International Journal of Biological Engineering

International Journal of Biological Engineering is an international peer-reviewed multidisciplinary journal publishing original scientific research in all fields of biological pharmacy. Original research work that contributes significantly to further the scientific knowledge in biological pharmacy will be appreciated.

Eugene Patkin

Editorial Board Member of International Journal of Biological Engineering

Head of Academic Department/Faculty, Lab. of Molecular Cytogenetics of Mammalian Development of Department of Molecular Genetics, Russia

Research Areas

Epigenetics, Genetics, Medical Genetics and Epigenetics, Molecular Genetics and Cytogenetics, Developmental Biology, Ecological Epigenetics, Non-Protein-Coding Tandem Repeats, Transgenic Mice, Cell Culture,

Education

1995DrBiological Sciences, Department of Biochemistry Biological Faculty, Leningrad State University
1980Ph.DDepartment of Biochemistry Biological Faculty, Leningrad State University

Experience

since 2000 Head of Lab. of Molecular Cytogenetics of Mammalian Development of Department of Molecular Genetics
since 1996Leading Scientist, Department of Molecular Genetics, IEM, RAMS
since 1994 Group Leader (Molecular Cytogenetics of Mammalian Development), Department of Molecular Genetics and Development
1989-1993Senior Scientist, Department of Embryology, IEM, RAMS
1973-1988Junior Scientist, Department of Embryology, Institute of Experimental Medicine (IEM) of the Russian Academy of Medical Sciences (RAMS)
1966-1972 Junior Scientist, NAVY Institute

