Advances in Analytical Chemistry

Advances in Analytical Chemistry is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of analytical chemistry. The journal publishes features and news articles about major advances, trends, and challenges in analytical chemistry. These articles include peer-reviewed features written by researchers and news stories that discuss novel analytical concepts and instruments.

Paraskevas Tzanavaras

Editorial Board Member of Advances in Analytical Chemistry

Assistant Professor, Chemistry Department, Laboratory of Analytical Chemistry, Aristotelian University of Thessaloniki, Greece

Research Areas

Analytical Chemistry, Automation, Quality Control

Education

1998-2003Ph.DChemistry Department, School of Natural Sciences, A.U.Th.
1993-1998B.ScAristotle University of Thessaloniki, School of Natural Sciences, Chemistry Department

Experience

2007-presentAcademic staff, Department of Chemistry, Aristotelian University of Thessaloniki, Greece
2004-2007Head of Quality Assurance and Control of Cosmopharm Ltd (Korinthos, Greece), manufacturer of pharmaceuticals and cosmetics

Publications: Journals

[1]  "Automated derivatization of pharmaceutically active thiols under flow conditions using an o-phthalaldehyde/glycine fluorogenic system and sequential injection analysis." T.D. Karakosta and P.D. Tzanavaras* Anal. Lett., in press.
[2]  "Automated pre-column derivatization of thiolic fruit-antibrowning agents by sequential injection coupled to high performance liquid chromatography using a monolithic stationary phase and an in-loop stopped-flow approach" T.D. Karakosta, P.D. Tzanavaras and D.G. Themelis* J. Sep. Sci., 34 (2011) 2240.
[3]  "Development and validation of an ultra-fast liquid chromatographic method for the quality control of famotidine formulations using a short monolithic stationary phase." P.D. Tzanavaras* Central Eur. J. Chem., 9 (2011) 446.
[4]  "Development and validation of a rapid HPLC method for the determination of five banned fat-soluble colorants in spices using a narrow-bore monolithic column." C.K. Zacharis*, F.S. Kika, P.D. Tzanavaras, P. Rigas and E.R. Kyranas Talanta, 84 (2011) 480.
[5]  "Ethyl propiolate as a post-column derivatization reagent for thiols: development of a green liquid chromatographic method for the determination of glutathione in vegetables." C.K. Zacharis, P.D. Tzanavaras* and A. Zotou Anal. Chim. Acta, 690 (2011) 122.
[6]  "HPLC separation of nimesulide and five impurities using a narrow-bore monolithic column: application to photo-degradation studies." C.K. Zacharis and P.D. Tzanavaras* Chromatographia, 73 (2011) 347.
[7]  "Automated tagging of pharmaceutically active thiols under flow conditions using monobromobimane." P.D. Tzanavaras* and T.D. Karakosta J. Pharm. Biomed. Anal., 54 (2011) 882.
[8]  "NBD-Cl as a post-column reagent for primary and secondary amines after separation by ion-exchange chromatography." C.K. Zacharis, P.D. Tzanavaras, P.N. Mouroutis and P. Rigas* Anal. Lett., 44 (2011) 1821.
[9]  "Automated determination of Captopril by flow and sequential injection analysis: a review" P.D. Tzanavaras* Anal. Lett., 44 (2011) 560.
[10]  "Derivatization of thiols under flow conditions using two commercially available propiolate esters." P.D. Tzanavaras*, A. Tsiomlektsis and C.K. Zacharis J. Pharm. Biomed. Anal., 53 (2010) 790.
[11]  "LC-determination of five paraben preservatives in saliva and toothpaste samples using UV detection and a short monolithic column." A. Zotou*, I. Sakla and P.D. Tzanavaras J. Pharm. Biomed. Anal., 53 (2010) 785.
[12]  "Solvent-based de-emulsification dispersive liquid-liquid microextraction combined with gas chromatography-mass spectrometry for determination of trace organochlorine pesticides in environmental water samples." C.K. Zacharis*, P.D. Tzanavaras, C. Roubos, K. Dima J. Chromatogr. A, 1217 (2010) 5896.
[13]  "On-line derivatization of N-acetylcysteine using ethyl-propiolate as a novel advantageous reagent and sequential injection analysis". P.D. Tzanavaras*, C.K. Zacharis and D.G. Themelis Anal. Lett., 43 (2010) 1889.
[14]  "High throughput automated determination of glutathione based on the formation of a UV-absorbing thioacrylate derivative" (Invited article) C.K. Zacharis and P.D. Tzanavaras* Comb. Chem. & High Through. Screen., 13 (2010) 461.
