International Journal of Tumor Therapy

International Journal of Tumor Therapy is an international journal publishing original research aticles, critical reviews, research notes, debate and short reports in all areas of tumor therapy. The journal aims to provide a forum for doctors and academicians all over the world to promote, share, and discuss various new issues and developments in tumor therapy related problems.


Pappa Srinivasan

Editorial Board Member of International Journal of Tumor Therapy

Assistant Professor, Alagappa University, India

Research Areas

Phage Therapy, Disease Management of Aquaculture, Molecular Interactions Between the Aquatic Animals and Microbes, Cancer Biology, Plant Derived Bioactive Compounds

Education

Ph.DDept. of Biotechnology, University of Madras, Chennai, India.
M.ScJamal Mohamed College, Bharathidasan University, Thiruchirappalli, India
B.ScA.V.V.M. Sri Pushpam College, Bharathidasan University, Thiruchirappalli, India

Experience

2008-presentAssistant Professor, Dept. of Bioinformatics Alagappa University, Karaikudi
2006-2008Research Officer: Acme ProGen Biotech India Pvt. Ltd., Salem, and Medox Biotech India Pvt. Ltd., Chennai, India
2003-2006Teaching cum Research Fellow: Dept of Biotechnology, University of Madras, Guindy Campus, Chennai
2000-2003Tamil Nadu Junior Research Fellowship: Dept of Biotechnology, Univ. of Madras, Guindy Campus, Chennai

Membership

Member, Asian Fisheries Society, Malaysia
Member, QUICK Cell, NAAC Division, Alagappa University
Member, Environmental Awareness Programme, NAAC Division, Alagappa University
Member, Ph.D Doctoral Committee, Dr. MGR University, Chennai
Member, Ph.D Doctoral Committee, Alagappa University
Member, Ph.D Doctoral Committee, Dept of Eco-Biotechnology, Bharathidasan University
Member, Valuation Board for Bioinformatics, Dept of Bioinformatics, Bharathiar University
Life Member, Indian Science Congress Association, Kolkata
Member, Board of Studies in Bioinformatics, Alagappa University
Member, Board of Studies in Biotechnology, Alagappa University
Member, Board of Studies in Microbiology and Medical lab technology, Alagappa University
Chairman, Valuation Board for the PG Bioinformatics, Department of Bioinformatics and affiliated colleges of the Alagappa University
Member, PG Examination evaluation board, University Affiliated Colleges, Alagappa University
Member, UG Examination evaluation board, University Affiliated Colleges, Alagappa University
Representative, Alagappa University DDE examinations, Alagappa University
Question paper setter for PG department of Bioinformatics, Thiagarajar College, Madurai
Question paper setting for the PG students of bioinformatics department, Alagappa University from Nov 2009
Question Paper setter and evaluator for the DDE exams of Alagappa University PG and UG exams from year of Apr 2009 (Different Biological Science papers)

