American Journal of Biomedical Engineering

American Journal of Biomedical Engineering provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes.

Sergey Dorozhkin

Editorial Board Member of American Journal of Biomedical Engineering

Research Scientist, Ecoinstrument Co., Russia

Research Areas

Hydroxyapatite, Calcium Phosphate, Bioceramics, Biomaterials, Biomineralization

Education

1992Ph.DInorganic chemistry and chemical technology
1984M.ScChemical technology
1982BAChemical technology

Experience

presentAn engineer on the laboratory equipment testing and verification at EcoInstrument company (Moscow, Russia)
2003-2004A research and development (R&D) industrial position on the sol-gel process of silica-contained a-tricalcium phosphate/hydroxyapatite manufacturing at Millennium Biologix, Inc. (Kingston, Ontario, Canada)
2002-2004A post-doctoral position on mechanical properties of porous bioresorbable scaffolds made of calcium phosphates, as well as on tissue engineering at the Department of Mechanical Engineering of Queen’s University (Kingston, Ontario, Canada)
2000-2002A post-doctoral position on biomimetic crystallization of calcium phosphates from simulated body fluid (SBF) and biomaterials at the Department of Inorganic Chemistry of Ruhr University of Bochum (Germany)
1999-2000A post-doctoral position on biomimetic crystallization calcium phosphates and biomineralization at the Department of Ceramics and Glass Engineering at Aveiro University (Portugal)

