International Journal of Tumor Therapy

International Journal of Tumor Therapy is an international journal publishing original research aticles, critical reviews, research notes, debate and short reports in all areas of tumor therapy. The journal aims to provide a forum for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in tumor therapy related problems.

Gabriella Marfe

Editorial Board Member of International Journal of Tumor Therapy

Research Scientist, University of Rome "Tor Vergata" Faculty of Medicine, Department of Experimental Medicine and Biochemical Sciences, Italy

Research Areas

Cancer Cell Lines, Cancer Stem Cells. Stem Cells, Apoptosis, Resistance To Tkis


1993-1996Ph.DAcademisch Ziekenhuis Free University Hospital, Amsterdam Holland
1992M.S.University of Naples "Federico II"
1982B.SUniversity of Naples "Federico II"

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Blood derived stem cells: An ameliorative therapy in veterinary ophthalmology.Marfe G, Massaro-Giordano M, Ranalli M, Cozzoli E, Di Stefano C, Malafoglia V, Polettini M, Gambacurta A.J Cell Physiol. 2011 Jul 25. doi: 10.1002/jcp.22953. [Epub ahead of print]
[2]  Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-{kappa}B.Tafani M, Schito L, Pellegrini L, Villanova L, Marfe G, Anwar T, Rosa R, Indelicato M, Fini M, Pucci B, Russo MA.Carcinogenesis. 2011 Aug;32(8):1167-75. Epub 2011 Jun 3.
[3]  Sphingosine kinase 1 overexpression is regulated by signaling through PI3K, AKT2, and mTOR in imatinib-resistant chronic myeloid leukemia cells.
[4]  Marfe G, Di Stefano C, Gambacurta A, Ottone T, Martini V, Abruzzese E, Mologni L, Sinibaldi-Salimei P, de Fabritis P, Gambacorti-Passerini C, Amadori S, Birge RB.Exp Hematol. 2011 Jun;39(6):653-665.e6. Epub 2011 Mar 8.PMID:
[5]  Pyrrolo[1, 2-b][1, 2, 5]benzothiadiazepines (PBTDs) exert their anti-proliferative activity by interfering with Akt-mTOR signaling and bax:bcl-2 ratio modulation in cells from chronic myeloid leukemic patients.Di Stefano C, Marfe G, Trawinska MM, Sinibaldi-Salimei P, Silvestri R, Amadori S, Abruzzese E.Cancer Sci. 2010 Apr;101(4):991-1000.
[6]  2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin modifies expression and nuclear/cytosolic localization of bovine herpesvirus 1 immediate-early protein (bICP0) during infection.
[7]  Fiorito F, Marfè G, Granato GE, Ciarcia R, De Blasio E, Tafani M, Florio S, De Martino L, Muzi G, Pagnini U, Giordano A.J Cell Biochem. 2010 Oct 1;111(2):333-42.PMID:
[8]  The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners.Marfe G, Tafani M, Pucci B, Di Stefano C, Indelicato M, Andreoli A, Russo MA, Sinibaldi-Salimei P, Manzi V.BMC Physiol. 2010 May 12;10:7.PMID:
[9]  Bid cleavage, cytochrome c release and caspase activation in canine coronavirus-induced apoptosis.De Martino L, Marfé G, Longo M, Fiorito F, Montagnaro S, Iovane V, Decaro N, Pagnini U.Vet Microbiol. 2010 Feb 24;141(1-2):36-45. Epub 2009 Sep 11.
[10]  In vitro anti-leukaemia activity of pyrrolo[1, 2-b][1, 2, 5]benzothiadiazepines (PBTDs).Marfe G, Di Stefano C.Recent Pat Anticancer Drug Discov. 2010 Jan;5(1):58-68. Review.
[11]  Analysis of apoptosis induced by Caprine Herpesvirus 1 in vitro.Longo M, Fiorito F, Marfè G, Montagnaro S, Pisanelli G, De Martino L, Iovane G, Pagnini U.Virus Res. 2009 Nov;145(2):227-35. Epub 2009 Jul 18.PMID:
[12]  Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells.Marfe G, Pucci B, De Martino L, Fiorito F, Di Stefano C, Indelicato M, Aventaggiato M, Russo MA, Tafani M.Int J Cancer. 2009 Nov 1;125(9):2077-85.
[13]  Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction.Marfe G, Tafani M, Indelicato M, Sinibaldi-Salimei P, Reali V, Pucci B, Fini M, Russo MA.J Cell Biochem. 2009 Mar 1;106(4):643-50.