International Journal of Internal Medicine

International Journal of Internal Medicine is aimed to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. It is an international journal dedicated to the latest advancement of internal medicine.

Vladimir Jurisic

Editor-in-Chief of International Journal of Internal Medicine

Professor, School of Medicine, University of Kragujevac, Serbia

Research Areas

Interna Medicine, Hematology, Immunology, Oncology


2001Ph.DUniversity of Belgrade, Yugoslavia
1997M.ScUniversity of Belgrade, Yugoslavia
1993-1997Postgraduate University of Belgrade, Yugoslavia


2006-presentProfessor at School of Medicine, University of Kragujevac, Serbia
2001-presentAssistant Professor, School of Medicine, University of Kragujevac, Serbia
1998-2001Assistant of School of Dentistry, University of Belgrade, Belgrade
1994-presentAssistant at School of Medicine, University of Kragujevac, Serbia
1992-2001Researcher at Institute of Oncology and Radiology, School of Medicine, University of Belgrade

Academic Achievement

ISICR for participation at ICS-ISICR Cytokine 2011, Florence, Italy
ISICR cytokine travel award for participation at 2010 Chigaco, USA
SLB society for participation at meeting Lisbone, 2009, Portugal
EFIS bursary for participation at cell signal conference, 2009, Balaton, Hungary
EFIS felowship for participation at ECI Conference Berlin, 2009, Germany
ISOBM award for lecture at Conference, Tokyo, Japan, 2008
ESMO travel grant for LUGANO Lymphoma Conference (ECLU), Lugano, Switzerland, 2007
EFIS travel Grant for participation at Immunology Conference, Evora, Portugal, October, 2006
Travel grant for lecture presentation, Cell differentiation Conference, Innsbruck, Austria, October 2006
ARIG grant, European Immunology Conference, Paris, 2006
Award of International Cytokine Association for presentation in Vienna, 2006
UNESCO award for presentation of research data in Budapest, FEBS, July, 2005
ESMO award for Participation at working party of ESMO Budapest, June 2005
Travel award of EHA for presentation in Geneva, Switzerland, 2004
Federica Fisher Foundation award of ISEC, for presentation in USA, October 2004
Testimonial Award: "INTERNATIONAL SCIENTIST OF THE YEAR 2002", Cambridge, International Bibliographic Centre
Travel award of ECCO-12, Copenhagen, Denmark, 2003
The award of International Association for interferon and cytokine research for presentation at Conference, Turin, Italy, 2002
Awards of European School of Oncology (ESO) and Athens University, Greece for participation at ESO courses: 1995, 1997, 1999, 2002, Athens, Greece
Travel award of ECCO-10 for conference, Lisbon, Portugal 2001
The Award of EACR Committee for quality of submissions, EARC XV, Sweden, 1998
The Award of EACR Committee for quality of submissions, ECCO-8, Paris, 1995


Member of European Association for cancer Research (EACR)
Member of European association of Medical Oncology (ESMO)
Member of Society for Leukocyte Biology (SLB)
Member of International Society of Oncology and Biomarkers (ISOBM)
Member of Serbian association of Haematology
Member of Serbian association of Immunology

