| [1] | Luk Su*, Lee TK* Lee DT, Chiu YT, Ma S, Ng IO, Wong YC, Wong YC, Chan FL, Ling MT. Chemopreventive effect of PSP through targeting of prostate cancer stem-like population. PLoS One 2011; 6:e19804 (*contributed equally)(IF 4.35; Rank 10 of 70 in Biology Category) |
| [2] | Lee TK*, Murthy S*, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau S, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh YP. Carboxypeptidase E spice isoform is a novel tumor inducer and biomarker for predicting future metastasis in human cancers. J Clin Invest 2011; 121:880-92. (*contributed equally) (IF 15.38; Rank 2 of 93 in Medicine, Research & Experimental Category) |
| [3] | Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. CD24+ liver tumor-initiating cells drive self-renewal and tumor initiation through Stat3-mediated nanog regulation. Cell Stem Cell 2011; 9:50-63 (IF 23.56; Rank 4 of 162 in Cell Biology Category) |
| [4] | Ma S, Tang KH, Chan YP, Lee TK, Kwan PS, Castilho A, Ng IO, Man K, Lo CM, Wong N, To KF, Zheng BJ, Lai PB, Chan KW, Guan XY. miR-130b promotes CD133+ liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010; 7:694-707. (IF 23.56; Rank 4 of 162 in Cell Biology Category) |
| [5] | Ma S, Chan YP, Kwan PS, Lee TK, Yan M, Tang KH, Ling MT, Vielkind J, Guan XY, Chan KW. microRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2. Cancer Res 2011; 71:583-92. (IF 7.54; Rank 13 of 166 in Oncology Category) |
| [6] | Lee TK, Castilho A, Cheung VC, Tang KH, Ma S, Ng IO. Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation. Hepatology 2010; 53:160-70. (IF 10.84; Rank 2 of 66 in Gastroenterology & Hepatology Category) |
| [7] | Luk Su, Yap WN, Chiu YT, Lee DT, Ma S, Lee TK, Vasireddy RS, Wong YC, Ching YP, Nelson C, Yap YL, Ling MT. Gamma-tocotrienol as an effective agent in targeting prostate stem cell-like population. Int J Cancer 2010; 128:2182-91 (IF 4.72; Rank 30 of 166 in Oncology Category) |
| [8] | Ng KT, Lee TK, Cheng Q, Wo JY, Sun CK, Guo DY, Lim ZX, Lo CM, Poon RT, Fan ST, Man K. Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on homeoprotein Six1. Int J Cancer 2010; 127: 859-72. (IF 4.72; Rank 30 of 166 in Oncology Category) |
| [9] | Lee TK, Castilho A, Ma S, Ng IO. Liver cancer stem cells: Implications for a new therapeutic target. Liver Int 2009; 29: 955-65. (IF 2.98; Rank 18 of 66 in Gastroenterology & Hepatology Category) |
| [10] | Lee TK, Castilho A, Ma S, Ng IO. Epithelial-mesenchymal transition in cancer stem cells. In: Cancer Stem Cells (Ed. XY Guan). Research Signpost 2010, ISBN: 978-81-7895-465-3. |
| [11] | Liu LX, Lee NP, Chan VW, Xue W, Zender L. Zhang C, Mao M, Dai H, Wang XL, Xu MZ, Lee TK, Ng IO, Chen Y, Kung HF, Lowe SW, Poon RT, Wang JH, Luk JM. Targeting caderin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology 2009; 50:1453-63. (IF 10.84; Rank 2 of 66 in Gastroenterology & Hepatology Category) |
| [12] | Ma S, Lee TK, Zheng BJ, Chan KW, Guan XY. CD133+ HCC cancer stem cells promote chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008; 27: 1749-58. (IF 7.21; Rank 14 of 166 in Oncology Category) |
