Advances in Analytical Chemistry

Advances in Analytical Chemistry is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of analytical chemistry. The journal publishes features and news articles about major advances, trends, and challenges in analytical chemistry. These articles include peer-reviewed features written by researchers and news stories that discuss novel analytical concepts and instruments.


Yurong Lai

Editorial Board Member of Advances in Analytical Chemistry

Research Scientist, Pharmacokinetics, Dynamics and Metabolism, World Wide Research and Development, Pfizer Inc, USA

Research Areas

Pharmaceutics Science, Pharmacokinetics, Toxicokinetics, Drug Transporter, Cellular Biology, Bioanalytical

Education

2007EMBA courseRoss School of Business, University of Michigan
1998Ph.DSapporo Medical University, Japan
1987Bachelor of Medicine (MD)Fujian Medical University, P.R China

Experience

2004-presentDiscipline leader/Sr. Principal Scientist: Pharmacokinetics, Dynamics and Metabolism (PDM), Pfizer Global Research & Development, Groton Laboratories
2001-2004Research Associate: Department of Pharmaceutics, University of Washington
1998-2001Research Fellow of Japanese Society of Promotion of Science (JSPS): Department of Pathology/Pathophysiology, Hokkaido University Graduate School of Medicine, Japan

Academic Achievement

Member, American Association of Pharmaceutical Scientist (AAPS), ISSX and ASPET
Committees Member (2006-present) of Drug Transport Focusing Committee of American Association of Pharmaceutical Scientist (AAPS). Chaired symposium (2007 and 2008, 2009 and 2010) for AAPS annual meeting
2002 AAPS (American Associate of Pharmaceutical Scientists) Postdoctoral Fellows Award
Research Fellowship, JSPS
Research Award, Hokkaido Governmental fellowship, Japan
Fellowship, Sasakawa, Japan
Fellowship, Japan-China Medical Association
Adhoc Scientific Reviewer/guest editor