Publications: Journals

[1]  Melikhov I.V., Dorozhkin S.V., Nikolaev A.L., Kozlovskaya E.D., Rudun V.N.: Dislocations and the rate of dissolution of solids. Russ. J. Phys. Chem. 1990, 64 (12), 1746-1750.
[2]  Dorozhkin S.V., Nikolaev A.L.: Experimental determination of the rates of growth of epitaxial crystals on a dissolving support. Russ. J. Phys. Chem. 1991, 65 (6), 871-874.
[3]  Dorozhkin S.V., Dubinin V.G.: Investigations of the dissolution mechanism of the Kola apatite crystals with a scanning electron microscopy. Transactions of the Research Institute of Fertilisers and Insectofungicides (NIUIF) Moscow, USSR. 1991, No. 260, 248-254.
[4]  Dorozhkin S.V.: Dissolution kinetics of single crystals of the Kola apatite in phosphoric acid solutions. Transactions of the Research Institute of Fertilisers and Insectofungicides (NIUIF) Moscow, USSR. 1991, No. 260, 269-286.
[5]  Dorozhkin S.V.: The formation and development of epitaxial coatings of CaSO4.0.5H2O on surface of the Kola apatite under conditions, simulating the hemihydrate process of phosphoric acid production. Russ. J. Appl. Chem. 1991, 64 (9), 1666-1670.
[6]  Dorozhkin S.V., Nikolaev A.L., Melikhov I.V., Saparin G.V., Bliadze V.G.: Chemical preparation of dielectrics for studying their microtopography by the SEM. Scanning 1992, 14 (2), 112-117.
[7]  Dorozhkin S.V., Rudun V.N.: Scanning electron microscopy investigations of etching Khibiny apatite crystal surface in phosphoric acid solutions. Soviet Chem. Industry 1992, 24 (2), 96-99.
[8]  Melikhov I.V., Dorozhkin S.V., Nikolaev A.L., Rudun V.N.: Thopochemical formation of porous materials. Inorg. Mater. 1992, 28 (4), 672-677.
[9]  Sirota I.S., Dorozhkin S.V., Kruchinina M.V., Melikhov I.V.: Phase transformation and dehydration of calcium sulfate dihydrate in solution studied by SEM. Scanning 1992, 14 (5), 269-275.
[10]  Melikhov I.V., Dorozhkin S.V., Nikolaev A.L., Voronina N.Yu.: Transition from congruent to incongruent dissolution. Russ. J. Phys. Chem. 1992, 66 (8), 1108-1111.
[11]  Dorozhkin S.V., Dolgonosov B.M.: Rational organisation of the stage of dissolving apatite in the manufacture of wet-process phosphoric acid. Soviet Chem. Industry 1992, 24 (9), 521-525.
[12]  Dorozhkin S.V.: Character of the etching of the surface of Khibiny fluorapatite crystals and the formation of epitaxial coatings of calcium acid phosphates under the conditions of the manufacture of double superphosphate. Soviet Chem. Industry 1992, 24 (11), 651-654.
[13]  Melikhov I.V., Sirota I.S., Dorozhkin S.V., Gorbachevskii A.Ya.: The change in the solid phase conversion route due to an impurity. Russ. J. Phys. Chem. 1993, 67 (3), 519-524.
[14]  Dorozhkin S.V.: On the problem of chemical mechanisms of fluorapatite dissolution in acids. (An attempt at nonconventional interpretation of the results obtained by instrumental physicochemical methods of crystal surface analysis). Russ. J. Inorg. Chem. 1993, 38 (7), 1025-1030.
[15]  Dorozhkin S.V.: On the block structure of fluorapatite crystals. Russ. J. Inorg. Mater. 1993, 29 (7), 900-901.
[16]  Dorozhkin S.V.: Dissolution kinetics of fluorapatite. Phosphorus & Potassium 1993, No. 186, 24-26.
[17]  Sirota I.S., Dorozhkin S.V., Kruchinina M.V., Rudin V.N., Melikhov I.V.: The mechanism and ways of monitoring the rate of phase transition of calcium sulfate dihydrate into semihydrate in sulfophosphoric acid media. Soviet Chem. Industry 1993, 25 (6), 43-48 and Russ. J. Appl. Chem. 1993, 66 (10), 1651-1656.
[18]  Sirota I.S., Dorozhkin S.V., Kruchinina M.V., Rudin V.N., Melikhov I.V.: Mechanism of the phase transition of calcium sulfate dihydrate into the semihydrate under conditions of two-stage production of wet-process phosphoric acid. Soviet Chem. Industry 1993, 25 (9), 43-46 and Russ. J. Appl. Chem. 1993, 66 (12), 2005-2009.
[19]  Sirota I.S., Dorozhkin S.V., Kruchinina M.V., Rudin V.N., Melikhov I.V., Klassen P.V.: Impulse regulation of the phase transformation of calcium sulfate dihydrate into hemihydrate under conditions of double-stage wet-process phosphoric acid production. Soviet Chem. Industry 1993, 25 (10), 493-495.
[20]  Sirota I.S., Dorozhkin S.V., Kruchinina M.V., Melikhov I.V.: Influence of impurities on the phase transition of calcium sulfate dihydrate into the semihydrate in sulfophosphoric acid solutions. Soviet Chem. Industry 1993, 25 (12), 632-634.
[21]  Dorozhkin S.V.: Mechanism of the acidic dissolution of fluorapatite: state-of-the-art. Russ. J. Inorg. Chem. 1994, 39 (2), 217-221.
[22]  Dolgonosov B.M., Dorozhkin S.V., Melikhov I.V., Rudin V.N.: Optimisation of the dissolution of raw phosphate in the production of wet-process phosphoric acid. Russ. J. Theoret. Found. Chem. Engin. 1994, 28 (4) 359-367.
[23]  Dorozhkin S.V.: How should the chemist think? Chemistry & Life 1994, No. 12, 62-66 (in Russian).
[24]  Bozhevol'nov V.E., Nikolaev A.L., Dorozhkin S.V., Kozlovskaya E.D., Melikhov I.V.: Reactivity of fluorapatite. Russ. J. Phys. Chem. 1995, 69 (3), 387-392.
