International Journal of Brain and Cognitive Sciences

International Journal of Brain and Cognitive Sciences is to provide a single platform for publishing original experimental and review articles on the trends and advances of mind study. It specializes in articles that cover the latest developments and pinpoints directions for future research on mind and cognitive sciences.

Bart Ellenbroek

Editorial Board Member of International Journal of Brain and Cognitive Sciences

Associate Professor, Victoria University of Wellington, School of Psychology, New Zealand

Research Areas

Behavioral Neuroscience

Education

1984-1988Ph.DMedical Faculty. Catholic University Nijmegen, the Netherlands (Supervisor: Prof A.R. Cools)
1979-1982M.ScCatholic University Nijmegen, the Netherlands Major: Neuropsychopharmacology
1976-1979B.ScCatholic University Nijmegen, the Netherlands

Experience

2011-presentAssociate Professor, Victoria University Wellington, New Zealand School of Psychology
2006-2011Principal Scientist at Evotec AG, Hamburg, Germany Dept Neuropharmacology
1999-2006Associate Professor at the Catholic University of Nijmegen, the Netherlands Dept. of Psychoneuropharmacology
1988-1999Assistant Professor at the Catholic University of Nijmegen, the Netherlands. Dept. of Psychoneuropharmacology

Academic Achievement

NICI project KUN MED III.069901 (1999-2003) The role of stress and noradrenaline in an animal model for schizophrenia (University Grant)
Solvay Project (2001-2004) Examination of compounds on the PPI deficit induced by early maternal deprivation in rats (Industrial Grant)
Senter IOP Genomics IGE01017 (2003-2007) Reverse genetics by resequencing of mutagenized animals: making a "knock-out"-library of the rat (National Grant)
ZonMW (2003-2007) Role of gene-environment interactions in alcohol addiction (National Grant)
ZonMW (2003-2007) Interactions between MDMA and alcohol, cannabis and physical exercise in humans (National Grant)
IAP 2003.071 (2004-2005) Homecage Phenotyper. Development of a system forv automated high-throughput phenotyping of rodent behavior and physiology in the home cage (European Union Grant)
RU (2006-2009) The role of dopamine D1 receptors in the long-term effects in addiction (University Grant)
TopPharma Institute grant (2006-2010) Novel susceptibility pathways and drug targets for psychosis (International Grant)
Neuromodel EU Grant (2008-2012) Academic-industrial initial training network on innovative treatment approaches of Huntington's and Parkinson's disease (European Union Grant)
Michael J Fox Foundation (2010-2011) Investigation of PDE10a Inhibitors for Parkinson's Disease (International Grant)

