Journal of Microbiology Research

Journal of Microbiology Research aims to publish all the latest and outstanding research articles, reviews and letters in all areas of major importance to techniques of microbiology and applied research. It publishes high quality research and review papers on novel aspects of microbiology, including environmental, food, agricultural, medical, pharmaceutical, veterinary, soil, water and biodeterioration.

Adhar C Manna

Editorial Board Member of Journal of Microbiology Research

Assistant Professor, Department of Biological Sciences,Presidency University, India

Research Areas

Bacterial Pathogenesis, Gene Regulation, Proteomics, DNA-Protein and Protein-Protein Interaction, Host-Pathogen interaction, S.aureus;vaccine development, antibacterial development, nanoparticals as an antimicrobial

Education

1994Ph.D.Molecular Biology, Jawaharlal Nehru University, India
1991M.Phil.Molecular Biology, Jawaharlal Nehru University, India
1987M.Sc.Biotechnology, Jawaharlal Nehru University, India
1984B.Sc.Physics (Honors), University of Calcutta, India

Experience

2005-2012Assistant Professor, Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota
2001-2005Research Assistant Professor, Microbiology & Immunology Department, Dartmouth Medical School
1999-2001Scientist E.I, Central Drug Research Institute, India
1996-1999Postdoctoral Fellow/Associate, Division of Bacterial Pathogenesis, The Rockefeller University
1994-1996Research Associate, Microbiology & Immunology Department, Duke University Medical Center
1988-1993Junior/Senior Research Fellow, School of Environmental Sciences, Jawaharlal Nehru University, India
1987-1988Research Scientist B, Genetic Engineering, Jawaharlal Nehru University, India

Academic Achievement

Dean's Team Award, South Dakota State University, 2005
Junior/Senior Research Fellowship for post graduate studies, Govt. of India, 1988-1993
GATE Engineering Scholarship for post graduate studies, Govt. of India, 1988
Scholarship, Master Degree Program in Biotechnology, Govt. of India. 1985-1987
National Scholarships, Govt. of India, 1985

Membership

Member, American Society for Microbiology, 2001-
Member, American Association of Advancement of Science, 2001-
Member, Sigma Xi, The Scientific Research Society, 2007-

