American Journal of Biochemistry

American Journal of Biochemistry is a peer-reviewed international journal dedicated to provide an active forum to the global scientific community for publishing and disseminating high quality research work in the field of biochemistry.

Andrei Surguchov

Editorial Board Member of American Journal of Biochemistry

Professor, Kansas University Medical Center and Vamckc, USA

Research Areas

Biochemistry of Amyloids, Protein Folding, Protein Aggregation, Transcriptional Regulation, Micrornas


B.S.Biochemistry, Moscow State University, Russia
M.S.Molecular Biology, Moscow State University
Ph.DMolecular Biology, Cardiology Research Center, Moscow, Russia


2002-presentVA Medical Center and Kansas University Medical Center Head, Laboratory of Retinal Biology
1998-2001Washington University School of Medicine, St. Louis Research Associate Professor
1995-1998University of Utah, Salt Lake City Senior
1992-1995Baylor College of Medicine, Houston Assistant Professor, Associate Director of the Laboratory of Lipid metabolism
1976-1991Cardiology Research Center, Moscow, Russia Head, laboratory of Molecular Biology

Academic Achievement

Award of the Fellowship of French Centre National des Rescherches Scientific


Fellowship of World Health Organization (WHO)
Fellowship to visit National Heart, Lung and Blood Institute, NIH, Bethesda, USA (Head: Dr. Bryan Brewer)
Fellowship of German Ministry of Science (DeutscheForschungGemeinshaft) Munich
Fellowship to visit Baker Institute, Prahran, Melbourne, Australia (Head: Dr. Alex Bobik)
Member and alternative Chair of R@D Committee, VA Medical Center, Kansas City (current)
Reviewer in Special Emphasis Panel/Scientific Review Group CSR/National Institute of Health (NIH) for Challenge Grants (Panel # 3)
Included in Marquis Who's Who in America, 2007-2010 editions