Publications: Journals

[1]  Cools AR, Ellenbroek BA and van den Heuvel CM (1983) Picrotoxin microinjections into the brain: A model of abrupt withdrawal 'jumping' behaviour in rats not exposed to any opiate? Europ J Pharmacol 90: 237-243.
[2]  Cools AR, Coolen JMM, Smit JCA and Ellenbroek BA (1984) The striato-nigrocollicular pathway and explosive running behaviour: Functional interaction between neostriatal dopamine and collicular GABA. Europ J Pharmacol 100: 71-77.
[3]  Ellenbroek BA, Schwarz M, Sontag KH and Cools AR (1984) The role of the colliculus superior in the expression of muscular rigidity. Europ J Pharmacol 104: 117-123.
[4]  Ellenbroek BA, Schwarz M, Sontag KH and Cools AR (1985) The importance of the striato-nigro-collicular pathway in the expression of haloperidol-induced tonic electromyographic activity. Neurosci Lett 54: 189-194.
[5]  Ellenbroek BA Schwarz M, Sontag KH, Jaspers R and Cools AR (1985) Muscular rigidity and delineation of a dopamine-specific neostriatal subregion: Tonic EMG activity in rats. Brain Res 345: 132-140.
[6]  Ellenbroek BA, Klockgether T, Turski L and Schwarz M (1986) Distinct sites of functional interaction between dopamine, acetylcholine and gamma-aminobutyrate within the neostriatum: An electromyographic study in rats. Neuroscience 17: 79-88.
[7]  Schwarz M, Ikonomidou C, Klockgether T, Turski L, Ellenbroek BA and Sontag KH (1986) The role of striatal cholinergic mechanisms for the development of limb rigidity: An electromyographic study in rats. Brain Res 373: 365-372.
[8]  Spruijt BM, Cools AR, Ellenbroek BA and Gispen WH (1986) Dopaminergic modulation of ACTH-induced grooming. Europ J Pharmacol 120: 249-256.
[9]  Spruijt BM, Ellenbroek BA, Cools AR and Gispen WH (1986) The colliculus superior modulates ACTH-induced excessive grooming. Life Sci 39: 461-470.
[10]  Cools AR, Ellenbroek BA, Van Den Bos R and Gelissen MAW (1987) Mesolimbic noradrenaline: Specificity, stability and dose dependency of individual-specific responses to mesolimbic injections of alpha-noradrenergic agonists. Behav Brain Res 25: 49-61.
[11]  Ellenbroek BA (1987) De poottest: een nieuw diermodel voor neuroleptica. Chem Mag nov: 708-709.
[12]  Ellenbroek BA, Peeters BW, Honig WM and Cools AR (1987) The paw test: A behavioural paradigm for differentiating between classical and atypical neuroleptic drugs. Psychopharmacology 93: 343-348.
[13]  Cools AR, Spruyt BM and Ellenbroek BA (1988) Role of central dopamine in ACTH-induced grooming behavior in rats. Ann N Y Acad Sci 525: 338-349.
[14]  Ellenbroek BA and Cools AR (1988) The paw test: An animal model for neuroleptic drugs which fulfils the criteria for pharmacological isomorphism. Life Sci 42: 1205-1213.
[15]  Ellenbroek BA, van den Hoven J and Cools AR (1988) The nucleus accumbens and forelimb muscular rigidity. Exp Brain Res 72: 299-304.
[16]  Ellenbroek BA and Cools AR. (1989) Schizofrenie en antipsychotica: Wat kan preklinisch onderzoek bijdragen? TGO 17: 169-173.
[17]  Ellenbroek BA and Cools AR (1989) Diermodellen met construct validiteit voor chizofrenie. Acta Neuropsychiatr 1: 20-25.
[18]  Ellenbroek BA, Willemen A and Cools AR (1989) Are antagonists of dopamine D1 receptors drugs that attenuate both positive and negative symptoms of schizophrenia? A pilot study in Java monkeys. Neuropsychopharmacology 2: 191-199.
[19]  Cools AR, Brachten R, Heeren D, Willemen A and Ellenbroek BA (1990) Search after the neurobiological profile of individual-specific features of Wistar rats. Brain Res Bull 24: 49-69.
[20]  Ellenbroek BA and Cools AR (1990) Animal models with construct validity for schizophrenia. Behav Pharmacol 1: 469-490.
[21]  Cools AR and Ellenbroek BA (1991) The limbic-striatal interaction: A seesaw rather than a tandem. Behav Brain Sci 14: 22.
[22]  Ellenbroek BA, Artz MT and Cools AR (1991) The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine. Europ J Pharmacol 196: 103-108.
[23]  Cools AR, Prinssen EPM and Ellenbroek BA (1992) Interaction between aminergic systems in mesolimbic structures: the importance of 5-HT2, D2 and D1 receptors in the olfactory tubercle for the atypical profile off neuroleptics. Clin Neuropharmacol 15: 618a-619a.
[24]  Ellenbroek BA and Cools AR (1992) Neuroleptica: Preklinische en klinische verschillen. Acta Neuropsychiat 4: 90-96.
[25]  Ellenbroek BA, Hoeks B and Cools AR (1992) Information statistical analysis and the frequential method of data collecting: Description and illustration of a new model in the study of animal behaviour. Behaviour 121: 35-60.
[26]  Ellenbroek BA Prinssen EPM and Cools AR (1992) The azaphenothiazine prothipendyl is an atypical neuroleptic acting through dopamine D1 and D2 receptors. Neurosci Res Comm 11: 155-161.
[27]  Cools AR, Dierx J, Coenders C, Heeren D, Ried S, Jenks B and Ellenbroek BA (1993) Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in novelty-induced changes in hippocampal dynorphin B expression and two way active avoidance: a new key in the search for the role of the hippocampal-accumbens axis. Behav Brain Res 30: 213-221.