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Balogh, LM, Kimoto, E, Chupka J, Zhang H, Lai Yurong* (2011) Quantification by SIL and SILAC Mass Spectrometry Approaches: Studies on the OATP Family. Analytical Chemistry. Submission.
[2]  Kimoto E, Walsky R, Zhang H, Bi Y, Whalen K, Yang Y, Linder C, Xiao Y, Iseki K, Fenner K, El-Kattan A and Lai Yurong* (2011) Differential modulation of cytochrome P450 activity in sandwich cultured human hepatocytes and the impact on in vitro hepatic uptake and biliary excretion Drug Metab Dispos. (under revision).
[3]  Pfefferkorn JA, Litchfield J, Hutchings R, Cheng XM, Larsen SD, Auerbach B, Bush MR, Lee C, Erasga N, Bowles DM, Boyles DC, Lu G, Sekerke C, Askew V, Hanselman JC, Dillon L, Lin Z, Robertson A, Olsen K, Boustany C, Atkinson K, Goosen TC, Sahasrabudhe V, Chupka J, Duignan DB, Feng B, Scialis R, Kimoto E, Bi YA, Lai Yurong, El-Kattan A, Bakker-Arkema R, Barclay P, Kindt E, Le V, Mandema JW, Milad M, Tait BD, Kennedy R, Trivedi BK and Kowala M (2011) Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution. Bioorg Med Chem Lett 21:2725-2731.
[4]  Zhang Y, Li N, Brown PW, Ozer JS and Lai Yurong* (2011) Liquid chromatography/tandem mass spectrometry based targeted proteomics quantification of P-glycoprotein in various biological samples. Rapid Commun Mass Spectrom 25:1715-1724.
[5]  Li Di, Carrie Whitney-Pickett, John P. Umland, Hui Zhang, Xun Zhang, David F. Gebhard, Yurong Lai, James J. Federico Iii, Ralph E. Davidson, Russ Smith, Eric L. Reyner, Caroline Lee, Bo Feng, Charles Rotter, Manthena V. Varma, Sarah Kempshall, Kath Fenner, Ayman F. El-Kattan, Theodore E. Liston, Matthew D. Troutman. (2011) Development Of A New Permeability Assay Using Low-Efflux Mdckii Cells J Pharm Sci Doi: 10.1002/Jps.22674.
[6]  Lei Diao, Na Li, Timothy G. Brayman, Kathy J.Hotz and Yurong Lai* (2010) Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-alpha, IL-6 and IL-1beta. J Biol Chem. doi: 10.1074/jbc.M110.107805.
[7]  Yiding Hu, Kathleen E. Sampson, Li Xing, Na Li, Bruce R. Heyde, Jin Xie and Yurong Lai* Two Branched Polar Groups and Polar Linker Moieties of Thiophene Amide Derivatives Are Essential For MRP2/ABCC2 Recognition. Drug Metab Lett, 2010 4(4):000-000.
[8]  Yiding Hu, Shengtian Yang, Barclay F Shilliday, Bruce R Heyde, Kathy M Mandrell, Russell H Robins, Jin Xie, Matthew T Reding, Yurong Lai and David C Thompson (2010) Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P-450 Enzymes. Drug Metab Dispos. doi:10.1124/dmd.110.032581.
[9]  Yurong Lai*, Kathleen E. Sampson, Larissa M. Balogh, Timothy G. Brayman, Steven R. Cox, Wade J. Adams, Vikas Kumar and Jeffrey C. Stevens (2010) Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. DOI:10.1124/jpet.110.170753.
[10]  Yurong Lai*, Kathleen E. Sampson and Jeffrey C. Stevens (2010) Evaluation of drug transporter interactions in drug discovery and development. Comb Chem High Throughput Screen 13:112-134.
[11]  Na Li, Pratap Singh, Kathy K. Mandrell and Yurong Lai* (2010) Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters. Mol Pharmaceutics 7:630-641.
[12]  Yurong Lai* Identification of Interspecies Difference in Hepatobiliary Transporters to Improve Extrapolation of Human Biliary Secretion. Expert Opinion on Drug Metabolism and Toxicology 2009 5(10)1-13.
[13]  Li Xing, Yiding Hu and Yurong Lai* Advancement of structure-Activity Relationships of Multidrug-Resistance Associated Protein 2 (MRP2/ABCC2) Interactions. AAPS Journal. 2009 11 (3): 406-413.