Publications: Journals

[1]  Srdic-Rajic T, Jurisic V, Andrejevic S, Bonaci-Nikolic B, Bowker T, Concas D, Metlas R. Naturally occurring V region connected antibodies inhibit anti-dsDNA antibody reactivity with dsDNA. Immunobiology. 2011, Jul 26, in press
[2]  Zaric B, Perin B, Becker HD, Herth FF, Eberhardt R, Jovanovic S, Orlic T, Panjkovic M, Zvezdin B, Jovelic A, Bijelovic M, Jurisic V, Antonic M. Combination of narrow band imaging (NBI) and autofluorescence imaging (AFI) videobronchoscopy in endoscopic assessment of lung cancer extension. Med Oncol. 2011 Aug 9, in press
[3]  Jurisic V, Pavlovic S, Colovic N, Djordjevic V, Jankovic G, Colovic M. Acute Myeloid Leukemia Associated With Near-Tetraploid Karyotype and Mutations in the FLT3 Gene. Lab Med, 2011, 42:540-543.
[4]  Konjevic G, Radenkovic S, Srdic T, Jurisic V, Stamatovic Lj, Milovic M. Association of decreased NK cell activity and IFNγ expression with pSTAT dysregulation in breast cancer patients. J BUON. 2011, 16(2):219-26.
[5]  Colović N, Jurišić V, Terzić T, Jevtovic D, Colović M. Alveolar Granulocytic Sarcoma of the Mandible in a Patient with HIV. Onkologie. 2011;34(1-2):55-8.
[6]  Јurisic V, Srdic-Rajic T, Konjevic G, Bogdanovic G, Colic M. TNF-α Induced apoptosis is accompanied with Rapid CD30 and Slower CD45 Shedding from K-562 Cells. J Membrane Biol. 2011, 239(3):115-22
[7]  Colović M, Jurisic V, Bila J, Colović N, Palibrk V. FGF-R3 and OPG expression in patient with multiple myeloma following systemic sclerosis: case report and review of the literature. Int J Hematol. 2011, Feb;93(2):228-31.
[8]  Bogdanov M, Perisic M, Jurisic V, Stojacic-Djenic S, Kerkez MM. Ultrasonographic examination of the liver circulation in patients with liver metastasis from colorectal cancer. J BUON. 2010 Apr-Jun;15(2):378-81.
[9]  Jurisic V, Colovic N, Konjevic G, Minic I, Colovic M. An Aggressive Extramedullary Cutaneous Plasmacytoma Associated with Extreme Alterations in the Innate Immune System. Onkologie, 33(3), 2010, 113-116.
[10]  Stankovic S, Konjevic G, Gopcevic K, Jovic V, Inic M, Jurisic V. Activity of MMP-2 and MMP-9 in sera of breast cancer patients. Pathol Res Pract. 2010, 15;206(4):241-7
[11]  Vuletic A, Konjevic G, Milanovic D, Ruzdijic S, Jurisic V. Antiproliferative Effect of 13-cis-Retinoic Acid is Associated with Granulocyte Differentiation and Decrease in Cyclin B1 and Bcl-2 Protein Levels in G0/G1 Arrested HL-60 Cells. Pathol Oncol Res. 2010,16(3):393-401
[12]  Konjević G, Mirjačić Martinović K, Vuletić A, Jurisić V, Spužić I. Distribution of Several Activating and Inhibitory Receptors on CD3(-)CD16 (+) NK Cells and Their Correlation with NK Cell Function in Healthy Individuals. J Membrane Biol. 2009, Aug;230(3):113-23
[13]  Ravanić DB, Pantović MM, Milovanović DR, Dukić-Dejanović S, Janjić V, Ignjatović DR, Jović SD, Jurisić V, Jevtović I. Long-term efficacy of electroconvulsive therapy combined with different antipsychotic drugs in previously resistant schizophrenia. Psychiatr Danub. 2009 Jun;21(2):179-86.
[14]  Colović N, Peruničić M, Jurišić V, Colović M. Specific skin lesions in hairy cell leukemia at presentation: case report and review of literature. Medical Oncology, 2010, 27(2):559-61.
[15]  Colovic N, Jurisic V, Terzic T, Atkinson HD, Colovic M. Chemoimunotherapy for Bcl-2 and MUM negative aggressive primary cutaneous B-cell non-Hodgkin's lymphoma. Archive of Dermatology Research, 2009, 301(9):689-92.
[16]  Konjevic G, Martinovic M K, Jurisic V, Babovic N, Spuzic I. Biomarkers of suppressed natural killer cell function in metastatic melanoma: Decreased NKG2D and increased CD158a receptor on CD3-CD16+ NK cells. Biomarkers, 2009, Vol. 14, 4, 258-270.
[17]  Jurisic V, Pavlović S, Čolović N, Djordjević V, Bunjevački V, Janković G, Čolović M. Single Instutute study of FLT3 Mutation in Acute Myeloid Leukemia with ear Tetraploidy in Serbia. Journal of Genetics, 2009, 88(2):149-52.
[18]  Jurisic V, Terzic T, Colic S, Jurisic M. The concentration of TNF-α correlated with number of inflammatory cells and degree of vascularisation in radicular cysts. Oral Disease, 2008, 7, 600-605.
[19]  Jurisic V, Terzic T, Pavlovic S, Colovic M. Elevated TNF alpha and LDH associated with diffuse osteolytic lesions in leukemic transformation of myelofibrosis. Pathology-Research and Practise, 2008, 204, 129-132.
[20]  Jurisic V, Colovic N Kraguljac N, H.D Atkinson, Colovic M. Analysis of CD23 antigen expression in B-chronic lymphocytic leukemia and its correlation with clinical parameters. Med Oncology 2008, 25(3), 315-322.
