American Journal of Chemistry

American Journal of Chemistry is a peer-reviewed chemistry journal. It is aimed to publish all the latest and outstanding research articles, reviews and letters in all areas of Chemistry.


Sergey Ryabukhin

Editorial Board Member of American Journal of Chemistry

Assistant Professor, The Institute of High Technologies, Kyiv National Taras Shevchenko University, Ukraine

Research Areas

Combinatorial Chemistry, Drug Discovery, Medicinal Chemistry, Organic Synthesis, Heterocyclic Chemistry, Parallel Synthesis, Multicomponent and One-Pot Reactions, Mechanisms of Organic Reactions

Education

2008Ph.DOrganic Chemistry, Kyiv National Taras Shevchenko University
2001M.ScKyiv National Taras Shevchenko University

Experience

2010-present Founder and Vice-President Chemistry of CURPLYX DRS Chemistry & Biology CRO
2010-present Assistant Professor, Head of Combinatorial Chemistry Department, The Institute of High Technologies, Kyiv National Taras Shevchenko University
2006-2010R&D Director of Enamine Ltd
2004-2006Head of Combinatorial Chemistry Department, Enamine Ltd
2002-2004Senior Researcher, Combinatorial Chemistry Department, Enamine Ltd
2001-2002Staff Scientist, Combinatorial Chemistry Department, Enamine Ltd

Academic Achievement

1996-Silver Medal in Ukrainian Chemistry Olympiad
1996-Bronze Medal in International Mendeleev Olympiad
1997-ISSEP Grant for students
2005-A.I. Kiprianov Award of National Academy of Sciences of Ukraine