[28]  Cools AR, Ellenbroek BA, Heeren D and Lubbers L (1993) Use of high and low responders to novelty in rat studies on the role of the ventral striatum in radial maze performance: effects on intra-accumbens injections of sulpiride. Can J Physiol Pharmacol 71: 335-342.
[29]  Cools AR, Rots NY, Ellenbroek BA and deKloet ER (1993) Bimodal shape of individual variation in behaviour of Wistar rats: the overall outcome of a fundamentally different make-up and reactivity of the brain, endocrine and immunological system. Neuropsychobiology 28: 100-105.
[30]  Ellenbroek BA (1993) The treatment of schizophrenia: A clinical and preclinical evaluation of neuroleptic drugs. Pharmacol Ther 57: 1-78.
[31]  Hoeks B and Ellenbroek BA (1993) A neural basis for a quantitative pupillary model. J Psychophysiol 7: 315-324.
[32]  Prinssen EPM, Ellenbroek BA, Stamatovic B and Cools AR (1993) The effects of haloperidol and raclopride in the paw test are influenced similarly by SCH 39166. Europ J Pharmacol 231: 275-280.
[33]  Ellenbroek BA, Prinssen EPM and Cools AR (1994) The role of serotonin receptor subtypes in the behavioural effects of neuroleptic drugs. A paw study in rats. Europ. J. Neurosci., 6: 1-8.
[34]  Peeters BWMM, Ramakers GMJ, Ellenbroek BA, Vossen JMH and Coenen AML (1994) Interactions between NMDA and nonNMDA receptors in nonconvulsive epilepsy in the WAG/Rij inbred strain. Brain Res Bull 33: 715-718.
[35]  Prinssen EPM, Ellenbroek BA and Cools AR (1994) Peripheral and central noradrenergic modulation of the behavioural effects of clozapine in the paw test. Br J Pharmacol 112: 769-774.
[36]  Prinssen EPM, Ellenbroek BA and Cools AR (1994) Combined antagonism of adrenoceptors and dopamine and 5-HT receptors underlies the atypical profile of clozapine. Europ J Pharmacol 262: 167-170.
[37]  Cools AR, Prinssen EPM and Ellenbroek BA (1995) The olfactory tubercle as a site of action of neuroleptics with an atypical profile in the paw test: effect of risperidone, prothipendyl, ORG 5222, sertindole and olanzapine. Psychopharmacology 119: 428-439.
[38]  Ellenbroek BA and Cools AR (1995) Maternal separation reduces latent inhibition in the conditioned taste aversion paradigm. Neurosci Res Comm 17: 27-33.
[39]  Ellenbroek BA and Cools AR (1995) Towards an integration of animal models and clinical concepts in schizophrenia. Acta Neuropsychiatr 7: S64-S67.
[40]  Ellenbroek BA, Geyer MA and Cools AR (1995) The behavior of APO-SUS rats in animal models with construct validity for schizophrenia. J Neurosci 15: 7604-7611.
[41]  Prinssen EPM, Ellenbroek BA, Stamatovic B and Cools AR (1995) Role of striatal dopamine D2 receptors in the paw test, an animal model for the therapeutic efficacy and extrapyramidal side effects of neuroleptic drugs. Brain Res 673: 283-289.
[42]  Ellenbroek BA, Budde S and Cools AR (1996) Prepulse inhibition and latent inhibition: The role of dopamine in the medial prefrontal cortex. Neuroscience 75: 535-542.
[43]  Ellenbroek BA, Lubbers LJ and Cools AR (1996) Activity of "Seroquel" (ICI 204, 636) in animal models for atypical properties of antipsychotics: A comparison with clozapine. Neuropsychopharmacology 15: 406-416.
[44]  Knobbout DA, Ellenbroek BA and Cools AR (1996) The influence of social struc ture on social isolation in amphetamine-treated Java monkeys (Macaca fascicularis). Behav Pharmacol 7: 417-429.
[45]  Ellenbroek BA, Knobbout DA and Cools AR (1997) The role of mesolimbic and nigrostriatal dopamine in latent inhibition as measured with the conditioned taste aversion paradigm. Psychopharmacology 129: 112-120.
[46]  Kavelaars A, Heijnen CJ, Ellenbroek B, van Loveren H and Cools A (1997) Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in their susceptibility to inflammatory and infectious diseases: A study on rats with groupspecific differences in structure and reactivity of hypothalamic-pituitary-adrenal axis. J Neurosci 17: 2580-2584.
[47]  Cools AR, Ellenbroek BA, Gingras MA, Engbersen A and Heeren D (1997) Differences in vulnerability and susceptibility to dexamphetamine in Nijmegen high and low responders to novelty: a dose-effect analysis of spatio-temporal programming of behaviour. Psychopharmacology 132: 181-187.
[48]  Dirksen R, Ellenbroek B, van Egmond J and Cools AR (1997) Responses of propofol in relation to GABA functionality of discrete parts of the brain of rats. Pharmacol Biochem Behav 57: 727-735.
[49]  Ellenbroek BA, vandenKroonenberg PTJM and Cools AR (1998) The effects of an early stressful life event on sensorimotor gating in adult rats. Schizophr Res 30: 251-260.
[50]  Ellenbroek BA and Cools AR (1998) The neurodevelopmental hypothesis of schizophrenia: Clinical evidence and animal models. Neurosci Res Comm 22: 127-136.
[51]  van Luijtelaar, ELJM, Miller CAFJ, Coenen AML, Drinkenburg WHIM and Ellenbroek BA (1998) Differential effects of non-REM and REM Sleep on sensory gating in rats. Acta Neurobiol Exp 58: 263-270.
[52]  Ellenbroek BA (1998) Early life stressors and late life consequences as animal models for schizophrenia. Europ Neuropsychopharmacol 8: S95-S96.
[53]  Ellenbroek BA, van Luijtelaar ELJM, Frenken M and Cools AR (1999) Sensory gating in rats: Lack of correlation between auditory evoked potential gating and prepulse inhibition. Schizophr Bull 25: 777-788.