[21]  Colovic N, Jurisic V, Colovic M. Malignant histiocytosis with central nervous system involvement in single patients with review of literature. Journal of BUON, 2007, 12, 539-542.
[22]  Jurisic V, Colic S, Jurisic M. Difference in TNF-α between radicular and keratocyst (odontogenic tumour) in maxillofacial region. Acta Medica (Hradec Kralove), 2007, 50(4), 233-238.
[23]  Bogdanovic G, Jakimov D, Stojiljkovic B, Jurisic V. The cell growth, morphology and immunocytochemistry of novel cell line established from a bone marrow of the patients with therapy related-myelodisplastic syndrome, entitled PC-MDS. Med Oncology, 2007, 24:419-424.
[24]  Jurisic V, Srdic T, Konjevic G, Markovic O, Colovic M. Clinical stage-depending increase of NK cell activity in multiple myeloma patients. Med Oncology 2007, 24, 312-327.
[25]  Popovic B, Jekic B, Novakovic I, Lukovic LJ, Tepavcevic Z, Jurisic V, Vukadinovic M, Milasin J. Bcl-2 expression in oral squamous cell carcinoma. Ann N Y Acad Sci, 2007; 1095:19-25
[26]  Bogdanovic G, Jurisic V, Kraguljac N, Mrdjanovic J, Jakimov D, Krtolica K, Dragic M, Magic Z, Stoiljkovic B, Andrejevic Lj, SrdicT, Baltic M, Popovic S. characteristics of novel myeloid precursor cell line, PC-MDS, established from a bone marrow of the patient with therapy related myelodisplastic syndrome. Leukemia Research, 2007, 31, 1105-1113.
[27]  Konjevic G, Mirjacic-Martinovic K, Vuletic A, Jovic V, Jurisic V, Babovic N, Spuzic I. Low expression of CD161 and NKG2D activating receptor is associated with impaired NK cell cytotoxicity in metastatic melanoma patients. Clinical Experimental Metastasis. 2007,24, 1-11.
[28]  Bakrac M, Jurisic V, Kostic T, Popovic V, Pekic S, Kraguljac N and Colovic M. Pure red cell aplasia associated with type I autoimmune polyglandular syndrome: successful response to therapy with mycophenolate mofetil: case report and review of literature, Journal of Clinical Pathology, 2007, 60, 715-736.
[29]  Colovic M, Jurisic V, Pavlovic S, Terzic T, Colovic N. FLT3/D835 mutation and inversion of chromosome 16 in leukemic transformation of myelofibrosis. European Journal of Internal Medicine, 2006, 17, 434-435.
[30]  Colovic M, Jurisic V, Jankovic G, Jovanovic D, Dimitrijevic J. Interferon  sensibilization-induced fatal renal insufficiency in a patient with chronic myeloid leukemia. Case report and review of literature. J Clinical Pathology, 2006, 59, 879-881.
[31]  Jurisic V, Bogdanovic G, Kojic V, Jakimov D, Srdic T. TNF-alpha effects on Raji cells at different cellular level estimated by various methods. Annals of Haematology, 2006, 85; 86-94.
[32]  Jurisic V, Kraguljac N, Konjevic G, Spuzic I. TNF- induced changes in cell membrane antigen expression on K-562 cells is associated with increased LDH release. Neoplasma, 2005, 1, 25-32.
[33]  Jurisic V, Bogunovic M, Colovic N, Colovic M. Indolent course of cutaneous Hodgkin disease. Journal of Cutaneous Pathology, 2005, 32, 176-178.
[34]  Jurisic V, Bogdanovic G, Srdic T, Jakimov D, Mrdjanovic J, Baltic M, Baltic V.V. Modulation of TNF- activity in tumor PC cells using anti-CD45 and anti CD95 monoclonal antibody. Cancer Letters, 2004, 214, 55-61.
[35]  Jurisic V, Konjevic G, Jancic-Nedeljkov R, Sretenovic M, Banicevic B, Colovic M, Spuzic I. The comparison of spontaneous LDH release from cultured PBMC with sera LDH activity in Non-Hodgkin's lymphoma patients. Medical Oncology, 2004, 21, 179-185
[36]  Jurisic V, Bumbasirevic V, Konjevic G, Djuricic B, Spuzic I. TNF-alpha induced changes in LDH isotype profile following triggering of apoptosis in PBMC of non-Hodgkin's lymphoma. Annals of Haematology, 2004, 83, 84-91.
[37]  Konjevic G, Jovic V, Jurisic V, Jelis S, Radulovic S, Spuzic I. IL-2-mediated augmentation of NK cell activity and activation antigen expression on NK and T cell subsets in patients with metastatic melanoma treated with interferon- and DTIC. Clinical and Experimental metastasis, 2003, 20 (7):647-655
[38]  Jurisic V. Estimation of cell membrane alteration after drug treatment by LDH release. Blood, 2003, 101, 2894.
[39]  Jurisic V, Jancic-Nedeljkov R, Konjevic G, Spuzic I. Decrease of NK cell activity and characteristics of peripheral blood mononuclear cells (PBMC) in a haemochromatosis. Haema, 2003, 6, 85-88.