| [13] | Ma S+, Chan KW, Lee TK, Tang KH, Wo JY, Zheng BJ, Guan XY. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res 2008; 6:1146-53. (+Most cited 2008 paper from Mol Cancer Res) (IF 4.16; Rank 41 of 166 in Oncology Category) |
| [14] | Ling MT, Chiu YT, Lee TK, Leung SC, Fung MK, Wang X, Wong KF, Wong YC. Id-1 induces proteasome-dependent degradation of the HBX protein. J Mol Biol 2008; 382:34-43. (IF 3.87; Rank 80 of 283 in Biochemistry & Molecular Biology Category) |
| [15] | Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, Zheng BJ, Guan XY. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007; 132:2542-56. (IF 12.89; Rank 1 of 66 in Gastroenterology & Hepatology Category) |
| [16] | Ma S, Guan XY, Lee TK, Chan KW. Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma. Hum Pathol 2007; 38:1201-6. (IF 2.96; Rank 19 of 71 in Pathology Category) |
| [17] | Lee TK, Poon RT, Wo JY, Ma S, Guan XY, Myers JN, Yuen AP. Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model. Cancer Res 2007; 67:8800-9. (IF 7.51; Rank 13 of 166 in Oncology Category) |
| [18] | Lee TK, Poon RT, Man K, Guan XY, Ma S, Liu XB, Myers JN, Yuen AP. Fascin over-expression is associated with aggressiveness of oral squamous cell carcinoma. Cancer Lett 2007; 253:308-15. (IF 3.74; Rank 52 of 166 in Oncology Category) |
| [19] | Zhang X, Ling MT, Wang Q, Lau CK, Leung SC, Lee TK, Cheung AL, Wong YC, Wang X. Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells. J Biol Chem 2007; 282:33284-94. (IF 5.32; Rank 48 of 283 in Biochemistry & Molecular Biology Category) |
| [20] | Man K, Ng KT, Lo CM, Ho JW, Sun BS, Sun CK, Lee TK, Poon RT, Fan ST. Ischemia-reperfusion of small liver remnant promotes liver tumor growth and metastases-activation of cell invasion and migration pathways. Liver Transpl 2007; 12:1669-77. (IF 3.72; Rank 4 of 24 in Transplantation Category) |
| [21] | Sun CK, Ng KT, Sun BS, Ho JW, Lee TK, Ng IO, Poon RT, Lo CM, Liu CL, Man K, Fan ST. The significance of proline-rich tyrosine kianse2 (Pyk2) on hepatocellular progression and recurrence. Br J Cancer 2007; 97:50-7. (IF 4.34; Rank 35 of 166 in Oncology Category) |
| [22] | Pang R, Lee TK, Poon RT, Fan ST, Wong KB, Kwong YL, Tse E. Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis. Gastroenterology 2007; 132:1088-103. (IF 12.89; Rank 1 of 66 in Gastroenterology & Hepatology Category) |
| [23] | Ng KT, Man K, Ho JW, Sun CK, Lee TK, Zhao Y, Lo CM, Poon RT, Fan ST. Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway. Int J Oncol 2007; 30:375-80. (IF 2.44; Rank 83 of 166 in Oncology Category) |
| [24] | Ng KT, Man K, Sun CK, Lee TK, Poon RT, Lo CM, Fan ST. Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma. Br J Cancer 2006; 95: 1050-5. (IF 4.34; Rank 35 of 166 in Oncology Category) |
| [25] | Man K, Zhao Y, Xu A, Lo CM, Lam KS, Ng KT, Ho JW, Sun CK, Lee TK, Li XL, Fan ST. Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival. Am J Transplant 2006; 6:467-76. (IF 6.43; Rank 1 of 24 in Transplantation Category) |
| [26] | Zhou C, Ling MT, Lee TK, Man K, Wang X, Wong YC. FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase. Cancer Lett 2006; 233:36-47. (IF 3.74; Rank 52 of 166 in Oncology Category) |
