International Journal of Tumor Therapy

International Journal of Tumor Therapy is an international journal publishing original research aticles, critical reviews, research notes, debate and short reports in all areas of tumor therapy. The journal aims to provide a forum for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in tumor therapy related problems.


Rajiv Gude

Editorial Board Member of International Journal of Tumor Therapy

Research Scientist, Cancer Research Institute, Advanced Centre For Treatment Research & Education In Cancer (Actrec), Tata Memorial Centre, India

Research Areas

Antimetastasis & Antiangiogenic Drug Study In Vitro & In Vivo

Education

1985Ph.DUniversity of Bombay, Biochemistry
1978M.ScUniversity of Bombay, Applied Biology
1974B.ScUniversity of Bombay, Microbiology

Experience

2005-presentCancer Research Institute, ACTREC, Navi Mumbai, Scientific Officer ‘E'
1997-2005Cancer Research Institute ACTREC, Navi Mumbai, Scientific Officer ‘D'
1993-1997Cancer Research Institute, Mumbai, Scientific Officer ‘C'
1986-1993Cancer Research Institute, Mumbai, Scientific Officer ‘B'
1980-1985Cancer Research Institute, Mumbai, Scientific Assistant
1979-1980Cancer Research Institute Mumbai on DST project, Research Assistant
1974-1978G.S.Medical and K.E.M.Hospital, Mumbai, Research Fellow

Academic Achievement

Best paper presentation award in conference "Indian Society of Hematology & Blood Transfusion". for the paper "Effect of Pentoxifylline on mouse bone marrow spleen colony forming assay (S-CFA)". Bombay, 1993
Best Poster Presentation award for "Pentoxifylline Augments the in vitro anti metastatic effects of Suramin in B16F10 melanoma" in the Third Workshop on Drug Discovery and Development in New Millennium , Chandigarh, 2006
Best Poster Presentation award for "Evaluation of antimetastatic and antiangiogenic activity of hydroalcoholic extract of Phyllanthus Emblica (Amla) on B16F10 melanoma in 25 th Annual Convention of the Indian Association for Cancer Research, ACTREC, Navi