[54]  DeBruin NMWJ, Ellenbroek BA, Cools AR, Coenen AML, and van Luijtelaar ELJM (1999) Differential effects of ketamine on gating of auditory evoked potentials and prepulse inhibition. Psychopharmacology 142: 9-17.
[55]  Sluyter F and Ellenbroek BA (1999) Behavioural genetics: An introduction. Acta Neuropsychiatr 11: 42-44.
[56]  Talamini LM, Ellenbroek B, Koch T and Korf J (1999) Prepulse-inhibitie en habituatie in ratten met cerebrale ontwikkelingsstoornissen; implicaties voor schizofrenie. Acta Neuropsychiatr 11: 110-113.
[57]  De Bruin NMWJ, van Luijtelaar ELJM, Jansen SL, Cools AR and Ellenbroek BA (2000) Dopamine characteristics in different rat genotypes: the relation to absence epilepsy. Neurosci Res 38: 165-173.
[58]  De Hert M and Ellenbroek BA (2000) Animal models of schizophrenia. Neurosci Res Comm 26: 279-288.
[59]  Ellenbroek BA and Cools AR (2000) The long-term effects of maternal deprivation depends on the genetic background. Neuropsychopharmacology 23: 99-106.
[60]  Ellenbroek BA and Cools AR (2000) Animals models for the negative symptoms of schizophrenia. Behav Pharmacol 11: 223-233.
[61]  Ellenbroek BA, Sluyter F and Cools AR (2000) The role of genetic and early environmental factors in determining apomorphine susceptibility. Psychopharmacology 148: 124-131.
[62]  Lanser MG, Ellenbroek BA, Cools AR and Zitman FG (2000) Perseveration in schizophrenic patients: A neuropsychological approach for research. Acta Neuropsychiatr 12: 27-31.
[63]  Lanser MG, Ellenbroek BA, Cools AR and Zitman FG (2000) Set-maintenance and set-shifting problems in schizophrenic subtypes: relationship to dysfunctions of the fronto-striatal loops. Acta Neuropsychiatr 12: 32-37.
[64]  Sluyter F, Hof MWP, Ellenbroek BA, Degen SB and Cools AR (2000) Genetic, sex and early environment effects on the voluntary alcohol intake in Wistar rats. Pharmacol Biochem Behav 67: 1-8.
[65]  Talamini LM, Ellenbroek B, Koch T and Korf J (2000) Impaired sensory gating and attention in rats with developmental abnormalities of the mesocortex. Implications for schizophrenia. Ann N Y Acad Sci. 911: 486-94.
[66]  De Bruin, NMWJ, Ellenbroek BA, van Schaijk WJ, Cools AR, Coenen AML and van Luijtelaar ELJM (2001) Sensory gating of auditory evoked potentials in rats: Effect of repetitive stimulation and the interstimulus interval. Biol Psychol 55: 195-213.
[67]  Ellenbroek BA, Liegeois JF, Bruhwyler J and Cools AR (2001) The effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity in animal models for schizophrenia. J Pharmacol Exp Ther 298: 386-391.
[68]  Van Luijtelaar G, Fabene, PF, de Bruin N, Jongema C, Ellenboek BA and Veening JG (2001) Neural correlates of sensory gating in the rat: decreased fos expression induction in the lateral septum. Brain Res Bull 54: 145-151.
[69]  Lanser MG, Ellenbroek BA, Zitman FG, Heeren DJ and Cools AR (2001) The role of medial prefrontal cortical dopamine in spontaneous flexibility in the rat. Behav Pharmacol 12: 163-171.
[70]  De Bruin NMWJ, van Luijtelaar ELJM, Cools AR and Ellenbroek BA (2001) Auditory information processing in rat genotypes with different dopaminergic properties. Psychopharmacology 156: 352-359.
[71]  De Bruin NMWJ, Ellenbroek BA, van Luijtelaar ELJM, Cools AR and Stevens KE (2001) Effects of quinpirole microinjections in nucleus accumbens core and shell on hippocampal and cortical auditory sensory gating in rats. Neuroscience 105: 169-180.
[72]  De Bruin NMWJ, van Luijtelaar ELJM, Cools AR and Ellenbroek BA (2001) Dopamine characteristics in rat genotypes with distinct susceptibility to epileptic activity: apomorphine-induced stereotyped gnawing and novelty/amphetamine-induced locomotor stimulation. Behav Pharmacol 12: 517-525.
[73]  Ellenbroek BA and Cools AR (2002) Early maternal deprivation and prepulse inhibition: The role of the post-deprivational environment. Pharmacol Biochem Behav 73: 177-184.
[74]  Ellenbroek BA, Lubbers LJ and Cools AR (2002) The role of hippocampal dopamine receptors in prepulse inhibition. Eur J Neurosci 15: 1237-1243.
[75]  Ellenbroek BA and Cools AR (2002) Diermodellen voor de cognitieve stoornissen bij schizofrenie. Tijdschr Voor Psychiatr 44: 721-725.
[76]  Ellenbroek BA and Cools AR (2002) Apomorphine susceptibility and animal models for psychopathology: Genes and environment. Behav Gen 32: 349-361.
[77]  Roceri M, Hendriks W, Racagni G, Ellenbroek BA and Riva MA (2002) Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus. Mol Psychiatry 7: 609-616.
[78]  Smits BW, Siero HL, Ellenbroek BA, Riksen NP, Cools AR, Rongen GA, Russel FGM and Smits P (2002) Stress susceptibility as a determinant of the response to adrenergic stimuli in mesenteric resistance arteries of the rat. J Cardiovasc Pharmacol 40: 678-683.
[79]  Husum H, Termeer E, Mathé AA, Bolwig TG and Ellenbroek BA (2002) Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitoningene related peptide in adult rats. Neuropharmacol 42: 798-806.
[80]  Lanser MG, Berger JC, Ellenbroek BA, Cools AR and Zitman FG (2002) Perseveration in schizophrenia: failure to generate a plan and relationship with the psychomotor poverty subsyndrome. Psychiatry Res. 112: 13-26.
