Frontiers in Science

Frontiers in Science is a peer-reviewed, open access journal that publishes original research articles as well as review articles in all areas of science and technology.

Jim Lagopoulos

Editor-in-Chief of Frontiers in Science

Associate Professor, The University of Sydney, Australia

Research Areas

Neuroscience, Neuroimaging, Psychiatry, Neurology


2000Ph.DPhilosophy, The University of Sydney, Sydney, Australia
1996MBiomedE MasterBiomedical Engineering, The University of NSW, Sydney, Australia
1992B.ScScience & Engineering, The University of Sydney, Sydney, Australia


presentAssociate Professor, The Brain and Mind Research Institute, Faculty of Medicine, The University of Sydney
2008-2010Scientific and Executive Director, Advanced Research and Clinical Highfield Imaging Centre, The University of Sydney
2007-2010Associate Professor, Department of Psychological Medicine, Northern Clinical School, The University of Sydney
2003-2007Senior Research Fellow, Mood Disorders Unit, School of Psychiatry, University of NSW
2000-2003Research Officer, Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
1998-2000Technical Support Officer, Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
1997-2007Intraoperative Neurophysiologist, Westmead Hospital, Department of Neurophysiology
1996-1997Research Officer, Prince of Wales Orthopaedics Laboratory, Prince of Wales Hospital

Academic Achievement

Chair, Psychiatry Neuroscience Committee
Advanced Research and Clinical High-field Imaging (ARCHI) Scientific Committee
Northern Sydney (Harbour) Human Research Ethics Committee
Postgraduate Coordinator (Psychiatry) Northern Clinical School
Westmead Hospital Scientific Advisory Committee
Neuroimaging Research Group, Mood Disorders Unit
University of Sydney Graduate Medical Program examiner


Organisation for Human Brain Mapping (OHBM)
International Society for Bipolar Disorders (ISBD)
IEEE Biomedical Engineering
International Society for Magnetic Resonance in Medicine (ISMRM)