[14]  Na Li, Yi-An Bi, David B Duignan and Yurong Lai* Hepatobiliary Transporter Expression Profiles in Sandwich Cultured Rat and Human Hepatocytes. Mol Pharmaceutics. 2009 6(4):1180-89.
[15]  Na Li, Joe Plandra, Olga V Nemirovskiy and Yurong Lai* LC-MS/MS Mediated Absolute Quantification and Comparison of Bile Salt Export Pump (BSEP) and Breast Cancer Resistance Protein (BCRP) in Livers and Hepatocytes across Species. Analytical Chem. 2009. 81(6)2251-9.
[16]  Haodan Yuan, Na Li and Yurong Lai* Evaluation of in vitro Models for Screening Alkaline Phosphatase Mediated Bioconversion of Phosphate Ester Prodrugs. Drug Metab. Dispos. 2009: 37:1443-1447.
[17]  Po-Chang Chiang, Jason W. Alsup , Bruce R. Heyde, Yurong Lai, Yiding Hu, and David Tung. Evaluation of Aerosol Delivery of Nanosuspension for Preclinical Pulmonary Drug Delivery. Nonoscale Res. Lett. 2009 4(3):254-261.
[18]  Po-Chang Chiang, Yiding Hu, Archie Thurston, Cynthia D. Sommers, Julia A. Guzova, Larry E. Kahn, Yurong Lai, and Jason D. Blom. Pharmacokinetic and pharmacodynamic evaluation of the suitability of using fluticasone and an acute rat lung inflammation model to differentiate lung versus systemic efficacy. J of Pharm Sci. 2009. 98:4534.
[19]  Yiding Hu, Kathleen Sampson, Anup Zutshi, Bruce Heyde, Kathy Mandrell and Yurong Lai*. Saturation of Mrp2/Abcc2 Mediated Hepatobiliary Secretion: Nonlinear Pharmacokinetics of A Pyrazole Compound in Rats after iv Bolus Administration. Drug Metab. Dispos. 2009 37:841-846.
[20]  Yurong Lai*, Po-Chang Chiang, Jason D Blom, Na Li, Kimberly Shevlin, Timothy G Brayman, Yiding Hu, Jon G. Selbo and George Hu. Comparison of in vitro Nanoparticles Uptake in Various Cell Lines and In Vivo Pulmonary Cellular Transport in Intratracheally Dosed Rat Model. Nonoscale Res Lett 2008 3:321-329.
[21]  Na Li, Yiqun Zhang, Fengmei Hua and Yurong Lai* Absolute Difference of Hepatobiliary Transporter MRP2/Mrp2 in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey and Human. Drug Metab. Dispos 2009 37:1-8.
[22]  Na Li, Olga V Nemirovskiy, Yiqun Zhang, Haodan Yuan, Jianming Mo, Chengjie Ji, Bo Zhang, Timothy G Brayman, Christopher Lepsy, Timothy G Heath and Yurong Lai*. Absolute Quantification of Multidrug Resistance-Associate Protein 2 (MRP2/ABCC2) Using LC-MS/MS. Anal. Biochem. 2008 380:211-222.
[23]  Rajgopal Govindarajan, Aimee H. Bakken, Kelly L. Hudkins, Yurong Lai, F. Javier Casado, Marcal Pastor-Anglada, Chung-Ming Tse, Jun Hayashi, and Jashvant D Unadkat. In Situ Hybridization and Immunolocalization of Concentrative and Equilibrative Nucleoside Transporters in the Human Intestine, Liver, Kidneys, and the Placenta Am J Physiol Regul Integr Comp Physiol 293 (2007) R1809-22.
[24]  Li, Meng; Yuan, Haodan; Song, Guotao; Zheng, Jenny; Hua, Fengmei; Baratta, Mike; Thurston, Archie; Lai, Yurong*. Identification of Interspecies Difference in Efflux Transporters of Hepatocyte from dog, rat, monkey and human. Euro J of Pharm. Sci, 2008 35:114-126.
[25]  Chen, Jing; Zhao, Xudong; Lai, Yurong; Suzuki, Arkira; Tomaru, Utano; Ishizu, Akihiro; Tkada, Akio, Ikeda, Hitoshil Kasahara, Masanori; Yosiki, Takashi. Enhanced production of p24 Gag protein in HIV-1-infected rat cells fused with uninfected human cells. Exp. Mol. Path. 83(1):125-130.
[26]  Yurong Lai *, Li Xing, Gena. Poda, Yiding Hu. Structure-Activity Relationships for Interactin with Multidrug Resistance Protein 2 (ABCC2/MRP2): The Role of Torsion Angles for a Series of Biphenyl-Substituted Heterocycles Drug Metab. Dispos. 2008 35:937-945.