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Patkin E.L., Kustova M.E., Dyban A.P. (1994): Spontaneous sister-chromatids differentiation (SCD) and sister-chromatid exchanges (SCEs)in chromosomes of mouse blastocyst. Cytogen. Cell Genet. 66, 31-32.
[2]  Patkin E.L., Kustova M.E., Noniaschvili E.M. (1994): DNA breaks in nuclei of preimplantation mouse embryo as revealed in situ. Cytobios 79, 235-240.
[3]  Patkin E.L., Kustova M.E., Noniaschvili E.M. (1995): DNA single-strand breaks in chromosomes of early mouse embryos as detected by in situ nick translation. Genome 38, 381-384.
[4]  Patkin E.L. (1997): Asymmetry of sister chromatids methylation of preimplantation mouse embryo chromosomes as revealed by nick translation in situ. Cytogenet. Cell Genet. 77, 82-83.
[5]  Patkin E.L., Kustova M.E., Perticone P.(1998) The influence of demethylation agents on the preimplanataion mouse development. Zygote,6,351-358.
[6]  Popov A., Baranova T.V., Suchkova I., Smirnov A., Golubkov V., Sorokin A., Patkin E. (1999) The modelling of heterochromatic regions in transgenic mice. Cytogenet. Cell Genet. 85, 95.
[7]  Suchkova I, Strunnikova M., Sorokin A., Golubkov V., Gaitskhoki V., Patkin E. (1999) The effect of foreign satDNA integration on F2 transgenic embryo development. Cytogenet. Cell Genet. 85, 108.
[8]  Suchkova O., Nikitina N., Sasina L. K., Slominskaja N. A., Golubkov V. I., Patkin E. L. (2004) Minisatellite UPS29 is unstable in Parkinson’s disease patients. Eur. J. Hum. Genet. 5 (Suppl). 135.
[9]  Zhebrun D.A., Shubina D.M., Slominska N.O, Suchkova I.O., Patkin E.L. (2006) Molecular genetic analysis of the intronic tandem repeat sequence of gene CENTB5 at human and mice. Eur. J. Med. Res., v.11, p.22.
[10]  Patkin E.L., M.E. Kustova, A.P. Dyban. 1994. Spontaneous sister-chromatids differentiation (SCD) and sister-chromatid exchanges (SCEs) in chromosomes of mouse blastocyst. Cytogen. Cell Genet.66, 31-32.
[11]  Patkin E. L. Asymmetry of sister chromatids methylation of preimplantation mouse embryo chromosomes as revealed by nick translation in situ. Cytogenet. Cell Genet. 1997. V. 77. P. 82.-83.
[12]  Patkin EL, Vaido AI, Kustova ME, Shiriaeva NV, Lopatina NG. Single-strand DNA breaks in brain cells of different rat strains under normal condition and during exposure to stress. Tsitologiia. 2001;43(3):269-73. .
[13]  Popov A., Golubkov V.I., Bader M., Suchkova I., Baranova T., Gaitskhoki V., Patkin E. 1999. The detection of transgenic animals with the help of PCR in situ. Tsitologiia. 1999. т.41. с.36-40.
[14]  Irina O. Suchkova1, Tatjana V. Baranova1, Maria E. Kustova, Tatjana V. Kisljakova2, Vadim B. Vassiliev1, Natalja O. Slominskaja1, Natalia V. Alenina, Eugene L. Patkin1 2004. Transsatellite DNA induces neoheterochromatin formation by recipient DNA in cells of embryonal teratocarcinoma stem cells. Tsitologiia, v.46, p.53-61,.
[15]   SlominskajaN.O., I.O. Suchkova, U.Rannug, E.L.Patkin. 2005. Modeling of human minisatellite MS32 somatic instability in mouse embryonal teratocarcinoma cell line F9. Eur. J. Hum. Genet. v. 13 (Suppl). p. 157.
[16]  Suchkova I.O.., Slominskaja N.O., Schubina D., Sasina L.K., Vassiliev V.B., Alenina N., Bader M., Patkin E.L. 2007. Molecular-genetical charcterization of nonhypervariable GC-rich minisatellite UPS29 of CENTB5 gene. Ecol. Genet. 5, 35-45.
[17]  Alenina N., Baranova T., Smirnow E., Bader M., Lippoldt A., Patkin E., Walther T. Cell-type specific expression of the Mas protooncogene in testis The Journ. Histochem. Cytochem. 2002, 50, 1-5.
[18]  Suchkova IO, Slominskaia NA, Kustova ME, Baranova TV, Golubkov VI, Sorokin AV, Vasil'ev B, Patkin EL. 2004. Instability of repetitive units of foreign centromeric satellite DNA in transgenic mice and transfected cells. Genetika. 2004 40(8):1034-45.
[19]  Patkin E.L. and Gaitskhoki V.S. (2000). Satellite DNA and diseases-possible mechanisms, Minisatellite instability. Russ. J. Genet., 36, 989-993.
[20]  Suchkova I.O., Baranova T.V., Kisljakova T.V., Slominskaja N., Alenina N., E. L. Patkin. 2004. Bovine satellite DNA induces heterochromatinization of host chromosomal DNA in cells of transsatellite mouse embryonal carcinoma. Tsitologiia. 46. 53-61.
[21]  Alenina N, Xu P, Rentzsch B, Patkin EL, Bader M. Genetically altered animal models for Mas and angiotensin-(1-7). Exp Physiol. 2008 May;93(5):528-37.
[22]  Sasina L, Suchkova I, Solovyev K, Slominska N, Baranov VS, Patkin E. Intra-intronic human minisatellite UPS29 associated with neurological diseases regulates reporter gene activity depending on its copy number in cell line F9. Europ. J. Hum. Genet. 2009, 17:295.
[23]  D. M. Shubina, I. O. Suchkova , N. A. Slominskaya, N. Alenina, M. Bader, and E. L. Patkin. CENTB5 Gene Expression in Humans and Mice. Molecular Biology, 2009, Vol. 43, No. 3, pp. 374-380,.
[24]  N. A. Slominskaya,1,* I. O. Suchkova,1 T. A. Klinskaya,1 M. A. Zabezhinsky,2 E. L. Patkin1 TRANSGENERATIONAL TRANSMISSION OF BOVINE SATELLITE DNA IN TRANSGENIC MICE Tsitologiia, 2006, 48, 522-529.
[25]  L. K. Sasina, N. A. Slominskaja, I. O. Suchkova, E. V. Pitsik, K. V. Solovyov, N. A. Grudinina, T. A. Klinskaja, E. L. Patkin1. HUMAN INTRA-INTRONIC MINISATELLITE UPS29 ASSOCIATED WITH NEUROLOGICAL DISEASES REGULATES REPORTER GENE EGFP EXPRESSION DEPENDING ON CELL TYPE.Tsitologiia, 2010, 52, 715-723.
[26]  Patkin E. L., Quinn John. 2010. Epigenetical mechanisms of susceptibility to complex human diseases. Ecol.Genet., 8, 44-56. I. O. Suchkovaa, D. M. Shubinaa, A. F. Yakimovskiib, E. V. Borisovac,.
[27]  N. G. Eliseevac, L. K. Sasinaa, T. V. Baranovaa, V. S. Baranovd, and E. L. Patkina Analysis of the Association of Minisatellite UPS29 of CENTB5 Gene with Parkinson’s Disease. Russian Journal of Genetics: Applied Research, 2011, Vol. 1, No. 2, pp. 128-137.