Publications: Journals

[1]  Srinivasan, P., Ramasamy, P. Brennan, G.P. and Hanna, R.E.B, 2007. Inhibitory effects of bacteriophages against shrimp pathogenic Vibrio spp. of the Indian aquaculture environment. Asian Journal of Animal and Veterinary Advances, 2(4): 166-183 (Med Sci Index: 5.04).
[2]  Srinivasan, P. and Ramasamy, P, 2009. Occurrence, distribution and antibiotic resistance patterns of Vibrio species associated with viral diseased shrimp of South Indian aquaculture environment. International Journal of Agriculture Sciences, 1(2): 1-10.
[3]  Manikandan, R., Sundaram, R., Srinivasan, P., Beulaja, S. and Arulvasu, C, 2009. Isolation of 1, 2 di-substituted idopyranose from Vitex negundo and its effects on diabetic rats. International Journal of Pharmaceutical Analysis, 1(2): 4-10.
[4]  Uma maheshwari, N., Josphine, A., Kannahi, M. and Srinivasan, P, 2010. Molecular characterization of probiotic bacteria, Bacillus spp. from shrimp aquaculture environment of Tamilnadu, India. Geobios, (Jodhpur) 37(1): 73-75.
[5]  Arulvasu, C., Prabhu, D., Manikandan, R., Srinivasan, P., D. Dinesh, G. Babu and S. Sellamuthu, 2010. Induction of apoptosis by the aqueous and ethanolic leaf extract of Vitex negundo L. in MCF-7 human breast cancer cells. International Journal of Drug Discovery, 2(1): 1-7.
[6]  Srinivasan, P., Sudha, A., Bharathajothi, P., Rajaguru, K., Rameshthangam, P., Manikandan, R. and Arulvasu. C, 2010. Effects of anti-inflammatory and antipyretic activity of Anisomeles malabarica R.Br. Journal of Pharmacy Research, 3 (7): 1598-1601 (IF: 1.09).
[7]  Arulvasu, C., Dinesh, D., Manikandan, R., Srinivasan, P., Radhakrishnan, N, 2010. Evaluation of anti-proliferative effect of sardine oil emulsion on A549 and HCT 15cancer cell lines. International Journal of PharmTech Research, 2(2): 1171-1177 (IF: 0.2334).
[8]  Arulvasu, C., Babu, G., Manikandan, R., Srinivasan, P., Radhakrishnan, N., Sellamuthu, S., Prabhu, D., Dinesh, D. 2010. Anti-Cancer Effect of Datura innoxia P.mill. Leaf Extract in vitro through Induction of Apoptosis in Human Colon Adenocarcinoma and Larynx Cancer Cell Lines. Journal of Pharmacy Research, 3 (7): 1485-1488 (IF: 1.09).
[9]  Sudha, A., Srinivasan, P., Natarajan Rameshkannan, N and Vanajothi, R, 2011. Protective effects of Achras zapota Linn. seed extract in carbon tetrachloride induced hepatotoxicity in rats. Inventi Rapid: Ethnopharmacology, 1(2): (Accepted) (RI Factor: 2.47).
[10]  Pappu Srinivasan, Arumugam Sudha, Ramar Manikandan and Chinnasamy Arulvasu, 2011. Molecular docking studies Of 1, 2 disubstituted Idopyranose from Vitex negundo with anti-diabetic activity of Type 2 Diabetes. International Journal of Pharma and Bio sciences, 2(1): 68-83.
[11]  P. Rameshthangam, P. Srinivasan, A. Krishnika and P. Ramasamy, 2011. White spot syndrome virus (WSSV): an overview. International Journal of Current Research and Review, 2(2): 028-041.
[12]  P. Srinivasan, A. Sudha, A. Shahul Hameed, and S. Prasanth Kumar, M. Karthikeyan, 2011. Screening of Medicinal Plants for inhibitors of NS5B Polymerase of Hepatitis C Virus (HCV) using Molecular Docking Studies. Journal of Pharmacy Research, 4(1): 136-140 (IF: 1.09).
[13]  P. Rameshthangam, P. Srinivasan, C. Arulvasu, D. Gowdhaman and P. Neeraja, 2011. Protein carbonylation as biomarker(s) in serum patients with type 2 diabetes. Journal of Pharmacy Research, 4(2): 348-351 (IF: 1.09).
[14]  S. Prasanth Kumar, Yogesh T. Jasrai, Saumya K. Patel, Himanshu A. Pandya and P. Srinivasan. 2011. In silico Development of Inhibitors Against Pantothenate Synthetase of Mycobacterium tuberculosis. Journal of Advanced Bioinformatics applications and Research, 2(2): 142-148.
[15]  Dhanachandra Singh, Kh., Kirubakaran, P., Manikandaprabhu, S., Nagamani, S., Srinivasan, P and Karthikeyan, M, 2011. Docking studies of adenosine analogues with NS5 methyltransferase of Yellow Fever Virus. Indian Journal of Microbiology. (Accepted - INJM- D-10-00159) (IF: 0.95)
[16]  Sengottuvelan, N., Srinivasan, P. and Kandasamy, M, 2011. DNA Cleavage Electrochemical and Magnetic studies of Scorpionand copperII complex. International Journal of ChemTech Research (Accepted).
[17]  B. Vaseeharan, P. Ramasamy, P. Srinivasan, R. Manikandan, C. Arulvasu, N. M. Prabhu,2011. Isolation and Characterization of Pharmaceutically important fungal microflora from Penaeus monodon culture system. Inventi Impact: PharmTech, (Accepted) (RI Factor: 1.42).
[18]  P. Srinivasan, S. Prasanth Kumar, M. Karthikeyan, J. Jeyakanthan, Y. Jasrai, H. Pandya, R. Rawal and S. Kantibhai Patel. 2011. Epitope based immunoinformatics and 1 molecular docking studies of Nucleocapsid protein (NP) and Ovarian Tumor (OTU) domain of Crimean-Congo haemorrhagic fever virus (CCHFV). Frontier in Bioinformatics & Computational Biology (Accepted).