Publications: Journals

[1]  Ryabukhin S.V., Naumchik, V.S., Plaskon, A.S., Grygorenko, O.O., Tolmachev, A.A. 3-Haloquinolines by Friedlander Reaction of α-Haloketones//J. Org. Chem., 2011, 76, 5774-5781
[2]  Bogolubsky A.V., Ryabukhin S.V., Pipko S.E., Lukin O., Shivanyuk A.N., Mykytenko D., Tolmachev A.A. A facile synthesis of unsymmetrical ureas//Tetrahedron, 2011, 67, 3619-3623
[3]  Ryabukhin S.V., Plaskon, A.S., Boron, S.Yu., Volochnyuk D.M., Tolmachev A.A. Aminoheterocycles as synthons for combinatorial Biginelli reactions//Molecular Diversity, 2011, 15, 189-195
[4]  Ryabukhin S.V., Ostapchuk, E.N. Plaskon, A.S., Volochnyuk D.M., Shivanyuk A.N. Tolmachev A.A.Chlorotrimethylsilane is an Efficient Promoter for the Biginelli Reaction//Adv. Exper. Med. Biol., 2011, 699, 12-13
[5]  Ryabukhin S.V., Plaskon, A.S., Bondarenko, S.S., Ostapchuk, E.N., Grygorenko, O.O., Shishkin, O.V., Tolmachev, A.A. Acyl pyruvates as synthons in the Biginelli reaction//Tetrahedron Lett., 2010, 51, 4229-4233
[6]  Volochnyuk D.M., Ryabukhin S.V., Plaskon A.S., Dmitriv Yu.V., Grygorenko O.O., Mykhailiuk P.K., Krotko D.G., Pushechnikov A., Tolmachev A.A. Approach to the Library of Fused Pyridine-4-carboxylic Acids by Combes-Type Reaction of Acyl Pyruvates and Electron-Rich Amino Heterocycles//J. Comb. Chem., 2010, 12, 510-518
[7]  Volochnyuk D.M., Ryabukhin S.V., Plaskon A.S., Grygorenko O.O. Organosilicon Compounds as Water Scavengers in Reactions of Carbonyl Compounds//Synthesis, 2009, 22, 3719-3744
[8]  Mityuk A.P., Volochnyuk D.M., Ryabukhin S.V., Plaskon A.S., Shivanyuk A.N., Tolmachev A.A. Recyclization Reactions of 5-For-myl-1,3-dimethyluracil with Ele-ctron-Rich Amino Heterocycles//Synthesis, 2009, 11, 1858-1864
[9]  Bogolubsky A.V., Ryabukhin S.V., Plaskon A.S., Stetsenko S.V., Volochnyuk D.M., Tolmachev A.A. Dry HCl in Parallel Synthesis of Fused Pyrimidin-4-ones//J. Comb. Chem., 2008, 10, 858-862
[10]  Bogolubsky A.V., Ryabukhin S.V., Pakhomov G.G., Ostapchuk E.N., Shivanyuk A.N., Tolmachev A.A. A Facile Synthesis of N-Carbamoylamino Acids//Synlett., 2008, 15, 2279-2282
[11]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Pipko S.E., Tolmachev A.A. Facile One-Pot Synthesis of 1,2,3,4-Tetrahydroquinoline-3-carboxylic Acids and Their Heterocyclic Analogs//Synth. Commun., 2008, 38, 3032-3043
[12]  Plaskon A.S., Ryabukhin S.V., Volochnyuk D.M., Gavrilenko K.S., Shivanyuk A.N., Tolmachev A.A. Synthesis of Quinolines from 3-Formylchromone//J. Org. Chem., 2008, 73, 6010-6013
[13]  Ryabukhin S.V., Plaskon A.S., Ostapchuk E.N., Volochnyuk D.M., Shishkin O.V., Tolmachev A.A. CF3-substituted 1,3-dicarbonyl compounds in the Biginelli reaction promoted by chlorotrimethylsilane//J. Fluor. Chem., 2008, 129, 625-631
[14]  Plaskon A.S., Ryabukhin S.V., Volochnyuk D.M., Shivanyuk A.N., Tolmachev A.A. A facile synthesis of imidazo[1,5-b]pyridazines from 3-Formylchromones//Heterocycles, 2008, 75, 1765-1772
[15]  Plaskon A.S., Ryabukhin S.V., Volochnyuk D.M., Shivanyuk A.N., Tolmachev A.A. A synthesis of 5-hetaryl-3-(2-hydroxybenzoyl)pyrroles//Tetrahedron, 2008, 64, 5933-5943
[16]  Ryabukhin S.V., Granat D.S., Khodakovskiy P.V., Shivanyuk A.N., Tolmachev A.A. One-pot synthesis of β-imidazolylpropionamides//Tetrahedron Lett, 2008, 49, 3997-4002
[17]  Plaskon A.S., Ryabukhin S.V., Volochnyuk D.M., Tolmachev A.A. A New One-Step Route for the Synthesis of Fused Pyrido[1,2-a]pyrimidin-4-ones//Synthesis, 2008, 7, 1069-1077
[18]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Pipko S.E., Tolmachev A.A. Chlorotrimethylsilane Mediated Synthesis of 5-(2-Hydroxybenzoyl)pyrimidines from 3-Formylchromones//Heterocycles, 2008, 75, 583-597