[25]  Dorozhkin S.V.: Chemical etching of natural fluorapatite crystals in acid solutions studied with the scanning electron microscopy. Scanning 1995, 17 (6), 355-360.
[26]  Dorozhkin S.V.: Process of epitaxial crystal growth for CaSO4.0.5H2O on a surface of dissolving fluorapatite crystals studied by scanning electron microscopy. Scanning 1996, 18 (2), 119-124.
[27]  Dorozhkin S.V.: Dissolution kinetics of single fluorapatite crystals in phosphoric acid solutions under the conditions of the wet-process phosphoric acid production. Adv. Synt. Catal. (formerly: J. Prakt. Chem. Chemiker-Zeitung) 1996, 338 (7), 620-626.
[28]  Dorozhkin S.V.: Fundamentals of the wet-process phosphoric acid production. 1. Kinetics and mechanism of the phosphate rock dissolution. Ind. Eng. Chem. Res. 1996, 35 (11), 4328-4335.
[29]  Dorozhkin S.V.: Fundamentals of the wet-process phosphoric acid production. 2. Kinetics and mechanism of CaSO4.0.5H2O surface crystallization and coating formation. Ind. Eng. Chem. Res. 1997, 36 (2), 467-473.
[30]  Dorozhkin S.V.: Surface reactions of apatite dissolution. J. Colloid Interface Sci. 1997, 191 (2), 489-497.
[31]  Dorozhkin S.V.: Acidic dissolution mechanism of natural fluorapatite. 1. Milli-and microlevels of investigations. J. Crystal Growth 1997, 182 (1-2), 125-132.
[32]  Dorozhkin S.V.: Acidic dissolution mechanism of natural fluorapatite. 2. Nanolevel of investigations. J. Crystal Growth 1997, 182 (1-2), 133-140.
[33]  Dorozhkin S.V.: Ecological principles of wet-process phosphoric acid technology. J. Chem. Technol. Biotechnol. 1998, 71 (3), 227-233.
[34]  Dorozhkin S.V.: Inorganic chemistry of the dissolution phenomenon: the dissolution mechanism of calcium apatites at the atomic (ionic) level. Comments Inorg. Chem. 1999, 20 (4-6), 285-299.
[35]  Dorozhkin S.V.: Interaction of several calcium phosphates with water at elevated temperatures. Russ. J. Inorg. Chem. 2000, 45 (5), 808-814.
[36]  Dorozhkin S.V.: Unreactiveness of calcium phosphates and hydroxypropylmethylcellulose in organic-mineral composites. Inorg. Mater. 2000, 36 (10), 1024-1031.
[37]  Dorozhkin S.V., Schmitt M., Bouler J.M., Daculsi G.: Chemical transformation of some biologically relevant calcium phosphates in aqueous media during a steam sterilization. J. Mater. Sci. Mater. Med. 2000, 11 (12), 779-786.
[38]  Dorozhkin S.V.: Is there a chemical interaction between calcium phosphates and hydroxypropylmethylcellulose (HPMC) in organic/inorganic composites? J. Biomed. Mater. Res. 2001, 54 (2), 247-255.
[39]  Dorozhkin S.V.: Systems of chemical equations as reasonable reaction mechanisms. J. Chem. Educ. 2001, 78 (7), 917-920.
[40]  Dorozhkin S.V.: The kinetics of crystallization of the products formed in the reaction between calcium chloride and potassium hydrophosphate in water. Russ. J. Phys. Chem. 2001, 75 (11), 1784-1787.
[41]  Dorozhkin S.V., Agathopoulos S.: Biomaterials: the market review. Chemistry & Life-21 century 2002, No. 2, 8-10 (in Russian).
[42]  Dorozhkina E.I., Dorozhkin S.V.: Application of the turbidity measurements to study in situ crystallization of calcium phosphates. Colloids and Surfaces A: Physiochem. Eng. Aspects 2002, 203 (1-3), 237-244.
[43]  Dorozhkin S.V.: A review on the dissolution models of calcium apatites. Prog. Crystal Growth and Charact. 2002, 44 (1), 45-61.
[44]  Dorozhkin S.V., Epple M.: Biological and medical significance of calcium phosphates. (Review) Angew. Chem. Int. Ed. 2002, 41 (17), 3130-3146; Die biologische und medizinische Bedeutung von Calciumphosphaten. (Aufsätze) Angew. Chem. 2002, 114 (17), 3260-3277.
[45]  Dorozhkina E.I., Dorozhkin S.V.: Surface mineralisation of hydroxyapatite in modified simulated body fluid (mSBF) with higher amounts of hydrogencarbonate ions. Colloids and Surfaces A: Physiochem. Eng. Aspects 2002, 210 (1), 41-48.
[46]  Dorozhkina E.I., Dorozhkin S.V.: Mechanism of the solid-state transformation of a calcium-deficient hydroxyapatite (CDHA) into biphasic calcium phosphate (BCP) at elevated temperatures. Chem. Mater. 2002, 14 (10), 4267-4272.
[47]  Dorozhkin S.V.: Solid-phase conversion of nonstoichiometric hydroxoapatite into two-phase calcium phosphate. Russ. J. Applied Chem. 2002, 75 (12), 1897-1902.
[48]  Dorozhkin S.V., Dorozhkina E.I.: The influence of bovine serum albumin on the crystallization of calcium phosphates from a revised simulated body fluid. Colloids and Surfaces A: Physiochem. Eng. Aspects 2003, 215 (1-3), 191-199.
[49]  Dorozhkina E.I., Dorozhkin S.V.: In vitro crystallization of carbonateapatite on cholesterol from a modified simulated body fluid. Colloids and Surfaces A: Physiochem. Eng. Aspects. 2003, 223 (1-3), 231-237.
[50]  Dorozhkina E.I., Dorozhkin S.V.: Structure and properties of the precipitates formed from condensed solutions of the revised simulated body fluid. J. Biomed. Mater. Res. A 2003, 67A (2), 578-581.
[51]  Dorozhkin S.V., Dorozhkina E.I., Epple M.: Precipitation of carbonateapatite from a revised simulated body fluid in the presence of glucose. J. Applied Biomaterials & Biomechanics 2003, 1 (3), 200-208.