Publications: Conferences/Workshops/Symposiums

[1]  Srinivasan, P., Sudha, A., Umamaheswari, N., and Vanajothi, R., Modeling of Quorum Sensing Regulatory Protein of Vibrio harveyi from shrimp aquaculture system and In silico Prediction of Active Drugs. Paper presented in the 9th Asian Fisheries & Aquaculture Forum, Organised by Shanghai Ocenan University, China, during April 21st - 25th. 2011.
[2]  Vanajothi, R., Sudha, A., Manikandan,R., Rameshthangam,P., and Srinivasan, P. PCR based genetic variability analysis of spotted bollworm Earias Vitella. Paper presented in the National Conference on "Emerging trends in Biological Research", Organized by Department of Zoology, University of Madras, during 21-22, February 2011.
[3]  P. Srinivasan, K. Sureka, T. Sudhan and P. Ramasamy. Characterization of Bacillus phage-PS1 isolated from shrimp aquaculture environment of Tamil Nadu, India. Paper presented in the National Conference on "Emerging trends in Biological Research", Organized by Department of Zoology, University of Madras, during 21-22, February 2011.
[4]  Rajamanikandan, S., Vanajothi, R., Sudha, A., Rameshthangam, P., and Srinivasan, P Computational detection of deleterious SNPs and their effect on sequence and structural level of the FGFR2 gene. Poster presented in the 2nd international conference on "System Biology and Bioinformatics" Organized by Department of Zoology, Annamalai University, Chidabaram, during 16th - 17th Febrauary, 2011.
[5]  Srinivasan, P., Sudha, A., Vanajothi, R., and Jothi Basu, M. In silico screening of
[6]  molecular docking simulation. Poster presented in the Workshop of the eattle-India Joint Research Training Program "Advanced Technologies and Research Proposal Development" organised by JNU, New Delhi, during 30 January -5 February, 2011.
[7]  P. Srinivasan, A. Sudha, N. Umamaheswari and R. Vanajothi. Homology modeling and molecular docking studies of Vibrio harveyi LuxR protein involved in Quorum sensing. Poster presented in the Workshop of the Seattle-India Joint Research Training Program "Advanced Technologies and Research Proposal Development" Organised by JNU, New Delhi, during 30 January -5 February, 2011.
[8]  Sudha, A., C. Ram Vignesh, P. Rameshthangam and P. Srinivasan. Anti-HRV 2 evaluation of MDL-860 and its analogues by structure- based virtual screening. Poster presented in the 3rd National Symposium cum Workshop on "Recent Trends in Structural Bioinformatics and Computer Aided Drug Design" Organized by Department of Bioinformatics, Alagappa University, Karaikudi , during 20th - 22nd December, 2010.
[9]  R. Vanajothi, M. D. Karthiga, R. Manikandan, C. Arulvasu and P. Srinivasan. Molecular docking studies on inhibition of Estrogen receptor and PI3 kinase by herbal derivative 1, 2 disubstituted idopyranose in breast cancer. Poster presented in the 3rd National Symposium cum Workshop on Recent Trends in Structural Bioinformatics and Computer Aided Drug Design Organized by Department of Bioinformatics, Alagappa University, Karaikudi , during 20th - 22nd December, 2010.
[10]  S. Rajamanikandan, V. Suryanarayanan, A. Sudha, R. Vanajothi, P. Srinivasan. DEK oncoprotein as a potential target for novel anticancer drug. Poster presented in the 3rd National Symposium cum Workshop on Recent Trends in Structural Bioinformatics and Computer Aided Drug Design Organized by Department of Bioinformatics, Alagappa University, Karaikudi , during 20th - 22nd December, 2010.
[11]  M. Nishandhini, K. Sureka, A. Sudha, P. Rameshthangam P. Srinivasan. Homology modelling of Protease from Proteus mirabilis and molecular docking for exploration of drugs. Poster presented in the 3rd National Symposium cum Workshop on Recent Trends in Structural Bioinformatics and Computer Aided Drug Design Organized by Department of Bioinformatics, Alagappa University, Karaikudi , during 20th - 22nd December, 2010.