| [27] | Man K, Su M, Ng KT, Lo CM, Zhao Y, Ho JW, Sun CK, Lee TK, Fan ST. Rapamycin attenuates liver graft injury in cirrhotic recipient—the significance of down-regulation of Rho-Rock-VEGF pathway. Am J Transplant 2006; 6:697-704. (IF 6.43; Rank 1 of 24 in Transplantation Category) |
| [28] | Xu X, Man K, Zheng SS, Liang TB, Lee TK, Ng KT, Fan ST, CM Lo. Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival. Liver Transpl 2006; 12:621-7. (IF 3.72; Rank 4 of 24 in Transplantation Category) |
| [29] | Pang R, Lee TK, Poon RT, Man K, Fan ST, Kwong YL, Tse E. PIN1 expression contributes to hepatic carcinogenesis. J Pathol 2006; 210:19-25. (IF 6.46; Rank 2 of 71 in Pathology Category) |
| [30] | Lee TK, Man K, Poon RT, Lo CM, Yuen AP, Ng IO, Ng KT, Leonard W, Fan ST. Stat5b activation enhances HCC aggressiveness through induction of epithelial-mesenchymal transition. Cancer Res 2006; 66:9948-56. (IF 7.54; Rank 13 of 166 in Oncology Category) |
| [31] | Lee TK, Poon RT, Yuen, AP, Ling MT, Wang XH, Wong YC, Guan XY, Man K, Tang ZY, Fan ST. Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. Clin Cancer Res 2006; 12:6910-9. (IF 6.74; Rank 16 of 166 in Oncology Category) |
| [32] | Lee TK, Poon RT, Yuen AP, Ling MT, Wang XH, Wong YC, Guan XY, Man K, Chau KL, Fan ST. Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res 2006; 12:5369-76. (IF 6.74; Rank 16 of 166 in Oncology Category) |
| [33] | Lee TK, Poon RT, Yuen AP, Man K, Yang ZF, Guan XY, Fan ST. Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. Clin Cancer Res 2006; 12:5082-9. (IF 6.74; Rank 16 of 166 in Oncology Category) |
| [34] | Ho JW, Man K, Sun CK, Lee TK, Poon RT, Fan ST. Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma. Mol Cancer Ther 2005; 4:1430-8. (IF 4.95; Rank 28 of 166 in Oncology Category) |
| [35] | Man K, Ng KT, Lee TK, Lo CM, Sun CK, Li X., Zhao Y, Ho JWY, Fan ST. FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers. Am J Transplant 2005; 5:40-9. (IF 6.43; Rank 1 of 24 in Transplantation Category) |
| [36] | Lee TK, Man K, Ho JW, Wang X H, Poon RT, Sun CK, Ng KT, Wong YC, Ng IO, Xu Y, Sun HC, Tang ZY, Xu RR, Fan ST. FTY720: a promising agent for the treatment of metastatic hepatocellular carcinoma. Clin Cancer Res 2005; 11:8458-66. (IF 6.74; Rank 16 of 166 in Oncology Category) |
| [37] | Lee TK, Man K, Ho JW, Wang XH, Poon RT, Sun CK, Ng KT, Wong YC, Ng IO, Xu R, Fan ST. Significance of the Rac signaling pathway in HCC cell motility: implication for a new therapeutic target. Carcinogenesis 2005; 26: 681-7. (IF 4.79; Rank 29 of 166 in Oncology Category) |
| [38] | Zhao Y, Man K, Lo CM, Ng KT, Li X L, Sun CK, Lee TK, Dai XW, Fan ST. Attenuation of small-for-size liver graft injury by FTY720: significance of cell-survival Akt signaling pathway. Am J Transplant 2004; 4:1399-1407. (IF 6.43; Rank 1 of 24 in Transplantation Category) |
| [39] | Li XL, Man K, Ng KTP, Lee TK, Lo CM, Fan ST. Insulin in UW solution exacerbates hepatic ischemia/reperfusion injury by energy depletion through IRS-2/SREBP-1c pathway. Liver Transplant 2004; 10: 1173-82. (IF 3.72; Rank 4 of 24 in Transplantation Category) |
