Advances in Analytical Chemistry

Advances in Analytical Chemistry is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of analytical chemistry. The journal publishes features and news articles about major advances, trends, and challenges in analytical chemistry. These articles include peer-reviewed features written by researchers and news stories that discuss novel analytical concepts and instruments.


Qing-Wen Zhang

Editorial Board Member of Advances in Analytical Chemistry

Assistant Professor, University of Macau, Macau

Research Areas

Herbal Medicine/Phytochemistry/Pharmaceutical Analysis

Education

2000Ph.DChina Pharmaceutical University, China
1997MasterChina Pharmaceutical University, China
1995BachelorChina Pharmaceutical University, China

Experience

2007-presentAssistant Professor, ICMS, University of Macau, Macau SAR
2003-2006Senior Research Chemist, ChromaDex Analytics, Inc. Boulder, Colorado, U.S.A.
2000-2003Postdoctoral Research Associate, Cancer Research Institute, Arizona State University, Arizona, U.S.A.
1999-2000Research Assistant, Department of Chemistry, The Hong Kong University of Science & Technology, Hong Kong
1995-2000Teaching Assistant and Research Assistant (part time), Department of Phytochemistry, China Pharmaceutical University, China

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Shao Qiu-hong, Yin Zhi-qi, Zhang Qing-wen, Ye Wen-cai, Zhao Shou-xun. Advances on Citrus medica L. var. sarcodactylis (Noot.) Swingle (accepted).
[2]  Xiao-cen Li, Zhi-Qi Yin, Xiao-Qi Zhang, Wen-Cai Ye, Qing-Wen Zhang*. Preparative Separation of Patchouli Alcohol from Patchouli Oil Using High Performance Centrifugal Partition Chromatography. The Journal of Essential Oil Research. (accepted).
[3]  Ying Chen, Qing-Wen Zhang*, Song-Lin Li, Yan Yi, Jing Zhao, Ying Wang, Wen-Cai Ye. Psidium guajava, a potential resource rich in corosolic acid revealed by high performance liquid chromatography. Journal of Medicinal Plant Research. 2011 (in press).
[4]  Huan Zhang, Qing-Wen Zhang*, Lei Wang, Xiao-Qi Zhang, Wen-Cai Ye, Yi-Tao Wang. Two new anthraquinone malonylglucosides from Polygonum cuspidatum. Natural Product Research (in press).
[5]  SHI Jun-min, HAN Wei-li, YE Wen-cai, Chan Shek-kiu, WANG Yi-tao, ZHANG Qing-wen. Phytochemical Investigation of Corydalis yanhusuo. Journal of natural products research and Development 2011 (in press).
[6]  Ying Wang, Mei Chen, Jing Zhang, Xiao-Li Zhang, Xiao-Jun Huang, Xin Wu, Qing-Wen Zhang, Yao-Lan Li, Wen-Cai Ye. Flavone C-Glycosides from the Leaves of Lophatherum gracile and Their in Vitro Antiviral Activity. Planta Medica (in press).
[7]  Yi Yan, Wu Xin, Wang Ying, Ye Wen-cai, Zhang Qing-wen*. Flavonoids from Flower of Hylocereus undatus. Journal of Chinese Medicinal Materials 2011 in press.
[8]  Gang Du, Haiyu Zhao, Yuelin Song, Qingwen Zhang* and Yitao Wang*. Rapid simultaneous determination of isoflavones in Radix puerariae using high-performance liquid chromatography-triple quadrupole mass spectrometry with novel shell-type column. Journal of Separation Science 2011. 34 (in press).
[9]  Li Li-yun, Yin Zhi-qi, Zhang Qing-wen, Ye Wen-cai, Zhao Shou-xun, Wang Jia-ju. Research progress on the Yunnan's folk medicine: Cynanchum otophyllum. Strait Pharmaceutical Journal. 2011, 23 (4): 1~5.