[12]  Vanajothi, R., Sudha, A., and Srinivasan, P. In silico docking analysis of secretory phospholipase with marine derived anti-inflammatory compounds. Paper presented in the Second National Conference on Bioprospecting of marine resources with special reference to Marine natural products and drug discovery, organized by Department of Oceanography and coastal area studies, Alagappa University, Thondi campus, during 25- 27, August 2010.
[13]  Sudha, A., Srinivasan, P and Manikandan, R. Hepatoprotective potentials of Achyranthus aspera extract against ethanol-induced oxidative stress in rats. Poster presented in the Indian Youth Science Congress, Organised by SRM University, Chennai, during 26-28, June 2010.
[14]  P. Srinivasan and P. Ramasamy. Inhibitory effects of Vibrio phages against bacterial diseases from shrimp industry in South India. World Tamil Conference 2010 held at Coimbatore, Tamil Nadu during June 2010.
[15]  K. Rajaguru, P. Srinivasan and P. Rameshthangam. Applications of Bioinformatics. World Tamil Conference 2010 held at Coimbatore, Tamil Nadu during June 2010.
[16]  K. Rajaguru, V. Suryanarayanan, P. Srinivasan*, P. Rameshthangam, R. Manikandan and P. Ramasamy. Inhibition of Vibrio species by medicinal plants through molecular docking studies. World Tamil Conference 2010 held at Coimbatore, Tamil Nadu during June 2010.
[17]  P. Rameshthangam, P. Srinivasan and K. Rajaguru. Applications of Biotechnology in Shrimp Culture Development. World Tamil Conference 2010 held at Coimbatore, TamilNadu during June 2010.
[18]  P. Rameshthangam, P. Srinivasan and P. Ramasamy. Prevention and Control of White Spot Syndrome Virus in Shrimp. World Tamil Conference 2010 held at Coimbatore, Tamil Nadu during June 2010.
[19]  P. Rameshthangam and P. Srinivasan. Modern approaches in Biotechnology. National Seminar on evolving strategies for employability of students in higher education organized by Department of Life Long Learning, Alagappa University, Karaikudi during 23rd & 24th April 2010.
[20]  Kh. Dhanachandra Singh, P. Kirubakaran, P. Srinivasan, M. Karthikeyan. Adenosine analogue - a potential inhibitor of DENV RNA dependent RNA polymerase (RdRp) in the Ist IFIP International conference on Bioinfomatics held at SVNIT, Surat during March, 25- 28, 2010.
[21]  A. Sudha and P. Srinivasan. Molecular docking study on inhibition of CDK-2 by plant- derived natural products. National workshop on Application of molecular modeling and structural bioinformatics held at Alagappa University, Karaikudi during January 27-29, 2010.
[22]  K. Rajaguru, S. Vishnu Priya, P. Rameshthangam and P. Srinivasan. Comparative analysis of the effect of natural and synthetic compounds to control pathogenic bacterium Proteus mirabilis by molecular docking studies. Third Indo-Korean joint seminar on Medicinal Plant Research held at Avinashilingam University, Coimbatore on 23rd February 2010.
[23]  K. Rajaguru, M. Pradeeba, P. Rameshthangam and P. Srinivasan. Restriction of the Pathogen, Burkholderia pseudomallei with natural derived compounds from the Medicinal Plants, Tamarindus indica and Dimocarpus longan by Molecular Docking Studies. International Conference on Bioinformatics and System Biology held at Annamalai University during February 19-21, 2010.
[24]  P. Srinivasan*, K. Rajaguru, R. Manikandan, C. Arulvasu and A. Sudha. Molecular docking studies on inhibition of CDK2 and GSK3 by herbal derivative 1, 2 disubstituted idopyranose in cancer. International Symposium on Emerging Trends in Biomedical and Nanobiotechnology: Relevance to Human at Acharya Nagarjuna University, Guntur during 19-21, December, 2009.
[25]  A. Sudha, P. Srinivasan, K. Rajaguru, and P. Rameshthangam. Protective effect of Achras zapota Linn. seed extract in carbon tetrachloride induced hepatotoxicity in rats. International Symposium on Emerging Trends in Biomedical and Nanobiotechnology: Relevance to Human at Acharya Nagarjuna University, Guntur during 19-21, December, 2009.
