American Journal of Medicine and Medical Sciences

American Journal of Medicine and Medical Sciences aims to promote communication among clinical researchers worldwide. This journal publishes original works within the area of clinical medicine. It is academically peer-reviewed and designed for all doctors, researchers, and health workers regardless of their medical specialties, or type of employment.


Iain Gow

Editorial Board Member of American Journal of Medicine and Medical Sciences

Lecturer, Queen Margaret University, UK

Research Areas

Biology of Magnesium, Mammary Physiology, Vascular Alpha Adrenergic Receptors, Plant Secondary Metabolites

Education

1987Ph.DMedicine, University of Edinburgh
1980B.ScBiological Sciences, University of Edinburgh

Experience

2007-presentLecturer, Dietetics, Nutrition, and Biological Sciences, School of Health Science
2006-2007Senior Research Fellow (Grade III), Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde
2004-2006Principal Scientist (Band 4) Animal Physiology Group, Hannah Research Institute (HRI), Ayr
2003-2006Head of Biological Resources, HRI, Animal Physiology Group, Hannah Research Institute (HRI), Ayr
1997-2004Senior Scientist (Band 5PD), Integrative Metabolism/Animal Physiology Group, Hannah Research Institute (HRI), Ayr
1996-1997Research Fellow (1A), Dept of Physiology, University of Edinburgh
1994-1996Temporary Lecturer (1B) Dept of Physiology, University of Edinburgh
1989-1994Research Fellow (1A/2) Dept of Physiology, University of Edinburgh
1987-1988Research Fellow (1A) Dept of Medicine, Western General Hospital, University of Edinburgh
1983-1987Research Associate (1B) Dept of Medicine, Western General Hospital, University of Edinburgh
1981-1983Research Technician (TG3), Dept of Medicine, Western General Hospital, University of Edinburgh

Membership

Member of Society for Endocrinology (National)
International Society for Heart Research (International)
Member of British Pharmacological Society (National)
Member of Scottish Cardiovascular Forum (National)
Member of British Society for Cardiovascular Research (National)
Member of Biochemical Society (National)
Member of Caledonian Society for Endocrinology (National)

