American Journal of Stem Cell Research

American Journal of Stem Cell Research is an international, peer-reviewed, worldwide, open access journal. It is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. The journal explains the special emphasis on basic translational and clinical research into stem cell therapeutics, including animal models and clinical trials.

Maurizio Pesce

Editorial Board Member of American Journal of Stem Cell Research

Staff Scientist, Cardiovascular Tissue Engineering Laboratory, Italy

Research Areas

Stem Cells, Cardiovascular, Regenerative Medicine, Tissue Engineering

Education

1991-1995Ph.DStudent in Embryology, School of medicine, University of Rome "Tor Vergata"

Experience

2001-presentSenior Scientist, Centro Cardiologico Monzino IRCCS, Milan, Italy
2001 Scientist, Laboratorio di Patologia Vascolare, IDI-IRCCS, Rome, Italy
1999-2000Associate Research at the School of Medicine, University of Rome, Tor Vergata, Rome, Italy
1996-1998Postdoctoral Fellow at the Gene Expression Programme, European Molecular Biology Laboratory (EMBL) Heidelberg, Germany

Publications: Journals

[1]  Burba, I., Colombo, G.I., Staszewsky, L. I., De Simone, M, Devanna, P., Nanni, S., Avitabile, D., Molla, F., Cosentino, S., Russo, I., De Angelis, N., Soldo, A.R., Biondi, A., Gambini, E., Gaetano, C., Farsetti, A., Pompilio, G., Latini, R., Capogrossi, M.C. and Pesce, M.*. Histone Deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34+ cells. PLoS ONE 6(7): e22158. doi:10.1371/journal.pone.0022158. IF 4.41
[2]  Pozzoli, O., Vella, P., Iaffaldano, G., Parente, V., Devanna, P., Lacovich, M., Lamia, C.L., Fascio, U., Longoni, D., Cotelli, F., Capogrossi, M.#, and Pesce, M*,#. Endothelial fate and angiogenic properties of human CD34+ progenitor cells in Zebrafish. Arterioscler. Thromb. Vasc. Biol. 2011, 31(7):1589-97. IF 7.21
[3]  Avitabile, D., Crespi, A., Brioschi, C., Parente, V., Toietta, G., Devanna, P., Baruscotti, M., Truffa, E., Scavone, A., Rusconi, A., Biondi, A., D'alessandra, Y., Vigna, E., DiFrancesco, D., Pesce, M., Capogrossi, M.C., and Barbuti, A. Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process. Am. J. Physiol. Heart Circul. Physiol. 2011, 300, H1875-H1884. IF 3.88
[4]  Gambini, E., Pompilio, G., Biondi, A., Alamanni, F., Capogrossi, M.C., Agrifoglio, M. and Pesce, M*. C-kit+ cardiac progenitors exhibit mesenchymal markers and preferential cardiovascular commitment. Cardiov. Res. 2011, 89(2), 362-73. IF 6.05
[5]  Pesce, M.*, Burba, I., Gambini, E., Prandi, F., Pompilio G. and Capogrossi M.C. Endothelial and cardiac progenitors: boosting, conditioning and (re)programming for cardiovascular repair. Pharmacol. Therapeut. 2011, 129 (1), 50-61. IF 8.69
[6]  Achilli, F., Malafronte, C., Lenatti, L., Gentile, F., Dadone, V., Gibelli, G., Maggiolini, S., Squadroni, L., Di Leo, C., Burba, I., Pesce, M., Mircoli, L., Capogrossi, M.C., Di lelio, A., Camisasca, P., Morabito, A., Pompilio, G. for the STEM-AMI Investigators. Granulocyte colony stimulating factor attenuates left ventricular remodelling after acute anterior STEMI. Results of the single blind, randomized, placebo controlled multicenter stem cell mobilization in acute myocardial infarction (STEM-AMI) trial. Eur. J Heart Fail., 2010, 12(10), 1111-1210. IF 4.51
[7]  Schuhmann, N.K., Pozzoli, O., Sallach, J., Huber, A., Avitabile, D., Perabo, L., Capogrossi, M.C., Hallek, M., Pesce, M.# and Büning, H#. Gene transfer into human cord blood-derived CD34+ cells by adeno-associated viral vectors. Exp. Hematol. 2010, 38(9), 707-717. IF 3.19
[8]  Burba, I., Devanna, P. and Pesce, M*. When Cells Become a Drug. Endothelial Progenitor Cells for Cardiovascular Therapy: Aims and Reality. Recent Pat. Cardiovasc. Drug Discov. 2010, 5(1), 1-10.
[9]  Gianella A., Guerrini U., Tilenni M., Sironi, L., Milano, G., Nobili, E., Vaga, S., Capogrossi, M.C., Tremoli, E and Pesce, M*. Magnetic resonance imaging of human endothelial progenitors reveals opposite effects on vascular and muscle regeneration into ischemic tissues. Cardiov. Res. 2010; 85(3) 503-513. IF 6.05