[15]  "Recent advances in the analysis of organic impurities of active pharmaceutical ingredients and formulations: a review" P.D. Tzanavaras* Curr. Org. Chem., 14 (2010) 2348.
[16]  "Rapid determination of methylxanthines in real samples by high performance liquid chromatography using the new FastGradient® narrow-bore monolithic column." P.D. Tzanavaras*, C.K. Zacharis and D.G. Themelis Talanta, 81 (2010) 1494.
[17]  "Generic automated fluorimetric assay for the quality control of gamma aminobutyric acid-analogue anti-epileptic drugs using sequential injection analysis". D.G. Themelis*, P.D. Tzanavaras and E.A. Boulimari Anal. Lett., 43 (2010) 905.
[18]  "Ethyl-propiolate as a novel and promising analytical reagent for the derivatization of thiols: study of the reaction under flow conditions." C.K. Zacharis*, P.D. Tzanavaras and D.G. Themelis J. Pharm. Biomed. Anal., 50 (2009) 384.
[19]  "Automated zone-sampling dilution by coupling sequential injection analysis to high-throughput HPLC for the direct determination of gemfibrozil." P.D. Tzanavaras*, D.G. Themelis and P. Rigas J. Sep. Sci., 32 (2009) 2819.
[20]  "Automated sample preparation coupled to sequential injection chromatography: on-line filtration and dilution protocols prior to separation." C.K. Zacharis, A. Verdoukas, P.D. Tzanavaras* and D.G. Themelis J. Pharm. Biomed. Anal., 49 (2009) 726.
[21]  "Development and validation of a micellar electrokinetic chromatography method for the purity control of nimesulide pharmaceuticals." C.K. Zacharis, P.D. Tzanavaras*, M. Notou, A. Zotou and D.G. Themelis J. Pharm. Biomed. Anal., 49 (2009) 201.
[22]  "Selective determination of cyanides by gas diffusion-stopped flow-sequential injection analysis and an on-line standard addition approach." D.G. Themelis*, S. Karastogianni and P.D. Tzanavaras Anal. Chim. Acta, 632 (2009) 93.
[23]  "Hybrid sequential injection-flow injection manifold for the spectrophotometric determination of total sulfite in wines using o-pthalaldehyde and gas-diffusion." P.D. Tzanavaras, E. Thiakouli and D.G. Themelis* Talanta, 77 (2009) 1614.
[24]  "Amperometric determination of cyanides at the low ppb level by automated preconcentration based on gas diffusion coupled to sequential injection analysis." C.K. Zacharis*, P.D. Tzanavaras, A.N. Voulgaropoulos* and B. Karlberg Talanta, 77 (2009) 1620.
[25]  "Novel automated assay for the quality control of mexiletine hydrochloride formulations using sequential injection and on-line dilution." P.D. Tzanavaras*, C.K. Zacharis and P. Rigas J. Pharm. Biomed. Anal., 48 (2008) 1254.
[26]  "Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological material: A review of analytical methods." C.K. Zacharis* and P.D. Tzanavaras J. Pharm. Biomed. Anal., 48 (2008) 483.
[27]  "Extraction of acyclovir from pharmaceutical creams prior to HPLC assay analysis. Optimization and validation of pre-treatment protocols." (invited article) P.D. Tzanavaras and C.K. Zacharis* Central Eur. J. Chem., 6 (2008) 140.
[28]  "Optimization and validation of a dissolution test for selegiline hydrochloride tablets by a novel rapid HPLC assay using a monolithic stationary phase." P.D. Tzanavaras*, D.G. Themelis, A. Zotou, J. Stratis and B. Karlberg J. Pharm. Biomed. Anal., 46 (2008) 670.
[29]  "Sequential-injection analysis: a useful tool for clinical and biochemical analysis." (invited article) A. Economou*, P.D. Tzanavaras and D.G. Themelis Curr. Pharm. Anal., 3 (2007) 249.
[30]  "Review of recent applications of flow injection spectrophotometry to pharmaceutical analysis." P.D. Tzanavaras* and D.G. Themelis Anal. Chim. Acta, 588 (2007) 1.
[31]  "Automated determination of flutamide by a validated flow-injection method. Application to dissolution studies of pharmaceutical tablets." P.D. Tzanavaras* and D.G. Themelis J. Pharm. Biomed. Anal., 43 (2007) 1820.
[32]  "Highly selective flow injection spectrophotometric determination of gold based on its catalytic effect on the oxidation of variamine blue by potassium iodate in aqueous N,N-dimethylformamide medium" D.G. Themelis*, A.V. Trellopoulos, P.D. Tzanavaras and M. Sofoniou Talanta, 72 (2007) 277.