[52]  Dorozhkin S.V.: Mechanism of solid-state conversion of non-stoichiometric hydroxyapatite to diphase calcium phosphate. Russ. Chem. Bull. (Int. Ed.) 2003, 52 (11), 2369-2375.
[53]  Dorozhkin S.V.: Composition and properties of crystals growing in the Ca2+-Mg2+-HPO2-4-HCO-3 system in the presence of Na+, K+, Cl-, and SO2-4 ions. Inorg. Mater. 2004, 40 (1), 66-72.
[54]  Dorozhkin S.V., Dorozhkina E.I., Epple M.: A model system to provide a good in vitro simulation of biological mineralization. Crystal Growth & Design 2004, 4 (2), 389-395.
[55]  Dorozhkin S.V.: Influence of a protein on the crystallization of calcium phosphates and carbonates from solutions simulating human blood plasma. Russ. J. Phys. Chem. 2004, 78 (5), 810-815.
[56]  Dorozhkin S.V.: Apatite "dead" and "alive". Science & Life 2004, No. 5, 40-44 (in Russian).
[57]  Dorozhkin S.V., Dorozhkina E.I.: A first approach to in vitro simulation of vascular calcification by the controlled crystallization of poorly crystalline calcium phosphates onto porous cholesterol. Proc. I. Mech. Eng. Part H: J. Engineering in Medicine 2005, 219 (H6), 477-482.
[58]  Dorozhkin S.V., Dorozhkina E.I.: In vitro simulation of vascular calcification by the controlled crystallization of amorphous calcium phosphates onto porous cholesterol. J. Mater. Sci. 2005, 40 (24), 6417-6422.
[59]  Dorozhkin S.V.: Calcium phosphates and human beings. J. Chem. Educ. 2006, 83 (5), 713-719.
[60]  Dorozhkin S.V.: In vitro mineralization of silicon containing calcium phosphate bioceramics. J. Am. Ceram. Soc. 2007, 90 (1), 244-249.
[61]  Dorozhkin S.V.: A hierarchical structure for apatite crystals. J. Mater. Sci. Mater. Med. 2007, 18 (2), 363-366.
[62]  Dorozhkin S.V.: Calcium orthophosphates. (Review) J. Mater. Sci. 2007, 42 (4), 1061-1095.
[63]  Dorozhkin S.V., Dorozhkina E.I.: Crystallization from a milk-based revised simulated body fluid. Biomed. Mater. 2007, 2 (2), 87-92.
[64]  Dorozhkin S.V.: Bioceramics based on calcium orthophosphates. (Review) Glass Ceram. 2007, 64 (11-12), 442-447.
[65]  Dorozhkin S.V.: A novel, environmentally friendly process for the fabrication of calcium phosphate bioceramics. Inorg. Mater. 2008, 44 (2), 207-210.
[66]  Dorozhkin S.V.: Calcium orthophosphate cements for biomedical application. (Review) J. Mater. Sci. 2008, 43 (9), 3028-3057.
[67]  Dorozhkin S.V.: Green chemical synthesis of calcium phosphate bioceramics. J. Applied Biomaterials & Biomechanics 2008, 6 (2), 104-109.
[68]  Dorozhkin S.V.: Calcium orthophosphate cements and concretes. (Review) Materials 2009, 2 (1), 221-291.
[69]  Dorozhkin S.V.: Calcium orthophosphate-based biocomposites and hybrid biomaterials. (Review) J. Mater. Sci. 2009, 44 (9), 2343-2387.
[70]  Dorozhkin S.V.: Calcium orthophosphates in nature, biology and medicine. (Review) Materials 2009, 2 (2), 399-498.
[71]  Dorozhkin S.V., Ajaal T.: Toughening of porous bioceramic scaffolds by bioresorbable polymeric coatings. Proc. I. Mech. Eng. Part H: J. Engineering in Medicine 2009, 223 (H4), 459-470.
[72]  Dorozhkin S.V.: Nano-sized and nanocrystalline calcium orthophosphates in biomedical engineering. (Review) J. Biomimetics, Biomaterials and Tissue Engineering 2009, 3, 59-92.
[73]  Dorozhkin S.V., Ajaal T.: Strengthening of dense bioceramic samples using bioresorbable polymers-a statistical approach. J. Biomimetics, Biomaterials and Tissue Engineering 2009, 4, 27-39.
[74]  Dorozhkin S.V.: Nanodimensional and nanocrystalline apatites and other calcium orthophosphates in biomedical engineering, biology and medicine. (Review) Materials 2009, 2 (4), 1975-2045.
[75]  Dorozhkin S.V.: Bioceramics of calcium orthophosphates. (Review) Biomaterials 2010, 31 (7), 1465-1485.
[76]  Dorozhkin S.V.: Nanosized and nanocrystalline calcium orthophosphates. (Review) Acta Biomater. 2010, 6 (3), 715-734.
[77]  Dorozhkin S.V.: Calcium orthophosphate bioceramics. (Review) J. Biomimetics, Biomaterials and Tissue Engineering 2010, 5, 57-100.
[78]  Jin H.B., Guo C.B., Mao K.Y., Dorozhkin S.V., Agathopoulos S.: Preparation of porous biphasic β-TCP/HA bioceramics with a natural trabecular structure from calcined cancellous bovine bone. J. Ceram. Soc. Jpn. 2010, 118 (1), 52-56.
[79]  Dorozhkin S.V.: Amorphous calcium (ortho)phosphates. (Review) Acta Biomater. 2010, 6 (12), 4457-4475.
[80]  Dorozhkin S.V.: Amorphous calcium phosphates. (Review) J. Biomimetics, Biomaterials and Tissue Engineering 2010, 7, 27-53.
[81]  Dorozhkin S.V.: Calcium orthophosphates as bioceramics: state of the art. (Review) J. Funct. Biomater. 2010, 1 (1), 22-107.
[82]  Dorozhkin S.V.: Medical application of calcium orthophosphate bioceramics. (Review) BIO 2011, 1 (1), 1-51.
[83]  Jin H.B., Oktar F.N., Dorozhkin S., Agathopoulos S.: Sintering behavior and properties of reinforced hydroxyapatite/TCP biphasic bioceramics with ZnO-whiskers. J. Composite Mater. 2011, 45 (13), 1435-1445.
[84]  Dorozhkin S.V.: Biocomposites and hybrid biomaterials based on calcium orthophosphates. (Review) Biomatter 2011, 1 (1), 3-56.