[10]  Gaipa, G., Tilenni, M., Straino, S., Burba, I., Zaccagnini, G., Belotti, D., Biagi E., Valentini, M., Perseghin, P., Parma, M. Di Campli, C., Biondi, A., Capogrossi M.C., Pompilio, G., Pesce M*. GMP-based CD133+ cells isolation maintains progenitor angiogenic properties and enhances standardization in cardiovascular cell therapy. J. Cell. Mol. Med. 2010; 14(6b), 1619-1634. IF 4.60
[11]  De Falco, E., Avitabile, D., Totta, P., Straino, S., Spallotta, F., Cencioni, C., Torella A.R., Rizzi, R., Porcelli, D., Zacheo, A., Di Vito, L., Pompilio, G., Napolitano, M., Melillo, G., Capogrossi, M.C., Pesce, M*. Altered SDF-1-mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus. J. Cell. Mol Med. 2009; 13(9B), 3405-3414. IF 4.60
[12]  Pompilio, G, Capogrossi, MC, Pesce, M, Alamanni, F, Di Campli, C, Achilli, F, Germani, A, Biglioli, P. Endothelial progenitor cells and cardiovascular homeostasis: clinical Implications. Int J Cardiol, 2009; 131: 156-167. IF 6.80
[13]  Orlandi, A., Pagani, F., Avitabile, D., Bonanno, G., Scambia, G., Vigna, E., Grassi, F., Eusebi, F., Fucile, S., Pesce, M.*, Capogrossi, M.C. Functional properties of cells obtained from human cord blood CD34+ stem cells and mouse cardiac myocytes in coculture. Am. J. Physiol. Heart Circul. Physiol. 2008; 294: H1541-H1549. IF 3.88
[14]  Pompilio, G., Steinhoff, G., Liebold, A., Pesce, M., Alamanni, F., Capogrossi, M.C., Biglioli, P. Direct Minimally Invasive Intramyocardial Injection of Bone Marrow-Derived AC133+ Stem Cells in Patients with Refractory Ischemia: Preliminary Results. Thorac. Cardiov. Surg. 2007; 55: 1-6. IF 0.74
[15]  Zangrossi, S., Marabese, M., Broggini, M., Giordano, R., D'Erasmo, M., Montelatici, E., Intini, D., Neri, A., Pesce, M., Rebulla, P., Lazzari, L. Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker. Stem Cells 2007; 25(7): 1675-1680. IF 7.87
[16]  Cianfarani, F., Zambruno, G., Brogelli, L., Sera, F. Lacal, P.M., Pesce, M., Capogrossi, M.C., Failla, M.C., Napolitano, M, Odorisio, T. Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am. J. Pathol. 2006; 169 (4): 1167-1182 . IF 5.22
[17]  Marcellini, M., De Luca, N., Riccioni, T, Ciucci, A., Orecchia, A., Lacal, P.M., Ruffini, F., Pesce, M., Cianfarani, F., Zambruno, G., Orlandi, O., Failla, C.M. Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor. Am. J. Pathol. 2006; 169 (2), 643-654. IF 5.22
[18]  Pompilio, G, Cannata, A, Pesce, M, Capogrossi, MC, Biglioli, P. Long lasting improvement of myocardial perfusion and chronic refractory angina after autologous intramyocardial PBSC transplantation. Cytotherapy 2005; 7(6): 494-496. IF 2.92
[19]  Lagostena L, Avitabile D, De Falco E, Orlandi A, Grassi F, Iachininoto MG, Ragone G, Fucile S, Pompilio P, Eusebi F, Pesce M*, Capogrossi MC. Electrophysiologic properties of mouse c-kit+ cells co-cultured onto mouse cardiac myocytes. Cardiov. Res. 2005; 66(3):482-92. IF 6.05
[20]  Kehler J, Tolkunova, E, Koshorzb, Pesce M, Gentile L, Boiani M, Lomeli H, Nagy A, McLaughlin J, Scholer HR, Tomilin, A. Oct4 is required for primordial germ cell survival. EMBO Rep. 2004; 5(11), 1078-83. IF 7.82
[21]  De Falco E, Porcelli D, Iachininoto MG, Torella AR, Truffa S, Orlandi A, Biglioli P, Napolitano M, Capogrossi MC, Pesce M*. SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood 2004; 104(12): 3472-82. IF 10.55
[22]  Pesce M*,#, Orlandi A#, Iachininoto MG, Straino S, Torella AR, Rizzuti V, Bonanno G, Scambia G, Pompilio G, Capogrossi MC. Myo/endothelial differentiation of human cord blood-derived stem cells in ischemic tissues. Circ. Res. 2003; 95, 93: e51-e63. IF 9.50
[23]  Pompilio G, Cannata A, Capogrossi MC, Alamanni F, Pesce M, Germani A, Biglioli P. Ital Heart J. 2002;3:1188-97.
[24]  Pesce M*, Klinger FG, De Felici M. Derivation in culture of primordial germ cells from cells of the mouse epiblast: phenotypic induction and growth control by Bmp4 signalling. Mech Dev. 2002;112:15-24. IF 2.95
[25]  Pesce M, Scholer HR. Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells. 2001;19:271-8. IF 7.87