Publications: Journals

[1]  Lagopoulos J, Gordon E, Lim CL, Barhamali H, Morris JG, Clouston P, Li WM, and Lesley J (1997). Automatic processing dysfunction in Parkinson's disease. Neurological Research 19(6):609-612.
[2]  Bahramali H, Gordon E, Lim CL, Li W, Lagopoulos J, Leslie J, Rennie C, and Meares RA (1997). Evoked related potentials associated with and without an orienting reflex. Neuroreport 8:2665-2669.
[3]  Lagopoulos J, Clouston P, Bahramali H, Gordon E, Li WM, Lesley J, and Morris JG (1998). Late components of the event-related potentials and their topography in Parkinson's disease. Movement Disorders 13:262-267.
[4]  Lagopoulos J, Gordon E, Bahramali H, Lim CL, Li WM, Clouston P, and Morris JG (1998). Dysfunctions of automatic (P300a) and controlled (P300b) processing in Parkinson's disease. Neurological Research 20:5-10.
[5]  Lagopoulos J, Barhamali H, Clouston P, Gordon E and Morris JG (1998). Decreased frontal P50 in Patients with Parkinson's Disease. Journal of EEG Research 2:17-22.
[6]  Harris A, Bahramali H, Lagopoulos J, Li W, Gordon E, and Wright J (1998). The effect of paradigm on alpha frequency in schizophrenia. International Journal of Neuroscience. 96(1-2):63-72.
[7]  Bahramali H, Gordon E, Lagopoulos J, Lim CL, Li W, Leslie J, and Wright J (1999). The effects of age on late components of the ERP and reaction time. Experimental Aging Research 25:69-80.
[8]  Lagopoulos J, Ward PB, Williams L, Rennie C., and Gordon E (2000). Functional MRI elucidates networks underlying the Orienting Reflex. Psychophysiology, 37: 61.
[9]  Williams LM, Brammer MJ, Skerrett D, Lagopoulos J, Rennie C, Kozek K, Olivieri G, Peduto T, and Gordon E (2000). The neural correlates of orienting: an integration of fMRI and skin conductance orienting. Neuroreport 11:3011-3015.
[10]  Williams LM, Phillips ML, Brammer MJ, Skerrett D, Lagopoulos J, Rennie C, Barhamali H, Olivieri G, David AS, Peduto T, and Gordon E (2001). Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and Skin Conductance Recording. Neuroimage 14:1070-1079.
[11]  Lang EW, Lagopoulos J, Griffith J, Kwok Y, Mudaliar Y, Mehdorn MH, and Dorsch NWC (2003). Noninvasive cerebrovascular autoregulation assessment in traumatic brain injury: Validation and utility. Journal of Neurotrauma 20(1): 69-75.
[12]  Lang EW, Kwok Y, Griffith J, Lagopoulos J, Mudaliar Y, and Dorsch NWC (2003). Hemispheric asymmetry and temporal profiles of cerebral pressure autoregulation in head injury. Journal of Clinical Neuroscience 10(6): 670-673.
[13]  Lang EW, Lagopoulos J, Griffith J, Kwok Y, Yam A, Mudaliar Y, Mehdorn HM, and Dorsch NWC (2003). Cerebral vasomotor reactivity testing in head injury: the link between pressure and flow. Journal of Neurology, Neurosurgery and Psychiatry 74(8): 1053-1059.
[14]  Schall U, Johnston P, Lagopoulos J, Jüptner M, Jentzen W, Thienel R, Dittmann-Balçar A, Bender S, and Ward PB (2003). Functional brain maps of Tower of London performance: A PET and fMRI study. Neuroimage 20(2): 1154-1161.
[15]  Malhi GS, Lagopoulos J, Soares J, and Vieta E. (2004). Brain Imaging of Mood Disorders: Functional understanding of neuroanatomy & neural circuits. In Mood Disorders. (P Joyce and P Mitchell, Eds.). UNSW Press. pp125-138.
[16]  Malhi GS, Lagopoulos J, Ward P, Kumari V, Mitchell PB, Parker GB, Ivanovski B, and Sachdev P (2004). Cognitive Generation of Affect in Bipolar Depression: an fMRI Study. European Journal of Neuroscience 19(3): 741-754.
[17]  Malhi GS, Lagopoulos J, Sachdev P, Mitchell PB, Ivanovski B, and Parker GB (2004). Cognitive generation of affect in hypomania: an fMRI study. Bipolar Disorders 6(4): 271-285.
[18]  Malhi GS, Lagopoulos J, Owen AM, and Yatham LN (2004). Bipolaroids: Functional imaging in bipolar disorder. Acta Psychiatrica Scandinavica 110(Supp 422): 46-54.
[19]  Olley A, Malhi GS, Mitchell PB, Batchelor J, Lagopoulos J, and Austin M-P (2005). When euthymia is just not good enough: the neuropsychology of bipolar disorder. Journal of Nervous and Mental Disease 193(5): 323-330.
[20]  Lang EW, Mudaliar Y, Lagopoulos J, Dorsch NWC , Yam A, Griffith J Mulvey J. A Review on Cerebral Autoregulation Assessment and Measurements (2005). In Australasian Anaesthesia (J Keneally, Ed.) Australian and New Zealand College of Anaesthetists. SOS Print and Media Group Sydney
[21]  Malhi GS, Berk M, Bourin M, Ivanovski B, Dodd S, Lagopoulos J, and Mitchell PB. (2005) Atypical Mood Stabilizers: a 'typical' role for atypical antipsychotics. Acta Psychiatrica Scandinavica 111(suppl 426): 29-38.