[33]  "Review on analytical methods for the determination of chlorine dioxide" (invited article) P.D. Tzanavaras*, D.G. Themelis* and F.S. Kika Central Eur. J. Chem., 5 (2007) 1.
[34]  "Rapid HPLC assay of acyclovir and its major impurity guanine in raw materials and pharmaceutical creams using a monolithic column and a flow gradient approach" P.D. Tzanavaras* and D.G. Themelis J. Pharm. Biomed. Anal., 43 (2007) 1526.
[35]  "Validated high-throughput HPLC assay for nimesulide using a short monolithic column" P.D. Tzanavaras* and D.G. Themelis J. Pharm. Biomed. Anal., 43 (2007) 1483.
[36]  "Development and validation of a high-throughput HPLC assay for the determination of caffeine in food samples using a monolithic column" P.D. Tzanavaras* and D.G. Themelis Anal. Chim. Acta, 581 (2007) 89.
[37]  "Optimization and validation of a dissolution test for famotidine tablets using flow injection analysis" P.D. Tzanavaras*, A. Verdoukas and T. Balloma J. Pharm. Biomed. Anal., 41 (2006) 437.
[38]  "Sequential Injection Analysis : Principles, Construction of a SIA Analyzer and Demonstration by a Simple Experiment" A. Economou*, P.D. Tzanavaras and D.G. Themelis J. Chem. Educ., 82 (2005) 1820.
[39]  "Development and validation of a flow injection assay for the dissolution studies of the anti-depressant drug venlafaxine." P.D. Tzanavaras*, A. Verdoukas and D.G. Themelis Anal. Sci., 21 (2005) 1515.
[40]  "Validated flow injection spectrophotometric assay for the quality and stability control of gemfibrozil tablets." P.D. Tzanavaras* and D.G. Themelis Anal. Lett., 38 (2005) 2165.
[41]  "Assay of the synthetic estrogen fosfestrol in pharmaceutical formulations using capillary electrophoresis." D.G. Themelis*, A.V. Trelopoulos, P.D. Tzanavaras and B. Karlberg J. Pharm. Biomed. Anal., 39 (2005) 559.
[42]  "Normal spectrophotometric and stopped-flow spectrofluorimetric sequential injection methods for the determination of alendronic acid, an anti-osteoporosis amino-bisphosphonate drug." P.D. Tzanavaras, C.K. Zacharis, G. Theodoridis*, Ε.Α. Kalaitzantonakis and A. Voulgaropoulos Anal. Chim. Acta, 547 (2005) 98.
[43]  "Determination of orthophosphate in urine by sequential injection analysis with on-line dilution and photometric detection." D.G. Themelis*, A. Economou, A. Tsiomlektsis and P.D. Tzanavaras Anal. Biochem., 330 (2004) 193.
[44]  "Rapid spectrofluorimetric determination of lisinopril in pharmaceutical tablets using sequential injection analysis." C.K. Zacharis, P.D. Tzanavaras, D.G. Themelis*, G. Theodoridis, A. Economou, P. Rigas Anal. Bioanal. Chem., 379 (2004) 759.
[45]  "Determination of boron in water and pharmaceuticals by sequential injection analysis and fluorimetric detection." A. Economou*, D.G. Themelis, H. Bikou, P.D. Tzanavaras and P.G. Rigas Anal. Chim. Acta, 510 (2004) 219.
[46]  "Automated sample preparation based on the sequential injection principle. Solid-phase extraction on a molecularly imprinted polymer coupled on-line to high-performance liquid chromatography." G. Theodoridis*, C.K. Zacharis, P.D. Tzanavaras, D.G. Themelis and A. Economou J. Chromatogr. A, 1030 (2004) 69.
[47]  "Determination of carbimazole and methimazole in pharmaceuticals by flow injection with chemiluminescence detection based on the inhibition of the Cu(II)-catalyzed luminol-hydrogen peroxide reaction." A. Economou*, P.D. Tzanavaras, M. Notou and D.G. Themelis. Anal. Chim. Acta, 505 (2004) 129.
[48]  "Sequential injection method for the direct spectrophotometric determination of bismuth in pharmaceutical products." P.D. Tzanavaras, D.G. Themelis* and A. Economou. Anal. Chim. Acta, 505 (2004) 167.
[49]  "Novel flow-injection spectrophotometric determination of fosinopril using UV-assisted digestion and an orthophosphates calibration graph." P.D. Tzanavaras and D.G. Themelis*. Anal. Chim. Acta, 481 (2003) 321.
[50]  "Flow injection manifold for the rapid spectrophotometric determination of fosfestrol, following on-line thermal induced digestion by peroxodisulfate ion and using an orthophosphate calibration graph." P.D. Tzanavaras and D.G. Themelis*. Talanta, 59 (2003) 207.
[51]  "Flow and sequential injection manifolds for the spectrophotometric determination of captopril based on its oxidation by Fe(III)." P.D. Tzanavaras, D.G. Themelis*, A. Economou and G. Theodoridis. Μicrochim. Acta, 142 (2003) 55.