[10]  Sun Jing, Yin Zhi-qi, Zhang Qing-wen, Ye Wen-cai, Wang Yi-tao, Zhao Shou-xun. Chemical constituents from ethyl acetate extract of Ganoderma lucidum 2011, 42(3): 220~223.
[11]  Xin Wu, Ying Wang, Xiao-Jun Huang, Chun-Lin Fan, Guo-Cai Wang, Xiao-Qi Zhang, Qing-Wen Zhang and Wen-Cai Ye.Three new glycosides from Hylocereus undatus. Journal of Asia Natural Products Research. 2011, 13(8): 728~733.
[12]  Wen-Jing Wang, Ying Wang, Qing-Wen Zhang, Xiao-Qi Zhang, Ting-Ting Yang, Yi Dai, Lei Wang, Lei-Hong Zhang & Wen-Cai Ye. Chemical constituents from Eupatorium chinense. Journal of Natural Product Research. 2011, 13(9): 845-850.
[13]  Sheng Ouyang, Lei Wang, Qing-Wen Zhang, Guo-Cai Wang, Ying Wang, Xiao-Jun Huang, Xiao-Qi Zhang, Ren-Wang Jiang, Xin-Sheng Yao, Chun-Tao Che, Wen-Cai Ye. Six new monoterpenoid indole alkaloids from the aerial part of Gelsemium elegans. Tetrahedron, 2011, 67(26): 4807-4813.
[14]  Zengtao Xu, Xiuping Chen, Qingwen Zhang, Lidian Chen, Yitao Wang. Corydalis yanhusuo WT Wang Extract Inhibits MCF-7 Cell Proliferation by Inducing Cell Cycle G2/M Arrest. AMERICAN JOURNAL OF CHINESE MEDICINE. 2011, 39 (3): 579-586.
[15]  Li Guo-Hui, Zhang Qing-Wen*, Wang Lei, Zhang Xiao-Qi, Ye Wei-Cai, and Wang Yi-Tao. New Isoflavone C-glycosides from Pueraria lobata. Helvetica Chimica Acta. 2011, 94 (3): 423-428.
[16]  Ying Bo Li, Zhu Qing Lin, Zai Jun Zhang, Mei Wei Wang, Huan Zhang, Qing Wen Zhang, Simon Ming-Yuen Lee, Yi-Tao Wang, Pui-Man Hoi. Protective, antioxidative and antiapoptotic effects of 2-methoxy-6-acetyl-7-methyl-juglone from Polygonum cuspidatum in PC12. Planta medica. 2011, 77(4):354-361.
[17]  Ying-Bo Li, Jian-Li Gao, Simon Ming-Yuen Lee, Qing-Wen Zhang, Pui-Man Hoi, Yi-Tao Wang. Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt. International Journal of Molecular Medicine. 2011,27(2):205-211.
[18]  Wei-Hua Huang, Qing-Wen Zhang*, Lan-Zhen Meng, Chun-Su Yuan, Chong-Zhi Wang, and Shao-Ping Li. Oplopanphesides A—C, three new phenolic glycosides from the root barks of Oplopanax horridus. Chemical & Pharmaceutical Bulletin. 2011, 59(5): 676-679.
[19]  Wen Jing-bing, Zhang Qing-wen, Yin Zhi-qi, Li Ya-ping, Han Xiao-wen, Ye Wen-cai. Flavonoids from the seeds of Oroxylum indicum (L.) Ven. Chinese Pharmaceutical Journal. 2011,46(3):170-173.
[20]  Yue Yu, Qing-Wen Zhang*, Shao-Ping Li. Preparative purification of coniferyl ferulate from Angelica sinensis oil by high performance centrifugal partition chromatography. Journal of Medicinal Plants Research.2011, 5(1):104-108.
[21]  Lei Wang; Zhi-Qi Yin; Qing-Wen Zhang; Xiao-Qi Zhang; Dong-Mei Zhang; Kang Liu; Yao-Lan Li; Xin-Sheng Yao; Wen-Cai Ye. Five New C21 Steroidal Glycosides from Periploca sepium. Steroids. 2011, 76(3):238-243.
[22]  Jian-Bo Wan, Qing-Wen Zhang*, Si-Jia Hong, Jia Gua, Wen-Cai Ye, Shao-Ping Li, Ming-Yuen Simon Lee, Yi-Tao Wang. 5,6-Didehydroginsenosides from the Roots of Panax notoginseng. Molecules. 2010; 15(11):8169-8176.
[23]  Yi Yan, Li Xiao-cen, Lai Cheong-meng, Zhang Qing-wen, Wang Yi-tao. Lingnan authentic herbs and diet culture. Macao Medicare and Healthcare, 2010, 11(4):33-34.
[24]  Li Guo-Hui, Zhang Qing-Wen*, Wang Yi-Tao. Chemical constituents from roots of Pueraria lobata. China Journal of Chinese Materia Medica. 2010, 35(23):3156-3159.
[25]  Wang Da-Hai,Yin Zhi-Qi,Zhang Qing-Wen,Ye Wen-Cai,Zhang Xiao-Qi,Zhang Jian. 2010, 35 (20):2704-2707.