[22]  Rasser PE, Johnston P, Lagopoulos J, Ward PB, Schall U, Thienel R, Bender S, Toga AW, and Thompson PM. (2005) Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching. Neuroimage 26(3): 941-951
[23]  Malhi GS, Lagopoulos J, Sachdev P, Ivanovski B, Shnier R (2005). An emotional Stroop functional MRI study of euthymic bipolar disorder. Bipolar Disorders 7(suppl.5): 58-69.
[24]  Lagopoulos J, Malhi GS, Ivanovski B, Cahill CM, and Morris JG (2005). A matter of motion or an emotional matter? Management of depression in Parkinson's disease. Expert Review of Neurotherapeutics 5(6): 803-810.
[25]  Yam AT, Lang EW, Lagopoulos J, Yip K, Griffith J, Mudaliar Y, and Dorsch NWC. (2005). Cerebral autoregulation and ageing. Journal of Clinical Neuroscience 12(6): 643-6.
[26]  Lagopoulos J, Malhi G, and Shnier R (2005). A fibre-optic system for recording skin conductance in the MRI scanner. Behaviour Research Methods 37(4): 657-664.
[27]  Malhi, GS, Cahill CM, Ivanovski B, Lagopoulos J (2006). A Neuropsychological 'Image' of Bipolar Disorder. Clinical Approaches in Bipolar Disorders 5(1): 2-13.
[28]  Malhi GS, Loo C, Cahill C, Lagopoulos J, Mitchell P, and Sachdev P (2006). "Getting physical": The management of neuropsychiatric disorders using novel physical treatments. Journal of Neuropsychiatric disorders and Treatment. 2(2): 165-179.
[29]  Lagopoulos J, Gordon E, Ward PB (2006). Differential BOLD responses to auditory target stimuli associated with a skin conductance response. Acta Neuropsychiatrica 18(2): 105-114.
[30]  Lagopoulos J, Malhi GS, Ivanovski B, Cahill C, Lang EW, Mudaliar Y, Dorsch N, Yam A, Griffith J, & Mulvey J (2006). Cerebrovascular autoregulation as a neuroimaging tool. Acta Neuropsychiatrica 18(2): 100-104.
[31]  Berntsen EM, Rasmussen IA jr, Samuelsen P, Xu J, Haraldseth O, Malhi GS, Lagopoulos J (2006). Putting the brain in jeopardy: A novel comprehensive and expressive language task? Acta Neuropsychiatrica 18(2): 115-119.
[32]  Malhi GS, Lagopoulos J (2006). Neuroimaging in neuropsychiatric disorders. Acta Neuropsychiatrica 18(2): 59.
[33]  Cahill CM, Malhi GS, Ivanovski B, Lagopoulos J, Cohen M (2006). Cognitive compromise in bipolar disorder with chronic cannabis use: cause or consequence? Expert Review of Neurotherapeutics 6(4): 591-598.
[34]  Gibson PRJ, Johnston S, Lagopoulos J, Cummine JL (2006). Transient loss of motor evoked responses associated with caudal injection of morphine in a patient with spondylolisthesis undergoing spinal fusion. Pediatric Anesthesia 16(5): 568-572.
[35]  Rasmussen IA jr, Haraldseth O, Berntsen EM, Samuelsen P, Xu J, Lagopoulos J, Malhi GS. (2006) The Tower of London in patients with traumatic brain injury: an fMRI study. Acta Neuropsychiatrica 18(5): 216-225.
[36]  Malhi GS, Lagopoulos J, Owen A, Ivanovski B, Sachdev P (2007). Reduced activation to implicit affect induction in euthymic bipolar patients: an fMRI study. Journal of Affective Disorders 97(1-3): 109-122.
[37]  Lagopoulos J (2007). Functional MRI: an overview. Acta Neuropsychiatrica 19(1): 64-65
[38]  Lagopoulos J, Ivanovski B, Malhi GS (2007). An event-related functional MRI study of working memory in euthymic bipolar disorder. Journal of Psychiatry and Neuroscience 32(3): 174-184.
[39]  Lagopoulos J and Malhi GS (2007). Modern neuroimaging: the meaning behind the pictures. Medicine Today 8(8) 29-31.
[40]  Malhi GS, Lagopoulos J, Sachdev P, Ivanovski B, Shnier R, Ketter T (2007). Is a lack of disgust something to fear? An fMRI facial emotion recognition study in euthymic bipolar disorder patients. Bipolar Disorders 9(4): 345-357.
[41]  Xu J, Rasmussen I-A, Lagopoulos J, Håberg AK (2007). Diffuse axonal injury in severe traumatic brain injury visualized using high resolution diffusion tensor imaging. Journal of Neurotrauma 24(5): 753-765.
[42]  Lagopoulos J (2007). Diffusion Tensor Imaging: an overview. Acta Neuropsychiatrica 19(2): 127-128
[43]  Gibson PRJ, Johnston S, Lagopoulos J, Cummine JL (2007). Transient loss of motor evoked responses associated with caudal injection of morphine in a patient with spondylolisthesis undergoing spinal fusion. Paediatric Anaesthesia 17(2): 198.
[44]  Xu J, Rasmussen Jr I-A, Berntsen EM, Moss K, Shnier R, Lagopoulos J, Malhi GS (2007). A growth in bipolar disorder? Acta Psychiatrica Scandinavica 115(3): 246-250.
