for the review of Challenge Grants, NIH
"Associate Member, American Association for Cancer Research
Active Member, American Association for Cancer Research
Active Member, American Association for Dental Research
Active Member, International Association for Dental Research
Member, UCLA Jonsson Comprehensive Cancer Center

Publications: Journals

[1]  Kim MS, Shin KH, Baek JH, Cherrick HM, Park NH. HPV-16, tobacco-specific N-nitrosamine, and N-methyl-N'-nitro-N-nitrosoguanidine in oral carcinogenesis. Cancer Research, 53:4811-4816, 1993.
[2]  Min BM, Baek JH, Shin KH, Gujuluva CN, Cherrick HM, Park NH. Inactivation of the p53 gene by either mutation or HPV infection is extremely frequent in human oral squamous cell carcinoma cell lines. European Journal of Cancer (Oral oncology), 30B:338-345, 1994.
[3]  Gujuluva CN, Baek JH, Shin KH, Cherrick HM, Park NH. Effect of UV-irradiation on cell cycle, viability and the expression of p53, gadd153 and gadd45 genes in normal and HPV-immortalized human oral keratinocytes. Oncogene, 9:1819-1827, 1994.
[4]  Shin KH, Min BM, Cherrick HM, Park NH. Combined effects of human papillomavirus-18 and N-methyl-N'-nitro-N-nitrosoguanidine on the transformation of normal human oral keratinocytes. Molecular Carcinogenesis, 9:76-86, 1994.
[5]  Baek JH, Gujuluva C, Shin KH, Park NH. Effect of actinomycin D on the cell cycle progression and the expression of p53, WAF1/CIP1, gadd45, and mdm-2 genes in human oral keratinocytes: Implication of human papillomavirus infection. International Journal of Oncology, 5:1023-1030, 1994.
[6]  Park NH, Gujuluva CN, Baek JH, Cherrick HM, Shin KH, Min BM. Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: an in vitro multistep carcinogenesis model. Oncogene, 10:2145-2153, 1995.
[7]  Shin KH, Tannyhill RJ, Liu X, Park NH. Oncogenic transformation of HPV-immortalized human oral keratinocytes is associated with the genetic instability of cells. Oncogene, 12:1089-1096, 1996.
[8]  Gujuluva C, Shin KH, Park NH. Role of HPV in tumorigenesis of oral keratinocytes: Implication of p53, p21WAF1/CIP1, gadd45, cyclins, cyclin-dependent kinase and PCNA in oral cancer. International Journal of Oncology, 8:21-28, 1996.
[9]  Shin KH, Park KJ, Kim SW, Lee SH, Lee SE, Jung HW, Kim HJ, Park JG. Germline mutations of VHL gene in Korean von Hippel-Lindau disease patients. Journal of Korean Cancer Association, 28:544-554, 1996.
[10]  Park NH, McQuirer J, Rutherford F, Shin KH, Liu X, Guo W, Bertolami CN. Genetic instability and the development of human oral cancer. International Journal of Oral Biology, 23:1-13, 1998.
[11]  Shin KH, Han HJ, Park JG. Growth suppression mediated by transfection of wild-type hMLH1 in human cancer cells expressing endogenous truncated hMLH1 protein. International Journal of Oncology, 12:609-615, 1998.
[12]  Shin KH, Yang YM, Park JG. Absence or decreased levels of the hMLH1 protein in human gastric carcinoma cell lines: implication of hMLH1 in alkylation tolerance. Journal of Cancer Research Clinical Oncology, 124:421-426, 1998.
[13]  Shin KH, Ku JL, Park JG. Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer. Journal of Human Genetics, 44:18-21, 1999.
[14]  Park KJ, Shin KH, Ku JL, Cho TJ, Lee SH, Choi IH, Phillipe C, Monaco AP, Porter DE, Park JG. Germline mutations in the EXT1 and EXT2 genes in Korean patients with hereditary multiple exostoses. Journal of Human Genetics, 44:230-234, 1999.
[15]  Shin KH, Ku JL, Kim WH, Lee SE, Lee C, Kim SW, Park JG. Establishment and characterization of 7 human renal cell carcinoma cell lines. BJU International, 85:130-137, 2000.
[16]  Shin KH, Park YJ, Park JG. Mutational analysis of the transforming growth factor beta type II receptor gene in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients. Clinical Cancer Research, 6:536-540, 2000.