[19]  Shivanyuk A.N., Ryabukhin S.V., Bogolyubsky A.V., Mykytenko D.M., Chupryna A.A., Heilman W., Kostyuk A.N., Tolmachev A.A. Enamine real database: making chemical diversity real//Chem. Today, 2007, 25, 58-59
[20]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Pipko S.E., Shivanyuk A.N., Tolmachev A.A. Combinatorial Knoevenagel Reactions//J. Сomb. Сhem., 2007, 9, 1073-1078
[21]  Ryabukhin S.V., Plaskon A.S., Naumchik, V.S., Volochnyuk D.M., Pipko S.E., Tolmachev A.A. Heterocyclic Ortho-Aminocarbonyl Compounds in the Friedländer Reaction Promoted by Chlorotrimethylsilane//Heterocycles, 2007, 71, 2397-2411
[22]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Tolmachev A.A. Chlorotrimethylsilane-Mediated Synthesis of 2-Aryl-1-chloro-1-heteroarylalkenes//Synthesis, 2007, 20, 3163-3170
[23]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Tolmachev A.A. Chlorotrimethylsilane-Mediated Synthesis of Functionalized 2-(2-Hydroxybenzoyl)pyrido[1,2-a]benzimidazoles//Synthesis, 2007, 20, 3155-3162
[24]  Ryabukhin S.V., Plaskon A.S., Ostapchuk E.N., Volochnyuk D.M., Shishkin O.V., Shivanyuk A.N., Tolmachev A.A. A One-Step Fusion of 1,3-Thiazine and Pyrimidine Cycles//Org. Lett., 2007, 9, 4215-4218
[25]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Shivanyuk A.N., Tolmachev A.A. A One-Pot Synthesis of 2,3-Dihydro-1H-benzimidazoles//J. Org. Chem., 2007, 72, 7417-7419
[26]  Bogolubsky A.V., Ryabukhin S.V., Stetsenko S.V., Chupryna A.A., Volochnyuk D.M., Tolmachev A.A. Synthesis of Thieno[2,3-d]pyrimidin-2-ylmethanamine Combinatorial Library with Four Diversity Points//J. Comb. Chem., 2007, 9, 661-667
[27]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Tolmachev A.A. Chlorotrimethylsilane Mediated Synthesis of Functionalized Fused Pyridines: Reaction of 3-Formylchromones with Electron-Rich Aminoheterocycles//Synthesis, 2007, 12, 1861-1871
[28]  Ryabukhin S.V., Volochnyuk D.M., Plaskon A.S., Naumchik V.S., Tolmachev A.A. Chlorotrimethylsilane Mediated Friedländer Synthesis of Polysubstituted Quinolines//Synthesis, 2007, 8, 1214-1224
[29]  Ryabukhin S.V., Plaskon A.S., Ostapchuk E.N., Volochnyuk D.M., Tolmachev A.A. N-Substituted Ureas and Thioureas in Biginelli Reaction Promoted by Chlorotrimethylsilane: Convenient Synthesis of N1-alkyl, N1-aryl-and N1,N3-dialkyl-3,4-Dihydropyrimidin-2(1H)-(thio)ones.//Synthesis, 2007, 3, 417-427
[30]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Tolmachev A.A. Synthesis of Fused Imidazoles and Benzothiazoles from (Hetero)Aromatic ortho-Diamines or ortho-Aminothiophenole and Aldehydes Promoted by Chlorotrimethylsilane//Synthesis, 2006, 21, 3715-3726
[31]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Tolmachev A.A. Synthesis of Fused Imidazoles and Benzothiazoles from (Hetero)Aromatic ortho-Diamines or ortho-Aminothiophenole and Aldehydes Promoted by Chlorotrimethylsilane//Synthesis, 2006, 21, 3715-3726
[32]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Tolmachev A.A. 3-Formylchloromones in Guareschi Synthesis of 5-(2-Hydroxybenzoyl)-2-pyridones//Synlett., 2004, 13, 2287-2290
[33]  Plaskon A. S., Tverdokhlebov A. V., Tolmachev A. A. 2-Benzothiazolylmethanol as precursor of 2-aryl-1-(2-benzothiazolyl)-1-ethanones//Synth. Commun., 2004, 34, 1483-1487

Publications: Books/Book Chapters

[1]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Tolmachev A.A. 2,4-Dimethylquinolin-3-yl)acetic acid//Nitrogen-Containing Heterocycles Ed. Kartsev V.G. Vol.2 ICSPF Moscow 2006, 375
[2]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Tolmachev A.A. 3-Bromo-2-(4-chlorophenyl)-4-methylquinoline//Nitrogen-Containing Heterocycles Ed. Kartsev V.G. Vol.2 ICSPF Moscow 2006, 376
[3]  Ryabukhin S.V., Plaskon A.S., Volochnyuk D.M., Tolmachev A.A. Nitrogen-Containing Heterocycles Ed. Kartsev V.G. Vol.2 ICSPF Moscow 2006, 377-378