[26]  Zhang Hai-Long, Zhang Qing-Wen*, Zhang Xiao-Qi, Ye Wen-Cai, Wang Yi-Tao. Chemical Constituents from the Roots of Morinda officinalis. Chinese Journal of Natural Medicine 2010, 8(3):192-195.
[27]  Cai Yan, Zhang Qing-wen, Li Zhi-jun, Fan Chun-lin, Wang Lei, Zhang Xiao-Qi, Ye Wen-cai. Chemical constituents from roots of Ilex asprella. Chinese Traditional and Herbal Drugs. 2010, 41(9): 1426-1429.
[28]  Fang Long, Fang Chun-lin, Wang Ying, Zhang Xiao-qi, Zhang Qing-wen, Zhang Jun-qing, Ye Wen-cai. Alkaloids from the leaves of nauclea officinalis. Acta Pharmaceutica Sinica. 2010, 45(6):747-751.
[29]  Ya Ji, Zhang Xiao-Qi, Wang Ying, Zhang Qing-Wen, Chen Jian-Xin and Ye Wen-Cai. Two new phenolic compounds from the roots of Ficus hirta. Natural Product Research, 2010, 24(7), 621-625.
[30]  Huang Wei-Hua, Zhang Qing-Wen*, Wang Chong-Zhi, Yuan Chun-Su and Li Shao-Ping. Isolation and Identification of Two New Polyynes from a North American Ethnic Medicinal Plant--Oplopanax horridus (Smith). Molecules. 2010, 15:1089-1096.
[31]  Du G., Zhao H.Y., Zhang Q.W., Li G.H., Yang F.Q., Wang Y., Li Y.C, Wang Y.T.. A rapid method for simultaneous determination of 14 phenolic compounds in Radix Puerariae using microwave-assisted extraction and ultra high performance liquid chromatography coupled with diode array detection and time-of-flight mass spectrometry. Journal of Chromatography A 2010,1217(5):705-714.
[32]  Dang Yuan-Ye, Li Xiao-Cen, Zhang Qing-Wen*, Li Shao-Ping and Wang Yi-Tao. Preparative isolation and purification of six volatile compounds from essential oil of Curcuma wenyujin using high performance centrifugal partition chromatography. Journal of separation Science. 2010, 33(11):1658-1664.
[33]  ZHANG Jing, WANG Ying, ZHANG Xiao-Qi, ZHANG Qing-Wen, YE Wen-Cai.(2009) Chemical Constituents from the Leaves of Lophatherum gracile. Journal of Chinese Natural Medicine. 2009, 7(6):428-431 (doi: 10.3724/SP. J. 1009.2009.00000).
[34]  Li Guo-Hui, Zhang Qing-Wen*, Hang Wei-Hua and Wang Yi-Tao. (2009) Isoflavone C-glycosides from Pueraria lobata. Asian Chemistry Letters. Vol 13, Nos 1&2: 35-40.
[35]  Dang Yuan-Ye, Chen Xiu-Ping, Zhang Qing-Wen, Wang Yi-Tao. Recent advances in pharmacological effects of capsaicin. Pharmacology and Clinics of Chinese Materia Medica 2009, 25(4):84-89.
[36]  Gao J. L., Shi J. M., Lee S. M., Zhang Q. W., Wang Y. T.. Angiogenic pathway inhibit of Corydalis yanhusuo and berberine in human umbilical-vein endothelial cells. Oncol. Res. 2009. 17(11-12):519-26.
[37]  Qian Z.M., Wan J.B., Zhang Q.W., Li S.P. Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 2008, 48(5): 1361-1367.
[38]  Gao JL, Shi JM, Heb K, Zhang QW, Li SP, Lee MY, Wang YT. Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase (MAPK) signaling pathways. Oncology Reports, 2008, 20, 819-824.
[39]  Gao XH, Zhang QW*, Li SP. Preparative separation of three compounds from essential oil of Curcuma longa using high performance centrifugal partition chromatography. Asian Chemistry Letters, 2008, 12 (1-2), 81-86.
[40]  Li P., Xu G.; Li S.-P., Wang Y.-T., Fan T.-P., Zhao Q.-S., Zhang Q.-W*. Optimizing Ultraperformance Liquid Chromatographic Analysis of 10 Diterpenoid Compounds in Salvia miltiorrhiza Using Central Composite Design. J. Agric. Food Chem. 2008; 56(4); 1164-1171.
[41]  Wan J. B., Zhang Q. W. *, Ye W. C. and Wang Y. T. Separation and purification of protopanaxatriol and protopanaxadiol type saponins from Panax notoginseng with macroporous resins. Separation & Purification Technology 2008, 60 (2): 198-205.