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Manna, A. C. 2011. Synthesis, characterization and antimicrobial activity of zinc oxide nanoparticles. Chapter on book title "Nano-Antimicrobials: Progress and Prospects" edited by N. Cioffi and M. Rai. Springer publisher (acepted).
[2]  Krishna R Raghupati, Ranjit T. Koodali*, and A. C. Manna*. 2011. Size dependent bacterial growth inhibition of zinc oxide nanoparticles Langmuir 27: 4020-4028.
[3]  Ballal, A. and A. C. Manna*. 2010. Control of thioredoxin reductase (trxB) transcription by SarA in Staphylococcus aureus. J. Bacteriol 192: 336-345.
[4]  Ray, B. and A. Ballal and A. C. Manna*. 2009. Transcriptional variation of regulatory and virulence genes due to different media in S. aureus. Microbial Path. 47: 94-100.
[5]  Ballal, A. and A. C. Manna*. 2009. Expression of the sarA family genes in different S. aureus. Microbiology 155: 2342-2352.
[6]  Ballal, A. and A. C. Manna*. 2009. Regulation of superoxide dismutase (sod) genes by SarA in Staphylococcus aureus. J Bacteriol. 191: 3301-3310.
[7]  Ballal, A., B. Ray, and A. C. Manna*. 2009. SarZ, a sarA family gene, is transcriptionally activated by MgrA and involved in the regulation of exoproteins synthesis in Staphylococcus aureus. J. Bacteriol 191: 1656-65.
[8]  Cheung, A. L., Nishina, K., and A. C. Manna. 2008. SarA of S. aureus binds to its own promoter to regulate gene expression. J. Bacteriol. 190: 2239-2243.
[9]  Jones, N., B. Ray, R. T. Koodali, and A. C. Manna*. 2008. Antibacterial activity of ZnO nanoparticle suspensions on broad spectrum of microorganisms. FEMS Microbiology Letters. 279:71-76.
[10]  Manna*, A. C. and B. Ray. 2007. Regulation and characterization of rot transcription in Staphylococcus aureus. Microbiology: 135:1538-1545.
[11]  Manna*, A.C. and A. L. Cheung. 2006. Expression of SarX, a Negative Regulator of agr and Exoproteins Synthesis, Is activated by MgrA in Staphylococcus aureus. J. Bacteriol. 188:4288-4299.
[12]  Manna*, A. C., and A. L. Cheung. 2006. Transcriptional regulation of the agr locus and the identification of DNA-binding residues of the global regulatory protein SarR in Staphylococcus aureus. Mol. Microbial. 60:1289-1301.
[13]  Manna$, A.C., Liu$, Y., C-H., Pan$, Kriksunov, I. A., Thiel, D. J., A. L. Cheung, and G. Zhang. 2006. Structural and Functional analyses of the global regulatory protein SarA from Staphylococcus aureus. Proc. Natl. Acad. Sci. USA. 103 :2392-2397 ($ equal authors).
[14]  Trotonda, M. P., A. C. Manna, A. L. Cheung, I. Lasa and J. R. Penades. 2005. SarA control Bap-dependent biofilm formation in Staphylococcus aureus. J. Bacteriol. 187: 5790-5798.
[15]  Cheung, A. L. and A. C. Manna*. 2005. The role of the distal sarA promoters in SarA expression. Infect. & Immun. 73: 4391-4394.
[16]  Tormo, M. A., M. Marti, J. Valle, A. C. Manna, A. L. Cheung, I. Lasa, and J. R. Penades. 2005. SarA is an essential positive regulator of Staphylococcus epidermidis biofilm development. J. Bacteriol. 187: 2348-2356.
[17]  Manna*, A. C., S. S. Ingavale, M. Maloney, W. van Wamel, and A. L. Cheung. 2004. Identification of sarV (SA2062), a new transcriptional regulator, is repressed by SarA and MgrA (SA0641) and involved in the regulation of autolysis in Staphylococcus aureus.J. Bacteriol. 185 : 5267-5280.
[18]  Xiong, Y-Q., A. S. Bayer, M. R. Yeaman, W. van Wamel, A. C. Manna., and A. L. Cheung. 2004. Impacts of sarA and agr in Staphylococcus aureus strain Newman on fibronectin-binding protein A gene expression and fibronectin adherence capacity in vitro and in experimental infective endocarditis. Infect. & Immun. 72: 1832-1836.
[19]  Schmidt, K. A., A. C. Manna, and A. L. Cheung. 2003. sarT influences the expression of sarS in S. aureus. Infect. & Immun. 71: 5139-5148.
[20]  R. Li, A. C. Manna, Dai, S., A. L. Cheung, and G. Zhang. 2003. The crystal structure of the SarS protein from Staphylococcus aureus. J. Bacteriol. 185: 4219-4225.
[21]  Manna*, A. C., and A. L. Cheung. 2003. SarU, a SarA homolog, is repressed by sarT and regulates the virulence genes in Staphylococcus aureus. Infect. & Immun. 71: 343-353.
[22]  Schmidt, K.A., A. C. Manna, S. Gill, and A.L. Cheung. 2001. SarT, a repressor of α-hemolysin in Staphylococcus aureus. Infect. & Immun. 69: 4749-4758.
[23]  Y. Liu, A. Manna, R. Li, W.E. Martin, R. C. Murphy, A. L. Cheung and G. Zhang. 2001. Crystal structure of the SarR protein from Staphylococcus aureus. Proc. Natl. Acad. Sci. USA. 98 : 6877-6882.
[24]  A. L. Cheung, K. Schmidt, B. Bateman, and A. C. Manna. 2001. SarS, a SarA homolog repressible by agr, is an activator of protein A synthesis in Staphylococcus aureus. Infect. & Immun. 69 : 2448-55.
[25]  Manna, A. and A. L. Cheung. 2001. Characterization of sarR, a modulator of sar expression in Staphylococcus aureus. Infect. & Immun. 69 : 885-896.
[26]  Wolz, C., P. Pohlmann-Dietze, A. Steinhuber, Y-t.Chien, A. Manna, W. van Wamel, and A. L. Cheung. 2000. Agr ˆindependent regulation of fibronectin-binding protein(s) by the regulatory locus sar in Staphylococcus aureus. Mol. Microbial. 36 : 230-243.
[27]  Chien, Y-t., A. C. Manna, S. Projan, and A. L. Cheung. 1999. SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J. Biol. Chem. 274 : 37169-37176.
[28]  Chien, Y-t, A. C. Manna, and A. L. Cheung. 1998. SarA level is an important factor for agr activation in Staphylococcus aureus. Mol. Microbial. 30: 991-1002.
[29]  Manna, A. C., M. G. Bayer, and A. L. Cheung. 1998. Transcriptional analysis of different promoters in the sar locus in Staphylococcus aureus. J. Bacteriol. 180: 3828-3836.
[30]  Bastia, D., A. C. Manna, and T. Sahoo. 1997. Termination of DNA replication in prokaryotic chromosome. Genetic Engineering 19: 101-119 (Review).
[31]  Manna, A. C., K.S. Pai, D. E. Bussiere, C. Davis, S. W. White and D. Bastia. 1996. Helicase-contrahelicase interaction and the mechanism of termination of DNA replication. Cell 87: 881-891.
[32]  Manna, A. C., K. S. Pai; D.E. Bussiere; S. W. White and D. Bastia. 1996. The dimmer-dimer interaction surface of the replication terminator protein of Bacillus subtilis and termination of DNA replication. Proc. Natl. Acad. Sci. USA. 93 : 3253-3258.
[33]  Sahoo, T., B. K. Mohanty, M. Lobert, A. C. Manna, and D. Bastia. 1995. The contrahelicase activities of the replication terminator proteins of Escherichia coli and Bacillus subtilis are helicase-specific and impede both helicase translocation and authentic DNA unwinding. J. Biol. Chem. 270 : 291 38-44.
[34]  Manna, A. C. and H. K. Das. 1997. The Azotobacter vinelandii chromosome. J. Genet. 76 : 55-60.
[35]  Manna, A. C. and H. K. Das. 1997. Characterization and mutagenesis of the leucine biosynthetic genes of Azotobacter vinelandii: an analysis of the rarity of amino acid auxotrophs. Mol. Gen. Genet. 254: 207-217.
[36]  Manna, A. C., and H. K. Das. 1994. The size of the chromosome of Azotobacter chroococcum. Microbiol. 140: 1237-1239.
[37]  Manna, A. C. and H.K. Das. 1993. Determination of the size of Azotobacter vinelandii chromosome. Mol. Gen. Genet. 241: 719-722.