[45]  Lagopoulos J (2007). Voxel-based morphometry made simple. Acta Neuropsychiatrica 19(3): 213-214
[46]  Lagopoulos J (2007). Event Related Potentials. Acta Neuropsychiatrica 19(4): 256-258
[47]  Lagopoulos J (2007). Electrodermal Activity. Acta Neuropsychiatrica 19(5): 316-317
[48]  Malhi GS, Ivanovski B, Wen W, Lagopoulos J, Moss K, Sachdev P (2007). Measuring Mania Metabolites: A longitudinal proton spectroscopy study of hypomania. Acta Psychiatrica Scandinavica 434: 57-66.
[49]  Lagopoulos J, Malhi GS (2007). A Functional Magnetic Resonance Study of Emotional Stroop in Euthymic Bipolar Disorder. Neuroreport 18(15): 1583-1587.
[50]  Fornito A, Malhi GS, Lagopoulos J, Ivanovski I, Wood SJ, Velakoulis D, Saling MM, McGorry PD, Pantelis C, Murat Yücel (2007). In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate/paracingulate cortex in bipolar disorder Acta Psychiatrica Scandinavica 116(6): 467-472.
[51]  Lagopoulos J (2007). Spectroscopy. Acta Neuropsychiatrica 19(6): 380-381
[52]  Malhi GS and Lagopoulos J (2007). Cutting Edge Neuropsychiatry. Acta Neuropsychiatrica 19(6): 316-317
[53]  Fornito A, Malhi GS, Lagopoulos J, Ivanovski B, Wood SJ, Velakoulis D, Saling MM, McGorry PD, Pantelis C, Yücel M (2008). Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder. Psychiatry Research: Neuroimaging 162(2):123-32.
[54]  Malhi GS, Lagopoulos J (2008). Making Sense of Neuroimaging in Psychiatry. Acta Psychiatrica Scandinavica 117(2): 100-117.
[55]  Hsu B, Lagopoulos J, Cree AK, Cummine JL (2008). Transcranial motor evoked potentials as the sole monitoring modality in spinal deformity surgery. Spine 33(10): 1100-1106.
[56]  Berntsen EM, Samuelson P, Lagopoulos J, Rasmussen I-A Jr, Håberg AK, Haraldseth O (2008). Mapping the Primary Motor Cortex in Healthy Subjects and Patients with Peri-Rolandic Brain Lesions Prior to Neurosurgery. Neurological Research 30(9): 968-973.
[57]  Lagopoulos J (2008). Eye Movements. Acta Neuropsychiatrica 20(1): 46-47.
[58]  Lagopoulos J and Degabriele R (2008). Feeling the heat: The electrode-skin interface during DCS. Acta Neuropsychiatrica 20(2): 98-100.
[59]  Malhi GS, Lagopoulos J, Das P, Moss K, Berk M, Coulston CM (2008). A functional MRI study of Theory of Mind in euthymic bipolar disorder patients. Bipolar Disorders 10(8): 943-956.
[60]  Lagopoulos J (2008). Cerebral Autoregulation. Acta Neuropsychiatrica 20(5): 271-272
[61]  Das P, Lagopoulos J, Saether O, Malhi GS (2008). Is computer tomography still useful as a neuroimaging tool in psychiatry? Expert Opinion in Medical Diagnostics 2(9): 1003-1011.
[62]  Degabriele RJ and Lagopoulos J (2008). A review of EEG and ERP studies in Bipolar Disorder. Acta Neuropsychiatrica 21(2): 58-66.
[63]  Lagopoulos J, Das P, Saether O, Malhi GS (2009). A review of imaging in psychiatry. The Open Medical Imaging Journal 3(1): 15-21.
[64]  Lagopoulos J, Das P, Saether O, Malhi GS (2009). A review of imaging in psychiatry. The Open Medical Imaging Journal 3(1): 15-21
[65]  Lagopoulos J, Xu J, Rasmussen I, Vik A, Malhi GS, Eliassen CF, Arntsen IE, Sæther JG, Hollup S, Holen A, Davanger S, Ellingsen O (2009). Increased theta and alpha EEG activity during nondirective meditation. Journal of Complementary and Alternative Medicine 15(11): 1187-1192.
[66]  Das P, Lagopoulos J (2009).Connectivity. Acta Neuropsychiatrica 21(2): 91-92
[67]  Naismith SL, Lagopoulos J, Ward PB, Davey C, Hickie IB (2010) Fronto-striatal correlates of impaired implicit sequence learning in major depression: an fMRI study. Journal of Affective Disorders 125 (1-3): 256-261.
[68]  Loo CK, Sachdev P, Martin D, Pigot M, Alonzo A, Malhi GS, Lagopoulos J, Mitchell P (2010). A double-blind, sham-controlled trial of transcranial direct current stimulation for the treatment of depression. International Journal of Neuropsychopharmacology 13(1): 61-69.
[69]  Malhi G, Tanious M, Cashman EL, Das P, Lagopoulos J (2010). Picturing emotional distress. Acta Neuropsychiatrica 22: 150-151.
[70]  Lagopoulos J and Malhi GS (2011). Impairments in "top-down" processing in bipolar disorder: a simultaneous fMRI-GSR study. Psychiatry Research: Neuroimaging 192: 100-108.
[71]  Degabriele R, Lagopoulos J, Malhi G (2011). Neural correlates of emotional face processing in bipolar disorder: An event-related potential study. Journal of Affective Disorders (in press-accepted 16 March 2011).
[72]  Degabriele R, Lagopoulos J, Ward PB. ERP Correlates of Inhibition in Bipolar Disorder. Neuroreport (in press- accepted 25 March 2011).