[42]  Chen X. J., Ji H., Zhang Q. W., Tu P. F., Wang Y. T., Guo B. L. and Li S. P. A rapid method for simultaneous determination of fifteen flavonoids in Epimedium using pressurized liquid extraction and ultra-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 2008, 46 (2):226-235.
[43]  Zhang Huang, Li Shaoping, Zhang Qingwen and Wang Yitao. Research Progress and comparison of pharmacological effects of Radix Angelica sinensis and Rhizoma chuanxiong. Lishizhen Medicine and Materia Medica Research. 2008, 19 (2):293-295.
[44]  Chen X. J., Guo B. L., Li S. P., Zhang Q. W., Tu P. F. And Wang Y. T. Simultaneous determination of fifteen flavonoids in Epimedium using pressurized liquid extraction and high-performance liquid chromatography. J Chromatogra. A 2007, 1063(1-2): 96-104.
[45]  Wang Wei, Zhang Qingwen*, Ye Wencai and Wang Yitao. Isoquinoline alkaloids from the rhizoma of Coptis chinensis. Chin J Nat Med. 2007, 5(5):348-350.
[46]  Wang Lei, Yin Zhi-Qi, Shen Wen-Bin, Zhang Qing-Wen and Ye Wen-Cai. New Pregnane and Diphenylmethane from the Root Barks of Periploca spium. Helvetica Chimica Acta. 2007, 90(8): 1581~1585.
[47]  Yu Yue, Zhang Qingwen and Li Shaoping. A rapid HPLC Method for determination of Conifery ferulate in Angelica sinensis China Journal of Pharmaceutical Science 2007, 16:197-201.
[48]  Tam C.U., Yang F.Q., Zhang Q.W.; Guan J. and Li S.P. Optimization and comparison of three methods for extraction of volatile compounds from Cyperus rotundus evaluated by gas chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2007, 44 (2): 444-449.
[49]  Chen Xiao-jia, Zhang Qing-wen, Ji Hui, Wang Yi-tao, Tu Peng-fei and Li Shao-ping. Comparison of UV spectrophotometry and HPLC on quantitative determination of total flavonoids from Herba Epimedii. Chinese Journal of Pharmaceutical Analysis. 2007, 27(5):625-630.
[50]  HONG Si-jia, WAN Jian-bo, ZHANG Qing-wen, ZHANG Yi, HU Guang, Lao Sandy Cheng-San, LEE Simon Ming-yuen and WANG Yi-tao. Proangiogeneic effect of Total Saponins of Panax notoginseng in Human Umbilical Vein Endothelial Cells (HUVEC). Pharmacology and Clinics of Chinese Material Medica. 2007, 23(2):28-30.
[51]  Pettit George R, Zhang Qingwen, Pinilla Veronique and Doubek Dennis L. Antineoplastic Agents 534. Isolation and Structure of Sansevistations 1 and 2 from the African Sansevieria ehrenbergii. Journal of Natural Products. 2005; 68(5); 729-733.
[52]  Pettit George R, Zhang Qingwen, Pinilla Veronique, Herald Delbert L., Doubek Dennis L. and Duke James A. Isolation and Structure of Gustastatin from the Brazilian Nut Tree Gustavia hesapetala. Journal of Natural Products. 2004, 67(6): 983-985.
[53]  Ye Wencai, Zhang Qingwen, Hsiao Wendy W. L., Zhao Shouxun, Che Chun-Tao. New lupane glycosides from Pulsatilla chinensis. Planta Medica. 2002, 68 (2): 183-186.
[54]  Zhang Qingwen, Ye Wencai, Zhao Shouxun and Che Chuntao. Study on the Chemical Constituents of Cimicifuga dahurica. Chinese Traditional & Herbal Drugs, 2002, 33 (8): 683-685.
[55]  Zhang Qingwen, Ye Wencai, Hsiao Wendy W. L., Zhao Shouxun and Che Chuntao. Cycloartane glycosides from Cimicifugae dahurica. Chemical & Pharmaceutical Bulletin, 2001, 49(11): 1468-1470.