[81]  Liegeois JF, Eyrolles L, Ellenbroek BA, Lejeune C, Carato P, Bruhwyler J, Geczy J, Damas J and DeLarge J (2002) New pyridobenzodiazepine derivatives: Modifications of the basic side chain differentially modulate binding to dopamine (D4.2, D2L) and serotonin (5-HT2A) receptors. J Med Chem 45: 5136-5149.
[82]  Teunis MAT, Kavelaars A, Voest E, Bakker JM, Ellenbroek BA, Cools AR and Heijnen CJ (2002) Reduced tumor growth, experimental metastasis formation, and angiogenesis in rats with a hyperreactive dopaminergic system FASEB J 16: 1465-1467.
[83]  Ellenbroek BA and Liegeois JF (2003) JL13, an atypical antipsychotic: A preclinical review. CNS Drug Rev 9: 41-56.
[84]  Kho KH, Verkes RJ, Eling P, Zwarts MJ, Ellenbroek B and van Luijtelaar G (2003) P50 gating is not affected by selective attention. J Psychophysiol 17: 23-29.
[85]  Riksen NP, Ellenbroek BA, Cools AR, Siero H, Rongen GA, Smits BW, Russel FGM and Smits P (2003) Stress susceptibility as a determinant of the release of endothelium derived relaxing and contracting factors in rat mesenteric arteries. J Cardiovasc Pharmacol 41: 625-631.
[86]  Ellenbroek BA and Riva MA (2003) Early maternal deprivation as an animal model for schizophrenia. Clin. Neuroscience 3: 297-302.
[87]  Geyer MA and Ellenbroek BA (2003) Animal behavior models of the mechanisms underlying antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatr 27: 1071-1079.
[88]  Ellenbroek BA (2003) Animal models in the genomic era: Possibilities and limitations with special emphasis on schizophrenia. Behav Pharmacol 14: 409-417.
[89]  Muntjewerff JW, vanderPut N, Eskes T, Ellenbroek BA, Steegers E, Blom H and Zitman F (2003) Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophrenia. Psychiatr Res 121: 1-9.
[90]  de Bruin NMWJ, van Luijtelaar ELJM, Cools AR and Ellenbroek BA (2003) Filtering Disturbances in Schizophrenic Patients. Gating of Auditory Evoked Potentials and Prepulse Inhibition of the Acoustic Startle Response Compared. Emphasis on the Role of Dopamine Curr Neuropharmacol 1: 47-87.
[91]  Streijger F, Jost RJ, Oerlemans F, Ellenbroek BA, Cools AR, Wieringa B and van der Zee CEEM (2004) Mice lacking the UbCKmit isoform of creatine kinase reveals lo wer spatial learning acquisition, diminished exploration and habituation, and reduced acoustic startle reflex responses. Moll Cell Biochem 256: 305-318.
[92]  Ellenbroek BA, de Bruin NMWJ, van den Kroonenburg PTJM, van Luijtelaar ELJ M and Cools AR (2004) The effects of early maternal deprivation on auditory infor mation processing in adult Wistar rats. Biol Psychiatr 55: 701-707.
[93]  Ellenbroek BA (2004) Pre-attentive processing and schizophrenia: Animal studies. Psychopharmacology 174: 65-74.
[94]  Ellenbroek BA (2004) Diermodellen voor psychofarmaca en hersenziekten Neuropraxis 6: 161-165.
[95]  van der Elst MCJ, Roubos EW, Ellenbroek BA, Veening JG and Cools AR (2005) Apomorphine-susceptible rats and apomorphine-unsusceptible rats differ in the tyrosine hydroxylase-immunoreactive network in the Nucleus Accumbens core and shell. Exp Brain Res 116: 318-423.
[96]  Streijger F, Oerlemans F, Ellenbroek BA, Jost CR, Wieringa B and van der Zee CEEM (2005) Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit. Behav Brain Res 157: 219-234.
[97]  Degen SB, Ellenbroek BA, Wiegant VM and Cools AR (2005) The development of various somatic markers is retarded in an animal model for schizophrenia, namely apomorphine-susceptible rats. Behav Brain Res 157: 369-377.
[98]  van der Elst MCJ, Verheij NMM, Roubos EW, Ellenbroek BA Veening JG and Cools AR (2005) A single exposure to novelty differentially affects the accumbal dopaminergic system of apomorphine-susceptible and apomorphine-unsusceptible rats. Life Sci 76: 1391-1406.
[99]  Coolen MW van Loo KM, van Bakel NNHM, Pulfotrd DJ, Serneels L, de Strooper B, Ellenbroek BA, Cools AR and Martens GJM (2005) Gene dosage effect on secretase component Aph-1b in a rat model for neurodevelopmetnal disorders. Neuron 45: 497-503.
[100]  van der Kam EL, Coolen JCM, Ellenbroek BA and Cools AR (2005) The effect of stress on alcohol consumption. Mild acute and sub-chronic stressors differentially affect apomorphine-susceptible and unsusceptible rats. Life Sci 76: 1759-1770.
[101]  van der Kam EL, Coolen JCM, Ellenbroek BA and Cools AR (2005) Gene-environment interactions determine the individual variability in cocaine selfadministration. Neuropharmacology 48: 685-695.
[102]  Ellenbroek BA, van der Kam, EL, van der Elst MCJ and Cools AR (2005) Individual differences in drug dependence in rats: The role of genetic factors and life events. Eur J Pharmacol 526: 251-258.
[103]  Ellenbroek BA, Derks N and Park HJ (2005) Early maternal deprivation retards normal neurodevelopment in Wistar rats. Stress 8: 247-257.
[104]  Coolen MW van Loo KM, van Bakel NNHM, Ellenbroek BA, Cools AR and Martens GJM (2006) Reduced Aph-1b expression causes tissue and substratespecific changes in -secretase activity in rats with a complex phenotype. FASEB J 20: 170-172.
[105]  Smits BMG, Mudde JB, van de Belt J, Verheul M, Olivier J, Homberg J, Guryev V, Cools AR, Ellenbroek BA, Plasterk RHA and Cuppen E (2006) Generation of gene knockouts and mutant models in the laboratory rat by ENU driven target-selected mutagenesis. Pharmacogen Genom 16: 159-170.