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Gow IF (2001) Resting Serum Insulin is Reduced During Magnesium Infusion in Sheep. In: Rayssiguier Y, Mazur, A., Durlach, J. (Eds). Advances in Magnesium Research: Nutrition and Health. London: John Libbey. p. 385-387
[2]  Edwards, CRW, Al-Dujaili, EAS, Boscero, M, Gow IF, and Williams, BC (1982) Peptidergic and monoaminergic regulation of secretion. In: Mantero, F, Biglieri, EG, and Edwards, CRW. (Eds). Serono symposium No. 50. London: Academic Press: 11-18
[3]  Shennan DB, Thomson J, Davidson J, Gow IF (2006). Properties of volume-activated taurine efflux from human breast cancer cells. Adv Exp Med Biol, 583, 109-16
[4]  Allan GJ, Tonner E, Szymanowska M, Shand JH, Kelly SM, Phillips K, Clegg RA, Gow IF, Beattie J, Flint DJ. (2006) Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action. Endocrinology, 147, 338-49
[5]  Gow IF, Thomson J, Davidson J, Shennan DB (2005) The effect of a hyposmotic shock and purinergic agonists on K+(Rb+) efflux from cultured human breast cancer cells. Biochim Biophys Acta, 1712, 52-61
[6]  Travers MT, Gow IF, Barber MC, Thomson J, Shennan DB (2004) Indoleamine 2, 3-dioxygenase activity and L-tryptophan transport in human breast cancer cells Biochim Biophys Acta, 1661, 106-12
[7]  Shennan DB, Thomson J, Gow IF, Travers MT, Barber MC (2004) L-leucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): kinetics, regulation by estrogen and molecular identity of the transporter. Biochim Biophys Acta, 1664, 206-16
[8]  Gow IF, Mitchell E, Wait M (2003) Adrenergic receptors in the bovine mammary artery. Biochem Pharmacol, 65, 1747-53
[9]  Gow IF, Mitchell E, Wait M (2003) Intravenous magnesium reduces the rate of glucose disposal in lactating sheep. Exp Physiol, 88, 533-40
[10]  Gow IF (2002) Changes in Ionised Mg2+ and Ca2+ in Maternal Serum During Weaning in Goats. Magnesium Research, 15, 199-202
[11]  Shennan DB, Grant AC, Gow IF (2002) The effect of hyposmotic and isosmotic cell swelling on the intracellular [Ca2+] in lactating rat mammary acinar cells. Molecular & Cellular Biochemistry, 233, 91-7
[12]  Gow IF (2001) [Support staff banned from being authors] Measurement of ionised magnesium in HEPES-buffered serum samples. Analytica Chimica Acta, 432, 143-149
[13]  Gow IF (2000) Response of isolated ruminant mammary arteries to the long R3 analogue of insulin-like growth factor I. Experimental Physiology, 85, 275-9
[14]  Grant AC, Gow IF, Zammit VA, Shennan DB (2000) Regulation of protein synthesis in lactating rat mammary tissue by cell volume. Biochimica et Biophysica Acta, 1475, 39-46
[15]  Shennan DB, Gow IF (2000) Volume-activated K(+)(Rb(+)) efflux in lactating rat mammary tissue. Biochimica et Biophysica Acta, 1509, 420-8
[16]  Gow IF, Cumming A, Sykes A (1999) Suppression of aggregation and calcium mobilisation in bovine platelets by external magnesium. Platelets, 10, 306-311
[17]  Gow IF, Flatman PW, Ellis D (1999) Lithium induced changes in intracellular free magnesium concentration in isolated rat ventricular myocytes. Molecular and Cellular Biochemistry, 198, 129-133
[18]  Gow IF, Cumming A (1997) The effect of external magnesium on cytosolic free ionized calcium in bovine blood platelets. Journal of Physiology-London, 499P, P61-62
[19]  Handy RD, Ellis D, Gow IF, Flatman PW (1996) Regulation of intracellular ionized magnesium concentration by Na+-Mg2+ exchange in isolated rat ventricular myocytes. Journal of Physiology-London, 495P, P168
[20]  Handy RD, Gow IF, Ellis D, Flatman PW (1996) Na-dependent regulation of intracellular free magnesium concentration in isolated rat ventricular myocytes Journal of Molecular & Cellular Cardiology, 28, 1641-51
[21]  Gow IF, Ellis D (1996) Transmembrane movements of lithium in isolated sheep-heart Purkinje fibres. Journal of Molecular and Cellular Cardiology, 28, 299-310
[22]  Do E, Baudet S, Gow IF, Ellis D, Noireaud J (1995) Intracellular pH During Hypoxia in Normal and Hypertrophied Right Ventricle of Ferret Heart. Journal of Molecular and Cellular Cardiology, 27, 927-939
[23]  Gow IF, Sykes AJ (1995) Magnesium Prolongs the Duration of Thrombin-Induced Shape Changes in Bovine Platelets. British Journal of Pharmacology, 116, P407
[24]  Gow IF, Latham T, Ellis D, Flatman PW (1995) Measurement of intracellular ionized magnesium concentration in myocytes isolated from the septomarginal band of sheep hearts. Magnesium Research, 8, 223-32
[25]  Waugh C, Dockrell M, Edwards CRW, Elder A, Flapan A, Mitchell J, Williams BC, Gow IF (1994) Simultaneous measurement by radioimmunoassay of β-thromboglobulin and serotonin released from thrombin-stimulated human platelets. European Journal of Haematology, 52, 180-181