[26]  Butteroni C, De Felici M, Scholer HR, Pesce M*. Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins. J Mol Biol. 2000;304:529-40. IF 4.00
[27]  Pesce M, Scholer HR. Oct-4: control of totipotency and germline determination. Mol Reprod Dev. 2000;55:452-7. IF 2.39
[28]  Pesce M, Marin Gomez M, Philipsen S, Scholer HR. Binding of Sp1 and Sp3 transcription factors to the Oct-4 gene promoter. Cell Mol Biol. 1999;45:709-16. IF 0.83
[29]  Pesce M, Anastassiadis K, Scholer HR. Oct-4: lessons of totipotency from embryonic stem cells. Cells Tissues Organs. 1999;165:144-52. IF 2.30
[30]  De Felici M, Di Carlo A, Pesce M, Iona S, Farrace MG, Piacentini M. Bcl-2 and Bax regulation of apoptosis in germ cells during prenatal oogenesis in the mouse embryo. Cell Death Differ. 1999;6:908-15. IF 9.05
[31]  Pesce M, Gross MK, Scholer HR. In line with our ancestors: Oct-4 and the mammalian germ. Bioessays. 1998;20:722-32. IF 4.47
[32]  Pesce M, Wang X, Wolgemuth DJ, Scholer H. Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev. 1998;71:89-98. IF 2.82
[33]  De Felici M, Pesce M, Giustiniani Q, Di Carlo A. In vitro adhesiveness of mouse primordial germ cells to cellular and extracellular matrix component substrata. Microsc Res Tech. 1998;43:258-64. IF 1.71
[34]  Pesce M, Di Carlo A, De Felici M. The c-kit receptor is involved in the adhesion of mouse primordial germ cells to somatic cells in culture. Mech Dev. 1997;68:37-44. IF 2.95
[35]  Dolci S, Grimaldi P, Geremia R, Pesce M, Rossi P. Identification of a promoter region generating Sry circular transcripts both in germ cells from male adult mice and in male mouse embryonal gonads. Biol Reprod. 1997;57:1128-35. IF 3.87
[36]  Pesce M, Canipari R, Ferri GL, Siracusa G, De Felici M. Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylate cyclase and promotes proliferation of mouse primordial germ cells. Development. 1996;122:215-21. IF 6.89
[37]  Morena AR, Boitani C, Pesce M, De Felici M, Stefanini M. Isolation of highly purified type A spermatogonia from prepubertal rat testis. J Androl. 1996;17:708-17. IF 3.14
[38]  De Felici M, Di Carlo A, Pesce M. Role of stem cell factor in somatic-germ cell interactions during prenatal oogenesis. Zygote. 1996;4:349-51. IF 1.24
[39]  Pesce M, De Felici M. Purification of mouse primordial germ cells by MiniMACS magnetic separation system. Dev Biol. 1995;170:722-5. IF 4.09
[40]  De Felici M, Pesce M. Immunoaffinity purification of migratory mouse primordial germ cells. Exp Cell Res. 1995;216:277-9. IF 3.60
[41]  Pesce M, De Felici M. Apoptosis in mouse primordial germ cells: a study by transmission and scanning electron microscope. Anat Embryol (Berl) (continued as Brain Struct Funct) 1994;189:435-40. IF 4.98
[42]  De Felici M, Pesce M. Growth factors in mouse primordial germ cell migration and proliferation. Cytokine Growth F Rev 1994;5:135-43. IF 8.23
[43]  De Felici M, Pesce M. Interactions between migratory primordial germ cells and cellular substrates in the mouse. Ciba Found Symp. 1994;182:140-50.
[44]  Pesce M, Farrace MG, Piacentini M, Dolci S, De Felici M. Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis). Development. 1993;118:1089-94. IF 6.89
[45]  Pesce, M., Siracusa, G., Giustiniani, De Felici, M. Histotypic in vitro reorganization of dissociated cells from mouse fetal gonads. Differentiation. 1994; 56:137-42. IF 3.06
[46]  Dolci S, Pesce M, De Felici M. Combined action of stem cell factor, leukemia inhibitory factor, and cAMP on in vitro proliferation of mouse primordial germ cells. Mol Reprod Dev. 1993;35:134-9. IF 2.39
[47]  De Felici M, Dolci S, Pesce M. Proliferation of mouse primordial germ cells in vitro: a key role for cAMP. Dev Biol. 1993;157:277-80. IF 4.09
[48]  Cataldi E, De Merich D, Pesce M, Cioni C. Ultrastructural study of the esophagus of seawater-and freshwater-acclimated Mugil cephalus (Perciformes, Mugilidae), euryhaline marine fish. J Morphol. 217(3) 1993; 337-345. IF 1.77
[49]  De Felici M, Dolci S, Pesce M. Cellular and molecular aspects of mouse primordial germ cell migration and proliferation in culture. Int J Dev Biol. 1992;36:205-13. IF 2.86