[56]  Ye Wencai, Zhang Qingwen, Che Chuntao and Zhao Shouxun. Four New Oleanane Saponins from Anemone anhuiensis. Chemical & Pharmaceutical Bulletin, 2001, 49 (5): 632-634.
[57]  Zhang Qingwen, Ye Wencai, Che Chuntao and Zhao Shouxun. Chemical Studies on Anemone anhuiensis, China Journal of Chinese Materia Medica, 2001,26 (9):612-614.
[58]  Ye Wencai, Zhang Qingwen, Zhao Shouxun and Che Chuntao. Antisweet Saponins from Gymnema sylvestre., Journal of Natural Products, 2001, 64 (2): 232-235.
[59]  Ye Yinying, He Daowei, Ye Wencai, Zhang Qingwen and Zhao Shou-xun. Induction of apoptosis melanoma cell lines with betulinic acid and derivatives. Journal of Southeast University (Medical Science Edtion), 2002, 21 (3): 203-206,212.
[60]  Ye Wencai, Zhang Qingwen, Pan Guoshi, Che Chuntao and Zhao Shouxun. Two Unusual Oleanane Saponins from Anemone anhuiensis. Planta Medica, 2001,67 (6): 590-592.
[61]  Zhang Qingwen, Ye Wencai, Che Chuntao and Zhao Shouxun. Cycloartane Triterpenes and glycosides from Cimicifuga acerina. Acta Pharm. Sinica., 2001, 36 (4): 287-291.
[62]  Ye Yinying, He Daowei, Ye Wencai, Zhang Qingwen and Zhao Shou-xun. Differentiation of B16 melanoma cells induced by 23-hydroxylbetulinic acid. Zhongguo shenghua yaowu zazhi, 2001, 22 (4): 163-166.
[63]  Zhang Qingwen, Ye Wencai, Che Chuntao and Zhao Shouxun. Two new saponins from Anemone anhuiensis. China Chemical Letters, 2000, 11 (8): 697-700.
[64]  Ye Wencai, Zhang Qingwen, Liu Xin, Che Chuntao and Zhao Shouxun. Oleanane Saponins from Gymnema sylvestre. Phytochemistry, 2000, 53 (8): 893-899.
[65]  Zhang Qingwen, Ye Wencai, Yan Xiangzhong, Zhu Guang, Che Chuntao and Zhao Shouxun. Sucrase Inhibitory Saponins from Pulsatilla cernua. Journal of Natural Products, 2000, 63 (2): 276-278.
[66]  Zhang Qingwen, Ye Wencai, Che Chuntao and Zhao Shouxun. Chemical Study on Cimicifuga acerina. Chinese Traditional & Herbal Drugs, 2000, 31 (4): 252-253.
[67]  Ye Yinying, He Daowei, Ye Wencai, Zhang Qingwen and Zhao Shou-xun. The Study of 23-hydroxyl Betulinic Acid against Melanoma in vivo and in vitro. Zhongguo Zhongliu yu Kangfu, 2000, 7 (1):5-7.
[68]  Zhang Qingwen, Ye Wencai, Che Chuntao and Zhao Shouxun. Triterpene Saponins from Pulsatilla cernua. Acta Pharm. Sinica, 2000, 35 (10): 756-759.
[69]  Zhang Qingwen, Ye Wencai, Che Chuntao and Zhao Shouxun. A New Cycloartane Glycoside from Cimicifuga acerina. Journal of Asia Natural Products, 1999, 2(1): 45-49.
[70]  Ye Wencai, Pang Guoshi, Zhang Qingwen, Che Chuntao and Zhao Shouxun. Five New Triterpenes Saponin from Pulsatilla patens var. multifida. Journal of Natural Products, 1999, 62: 233-237.
[71]  Ye Wencai, Zhang Qingwen, Che Chuntao, Ye Tao and Zhao Shouxun. Cycloartane Glycosides from Cimicifuga dahurica. Planta Medica. 1999, 65: 770-772.
[72]  Liu Junhua, Zhang Zhenhua, Zhang Qingwen, Ye Wencai and Zhao Shouxun. Determination of Anemoside B4 in Chinese Traditional Medicine "Bai-Tou-Weng" by HPLC. Chinese Wild Plant Resources. 1999, 18 (6): 37-38.
[73]  Liu xing, Ye Wencai, Xuderan, Zhang Qingwen, Che Chuntao and Zhao Shouxun, Chemical Study on Triterpene and Saponins from Gymnema sylvestre. Journal of China Pharmaceutical university.1999, 30: 174-176.
[74]  Zhang, Qingwen; Ye, Wencai; Che, Chuntao and Zhao, Shouxun. Spectroscopic Characteristic and Chemical Properties of Cycloartane Triterpenoids in Genus Cimicifugae. Journal of China Pharmaceutical University, 1998, 29: 56-59.