[27]  Eun-Woo Lee, Yurong Lai, Huixia Zhang and. Jashvant D Unadkat. Identification of the Mitochondrial Targeting Signal of the Human Equilibrative Nucleoside Transporter 1 (hENT1): Implications for Interspecies Differences in Mitochondrial Toxicity of Fialuridine. J. Biol. Chem. 2006 281(24):16700-6.
[28]  Anita A Mathias, Lillian Maggio-Price, Yurong Lai, Anshul Gupta, and Jashvant D.Unadkat. Changes in pharmacokinetics of anti-HIV protease inhibitors during pregnancy: the role of CYP3A and P-glycoprotein. JPET 316:1202-1209, 2006.
[29]  Yurong Lai, Eun-Woo Lee, Carl C. Ton, Shashi Vijay, Huixia Zhang and Jashvant D. Unadkat. Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) impact guanosine sensitivity and membrane expression, respectively. Am J Physiol Cell Physiol. 2005 288(1):C39-45.
[30]  Yurong Lai, Chung-Ming Tse and Jashvant D. Unadkat. Mitochondrial Expression of the Human Equilibrative Nucleoside Transporter 1 (hENT1) Results in Enhanced Mitochondrial Toxicity of Antiviral Drugs. J. Biol. Chem. 2004 279(6):4490-4497.
[31]  Lixin Yang, Hitoshi Ikeda, Yurong Lai, Takashi Yoshiki, Kenzo Takada. Epstein-Barr virus infection of rat lyphocytes expressing human CD21 results in restricted latent viral gene expression and not in immunoblastic transformation. J. Of Med. Virology 2003. 70:126-130.
[32]  Yurong Lai, Aimee H. Bakken, and Jashvant D Unadkat. Simultaneous expression of hCNT1-CFP and hENT1-YFP in MDCK cells: localization and vectorial transport studies. J. Biol. Chem. 2002 277(40):37711-7.
[33]  Dhruba J. SenGupta, Pek Y. Lum, Yurong Lai, Elena Shubochkina. Aimee H Bakken, Glenda Schneider, and Jashvant D. Unadkat. A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine. Biochemistry. 2002 41(5):1512-9.
[34]  Naoki Sugawara, Tomoki Ohta, Yurong Lai, Chieko Sugawara, Motoyuki Yuasa, Masao Nakamura, Mamoru Tamura. Iron depletion prevents adenine nucleotide decomposition and an increase of xanthine oxidase activity in the liver of the Long Evans Cinnamon (LEC) rat, an animal model of Wilson's disease. Life Sci. 1999 65(13):1423-1431.
[35]  Naoki Sugawara, Yurong Lai, and Chieko Sugawara. Therapeutic effects of tetrathiomolybdate on hepatic dysfunction occurring naturally in Long-Evans Cinnamon (LEC) rats: a bona fide animal model for Wilson's disease. Res. Commun. Mol. Pathol. Pharmacol. 1999 103(2):177-87.
[36]  Naoki Sugawara, Toshiko Ikeda, Yurong Lai and Chieko Sugawara. The effect of subcutaneous tetrathiomolybdate administration on copper and iron metabolism, including their regional redistribution in the brain, in the Long-Evans Cinnamon Rat, a bona fide Animal model for Wilson's disease. Pharmacology & Toxicology 1999 82:211-217.
[37]  Naoki Sugawara, Yurong Lai, and Chieko Sugawara. Biliary Excretion of Heavy Metals in Eisai Hyperbilirubinemic Rat. Jpn. Pharmacol Ther. 1998 26(suppl):45-48.
[38]  Naoki Sugawara, Yurong Lai. Decreases hepatobiliary secretion of inorganic mercury, its deposition and toxicity in the Eisai hyperbilirubinemic rat with no hepatic canalicular organic anion transporter. Toxicology. 1998 126:23-31.
[39]  Yurong Lai*, Wei Wu, Hong Chen, Zhang-Jing Wang, Lu-Xin Liao, Xiao-Rong Huang. The influence of Cd and/or Se orally given on hepatic enzymes activities, and metals concentrations in liver and kidney of Wistar rats. J. Of Toxicology 1998 12(1):28-30.
[40]  Yurong Lai and Naoki Sugawara. Role of Cu and Fe on the onset of hepatitis on Long-Evans Cinnamon (LEC) rats. J. Nor. Occ. Health 1997 41:11-14.