[106]  Coolen MW van Loo KM, Ellenbroek BA, Cools AR and Martens GJM (2006) Ontogenic reduction of Aph-1b mRNA and in -secretase activity in rats with a complex phenotype. Mol Psychiatry 11: 787-793..
[107]  van der Kam EL, Coolen JCM, Ellenbroek BA and Cools AR (2006) The expression of cocaine-induced conditioned place preference in apomorphine susceptible and unsusceptible rats. Behav Pharmacol 17: 331-340.
[108]  Ellenbroek BA, Zhang X and Jin GZ (2006) The effects of (-)stepholidine in animals models for schizophrenia. Acta Pharmacol Sinica 27: 1111-1118.
[109]  van der Linden D, Massar SAA, Schellekens AFA, Ellenbroek BA and Verkes RJ (2006) Disrupted sensorimotor gating due to mental fatigue: Preliminary evidence. Int J Psychophysiol 62: 168-173.
[110]  Homberg J, Mudde J, Braam B, Ellenbroek B and Cuppen E (2006) Blood pressure in mutant rats lacking the 5-hydroxytryptamine (5-HT) transporter. Hypertension 48: 115-116.
[111]  van der Elst MCJ, Wunderink YS, Ellenbroek BA and Cools AR (2007) Differences in the cellular mechanism underlying the effects of amphetamine on prepulse inhibition in apomorphine-susceptible and apomorphine-unsusceptible rat. Psychopharmacol 190:93-102.
[112]  Homberg JR, Olivier JDA, Smits BMG, Mul JD, Mudde J, Verheul M, Nieuwenhuizen OFM, Ronken E, Cremers T, Schoffelmeer ANM, Ellenbroek BA and Cuppen E (2007) Generation and characterization of the serotonin transporter knockout rat: A selective disturbance of the serotonergic system, Neuroscience 146: 1662-1676.
[113]  Olivier JDA, van der Hart NGC, van Swelm RPL, Deeren PJ, Homberg JR, Cremers T, Deen PMT, Cuppen E, Cools AR and Ellenbroek BA (2008), A study in male and female 5-HT transporter knockout rats: An animal model for anxiety and depression disorders. Neuroscience 152: 573-584.
[114]  Olivier JDA, Jans LAW, Korte-Bouws GAH, Korte SM, Deen PMT, Cools AR, Ellenbroek BA and Blokland A (2008) Acute tryptophan depleting dosedependently impairs object memory in serotonin transporter knockout rats. Psychopharmacology 200: 243-254.
[115]  Homberg JR, de Boer SF, Raaso HS, Olivier JDA, Verheul M, Ronken E, Cools AR, Ellenbroek BA, Schoffelmeer ANM, Vanderschuren LJMJ, de Vries TJ and Cuppen E (2008) Adaptations in pre-and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology 200: 367-380.
[116]  Olivier JDA, Cools AR, Olivier B, Homberg JR, Cuppen E and Ellenbroek BA (2008) Stress-induced hyperthermia and basal body temperature are mediated via different 5-HT1A receptor populations: A study in SERT knockout rats. Eur J Pharmacol 590: 190-197.
[117]  Gemkow MJ, Davenport AJ, Harich S, Ellenbroek BA, Cesura A and Hallett D (2009) The histamine H3 receptor as a therapeutic drug target for CNS Drug Discov Today 14: 509-515.
[118]  Olivier JDA, Jans L, Blokland A, Broers Nick, Homberg JR, Ellenbroek BA and Cools AR (2009) Serotonin transporter deficiency in rats contributes to impaired object memory. Genes Brain Behav 8: 829-834.
[119]  Fernandez-Espejo E, Viveros MP, Nunes L, Ellenbroek BA and Rodriguez de Fonseca F (2009) Role of cannabis and endocannabinoids in the genesis of schizophrenia. Psychopharmacol 206: 531-549.
[120]  Molteni R, Calabrese F, Maj PF, Olivier JDA, Racagni G, Ellenbroek BA and Riva MA (2009) Altered expression and modulation of activity-related cytoskeletal associated protein (Arc) in serotonin transporter knockout rats. Eur Neuropsychopharmacol 19: 898-904.
[121]  Schellekens AEA, Grootens KP, Neef C, Movig KLL, Buitelaar JK, Ellenbroek B and Verkes RJ (2009) Effect of apomorphine on cognitive performance and sensorimotor gating in humans. Psychopharmacol 207: 559-569.
[122]  Schellekens AEA, van Oosterwijck AWAA, Ellenbroek B, de Jong CAJ, Buitelaar JK, Cools L and Verkes RJ (2010) The dopamine agonist apomorphine differentially affects cognitive performance in alcohol dependent patients and healthy controls. Europ Neuropsychopharmacol 19: 68-73.
[123]  Olivier JDA, Cools AR, Deen PMT, Olivier B and Ellenbroek BA (2010) Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters. Eur J Pharmacol 629: 7-11.
[124]  Molteni R, Cattaneo A, Calabrese F, Macchi F, Olivier JDA, Racagni G, Ellenbroek BA, Gennarelli M and Riva MA (2010) Reduced function of the serotonin transporter is associated with decreasedexpression of BDNF in rodents as well as in humans. Neurobiol Dis 37: 747-755.
[125]  Mul JD, Yi CX, van den Berg SAA, Ruiter M, Toonen PM, van der Elst MCJ, Voshol PJ, Ellenbroek BA, Andries Kalsbeek A, la Fleur SE, and Cuppen E (2010) Pmch expression during early development is critical for normal energy homeostasis. Am J Physiol Endocrinol and Metabol 298:E477-88.
[126]  Calabrese F, Molteni R, Cattaneo A, Macchi F, Racagni G, Gennarelli M, Ellenbroek BA and Riva MA (2010) Chronic duloxetine treatment normalizes altered BDNF expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Mol Pharmacol 77: 846-853.
[127]  Ellenbroek BA (2011) Psychopharmacological treatment of schizophrenia: What do we have, and what could we get? Neuropharmacol in press.

