American Journal of Biochemistry

American Journal of Biochemistry is a peer-reviewed international journal dedicated to provide an active forum to the global scientific community for publishing and disseminating high quality research work in the field of biochemistry.

Namrata Jayanth

Research Leader, Charles River Laboratories, Netherlands

Research Areas

Biochemistry, Mechanistic Biology, Drug Discovery, Invitro Pharmacology, Oncology, Immunology, Biophysics

Education

2006-2012PhDTata Institute of Fundamental Research (TIFR), India
2012-2014Postdoctoral FellowUniversity of Cambridge, UK and InSTEM, India
2014-2016Postdoctoral AssociateMassachusetts Institute of Technology (MIT), USA

Experience

2016-2019Principal Investigator (Dicovery Biology) , Bristol Myers Squibb (BMS)
2019-2021Senior Principal Investigator (Dicovery Biology) , Bristol Myers Squibb (BMS)
2021-PresentResearch Leader (Charles River Laboratories)

Academic Achievement

Leadership Principles from Harvard Business School (2020)
Exercising Leadership from Harvard Business School (2021)
Certified by the Kaufman Teaching Certificate Program (KTCP), Massachusetts Institute of Technology (MIT), Cambridge, USA
Ferry Fund award for work on super-resolution studies of DNA repair in mammalian cells (2015-2016).
Mazumdar-Shaw International Oncology fellows program at MIT (2014-2016).
Ph.D. research fellowship from Council of Scientific and Industrial Research (CSIR), Government of India, for undertaking doctoral work (2006-2012).
Peer Reviewer: Royal Society of Chemistry (RSC) Advances, American Association for Science and Technology (AASCIT), Science Publishing Group, ASTESJ, PeerJ, Acta Scientific Pharmacology

Membership

American Chemical Society, Royal Society of Biology, Biophysical Society and International Chemical Biology Society

Publications: Journals

[1]  Namrata Jayanth, Srinivas Ramachandran and Mrinalini Puranik. Solution Structure of the DNA Damage Lesion 8-Oxoguanosine from Ultraviolet Resonance Raman Spectroscopy. Journal of Physical Chemistry A, 113 (8), 1459-1471 (2009).
[2]  Namrata Jayanth and Mrinalini Puranik. Methylation Stabilises the Imino Tautomer of dAMP and Amino Tautomer of dCMP in Solution. Journal of Physical Chemistry B, 115, 6234-6242 (2011).
[3]  Vishakha Karnawat, Namrata Jayanth and Mrinalini Puranik. Substrate Recognition in Multi-Substrate Nucleic Acid Binding Enzymes (Review). Current Science, 102 (2), 298-313 (2012).
[4]  Namrata Jayanth and Mrinalini Puranik. Mechanism of Lesion Recognition in E. coli Fpg: 8-oxoguanosine versus guanosine. Journal of Physical Chemistry B, 121 (23), 5679-5687 (2011).
[5]  Won-Ki Cho, Namrata Jayanth, Brian P. English, Takuma Inoue, J. Owen Andrews, William Conway, Jonathan B. Grimm, Jan-Hendrik Spille, Luke D.Lavis, Timothée Lionnet & Ibrahim I. Cisse. RNA Polymerase II cluster dynamics predict mRNA output in living cells. eLife, May 3;5. pii: e13617. doi: 10.7554/eLife.13617 (2016).
[6]  Won-Ki Cho, Namrata Jayanth, Susan Mullen, Tan TH, Jung YJ, Ibrahim I. Cisse. Super-resolution imaging of fluorescently labeled, endogenous RNA Polymerase II in living cells with CRISPR/Cas9-mediated gene editing. Scientific Reports. Oct 26;6:35949. doi: 10.1038/srep35949 (2016).
[7]  Namrata Jayanth, Nirmala Ogirala, Anil Yadav and Mrinalini Puranik. Structural basis for substrate discrimination by E.coli repair enzyme, AlkB. RSC Adv., 8, 1281 (2018).
[8]  J. Owen Andrews, William Conway, Won-Ki Cho, Arjun Narayanan, Jan-Hendrik Spille, Namrata Jayanth, Takuma Inoue, Susan Mullen, Jesse Thaler, and Ibrahim Cisse. qSR: a quantitative super-resolution analysis tool reveals the cell-cycle dependent organization of RNA Polymerase I in live human cells. Scientific Reports, 8, 7424 (2018).