[41]  Yurong Lai and Naoki Sugawara. Outputs of hepatic copper and cadmium stimulated by tetrathiomolybdate (TTM) injection to Long-Evans Cinnamon (LEC) rats pretreated with cadmium, and to Fischer rat pretreated with copper and cadmium. Toxicology. 1997 120:47-54.
[42]  Naoki Sugawara, Yurong Lai, Koji Arizono, Toshiichi Kitajima, Hideaki Inoue. Lack of biliary excretion of Cd linked to an inherent defect of the canalicular isoform of multidrug resistance protein (cMrp) does not abnormally stimulate accumulation of Cd in the Eisai hyperbilirubinemic (EHB) rat liver. Arch. Toxicol. 1997 71:336-339.
[43]  Motoyuki Yuasa, Chieko Sugawara, Yurong Lai, Naoki Sugawara. Iron Metabolism of the Long-Evans Cinnamon (LEC) Rat before the Oneset of Hepatitis. The Sapporo Med. J. 1996 65(6):451-462.
[44]  Yurong Lai and Naoki Sugawara. Effect of simultaneous preinjection of cadmium and selenium on hepatic and testicular dysfunction caused by subsequent challenge dose of cadmium. Bio. Res. on Trace Elem. 1996 7(1):29-36.
[45]  Yurong Lai, Wei Lin, Wei-Jun Guo, Yi-Biao Yeh, Chao-Chang Liu, Li-Yuan Lie, Heng-Guang Li. Study on the incidence of byssinosis and its relation with the bacterial endotoxins in the workers exposing to cotton dust. Chinese J. of Labor Health and Occup. Dis. 1996 14(6):359-361.
[46]  Naoki Sugawara, Yurong Lai, Chieko Sugawara. Accumulation of cadmium given orally in Long-Evans-Cinnamon (LEC) rats with an inherently abnormal copper metabolism. Toxicology. 1996 108:1-7.
[47]  Naoki Sugawara, Yurong Lai, Chieko Sugawara, Koji Arizono, Toshihiko Ariyoshi. Biliary excretion of exogenous cadmium, and endogenous copper and zinc in the Eisai Hyperbilirubinuria(EHB) rat with a near absence of biliary glutathione. Toxicology. 1996 112:87-94.
[48]  Naoki Sugawara, Yurong Lai, Motoyuki Yuasa, Sanjit Kumar Dhar and Koji Arizono. Biliary excretion of copper, manganese and horse-radish peroxidase in Eisai hyperbilirubinemic Mutant rats (EHBRs) with defective biliary excretion of glutathione. Bio. Trace Elem. Res. 1996 55:181-189.
[49]  Lu-Xin Liao, Qiao-Yun Li, Yurong Lai *. The distribution of elements: the relation of human metabolic enzyme activities and selenium level. Abroad Medicine: Medical Geographical Section 1995 16(2):53-55.
[50]  Lu-Xin Liao, Xiao-Rong Huang, Yurong Lai, Zhang-Jing Wang, Li-Xin Cai. Changes of contents of Selenium, Cadmium, Cupper, Zinc, Manganese in the organs of Wistar rats following the Selenium diet. Acta Nutrimenta Sinica 1995 17(3):279-283.
[51]  Lu-Xin Liao, Xiao-Rong Huang, Yurong Lai, Qiao-Yun Li. Changes of distribution of trace elements on hepatocytic organelles followed the high selenium and cadmium intake. J. Of Hygiene Research 1995 24(3):171-174.
[52]  Yurong Lai and Jiong-Liang Zhou. Experimental studies on the effects of abundance supplement of Zinc and Selenium in diet on liver damage induced by carbon tetrachloride. J. Of Toxicology 1995 9(2):80-84.
[53]  Yurong Lai and Jiong-Liang Zhou. Experimental studies on the effects of abundance supplement of Manganese and Germanium in diet on liver damage induced by carbon tetrachloride. J. Of Toxicology, 1995 9(2):84-88.
[54]  Yurong Lai and Jiong-Liang Zhou. The mechanism of liver peroxide damage caused by exogenous chemicals. Occupational Med. 1995 22(1):45-47.
[55]  Xiu-Yun Jiang, Zhi-Xin Wang and Yurong Lai. Population investigation on variety of serum zinc level in patients infected with hepatitis B virus. Fujian Preventive Med. 1994 3(4):7-9.