[17]  Shin KH, Park JG. Microsatellite instability is associated with genetic alteration but not with low levels of expression of the human mismatch repair genes hMSH2 and hMLH1. European Journal of Cancer, 36:925-931, 2000.
[18]  Jang JH, Shin KH, Park YJ, McKeehan WL, Park JG. Inactivation of FGFR3 via use of cryptic splicing sequences and aberrant splicing in colorectal cancer. Cancer Research, 60:4049-4052, 2000.
[19]  Park YJ, Shin KH, Park JG. Risk of gastric cancer in hereditary nonpolyposis colorectal cancer in Korea. Clinical Cancer Research, 6:2994-2998, 2000.
[20]  Jang JH, Shin KH, Park JG. Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 gene associated with human gastric and colorectal cancers. Cancer Research, 61:3541-3543, 2001.
[21]  Kim HS, Cho NB, Yoo JH, Shin KH, Park JG, Kim YI, Kim WH. Microsatellite instability in double primary cancers of the colorectum and stomach. Modern Pathology, 14:543-548, 2001.
[22]  Shin KH, Park YJ, Park JG. PTEN gene mutations in colorectal cancers displaying microsatellite instability. Cancer Letter, 174:189-194, 2001.
[23]  Shin KH, Choe G, Park YJ, Jang JH, Jung HW, Park JG. Establishment and characterization of nine human brain tumor cell lines. In Vitro Cellular and Development Biology, 37:623-628, 2001.
[24]  Shin KH, Shin JH, Kim JH, Park JG. Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early-onset colorectal cancer patients: Identification of three novel germline mutations in promoter of the hMSH2 gene. Cancer Research, 62:38-42, 2002.
[25]  Lee G, Kim YB, Kim JH, Kim MS, Shin KH, Won YS, Lee JI, Choung PH, Hyun BH, Min BM. Characterization of novel cell lines established from three human oral squamous cell carcinomas. International Journal of Oncology, 20:1151-1159, 2002.
[26]  Shin KH, Park KH, Hong HJ, Kim JM, Oh JE, Choung PH, Min BM. Prevalence of microsatellite instability, inactivation of mismatch repair genes, p53 mutation, and human papillomavirus infection in Korean oral cancer patients. International Journal of Oncology, 21:297-302, 2002.
[27]  Shin KH, Kim JM, No KS, Park KH, Oh JE, Min BM. Inactivation of PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas. International Journal of Oncology, 21:997-1001, 2002.
[28]  Shin JH, Ku JL, Shin KH, Shin YK, Kang SB, Park JG. Glutathione S-transferase M1 associated with cancer occurrence in Korean HNPCC families carrying the hMLH1/hMSH2 mutation. Oncology Reports, 10:483-486, 2003.
[29]  Kang MK, Kameta A, Shin KH, Baluda MA, Kim HR, Park NH. Senescence-associated genes in normal human oral keratinocytes. Experimental Cell Research, 287:272-281, 2003.
[30]  Kameta A, Kang MK, Shin KH, Park NH. Absence of hamTERT gene expression is associated with promoter hypermethylation in immortal hamster buccal pouch epithelial cells. International Journal of Oncology, 22:1351-1356, 2003.
[31]  Jeong SY, Shin KH, Shin JH, Ku JL, Shin YK, Park SY, Kim WH, Park JG. Microsatellite instability and mutations in DNA mismatch repair genes in sporadic colorectal cancers. Diseases of the Colon & Rectum, 46:1069-1077, 2003.
[32]  Shin KH, Kang MK, Dicterow E, Park NH. Hypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes. British Journal of Cancer, 89:1473-1478, 2003.