Publications: Books/Book Chapters

[1]  Pesce M., Farrace MG, Amendola A, Piacentini M, De Felici M. Stem cell factor regulation of apoptosis in mouse primordial germ cells. In (Jonathan Tilly and Jerome Strauss Eds.) Cell Death in Reproductive Physiology (Serono Symposia USA, Norwell, Massachusetts), 1997, Springer-Verlag, New York, 19-31. ISBN 10-0387983449.
[2]  De Felici M, Di Carlo A, Dolci S, Pesce M. Experimental in vitro approaches to the study of mouse primordial germ cell development. In (Mario Stefanini, Carla Boitani, Michela Galdieri, Raffaele Geremia and Fioretta Palombi Eds). Testicular function: form gene expression to gene manipulation (Ernst Shering Research Foundation, Workshop supplement 3), 1998, Springer-Verlag, New York, 23-39. ISBN 3-540-64156-4.
[3]  Pesce, M., Tilenni, M., Burba I. Disclosed and undisclosed properties of human endothelial progenitor cells. In (R.M. Mohan Ed.) Recent Advances in Heart and Circulatory Physiology, 2009, Global Research Network, Kerala, India, volume 1, 1-11.
[4]  Pesce, M., Pompilio, G. and Capogrossi MC. Endothelial progenitor cells from human cord blood: Magic bullets against ischemia? In (Niranjan Bhattacharya and Phillip Stubblefield Eds.) Regenerative Medicine Using Pregnancy-Specific Biological Substances, 2011, Springer-Verlag, UK, 205-215. DOI 10.1007/978-1-84882-718-9.
[5]  Pesce, M., Gambini, E., Pompilio, G. and Capogrossi MC. Cardiac stem cells: tales, mysteries and promises in heart generation and regeneration. In (Gustav Steinhoff Ed.) Regenerative Medicine, from Protocol to patient. Springer, 265-286. DOI 10.1007/978-90-481-9075-1.