American Journal of Bioinformatics Research

American Journal of Bioinformatics Research publishes all the newest and distinguished research articles, reviews and letters in all areas of bioinformatics and computational biology. Each issue contains a series of timely, in-depth written articles by leaders in the field, covering a wide range of the integration of biology with computer and information science.


Nigus Ambaye

Editorial Board Member of American Journal of Bioinformatics Research

Post-doctoral Fellow, St. Jude Children's Research Hospital, USA

Research Areas

Drug Design, Medicinal Chemistry, Synthetic Chemistry, Peptide and Protein Chemistry, Macromolecular Crystallography

Education

2008-2011Ph.DDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia
2004-2006M.S.Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Punjab, India
1998-2003B.PharmSchool of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

Experience

2011-presentPost doctoral Fellow, Department of Chemical biology and Therapeutics, St. Jude Children's Research hospital, Memphis, TN 38105
2006-2008Lecturer in Medicinal Chemistry, Department of Pharmaceutical Chemistry, School of Pharmacy, Addis Ababa University, P.O.BOX 1176, Addis Ababa
2003-2004Graduate Assistant, Department of Pharmaceutical Chemistry, School of Pharmacy, Addis Ababa University, P.O.Box 1176, Addis Ababa

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Nigus D. Ambaye, Menachem J. Gunzburg, Reece C.C. Lim, John T. Price, Matthew C.J. Wilce and Jacqueline A. Wilce. The discovery of Phenylbenzamide derivatives as a novel class of Growth factor bound protein 7 (Grb7) based anti-tumour agents. ChemMedChem, 2012, 10.1002/cmdc.201200400.
[2]  Nigus D. Ambaye and Jacqueline A. Wilce (2012) Grb7– a newly emerging target in pancreatic cancer. In: Pancreatic Cancer- Molecular Mechanism and Targets. Sanjay K. Srivastava (Ed.), ISBN 978-953-51-0410-0 InTech Education and Publishing, Austria, http: //www.intechopen.com/articles/
[3]  Menachem J. Gunzburg, Nigus D. Ambaye, Mark P. Del Borgo, Stephanie C. Pero, David N. Krag, Matthew C.J. Wilce and Jacqueline A.Wilce. Interaction of the nonphosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity. Journal of Molecular Recognition, 2012, 25, 57-67
[4]  Sanjeev Kumar Singh, Sunil Kumar Tripathi, Nigus Dessalew, Poonam Singh. Cyclin Dependent Kinase as Significant Target for Cancer Treatment. Current Cancer Therapy Reviews, 2012; 8, 225-235.
[5]  Ambaye ND, Pero SC, Gunzburg MJ, Yap M, Clayton DJ, Del Borgo MP, Perlmutter P, Aguilar MI, Shukla GS, Peletskaya E, Cookson MM, Krag DN, Wilce MC, Wilce JA. Structural Basis of Binding by Cyclic Nonphosphorylated Peptide Antagonists of Grb7 Implicated in Breast Cancer Progression. Journal of Molecular Biology, 2011, 412, 397-411.
[6]  Ambaye ND, Gunzburg MJ, Lim RC, Price JT, Wilce MC, Wilce JA. Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists. Bioorganic and Medicinal Chemistry, 2011, 9, 693-701
[7]  Ambaye ND, Lim RC, Clayton DJ, Gunzburg MJ, Price JT, Pero SC, Krag DN, Wilce MC, Aguilar MI, Perlmutter P, Wilce JA. Uptake of a cell permeable G7-18NATE construct into cells and binding with the Grb7-SH2 domain. Biopolymers (Peptide Science). 2011, 96, 181-188.
[8]  Menachem J. Gunzburg, Nigus D. Ambaye, Jack T. Hertzog, Mark P. Del Borgo, Stephanie C. Pero, David N. Krag, Matthew C. J. Wilce, Marie-Isabel Aguilar, Patrick Perlmutter and Jacqueline A. Wilce. Use of SPR to Study the Interaction of G7-18NATE Peptide with the Grb7-SH2 Domain. International Journal of Peptide Research and Therapeutics, 2010, 16, 177-184
[9]  Dessalew, N. QSAR study on dual SET and NET reuptake inhibitors: An insight into the structural requirement for antidepressant activity. Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24, 262-271.
[10]  Dessalew, N., Singh, S.K. 3D-QSAR CoMFA and CoMSIA study on benzodipyrazoles as cyclin dependent kinase 2 inhibitors. Medicinal Chemistry, 2008, 4, 313-321.
[11]  Dessalew, N., Mikre, W., Hymete, A. Multitarget selective antidepressants design: Latest developments, opportunities and challenges. Central Nervous System Agents in Medicinal Chemistry, 2008, 8, 131-142.
[12]  Dessalew, N. QSAR study on dual 5-HT1A and 5-HT1B antagonists: An insight into the structural requirement for antidepressant activity. Archiv der Pharmazie, 2008, 341, 314-322
[13]  Dessalew, N., Bharatam, P.V. Structure based de novo design of novel glycogen synthase kinase 3 inhibitors. Bioorganic and Medicinal Chemistry, 2007, 15, 3728-3736.
[14]  Dessalew, N., Bharatam, P.V. Identification of potential glycogen kinase-3 inhibitors by structure based virtual screening. Biophysical Chemistry, 2007, 128, 165-175.
[15]  Patel, D.S., Dessalew, N., Iqbal, P., Bharatam, P.V. Structure-based approaches in the design of GSK-3 selective inhibitors. Current Protein and Peptide Science, 2007, 8, 352-364
[16]  Dessalew, N., Bharatam, P.V. 3D-QSAR and molecular docking study on bisarylmaleimide series as glycogen synthase kinase 3, cyclin dependent kinase 2 and cyclin dependent kinase 4 inhibitors: An insight into the criteria for selectivity. European Journal of Medicinal Chemistry, 2007, 42, 1014-1027.
[17]  Dessalew, N., Patel, D.S., Bharatam, P.V. 3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3β inhibitors. Journal of Molecular Graphics and Modelling, 2007, 25, 885-895
[18]  Dessalew, N., Bharatam, P.V., Singh, S.K. 3D-QSAR CoMFA study on aminothiazole derivatives as cyclin-dependent kinase 2 inhibitors. QSAR and Combinatorial Science, 2007, 26, 85-91.
[19]  Dessalew, N., Bharatam, P.V. Investigation of potential glycogen synthase kinase 3 inhibitors using pharmacophore mapping and virtual screening. Chemical Biology and Drug Design, 2006, 68, 154-165.
[20]  Singh, S.K., Dessalew, N., Bharatam, P.V. 3D-QSAR CoMFA study on indenopyrazole derivatives as cyclin dependent kinase 4 (CDK4) and cyclin dependent kinase 2 (CDK2) inhibitors. European Journal of Medicinal Chemistry 2006, 41, 1310-1319.