Publications: Books/Book Chapters

[1]  Ellenbroek BA, Schwarz M, Sontag KH, Jaspers R and Cools AR (1987) Delineation of a particular subregion witin the neostriatum involved in the expression of muscular rigidity. In: The neurobiology of dopamine systems, (Eds. Winlow W and Markstein R), Manchester Univ. Press, Manchester, pp. 370-373.
[2]  Ellenbroek BA and Cools AR (1988) Psychoses en antipsychotica. Een dierexperimentele benadering. In: Proceedings of Symposium Schizofrenie, Amsterdam, pp. 1-6.
[3]  Ellenbroek BA (1988) Animal models for schizophrenia and neuroleptic drug action, including a survey on the research and treatment of schizophrenia. PhD thesis, Krips Repro Meppel, 429 p.
[4]  Ellenbroek BA and Cools AR (1989) Classical and atypical neuroleptic drugs: similarities and dissimilarities. In: Recent advances in pharmacology and therapeutics, (Eds Velasco M, Israel A, Romero E and Silva H) Elsevier, Amsterdam, pp. 25-36.
[5]  Cools AR, vandenBos R, Ploeger G and Ellenbroek BA (1991), Gating function of noradrenaline in the ventral striatum: its role in behavioural responses to environmental and pharmacological challenges. In: The mesolimbic dopamine system: from motivation to action, (Eds. Willner P and Scheel Krüger J) John Wiley and Sons, Chichester, pp. 141-173.
[6]  Ellenbroek BA and Cools AR (1991) The role of the dorsal and ventral striatum in the therapeutic and extrapyramidal side effects of neuroleptic drugs. In: The Basal Ganglia III, (Eds Bernardi G, Carpenter M, DiChiara G, Morelli M and Stanzione P) Plenum Press, New York, pp. 471-479.
[7]  Ellenbroek BA (1991) The ethological analysis of monkeys in a social setting as an animal model for schizophrenia, In: Animal models in psychopharmacology, Adv in Pharmacological Sciences, (Eds Olivier B, Slangen J and Mos J) Birkhauser verlag, Basel, pp. 265-284.
[8]  Ellenbroek BA and Cools AR (1993) Stereotyped behaviour, In: Methods in Behavioral Pharmacology, Techniques in the Behavioral and Neural Sciences vol 10, (Ed. van Haaren F) Elsevier, Amsterdam, pp. 519-538.
[9]  Cools AR, Prinssen EPM, Ellenbroek BA and Heeren DJ (1994) Role of olfactory tubercle and nucleus accumbens in the effects of classical and atypical neuroleptics: search for regional specificity. In: Strategies for studying brain disorders. vol 2, (Eds. Palamo T, Archer T and Beninger RJ) Farrand Press, Madrid, pp. 33-53.
[10]  Cools AR, Rots NY, Kloet ER de and Ellenbroek BA (1994) Apomorphine susceptible and apomorphine unsusceptible Wistar rats: a new tool in the search for the function of striatum in switching behavioural strategies. In: The basal ganglis IV, (Eds Percheron G, McKenzie JS and Feger J), Plenum Press, New York, pp.507-515.
[11]  Ellenbroek BA and Cools AR (1995) Animal models of psychotic disturbances. In: Advances in the neurobiology of schizophrenia, (Eds Den Boer JA, Westenberg HGM and van Praag HM), Wiley, Chichester, pp.89-109.
[12]  Miller CAFJ, Ellenbroek BA, Drinkenburg WHIM and van Luijtelaar ELJM (1995) Cortical and hippocampal sensory gating during sleep-wake states in rats. In: Sleep-wake research in the Netherlands, vol 6, (Eds Beersma GM and Coenen AML), Dutch society for sleep-wake research, Leiden, pp.91-96.
[13]  Ellenbroek BA and Cools AR (1996) Dopamine susceptibility and information processing. In: Dopamine Disease States. Strategies for studying brain disorders. vol 3, (Eds. Beninger RJ, Palamo T and Archer T) Editorial Cym, Madrid, pp. 447-462.
[14]  Den Boer JA, Louwerens JW and Ellenbroek BA (1996) Nieuwe ontwikkelingen op het gebied van atypische antipsychotica. In: Leerboek schizofrenie, (Eds Den Boer JA and van den Bosch RJ), De Tijdstroom, Utrecht, pp.287-310.
[15]  Ellenbroek BA and Cools AR (1996) Het Centrale Zenuwstelsel. In: Farmacologie, (Eds Sitsen JMA, Breimer DD, Cools AR, Saxena PR, Smits JFM and van Wimersma Greidanus TjB), Bunge, Utrecht, pp.69-152.
[16]  Ellenbroek BA and Cools AR (1997) Susceptibilidad de la dopamina y procesamiento de la informacion. In: Estados patologicos de la dopamina (Eds. Beninger RJ, Palamo T and Archer T) Editorial Cym, Madrid, pp. 447-462.