[52]  "Sensitive determination of captopril by flow injection analysis with chemiluminescence detection based on the enhancement of the luminol reaction." A. Economou*, D.G. Themelis, G. Theodoridis and P.D. Tzanavaras. Anal. Chim. Acta, 463 (2002) 249.
[53]  "Rapid spectrophotometric determination of fosfestrol following on-line hydrolysis by alkaline phosphatase using flow injection and chasing zones." P.D. Tzanavaras, D.G. Themelis* and B. Karlberg. Anal. Chim. Acta, 462 (2002) 119.
[54]  "Flow-injection spectrophotometric determination of the antibiotic fosfomycin in pharmaceutical products and urine samples after on-line thermal induced digestion." P.D. Tzanavaras and D.G. Themelis*. Anal. Biochem., 304 (2002) 244.
[55]  "Reversed flow-injection manifold for the spectrophotometric determination of captopril based on its inhibitory effect on the Co(II)-2,2΄-dipyridyl-2-pyridylhydrazone complex formation." P.D. Tzanavaras, D.G. Themelis*, A. Economou and G. Theodoridis. Talanta, 57 (2002) 575.
[56]  "Simultaneous flow-injection determination of fluoride, monofluorophosphate and orthophosphate ions using alkaline phosphatase immobilized on a cellulose nitrate membrane and an open-circulation approach." P.D. Tzanavaras and D.G. Themelis*. Anal. Chim. Acta, 467 (2002) 83.
[57]  "Solvent extraction flow-injection manifold for the simultaneous spectrophotometric determination of free cyanide and thiocyanate ions based upon on-line masking of cyanides by formaldehyde." (Part of PhD Thesis) D.G. Themelis* and P.D. Tzanavaras. Anal. Chim. Acta, 452 (2002) 295.
[58]  "Direct and selective flow-injection method for the simultaneous spectrophotometric determination of calcium and magnesium in red and white wines using on-line dilution based on "zone sampling"." D.G. Themelis*, P.D. Tzanavaras, A. V. Trellopoulos and M.C. Sofoniou. J. Agric. Food Chem., 49 (2001) 5152.
[59]  "Rapid flow-injection spectrophotometric determination of monofluorophosphates in toothpastes after on-line hydrolysis by alkaline phosphatase immobilized on a cellulose nitrate membrane." (Part of PhD thesis) P.D. Tzanavaras and D.G. Themelis*. Analyst, 126 (2001) 1608.
[60]  "Flow injection manifold for the simultaneous spectrophotometric determination of Fe(II) and Fe(III) using 2,2΄-dipyridyl-2-pyridylhydrazone and a single-line double injection approach." D.G. Themelis*, P.D. Tzanavaras, F.S. Kika and M.C. Sofoniou. Fresenius' J. Anal. Chem., 371 (2001) 364.
[61]  "On-line dilution flow injection manifold for the selective spectrophotometric determination of ascorbic acid based on the iron(II)-2, 2-dipyridyl-2-pyridyl hydrazone complex formation." D.G. Themelis*, P.D. Tzanavaras and F.S. Kika. Talanta, 55 (2001) 127.
[62]  "Simple, rapid reagent-injection spectrophotometric determination of fluorides in pharmaceutical formulations." D.G. Themelis*, P.D. Tzanavaras and H.D. Tzanavaras. J. Pharm. Biomed. Anal., 25 (2001) 971.
[63]  "Flow injection manifold for the direct spectrophotometric determination of bismuth in pharmaceutical products using methylthymol blue as colour forming agent." D.G. Themelis*, P.D. Tzanavaras and J.K. Papadimitriou. Analyst, 126 (2001) 247.
[64]  "Simultaneous spectrophotometric determination of fluoride and monofluorophosphate ions in toothpastes using a reagent-injection manifold." (Part of PhD Thesis) D.G. Themelis* and P.D. Tzanavaras. Anal. Chim. Acta, 429 (2001) 113.
[65]  "Reagent-injection spectrophotometric determination of citric acid in beverages and pharmaceutical formulations based on its inhibitory effect on the iron(III) catalytic oxidation of 2, 4-diaminophenol by hydrogen peroxide." (Part of PhD Thesis) D.G. Themelis* and P.D. Tzanavaras. Anal. Chim. Acta, 428 (2001) 23.
[66]  "Normal and differential demasking flow injection manifold for the direct spectrophotometric deterimnation of zinc(II) in biological materials and pharmaceutical formulations." D.G. Themelis*, P.D. Tzanavaras, A.A. Liakou, H.D. Tzanavaras and J.K. Papadimitriou. Analyst, 125 (2000) 2106.
[67]  "Direct, selective flow injection spectrophotometric determination of calcium in wines using methylthymol blue and an on-line cascade dilution system." D.G. Themelis*, P.D. Tzanavaras, A.N. Anthemidis and J. Stratis. Anal. Chim. Acta, 402 (1999) 259.