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Gude R.P., Chitnis M.P., Rao S.G.A. Effect of Pentoxifylline, a multidrug resistance reversal agent, on haemopoietic stem cell homing. Cell Biology International, 18(2) pp 79-84, 1994.
[2]  Gude R.P., Ingle A.D., Rao S.G.A. Inhibition of lung homing of B16 F10 by Pentoxifylline on microfilament depolymerising agents. Cancer Letters, 106, 171-176, 1996.
[3]  Gude R.P., Binda M.M., Lopez Presas H., Bonfil R.D. Antiangiogenic and antimetastatic effect of Pentoxifylline on B16 F10 melanoma. Proc. Of American Association for Cancer Research Vo.39, # 2134, 1998.
[4]  Gude R.P., Binda M.M., Lopez Presas H., Klein-Szanto A.J.P., Bonfil R.D. Studies on the mechanisms responsible for inhibition of experimental metastasis of B16 F10 murine melanoma by Pentoxifylline. Journal of Biomedical Science Vol. 6 (No.2), 133-141, 1999.
[5]  Gude R.P., Ingle A.D., Rao S.G.A. (1999). In vitro and In vivo studies of Nicotinic acid in an experimental metastasis model of B16F10 melanoma. Indian J.Pharm.Sci. 61(5), 287-292, 1999.
[6]  Sant V.P., Nagarsenker M.S., Rao S.G.A., Gude R.P. Enhancement of antimetastatic activity of Pentoxifylline by encapsulation in conventional liposomes and sterically stabilized liposomes in murine experimental B16F10 melanoma model. J.Pharm. Parmacol, 52, 1461-1466, 2000.
[7]  Gaikwad S.Y., Jagtap A.G., Ingle A.D., Rao S.G.A., Gude R.P. Antimetastatic efficacy of Neosomal Pentoxifylline and its combination with activated macrophages in murine B16F10 melanoma model. Cancer Biotherapy & Radiopharmaceuticals 15: 605-615, 2000.
[8]  Gude R.P., Binda M.M., Bonfil R.D. et al. Inhibition of endothelial cell proliferation and tumor induced angiogenesis by Pentoxifylline. Journal of Cancer Research & Clinical Oncology 27, 625-630, 2001.
[9]  Gude R.P., Menon L.G., Rao S.G.A. Effect of caffeine, a xanthine derivative, on murine experimental B16F10 melanoma model. Journal Experimental and Clinical Cancer Research 20, 145-150, 2001.
[10]  Menon L.G., Ingle A.D., Gude R.P. Tumor regression of B16F10 melanoma in vivo by prevention of neovascularization: Study on theophylline. Cancer Biotherapy and Radiopharmaceuticals, Volume 2, 213-217, April 2002.
[11]  Gude R.P., Jadhav M.G., Rao S.G.A., Jagtap A.G. Effects of niosomal cisplatin and combination of the same with Theophylline and with activated macrophages in murine B16F10 melanoma model. Cancer Biotherapy & Radiopharmaceuticals 17, 183-192, 2002.
[12]  Shukla V., Gude R.P. Potentiation of antimetastatic activity on Penotoxifylline in B16F10 and B16F1 melanoma cells through inhibition of glutathione content. Cancer Biotherapy and Radiopharmaceuticals, 18, 551-564, 2003.
[13]  Shukla V., Gude R.P. Potentiation of lipid peroxidation in B16F10 and B16F1 melanoma cells by caffeine, methylxnthine derivative: Relationship to intracellular glutathione. "Chemotherapy" [Karger] 49, 71-75, 2003.
[14]  Shukla V., Gude R.P. Amelioration of B16F10 melanoma cells induced oxidative stress in DBA/2 mice by Pentoxifylline. Journal Experimental and Clinical Cancer Research 22, 407-410, 2003.
[15]  Sant V.P., Nagarsekar M.S., Rao S.G.A., Gude R.P. Sterically stabilized Etoposide liposome: Evaluation of antimetastatic activity and its potentiation by combination with sterically stabilized Pentoxifylline Liposome in mice. Cancer Biotherapy & Radiopharmaceutical 18, 811-818, 2003.
[16]  Srivastava R., Ratheesh A, Gude R.P., K.V.K.Rao, Panda D, Subrahmanyam G.Resveratrol inhibits type II phosphotidylinositol 4-kinase : Akey component in pathways of phosphoinositide turn over.Biochemical Pharmacology70(7) :1056-1065, 2005
[17]  Dua P and Gude R.P.Antiproliferative and Antiproteolytic activity of Pentoxifylline in culture of B16F10 melanoma cells Cancer Chemotherapy and Pharmacology 58:195-202, 2006.
[18]  Dua P, Ingle A, Gude R.P. Suramin augments the antitumor and antimetastatic activity of Pentoxifylline in B16 F10 melanoma. International J. Cancer, 121:1600-08, 2007
[19]  Ratheesh A., Ingle A, Gude R.P. Pentxifylline modulates cell surface integrin expression and integrin mediated adhesion of B16F10 cells to extracellular matrix components. Cancer Biology & Therapy 6(11):1743-1752, 2007
[20]  Dua P & Gude R.P.Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organization. European J Cancer 44:1587-95, 2008
[21]  Shenoy V; Rajyaguru TH, Gude R.P. and Murthy R.S.R Studies on the Paclitaxel loaded Glyceryl monostearate nanoparticles J of Microencapsulation 1-8, 2009
[22]  Shenoy V S, Gude R.P. Murthy R.S.R Paclitaxel-loaded glyceryl palmitostearate nanoparticles; in vitro release and cytotoxic activity J Drug Targeting 17(4): 304-310, 2009
[23]  Shah S, Pal A, Gude R, Devi S Synthesis and characterization of thermo-responsive copolymeric nanoparticles of poly ( methyl methacrylate –co-N-vinylcaprolactam European Polymer Journal 46:958-67, 2010
[24]  Jain M, Ratheesh A and Gude RP Pentoxifylline inhibits integrin mediated adherence of 12(S0-HETE and TNF alpha activated B16F10 cells to fibronectin and endothelial cells CHEMOTHERAPY (Karger publication) 56( 1) : 82-88, 2010
[25]  Salot S and Gude RP. MTA1 aids the AKT pathway by inhibiting expression of a key regulator, PTEN J Cancer Science & Therapy 2($): 114-119, 2010
[26]  Ratheesh A , Jain M & Gude RP.Antimetastatic action of Pentoxiphylline, a methyl xanthine derivative , through its effect on PKC mediated integrin transport in B16F10 melanoma cells.World J Oncology 1: 194-203, 2010
[27]  Date AA, Dhawan V, Patere S, Nagarsenker MS, Gude RP, Hassan PA, Aswal VK, Steiniger F, Thamm J, Fahr A Phospholipid based novel cationic nanocarriers (Leciplex) II: Improving therapeutic efficacy of Quercetin on oral administration Molecular Pharmaceutics (In Press, 2011)
[28]  Ukawala M, Choudhari k, Rajaguru T, Manjappa AS, Murthy R, Gude RP"Laminin receptor targeted etoposide loaded polymeric micelles: A novel approach for the effective treatment of tumor metastasis" J Drug Targeting ( In press, 2011)
[29]  Goel PN, Gude RPUnravelling the antimetastatic potential of Pentoxifylline, a methylxanthine derivative in Human MDA-MB-231 Breast Cancer Cells. Molecular & Cellular Biochemistry ( In Press, 2011)