[17]  Cools AR, Rots NY, Kloet ER de and Ellenbroek BA (1997) Wistar rats: Splitting high and low responders to novelty is necessary in basal ganglia research. In: Basal Ganglia V (Eds Ohye C, Kimura M and McKenzie JS), Plenum Press, New York, pp.
[18]  Van Luijtelaar ELJM and Ellenbroek BA (1998) Stemming en medicatie. In: Medicatie en gedrag. Bedoelde en onbedoelde effecten (Eds. De Vos L, Venselaar K and Timmermans G), Swets & Zeitlinger, Lisse, pp.47-70.
[19]  Ellenbroek BA and Cools AR (1999) Genetic make-up and susceptibility for psychopathology. In: Recent developments in comparative endocrinology and neurobiology (Eds. Roubos, ER, Wendelaar Bonga SE, Vaudry H and DeLoof A), Shaker, Maastricht, pp.300-304.
[20]  Ellenbroek BA (2000) The effects of olanzapine in animal models predictive of antipsychotic activity. In Olanzapine (Zyprexa): A novel new antipsychotic (Eds. Breier A, Bymaster F, Tollefson G, Tran P, Tye N and Herrera JM). Williams and Wilkins, pp.57-68.
[21]  Ellenbroek BA and Cools AR (2000) Atypical antipsychotics. Milestones in drug therapy. Birkhauser Verlag, Basel. 236 pages.
[22]  Ellenbroek BA and Cools AR (2000) Animal models for schizophrenia: An introduction. In: Atypical Antipsychotics. (Eds. Ellenbroek BA and Cools AR), Birkhauser Verlag, Basel, pp.35-53.
[23]  Ellenbroek BA and Cools AR (2000) Regional selectivity of antipsychotic drugs. In: Atypical Antipsychotics. (Eds. Ellenbroek BA and Cools AR), Birkhauser Verlag, Basel, pp.83-98.
[24]  Ellenbroek BA, Sams-Dodd F and Cools AR (2000) Simulation models for schizophrenia. In: Atypical Antipsychotics. (Eds. Ellenbroek BA and Cools AR), Birkhauser Verlag, Basel, pp.121-142.
[25]  Cools AR and Ellenbroek BA (2002) Animal models of personality. In: Textbook of Biological Psychiatry. (Eds. D'Haenen H, den Boer JA, Westenberg H and Willner P), John Wiley & Sons, Chichester, pp. 1333-1344.
[26]  Ellenbroek BA and Cools AR (2002) Animal models for schizophrenia. In: Textbook of Biological Psychiatry. (Eds. D'Haenen H, den Boer JA, Westenberg H and Willner P), John Wiley & Sons, Chichester, pp. 567-580.
[27]  Ellenbroek BA (2002) Schizophrenia and neurodevelopment. In: Schizophrenia: A Handbook (Ed. Paunovic D), Vanima Press, Valjevo.
[28]  Ellenbroek BA (2005) Dopamine and schizophrenia. In: Dopamine and gutamate in psychiatric disorders (Eds. Schmidt WJ and Reith MEA), Humana Press (Totowa) pp.153-168.
[29]  Ellenbroek BA, Geven EJ and Cools AR (2005) Rat strain differences in stress sensitivity. In: Handbook of stress and the brain (Eds. Steckler T, Kalin N and Reul JMHM), Elsevier, Amsterdam, pp. 75-87.
[30]  Ellenbroek BA (2008) Farmacologische keuzecriteria voor antipsychotica. In: Keuzeriteria voor antipsychotica (Eds. Verkes RJ and Bruggeman R), van Zuiden communicatie, Alphen aan de Rijn, pp. 13-23.
[31]  Ellenbroek BA (2008) The pharmacotherapy of schizophrenia: Past, present and possible future. In: Schizophrenia, sleep and acupuncture (Eds. Bosch P and van der Noort M), Hogrefe & Huber, Gottingen, pp.35-57.
[32]  Bosch P, Coenen AML, Ellenbroek BA and van der Noort M (2008) Acupunture and sleep: Can acupuncture be used in the treatment of insomnia and schizophrenia? In: Schizophrenia, sleep and acupuncture (Eds. Bosch P and van der Noort M), Hogrefe & Huber, Gottingen, pp.249-262.
[33]  Olivier JDA, Cools AR, Ellenbroek BA, Cuppen E and Homberg JR (2010), Serotonin transporter knockout rats. In: Experimental models in serotonin transporter research (Ed. Kalueff AV and LaPorte JL), Cambridge Univ Press, Cambridge, pp.170-213.
[34]  Ellenbroek BA (2010) Schizophrenia. In Encyclopaedia of behavioural Neuroscience vol 3 (Eds. Koob G, Thompson RF and LeMoal M), Oxford Academic Press, Oxford, pp.188-195.
[35]  Ellenbroek BA (2010) Animal models of schizophrenia. In Encyclopaedia of psychopharmacology part 19 (Ed Stolerman I), Springer Verlag, Heidelberg, pp. 1181-1186.