[40]  Jurisic V, Colovic M. Correlation of sera TNF-alpha with percentage of bone marrow plasma cells, LDH, beta-2 microglobulin, and clinical stage in multiple myeloma, Medical Oncology, 2002, 19(3), 133-139
[41]  Konjevic G, Jurisic V, Spuzic I. Association of NK cell dysfunction with changes in LDH characteristics of peripheral blood lymphocytes (PBL) in breast cancer patients. Breast Cancer Res Treat. 2001, 66(3): 255-263.
[42]  Jurisic V, Konjevic G, Banicevic B, Djuricic B, Spuzic I. Different alterations in lactate dehydrogenase (LDH) activity and profile of peripheral blood mononuclear cells in Hodgkin's and Non-Hodgkin's lymphomas. Eur. J. Haematology, 2000, 64: 259-266.
[43]  Jurisic V, Spuzic I, Konjevic G. A comparison of NK cell activity with effects of TNF-alpha against K-562 cells, determined by LDH release assay. Cancer Letters, 1999, 138: 67-72.
[44]  Konjevic G, Jurisic V, Banicevic B, Spuzic I, Difference in NK cell activity between patients with non-Hodgkin's lymphoma and Hodgkin's disease. Br. J. Haematology, 1999, 104: 144-151.
[45]  Konjevic G, Jurisic V, Spuzic I. Correction to the original lactate dehydrogenase (LDH) release assay for evaluation of NK cell cytotoxicity. J. Immunol. Methods, 1997, 200: 199-201
[46]  Konjevic G, Spuzic I. Jurisic V. In-vitro effects of cytokines and cytokines receptors on the activity of NK cells. Journal of B.O.U.O.N. 1996, 1(1): 47-52
[47]  Perišić M Jurišić V, Kerkez M. Doppler ultrasonography of hepatic artery in malignant liver tumors. Archive of Oncology, vol. 16, br. 3-4, str. 46-48, 2008.
[48]  Jurišić V. Bumbaširević V. In vitro assays for cell death determination. Archive of Oncology, vol. 16, br. 3-4, str. 49-54, 2008.
[49]  Colovic N, Jurisic V, Colovic M. Rituximab for primary cutaneous large B cell non Hodkins lymphoma. Archive of Oncology, 2008, 2, 16
[50]  Jurisic V, Sladjana Stojacic-Djenic, Colovic N, Konjevic G. Effects of cytokines on NK cell activity. Srp Arch Celok, Lek, 2008, 7 136, 423-429. (Review article).
[51]  Stojačić-Đenić S., Kerkez M., Jović D., Maksimović Ž., Jeftović I., Milić Ž., Perišić M., Jurišić V. Uporedna analiza ultrasonografije i mamografije sa histološkim nalazom dobijenim ex tempore u dijagnostici tumora dojke. Acta chirurgica Iugoslavica, vol. 55, br. 4, str. 37-41, 2008.
[52]  Colic S, Jurisic M, Jurisic V. Pathophysiological mechanism of the developing radicular cyst of the jaw. Acta Chirurgica Iugoslavica, 2008;55(1):87-92. (review article)
[53]  Jurisic V, Colovic N, Pavlovic S, Colovic M. Diffuse osteolytic lesions in leukemic transformation of myelofibrosis. Archive of Oncology, 2007, 15, 13-17.
[54]  Stojacic-Djenic S, Sarenac-Kovac R, Kerkez M, Jurisic V. Doppler hemodynamic study in evaluation of liver metastasis. Acta Chirurgica Iugoslavica, 2007, 2, 9-13.
[55]  Jurisic V. Characteristic of NK cell activity. Srp Arh Celok Lek. Belgrade, 2006, 134, 71-76 (review article).
[56]  Jurisic V, Kraguljac N, Banicevic B. Imunofenotipske karakteristike tokom transformacije Non-Hodgkinskih Limfoma (NHL) u B-hroničnu limfocitnu leukemiju (B-CLL). Pons, 2005, 2, (1)15-18.
[57]  Jurisic V, Radosavljavic N, Jeftovic I, Perisic M. The problems in early diagnosis of breast cancer patients in general hospital. Pons, 2005,
[58]  Colovic M, Jurisic V, Colovic N, Miljic P. Thrombocytic thrombocitopenic purpura: The clinics and pathology characteristics in terms of treatment, review article. Srpski archive za celokupno lekartsvo, 2003, 131, (7-8): 337-345.
[59]  Lazic P, Jurisic V, Perisic M. Problems in early diagnosis of the loco-regional breast cancer in general hospital. Archive of Oncology, 2002, 6:
[60]  Konjevic G, Jurisic V, Jakovljevic B, Spuzic I. Lactate dehydrogenase (LDH) in peripheral blood lymphocytes (PBL) of patients with solid tumors. Glas SANU, 2002, 47: 137-147.
[61]  Jurisic V. Biology and physiology of NK cells (review article). Medicus, 2001, (4): 1-7.
[62]  Jurisic V, Bogdanovic G, Srdic T, Kerenji A, Baltic M, Baltic V. V. The activity of TNF-alpha on PC cells pre-labelled with anti-CD45 and CD95 monoclonal antibodies. Archive of Studenica, 2000, 2: 56-59
[63]  Jurisic V, Jancic-Nedeljkov R, Konjevic G, Spuzic I. Characteristics of peripheral blood mononuclear cells (PBMC) and suppression of NK cell activity in a woman with chemochromatosis. Medicus, 2000, 1: 20-23.
[64]  Jurisic V, Konjevic G, Bumbasirevic V, Djuricic B, Spuzic I. TNF-a effects on induction of apoptosis on malignant lymphoma peripheral blood lymphocytes. Archive of Studenica. 1998,1: 49-52.