[26]  K. Rajaguru, A. Shahul Hameed, S. Prasanth Kumar, P. Srinivasan, M. Karthikeyan, Sanjeev Kumar Singh. Screening of Medicinal Plants for inhibitors of NSB5 Polymerase of Hepatitis C Virus (HCV) using Molecular Docking Studies. International Symposium on Emerging Trends in Biomedical and Nanobiotechnology: Relevance to Human at Acharya Nagarjuna University, Guntur during 19-21, December, 2009.
[27]  Kesavan, B., Vaseeharan, B., Srinivasan, P., Sanjeev Kumar Singh, Karthikeyan, M. Comparison of gene codes of cancer causing RNA virus. 9th Tamil Science Congress, Alagappa University, Karaikudi - 3 during 11th - 13th September 2009.
[28]  Arulvasu, C., Babu, K., Manikandan, R., Srinivasan, P., Dinesh, T., Prabhu, D. Role of plants in control of cancer. 9th Tamil Science Congress, Alagappa University, Karaikudi - 3 during 11th - 13th September 2009.
[29]  Dineshkumar, P.L., Mohamed Rabeek, N., Manikandaprabhu, S., Selvaraj, C., Sanjeev Kumar Singh., Karthikeyan, M., Srinivasan, P. In-silico Prediction of Vaccine Candidates against Botulism causing Clostridium botulinium by Reverse Vaccinology. 9th Tamil Science Congress, Alagappa University, Karaikudi - 3 during 11th - 13th September 2009.
[30]  Prasanth Kumar, S., Shahul Hameed, A., Rajaguru, K., Selvaraj, C., Karthikeyan, M., Sanjeev Kumar Singh., Srinivasan, P. Interaction of RFC and Brd4 proteins - A major event for initiation of eukaryotic genome replication - A framework of signaling pathway. 9th Tamil Science Congress, Alagappa University - 3 during 11th - 13th September 2009.
[31]  Rajaguru. K., Srinivasan, P., Sudha, A., Manikandan, R., Arulvasu, C. In-vitro Degradation and Docking analysis of the Insecticide, Lambda Cyhalothrin by the Antagonistic Organisms, Pseudomonas fluorescens and Trichoderma viride under Aerobic Condition. 9th Tamil Science Congress, Alagappa University, Karaikudi - 3 during 11th - 13th September 2009.
[32]  Rameshthangam, P. Srinivasan, P. Expression of serum protein profile in type 2 diabetes mellitus from South Tamilnadu - influence of diabetic environment and family history of diabetes. 9th Tamil Science Congress, Alagappa University, Karaikudi - 3 during 11th - 13th September 2009.
[33]  Sindhu, S., Nithya, G., Rajaguru. K., Selvaraj, S., Sanjeev Kumar Singh., Karthikeyan, M., Srinivasan, P. Molecular Docking and Pharmacological Studies on Anthrax causing Proteins and Drugs. 9th Tamil Science Congress, Alagappa University, Karaikudi - 3 during 11th - 13th September 2009.
[34]  Sudha, A., Rajaguru. K., Srinivasan, P., Manikandan, R., Rameshthangam, P. Phytochemical and Bioinformatics analysis of anti-inflammatory and anti-pyretic compounds of Anisomeles malabarica R.Br. 9th Tamil Science Congress, Alagappa University, Karaikudi - 3 during 11th - 13th September 2009.
[35]  Suji, G, Muthulakshmi, S., Rajaguru, K., Selvaraj, C., Sanjeev Kumar Singh., Karthikeyan, M., Srinivasan, P. In-silico Identification and comparison of metabolic pathways of Alzheimer's disease causing genetic agents in mammals. 9th Tamil Science Congress, Alagappa University, Karaikudi - 3 during 11th - 13th September 2009.
[36]  Venkatraghavan, R., Saravanan, S., Rajaguru, K., Dhanachandra Singh, Kh., Sanjeev Kumar Singh., Karthikeyan, M., Srinivasan, P. Phylogenetic Analysis of O-Antigen Producing Bacteria. 9th Tamil Science Congress, Alagappa University, Karaikudi - 3 during 11th - 13th September 2009.
[37]  Rameshthangam, P and P.Srinivasan. Environmental Impact of Aquaculture during shrimp production. UGC sponsored seminar on Promoting Environmental Values among the Teacher Trainees at Secondary Level organized by the Directorate of Distance Education & School of Education, Alagappa University, Karaikudi during 22nd & 23rd October 2009.