[26]  Gow IF, Dockrell M, Edwards CRW, Elder A, Grieve J, Kane G, Padfield PL, Waugh CJ, Williams BC (1992) The sensitivity of human blood platelets to the aggregating agent ADP during different dietary sodium intakes in healthy men. European Journal of Clinical Pharmacology, 43, 635-638
[27]  Gow IF, Dockrell, M, Waugh, C, and Williams, BC (1991) The relationship between platelet and platelet-rich plasma serotonin measurements. Platelets, 2, 161-162
[28]  Gow IF, Flapan AD, Morris M, Davies E, Williams BC, Padfield PL, Shaw TRD, Edwards CRW (1991) A Lack of Effect of Captopril on Platelet-Aggregation in Patients with Congestive-Heart-Failure. European Journal of Clinical Pharmacology, 41, 47-49
[29]  Gow IF, Ellis D (1990) Effect of Lithium on the Intracellular Potassium Concentration in Sheep Heart Purkinje-Fibers. Experimental Physiology, 75, 427-430
[30]  Gow IF, Jones DB, Billett J, France AJ, Edwards CR (1988) Platelet serotonin concentration in patients with finger-clubbing [letter]. Lancet, 2, 579
[31]  Gow IF, Corrie JET, Edwards CRW, Williams BC. The Stability of Tritiated Serotonin Stored at 4-Degrees-C Implications for Platelet Uptake Studies. Thrombosis Research 1988; 52: 263-268
[32]  Gow IF, Corrie JE, Williams BC, Edwards CR (1987) Development and validation of an improved radioimmunoassay for serotonin in platelet-rich plasma. Clinica Chimica Acta, 162, 175-88
[33]  Gow IF, Padfield PL, Reid M, Stewart SE, Edwards CR, Williams BC (1987) High sodium intake increases platelet aggregation in normal females. Journal of Hypertension 5, S243-6
[34]  Gow IF, Faulkner A (2000) Changes is serum ionised magnesium in lactating sheep during an intravenous glucose-tolerance test. Biochemical Society Transactions, 28, A26
[35]  Gow IF, Burns C, Shennan DB (1998) Volume-activated calcium transport in lactating rat mammary tissue. Biochemical Society Transactions, 26, S389
[36]  Riches PL, Gow IF (1998) The effect of lithium on bovine blood platelet function. Biochemical Society Transactions, 26, S391
[37]  Brown, SJ, Gow, IF, Williams, BC, Hayes, PC, and Dillon, J (1997) Zinc protoporphyrin alters the free calcium level in platelets from cirrhotics. Scottish Medical Journal, 42, p25-26
[38]  Gow IF, Ellis D (1992) Factors affecting the steady-state distribution of lithium in the sheep-heart Purkinje fibre. Biochemical Society Transactions, 20, 15S
[39]  Waugh CJ, Gow IF, Edwards CRW, Williams BC (1989). Application of a Novel Radioimmunoassay for Serotonin in the Detection of Aromatic L-Amino-Acid Decarboxylase Activity in Isolated Renal Cortical-Cells. Biochemical Society Transactions, 17, 163-164
[40]  Gow IF, Padfield PL, Reid M, Stewart S, Williams BC, Edwards CRW (1986) Sodium-Intake, Platelet-Aggregation, and Serotonin Levels in Normal Females. Journal of Endocrinology, 111, s40
[41]  Shaikh, S, Williams, BC, Gow, IF, Macdonald, A, and Edwards, CRW (1986) The effects of altering endogenous serotonin levels in the rat on the steroidogenic response of isolated zona glomerulosa cells to angiotensin II (AII) and serotonin (5HT) in vitro. Journal of Endocrinology, 111, s93
[42]  Wallace, J, Warnock, M, and Gow, IF (2011) The life and death of breast cancer cells: proposing a role for the effects of phytoestrogens on potassium channels. Journal of Membrane Biology, In Press
[43]  Gow IF (1999) Cardiovascular Effects of Insulin-like Growth Factor I. Hannah Research Institute Yearbook 38-47
[44]  Gow IF (1993) Mechanisms of lithium action: I. Ions and ion movement-potassium and the sodium-potassium pump. Reviews in Contemporary Pharmacotherapy, 4, 288-289
[45]  Gow IF, Williams BC (1989) Immunoassays for Antigens. Current Opinion in Immunology, 1, 940-947
[46]  Gow IF (2009) Final Report to the Scottish Government Rural and Environment Research and Analysis Directorate (RERAD). Pharmacological & Physiological Characterisation of the Rat Mammary Artery at Different Stages of Reproduction, 1-25
[47]  Gow IF (2006) Final Report to Scottish Executive Environment and Rural Affairs Department (SEERAD) Science and Research Group, Project HRI/131/03 Potassium and Chloride Transport in Normal and Tumorigenic Mammary Epithelial Cells, 1-5
[48]  Gow IF (2003) Final Report to Scottish Executive Environment and Rural Affairs Department (SEERAD) Agricultural and Biological Research Group, Project HRI/004/01 Regulation of tone in ruminant and rat mammary arteries 1-8
[49]  Gow IF (1999) Progress Report to Scottish Executive Environment and Rural Affairs Department (SEERAD) Agricultural and Biological Research Group, Project HRI/003/98 The role of nutritional and nutritionally-derived events in regulating mammary metabolism and milk production 1-5