[56]  Yi-Biao Yeh, Yurong Lai, Zhong-Nin Lin, Jia-Dun Wu, Rong-Ying Chen. Pathological damage of nasal mucosa of workers in furniture industry caused by different dusts by using multiple linear regression analysis. Chinese J. of Labor Health and Occup. Dis. 1993 11(4):220-222.
[57]  Yurong Lai *, Yi-Biao Yeh, Li-Hui Zhang, Zhi-Tai Shu, Shi-Yuan Lin, Shao-Chong Yuan, Cong-Hui Jiang. The population investigation in chronic effects of porcelain dust containing high level lead on workers in porcelain plant. Occupational Med. 1993 20(5):271-273.
[58]  Yurong Lai *, Yi-Biao Yeh, Li-Hui Zhang, Zhi-Tai Shu, Shao-Chong Yuan, Yi-Yuan Shu, Cong-Hui Jiang. The population investigation in chronic effects of porcelain dust containing high-level chromium on workers in porcelain plant. Chinese J. of Ind. Med. 1993 6(supl):82-83.
[59]  Shuan-Xin Kou, Yurong Lai, Cong-Hui Jiang, Shao-Chong Yuan, Yi-Yuan Shu, Yi-Biao Yeh, Li-Hui Zhang, Zhi-Tai Shu. Changes of trace elements in blood and urine sampling from the workers exposing to porcelain dust. J. of Fujian Med. Univ. 1993 27(2):173-175.
[60]  Yi-Biao Yeh, Yurong Lai, Biao Rong, Yi-Yuan Shu, Shao-Chong Yuan, Shi-Yian Lin. Pulmonary ventilation function of healthy porcelain workers, by using multivariate step regression analysis. J. of Fujian Med. Univ. 1993 27(2):168-170.
[61]  Yi-Biao Yeh, Yurong Lai, Zhong-Nin Lin, Jia-Dun Wu, Rong-Ying Chen, Bao-Zhu Li, Shuan-Xi Kou, Yi-Yuan Shu. Population investigation on the influence of nasal ciliary transferring velocity (NCTV) in the workers exposing to industrial dusts. Occupational Med. 1993 20(4):194-196.
[62]  Yi-Biao Yeh, Yurong Lai, Min-Qiang Zhang, Ping-Nan Wang, Bao-Zhu Li, Shuan-Xin Kou. The pathological damage investigation on ciliary function of nasal mucosa in the workers exposing to porcelain dust containing high level chromium. J. of Fujian Med. Univ. 1993 27(1):82-84.
[63]  Yurong Lai *, Yi-Biao Yeh, Li-Hui Zhang, Zhi-Tai Shu, Shi-Yian Lin, Shao-Chong Yuan, Cong-Hui Jiang. Population investigation in the workers exposing to different porcelain dusts; the relation of the objective phenomenon and lead exposures by using two-step cluster analysis. J. of Fujian Med. Univ. 1993 27(1):76-79.
[64]  Yurong Lai *, Yi-Biao Yeh, Li-Hui Zhang, Zhi-Tai Shu, Shao-Chong Yuan, Cong-Hui Jiang. Population investigation on chromium hazard in the workers exposing to color porcelain dust with heavy metals abundance. J. of Fujian Med. Univ. 1993 27(1):79-81.
[65]  Yi-Biao Yeh, Yurong Lai, Li-Qin Tu, Chen-Ming Duan, Bao-Zhu Li, Shuan-Xi Kou, et al. Industrial evaluation on environment and working condition of workers in porcelain plant. J. Of Fujian Med. Univ. 1993 27(1):73-75.
[66]  Yi-Biao Yeh, Yurong Lai, Hao-Jun Xu, Jia-Dun Wu, Rong-Ying Chen. The toxicokinetics analysis of phenol and its metabolic products in the population exposing to industrial stick using phenol as a media. Occupational Med. 1992 19:307-308.
[67]  Yi-Biao Yeh, Yurong Lai, Biao Rong, Yi-Yuan Shu, Shao-Chong Yuan, Shi-Yian Lin. Population investigation on the nasal mucosa fiber movement and pathological grading classification in workers exposed to dust by using multiple factors stepwise regression analysis. J. Of Fujian Med. Univ. 1992 26(1):67-70.
[68]  Yi-Biao Yeh, Yurong Lai, Wei Miao, Hua-Bei Lv, Xi-Jing Huang. Population investigation on the concentration of blood zinc and copper in miners, the efficacy of nutrients supplement tablet. Occupational Med. 1992 19(2):122-123.