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  A.P. Surguchov, M.V. Telkov and V.N. Smirnov. 1986. Absence of structural homology between sup1 and sup2 genes of yeast S. cerevisiae and identification of their transcripts. FEBS Letters, 206, 1, 147-150
[2]  Kushnirov, V.V., Ter-Avanesyan, M.D., Surguchov, A.P., Smirnov, V.N., Inge-Vechtomov, S.G. 1987. Localization of possible functional domains in sup2 gene product of the yeast S. cerevisiae. FEBS Letters, 215, 2, pp.257-260
[3]  Kushnirov V.V., Ter-Avanesyan, M.D., Surguchov A.P., V.N. Smirnov, S.G. Inge-Vechtomov. 1988. Nucleotide sequence of the sup2 gene of yeast S. cerevisiae. Gene, 66, pp. 45-54
[4]  V.A. Kosykh, A.P. Surguchov, E.E. Podrez, V.N. Smirnov. 1988. 7-ketocholesterol inhibits VLDL secretion by cultured human and rabbit hepatocytes. Biochim Biophys Res Comm 153, 3, pp. 1116-1122
[5]  V.A. Kosykh, E.A. Podrez, A.B. Novikov, A.P.Surguchov, V.N. Smirnov.1988. VLDL apoprotein secretion and apoB mRNA level in primary cultures of cholesterol loaded rabbit hepatocytes. FEBS Letters, v. 232, 1, pp. 103-106
[6]  A.P. Surguchov. 1987. Common genes for mitochondrial and cytoplasmic proteins. Trends in Biochemical Sciences (TIBS). v. 12, 9, pp. 335-339
[7]  A.P. Surguchov. 1988. Omnipotent nonsense suppressors: new clues to an old puzzle. Trends in Biochemical Sciences (TIBS), v. 13, 4, pp. 120-123
[8]  A.B. Sudarikov and A.P. Surguchov. 1988. Probe for rabbit apolipoprotein B gene. Nucleic Acids Research, v.16, 16, p. 8187
[9]  A.P. Surguchov. 1990. Apolipoprotein gene family: organization of upstream elements and regulation of gene expression. Biomedical Sciences, Turpin Transactions Ltd., Pion Ltd., v. 1, No. 4, pp. 344-354
[10]  A.P. Surguchov . 1991. Migration of promoter elements between genes: a role in transcriptional regulation and evolution. Biomedical Sciences (Turpin Transactions Ltd., Pion Ltd.), v. 2, pp. 22-28
[11]  A.P. Surguchov, E. Boerwinkle, R. Sharett, W. Patsch. 1994. Apolipoprotein E genotype and plasma lipid transport: insight into the role of the E4 allele from populational studies. Atherosclerosis, v.106, p.119
[12]  A.P. Surguchov, S. Liu, W. Patsch. 1995. Simple non-radioactive methods of analysis of polymorphic markers flanking human apolipoprotein C-III gene. Disease Markers, v. 12, pp. 167-174
[13]  Y.Ch. Lin-Lee, S. Soyal, S. Sanders, A. Surguchov, W. Patsch, 1995 Thyroid hormone influences conditional transcript elongation of the apolipoprotein A-I gene in rat liver. J. Lipid Research, v. 36, pp. 1586-1595.
[14]  A.P. Surguchov, G.P. Page, L. Smith, W. Patsch, E. Boerwinkle. 1996. Polymorphic markers in apo-lipoprotein C-III gene flanking regions and hyper-lipoproteinemia. Arteriosclerosis, Thrombosis and Vascular Biology, v.16, 8, pp.941-948
[15]  A. Surguchov, D. Bronson, P. Banerjec, J. Knowles, C. Ruiz, I. Subbaraya, K. Palczewski, W. Baehr. 1997 The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6. Genomics 39, 3, pp. 312-322
[16]  I.G. Surgucheva, W. Baehr, A. Surguchov. 1997. Differential effect of expression of heterologous genes in baculovirus transfer vector on the level of baculovirus protein expression. Mol Biol of the Cell, 139, 806
[17]  A. Surguchov, D. Bronson, P. Banerjec, J. Knowles, C. Ruiz, I. Subbaraya, K. Palczewski, W. Baehr. 1997 The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6. Genomics 39, 3, pp. 312-322.
[18]  A. Surguchov, I.Surgucheva, K. Howes, W. Baehr. 1999. Synoretin-a new retina protein belonging to the synuclein family. Molecular&Cellular Neuroscience, v.13, 95-103.
[19]  A. Surguchov, B. McMahon, E. Masliah, I. Surgucheva. 2001. Synucleins in ocular tissues. J Neurosci Res, 65, 68-77
[20]  A Surguchov, RE. Palazzo, and I Surgucheva. 2001. Gamma synucleins: subcellular localization in neuronal and non-neuronal cells and effect on signal transduction. Cell Motility and Cytoskeleton, 2001, 49, 218-228
[21]  Pronin AN, Morris AJ, Surguchov A, Benovic JL. 2000. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem., 275, 26515-26522
[22]  Surgucheva I., McMahan B, F. Ahmed, Tomarev S, Wax MB, Surguchov A. 2002. Synucleins in glaucoma: implication of gamma-synuclein in glaucomatous alterations in the optic nerve. J Neurosci Res, 68: 97-106.
[23]  Surgucheva I, Sivak, JM, Fini ME, Palazzo RE and Surguchov AP. 2003. Effect of-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys. 410:167-176.
[24]  Maurage CA, Ruchoux MM, De Vos R, Surguchov A, Destee A. 2004. Retinal involvement in dementia with Lewy bodies: A clue to hallucinations? Ann Neurol. 54(4):542-7.
[25]  Snyder HM, Mensah K, Surgucheva I, Festoff B, Surguchov A, Wolozin B. 2005. b-Synuclein prevents proteasomal inhibition by α-synuclein but not γ-synuclein. J Biol Chem, 280(9):7562-9.
[26]  Surgucheva, B. Yue, BC Park, S Tomarev and A. Surguchov. 2005. Interaction of myocilin with gamma-synuclein and its role in neurodegeneration in glaucoma. Cellular Molecular Neurobiology, 25, 6, 1009-1033.
[27]  Surgucheva I, Ninkina N, Buchman VL, Grasing K, A. Surguchov. 2005. Protein aggregation in retinal cells and approaches to cell protection. Cellular Molecular Neurobiology, 25, 6, 1051-1066.
[28]  Surgucheva I, McMahon B., Surguchov. 2006. Dynamic intracellular localization of-synuclein: a clue to its functions. Cell Motility and Cytoskeleton, 63, 8, 447-458. A. Surguchov. 2007. Synucleins in the eye: friends or foes? Experimental Eye Research, 86(1):1-2
[29]  Surgucheva I, Surguchov. 2008.-Synuclein: Cell-Type Specific Promoter Activity and Binding to Transcription Factors. J Mol Neuroscience, 2008; 35(3):267-71.
[30]  A. Surguchov. 2008. Molecular and cellular biology of synucleins. International Review of Cell and Molecular Biology, 270, 225-317.
[31]  I Surgucheva, A Shnyra, J Goldberg, A. Weisman and A Surguchov. 2008.-Synuclein is a marker of the retinal ganglion cells, Molecular Vision, 14:1540-1548.
[32]  I Surgucheva, V Shestopalov and A Surguchov. 2008. Effect of-synuclein silencing on apoptotic pathways in retinal ganglion cells. J Biol Chem, v. 284, (52):36377-85.
[33]  A. Surguchev, A. Surguchov. Conformational diseases: looking into the eyes. Brain Research, 2010, 81, 12-24.
[34]  Surgucheva I, McMahon B., A. Surguchov. 2010. Patterns of synucleins expression throughout lens development. Journal of Biophysical Chemistry, 1, 12-18.
[35]  A Surguchov. Antichaperonic activity, protein aggregation and diseases. Brain Research Journal, 2010, v 3, 1, 1-15.
[36]  Surgucheva I, Chidambaram K, Willoughby DA, A. Surguchov. MicroRNA regulates matrix metalloproteinase 9 expression. Aug 2010, the Journal of Ocular Biology, Diseases and Bioinformatics.
[37]  A. Surguchov. Two faced members of the family: the synucleins. In "Protein Aggregation", 2011, Nova Publishers (accepted).