| [40] | Pang R, Yuen J, Yuen M F, Lai CL, Lee TK, Man K, Poon RT, Fan ST, Wong CM, Ng IO, Kwong Y L, Tse E. PIN1 overexpression and beta-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma. Oncogene 2004; 23:4182-6. (IF 7.13; Rank 14 of 166 in Oncology Category) |
| [41] | Man K, Lee TK, Liang TB, Lo CM, Fung PC, Tsui SH, Li XL, Ng KT, Fan ST. FK 409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. Ann Surg 2004; 240:159-68. (IF 7.9; Rank 1 of 167 in Surgery Category) |
| [42] | Lee TK, Man K, Ling MT, Wang XH, Wong YC, Lo CM, Poon RT, Ng IO, Fan ST. Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway. Carcinogenesis 2003; 24:1729-36. (IF 4.79; Rank 29 of 166 in Oncology Category) |
| [43] | Lee TK, Man K, Poon RT, Lo CM, Ng IO, Fan ST. Disruption of p53-p21/WAF1 cell cycle pathway contributes to progression and worse clinical outcome of hepatocellular carcinoma. Oncol Rep 2004; 12:25-31. (IF 1.58; Rank 117 of 166 in Oncology Category) |
| [44] | Lee TK, Man K, Ho JW, Sun CK, Ng KT, Wang XH, Wong YC, Ng IO, Xu R, Fan ST. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis 2004; 25:2397-405. (IF 4.79; Rank 29 of 166 in Oncology Category) |
| [45] | Man K, Lo CM, Liu CL, Zhang ZW, Lee TK, Ng IO, Fan ST, Wong J. Effects of the intermittent Pringle manoeuvre on hepatic gene expression and ultrastructure in a randomized clinical study. Br J Surg 2003; 90:183-9. (IF 4.07; Rank 7 of 167 in Surgery Category) |
| [46] | Man K, Fan ST, Lo CM, Liu CL, Fung PC, Liang TB, Lee TK, Tsui S H, Ng IO, Zhang ZW, Wong J. Graft injury in relation to graft size in right lobe live donor liver transplantation: a study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression. Ann Surg 2003; 237:256-64. (IF 7.9; Rank 1 of 167 in Surgery Category) |
| [47] | Man K, Lo CM, Lee TK, Li XL, Ng IO, Fan ST. Intragraft gene expression profiles by cDNA microarray in small-for-size liver grafts. Liver Transpl 2003; 9:425-32. (IF 3.72; Rank 4 of 24 in Transplantation Category) |
| [48] | Li XL, Man K, Liu YF, Lee TK, Tsui SH, Lau CK, Lo CM, Fan ST. Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation. Transplantation 2003; 76:44-9. (IF 3.49; Rank 6 of 24 in Transplantation Category) |
| [49] | Ling MT, Wang X, Ouyang XS, Lee TK, Fan SY, Xu K, Tsao SW, Wong YC. Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth. Oncogene 2002; 21:8498-505. (IF 7.13; Rank 14 of 166 in Oncology Category) |
| [50] | Qin LF, Lee TK, Ng IO. Gene expression profiling by cDNA array in human hepatoma cell line in response to cisplatin treatment. Life Sci 2002; 70:1677-90. (IF 2.56; Rank 36 of 93 in Medicine, Research & Experimental Category) |
| [51] | Lee TK, Lau TC, Ng IO. Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines. Cancer Chemother Pharmacol 2002; 49:78-86. (IF 2.65; Rank 76 of 166 in Oncology Category) |
| [52] | Lee TK, Han JS, Fan ST, Liang ZD, Tian PK, Gu JR, Ng IO. Gene delivery using a receptor-mediated gene transfer system targeted to hepatocellular carcinoma cells. Int J Cancer 2001; 93:393-400. (IF 4.72; Rank 30 of 166 in Oncology Category) |
| [53] | Ng IO, Liang ZD, Cao L, Lee TK. DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on proliferation of hepatoma cell lines with deleted DLC-1. Cancer Res 2000; 60:6581-4. (IF 7.54; Rank 13 of 166 in Oncology Category) |