[69]  Yurong Lai *. The affecting factors for lung function determination; the estimating of physical effects in health volunteers by multiple factors stepwise regression analysis. J. Of Fujian Med. Univ. 1992 26(1):79-81.
[70]  Yi-Biao Yeh, Yurong Lai, Guang-Kai Yang. The efficacy of '851' treatment in anti-lipid peroxidation and the improvement of lung function relating to pneumoconiosis. International Occupational Lung Disease Proceeding (8th conference, Czechoslovakia) 1992 P1312-1317.
[71]  Yurong Lai *, Guang-Kai Yang, Rong-fen Pan. Clinical therapeutic efficacy evaluation of '851' on experimental rat silicosis. International Occupational Lung Disease Proceeding (8th conference, Czechoslovakia) 1992 P1301-1312.
[72]  Xiang-Lin Lian, Yurong Lai, Liang-Yuan Zhou. Suppressive effect of zinc administration on the Toxicity of mercury in rats. J. Of Fujian Med. Univ. 1991 25(4) :354-356.
[73]  Yi-Biao Yeh, Yurong Lai, Zuo Zhang, Guang-Kai Yang, Hua-Bei Lv, Xi-Jing Huang, Xian-Yi Chen. The investigation on pneumoconiosis morbidity in miners and a prediction model of the occurrence and development of Pneumoconiosis in Shaowu Mine, a long-term follow-up investigation. J. Of Fujian Med. Univ. 1991 25(1) :68-73.
[74]  Yi-Biao Yeh, Yurong Lai, Zhong-Min Wang, Fan-Wei Zeng, Xian-Yi Chen. Population investigation on academic abilities and the zinc and copper level in blood of primary school students in Fujian Shaowu district. J. of Chinese School Hygiene 1991 12(1):19-21.
[75]  Yurong Lai *, Miao Yu, Guang-Kai Yang, Hua-Bei Lv. Population follow-up investigation on the blood zinc and copper and the growth status in 209 children living in mineral district; the efficacy of trace elements nutrient tablet treatment. J. of Fujian Med. 1991 13(4):12-14.
[76]  Yurong Lai *, Jin-Liang Chen, Xiu-Yun Jiang, Guang-Kai Yang, Shi-Qing Yang, Wen-Xian Gao. The protective role of zinc in the toxic action of coal dust upon mouse macrophage. British J. of Industrial Med. 1991 48:838-840.
[77]  Yi-Biao Yeh, Yurong Lai, A-Liang Yeh. Normal Value of Residual Volume (RV) in Miners and Its Multivariate Regression Analysis Model. Chinese J. of Labor Health and Occup. Dis. 1990 8(3): 177-9.
[78]  Yi-Biao Yeh and Yurong Lai *. The Influence of Rheumatoid Factor in coal Miners' Pneumoconiosis in the Fujian Shaowu Colliery, South China. British J. of Industrial Med. 1990 47:143-4.
[79]  Yurong Lai *, Yi-Biao Yeh and Lui-Yu Qi. Population investigation on the blood level of zinc and copper from 230 Pregnant Women. J. Of Fujian Med. Univ. 1990 24(4): 354-6.
[80]  Yurong Lai *, Yi-Biao Yeh and Lui-Yu Qi. Prediction of the Incidence of Pneumoconiosis in Workers Working on Sand-road; prediction model of multiple factors stepwise analysis. J. of Fujian Med. 1989 11(3):23-6.
[81]  Yurong Lai *, Yi-Biao Yeh, Lui-Yu Qi. At Simultaneously detection of Zinc and Copper for micro-volume blood sample by using Potentiometric Stripping Analysis. J. of Fujian Med. Univ. 1989 23:170-3.

Publications: Books/Book Chapters

[1]  Sugawara, N., Lai, Yurong., and Sugawara, C. Does TTM-treatment alleviated hepatitis occurring naturally in Long-Evans Cinnamon (LEC) rats fed a copper normal diet? In Trace elements in Man and Animals. Edited by P.W.F. Fischer, M.R. L'Abbe, K.A. Cockell, and R.S. Gibson. NRC Research Press, Ottawa, Canada. pp. 570-571
[2]  Martin E. Dowty, Dean M. Messing, Yurong Lai, Leonid (Leo) Kirkovsky. ADME in ADMET for Medicinal Chemists: A practical Guide 2010 Wiley. DOI:10.1002/9780470915110.ch4