Publications: Books/Book Chapters

[1]  Jurisic V, Samardzic G, Colic S, Jurisic M. TNF- in radicular and otontogenic cysts. 6th Vienna, Austria, In Monduzzi Editore, Bolona, 2006,
[2]  Konjevic G, Jurisic V, Spuzic I. In-vitro effects of cytokines and cytokines receptors on the activity of NK cells. In Atypas G ed: Balkan Congress of Oncology, Monduzzi Editore, Bolona, 1996, 9-11.
[3]  Colovic M, Jurisic V. New treatment with monoclonal antibodies in haematology. In Tumor Immunotherapy, ed M Colic, Serbian Academy of Sciences and Arts (SANU) Belgrade, 2006, 41-58, (ISBN 86-7025-425-5)
[4]  Jurisic V, Srdic T, Konjevic G, Spuzic I. Investigation of Immunomodulating and cytotoxic effects of TNF alpha on K-562 erytroleukemic cell line. In Tumor Immunotherapy, ed M Colic, Serbian Academy of Sciences and Arts (SANU) Belgrade, 2006, 229-242 (ISBN 86-7025-425-5)
[5]  Jurisic V. Molecular mechanism of apoptosis regulation in neural diseases. Problems in new millennium. (Neural diseases). Ed. M Pantovic et al, University of Kragujevac, School of Medicine, 2006, 79-90, (ISBN 86-7760-004-3)
[6]  Jurisic V. Anaemia, leukaemia, disturbance in peripheral blood cells. Test's book for students, Ed: University of Kragujevac, School of Medicine, 2003.
[7]  Jurisic V, Zivancevic-Simonovic S. Pathophysiology of malignant disease. In General Pathophysiology Ed: University of Kragujevac, School of Medicine, 2002; 462-482.
[8]  Samardzic G, Jurisic V. Immune aspects of the regulation mechanisms. In: The homeostasis mechanism. Test's book for students. Ed: University of Kragujevac, School of Medicine. 2002; 34-56.
[9]  Jurisic V, Konjevic G, Bumbasirevic V, Spuzic I. Morphological changes in cultures lymphocytes of malignant lymphoma patients. In: Bumbasirevic V. 40 years of electronic microscopy in Serbia, Ed: Elite. Belgrade 1999: 29-30