American Journal of Biochemistry

American Journal of Biochemistry is a peer-reviewed international journal dedicated to provide an active forum to the global scientific community for publishing and disseminating high quality research work in the field of biochemistry.

Mengyao Jin

Post-doctoral Fellow, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, USA

Research Areas

Inflammation, atherosclerosis, drug-drug interaction, metabolism and obesity, substance abuse, HIV and AIDS, oxidative stress and cell signaling cascades

Education

2008-2012Ph.D.University of Missouri-Kansas City
2004-2008B.S.Soochow University

Publications: Journals

[1]  Jin, M., Ande, A., Kumar, A., and Kumar, S., Ethanol mediated regulation of cytochrome P450 2E1: Role of oxidative stress-mediated PKC/JNK/SP1 pathway, Cell Death and Disease. 2013;4: e554. (Impact factor: 5.33)
[2]  Jin, M., Kumar, A., and Kumar, S., Ethanol mediated induction of cytochrome P450 2A6: Role of oxidative stress-mediated PKC/Erk-Nrf2 pathway, PLoS ONE. 7, e35505, 2012. (Impact factor: 4.09)
[3]  Jin, M., Earla, R. Shah, A., Earla, R.L., Gupte, R., Mitra, A. K., Kumar, A., and Kumar, S., A LC-MS/MS method for concurrent determination of CYP2A6-mediated nicotine metabolites and analysis of nicotine-mediated oxidative stress in U937 macrophages, J. NeuroImmune Pharmacol., 7,289-299, 2012. (Impact factor: 3.53)
[4]  Jin, M., Arya, P. Patel, K., Singh, B., Silverstein, P., Bhat, H., Kumar, A., and Kumar, S., Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages, Alcohol Clin. Exp. Res., 35, 1-8, 2011. (Impact factor: 3.34)
[5]  Ande, A., Earla, R., Jin M., Silverstein, P.S., Mitra, A.L., Kumar, A., and Kumar S., An LC-MS/MS Method for Concurrent Determination of Nicotine Metabolites and the Role of CYP2A6 in Nicotine Metabolite-mediated Oxidative Stress in SVGA Astrocytes, Drug and Alcohol dependence. 125, 49-59, 2012. (Impact factor: 3.38)
[6]  Kumar, S., Earla, R., Jin, M., Mitra, A. K., and Kumar, A., Effect of ethanol on spectral binding, inhibition, and activity of CYP3A4 with an antiretroviral drug nelfinavir, Biochem. Biophys. Res. Commun., 402, 163-167, 2010. (Impact factor: 2.48)
[7]  Kumar S., Jin M., A need for the improvement of cytochrome P450 based transgenic plants for bioremediation. Petrol. Envir. Biotechnol. 3, 1-5, 2012. (Impact factor: 3.14*)
[8]  Kumar S., Jin M., Ande A., Silverstein P.S., Kumar A. Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: Role of cytochrome P450 isozymes. Expert Opinion on Drug Metabolism and Toxicology. 8, 1363-1375, 2012. (Impact factor: 3.12)
[9]  Liu, C., Jin, M., Zhang X., Studies on Preparation of Diclofenac Sodium Silk Fibroin-Chitosan Sustained-Release Microsphere and Its Characteristics in Vivo and in Vitro. Chinese Pharmaceutical Journal. 21, 1642-1647, 2009.
[10]  Zhang, Y, Jin, M., Zhu, J., Lu, Z., Zhang G., A clinical comparative study of venlafaxine and fluxetine in treatment of obsessive-compulsive disorder. Journal of Clinical Psychological Medicine. 4, 2008.

Publications: Conferences/Workshops/Symposiums

[1]  Jin, M., Kumar, A., and Kumar, S.. CYP2E1-mediated alcohol metabolism induces expressions of CYP2A6 and CYP2E1 through oxidative stress-induced PKC signaling cascades in monocytes and astrocytes. 18th SNIP Conference, Honolulu, HI, April 25-28, 2012
[2]  Jin, M., Earla, R. Shah, A., Rajya L. Earla, Gupte, R., Mitra, A. K., Kumar, A., and Kumar, S., A LC-MS/MS method for concurrent determination of CYP2A6-mediated nicotine metabolites and analysis of nicotine-mediated oxidative stress in U937 macrophages, American Society of Mass Spectrometry, Denver, CO, June 5-9, 2011
[3]  Jin, M., Earla, R., Shah, A., Gupte, R., Mitra, A.K., Kumar, A., and Kumar, S., The role of cytochrome P450 on alcohol/nicotine-mediated oxidative stress in U937 macrophages,17th SNIP Conference, Clearwater Beach, FL, April 6-10, 2011.
[4]  Jin, M., Silverstein, P., Kumar, A., Kumar, S., Cytochrome P450-mediated drug interactions and adverse effects, International Conference on Integrative & Personalized Medicine and 42nd Annual Conference of Indian Pharmacological Society, Kolkata, India, 2009.