[33]  Kang MK, Kameta A, Shin KH, Baluda MA, Park NH. Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells. Journal of Cellular Physiology, 199:364-370, 2004
[34]  Shin KH, Kang MK, Dicterow E, Kameta A, Baluda MA, Park NH. Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity. Clinical Cancer Research, 10:2551-2560, 2004
[35]  Shin KH*, Kang MK*, Yip FK, Park NH. Normal human oral keratinocytes demonstrate abnormal DNA end joining activity during replicative senescence. Mechanisms of Aging and Development, 126:475-479, 2005. *Equal contribution
[36]  Kang MK, Kim RH, Shin KH, Zhong W, Faull KF, Park NH. Senescence-associated decline in the intranuclear accumulation of hOGG1-alpha and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo. Experimental Cell Research, 310:186-195, 2005
[37]  Shin KH, Ahn JH, Kang MK, Lim PK, Yip FK, Baluda MA, Park NH. HPV-16 E6 oncoprotein impairs the fidelity of DNA end-joining via p53-dependent and-independent pathways. International Journal of Oncology, 28:209-216, 2006
[38]  Shin KH, Kang MK, Kim RH, Kameta A, Baluda MA, Park NH. Abnormal DNA end-joining activity in human head and neck cancer. International Journal of Molecular Medicine, 17:917-924, 2006
[39]  Shin KH, Kang MK, Kim RH, Christensen R, Park NH. Heterogeneous nuclear ribonucleoprotein G (hnRNP G) demonstrates tumor suppressive effect against oral squamous cell carcinoma cells. Clinical Cancer Research, 12:3222-3228, 2006
[40]  Kim RH, Kang MK, Shin KH, Oo ZM, Han H, Baluda MA, Park NH. Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes. Experimental Cell Research, 313:462-472, 2007
[41]  Kang MK, Kim RH, Kim SJ, Yip FK, Shin KH, Dimri GP, Christensen R, Han T, Park NH. Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival. British Journal of Cancer, 96:126-133, 2007
[42]  Shin KH, Kim RH, Kang MK, Kim R, Kim S, Lim PK, Yochim JM, Baluda MA Park NH. p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G. DNA Repair, 6:830-840, 2007
[43]  Shin KH*, Kim RH, Kim R, Kang MK, Park NH. hnRNP G elicits tumor suppressive activity in part by up-regulating the expression of Txnip. Biochem. Biophys. Res. Commun, 372:880-885, 2008 (*corresponding author)
[44]  Kim RH, Yochim JM, Kang MK, Shin KH, Christensen R, Park NH. HIV-1 Tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome. International Journal of Oncology, 33: 777-782, 2008
[45]  Kim RH, Kim R, Chen W, Hu S, Shin KH, Park NH, Kang MK. Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells. Carcinogenesis, 29: 2425-2431, 2008
[46]  Shin KH, Kang MK, Park NH. Heterogeneous nuclear ribonucleoprotein G, nitric oxide, and oral carcinogenesis. Nitric Oxide, 19:125-132, 2008
[47]  Kim RH, Lieberman MB, Lee R, Shin KH, Mehrazarin S, Oh J-E, Park NH, Kang MK. Bmi-1 extends the lifespan of normal human oral keratinocytes by inhibiting the TGF-β signaling. Experimental Cell Research, 316:2600-2608, 2010
[48]  Chen W, Dong Q, Shin KH, Kim RH, Oh JE, Park NH, Kang MK. Grainyhead-like 2 enhances the hTERT gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes. Journal of Biological Chemistry, 285:40852-40863, 2010
[49]  Shin KH*, Bae SD, Hong HS, Kim RH, Kang MK, Park NH. miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras. Biochem. Biophys. Res. Commun, 404:896-902, 2011 (*corresponding author)
[50]  Dong Q, Oh JE, Kim RH, Chen W, Shin KH, Park NH, Kang MK. Radioprotective effects of Bmi-1 involve epigenetic silencing of oxidase genes and enhanced DNA repair in normal human keratinocytes. J. Invest. Dermatol. 131:1216-1225, 2011
[51]  Kim RH, Lee RS, Williams D, Bae B, Woo J, Lieberman M, Oh J-E, Dong Q, Shin KH, Kang MK, Park NH. Bisphosphonate induces senescence in normal human oral keratinocytes. Journal of Dental Research, 90:810-816, 2011
[52]  Shin KH*, Pucar A, Kim RH, Bae SD, Chen W, Kang MK, Park NH. Identification of senescence-inducing microRNAs in human normal keratinocytes. International Journal of Oncology, 39: 1205-1211, 2011 (*corresponding author)
[53]  Shin KH*, Kim RH, Yu B, Chen C, Kang MK, Elashoff D, Christensen R, Park NH. Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer. Oral Oncology, In Press (*corresponding author)
[54]  Oh J-E, Kim RH, Shin KH, Park N-H, Kang MK. ΔNp63α triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes. Journal of Biological Chemistry, In Press