Publications: Books/Book Chapters

[1]  Dorozhkin S.V.: Calcium orthophosphate-based biocements and bioconcretes. In: Bioceramics: properties, preparation and applications. Kossler W., Fuchs J. (Eds.). Nova Science Publishers, New York, USA. 2009, 299 pp.; pp. 1-64.
[2]  Dorozhkin S.V.: Calcium orthophosphates as biomaterials and bioceramics. In: Bioceramics: properties, preparation and applications. Kossler W., Fuchs J. (Eds.). Nova Science Publishers, New York, USA. 2009, 299 pp.; pp. 65-158.
[3]  Dorozhkin S.V.: Calcium orthophosphate cements and concretes. In: Advances in condensed matter and materials research. Volume 7. Geelvinck H., Reynst S. (Eds.). Nova Science Publishers, New York, USA. 2010, 609 pp.; pp. 99-169.
[4]  Dorozhkin S.V.: Calcium orthophosphate-based biocomposites and hybrid biomaterials. In: Biomaterials developments and applications. (Advances in Biology and Medicine). Bourg H., Lisle A. (Eds.). Nova Science Publishers, New York, USA. 2010, 497 pp.; pp. 1-104.
[5]  Dorozhkin S.V.: Calcium orthophosphate cements and concretes. In: Biomaterials developments and applications. (Advances in Biology and Medicine). Bourg H., Lisle A. (Eds.). Nova Science Publishers, New York, USA. 2010, 497 pp.; pp. 105-175.
[6]  Dorozhkin S.V.: Calcium orthophosphate-based biocomposites and hybrid biomaterials. Nova Science Publishers, New York, USA. 2010, 169 pp.