Advances in Life Sciences

Advances in Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. All articles are rigorously reviewed. The journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms.

Jaromir Myslivecek

Editorial Board Member of Advances in Life Sciences

Associate Professor, Institute of Physiology, 1St Faculty of Medicine, Charles University, Czech Republic

Research Areas

G Coupled Receptors, Stress, Receptor Regulation, Muscarinic Receptors, Adrenoceptors, Dopamine Receptors


1999Ph.DCharles University, 1st Faculty of Medicine
1992M.D. Charles University, 1st Faculty of Medicine


2010-present Head, Institute of Helath studies, Technical University Liberec, Liberec, Czech Republic
2005-present Associate Professor of Physiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
2003-present Head, Laboratory of Neuroembryophysiology, Institute of Physiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
1999-2003 Research worker, Laboratory of Neurochemistry, Academy of Sciences of The Czech Republic
1992-1999 Ph.D. Studies in Neurosciences, Academy of Sciences of The Czech Republic
1992-2005Assistant Professor of Physiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  J. Myslivecek, S. Tucek: Binding of phenylcyclohexylglycoloyl ester of hydroxyethyldimethylhydrazonium (compound VUFB-3113) to muscarinic receptors in rat heart, salivary gland and cerebral cortex. Physiol. Res. 42: 433-435, 1993
[2]  J. Myslivecek, S. Trojan, S. Tucek: Biphasic changes of muscarinic and B-adrenergic receptors in rat heart atria during DFP treatment. Life Sci. 58: 26, 2423-2430, 1996
[3]  J. Myslivecek, V. Lisá., S, Trojan, S. Tucek: Heterologous regulation of the density of muscarinic and beta-adrenergic receptors in rat cardiomyocytes in culture. Life Sci 63: 13, 1169-82, 1998
[4]  J. Myslivecek, S. Trojan: Mechanisms of G-protein coupled receptor regulation. Sb. lek 101: 3, 205-213, 2000
[5]  J. Myslivecek, S. Trojan: Muscarinic receptor subtypes in the heart-how many and why? Sborn. lek., Vol. 102: 3, 47-56, 2001
[6]  J. Myslivecek, S. Trojan: Regulation of-adrenoceptors and muscarinic receptors in the heart. General Physiology and Biohysics 22: 1, 3-14, 2003
[7]  J. Myslivecek, J. Rícny, S. Tucek: Hydrocortisone affects the densities of cardiac muscarinic and adrenergic receptors. Chapter XIX. In: Cholinergic Mechanisms. Israel Silman, Hermona Soreq, Lili Anglister, Daniel M Michaelson, Abraham Fisher eds., Matin Dunitz Publ., London, 315-316, 2003, ISBN 1841840750
[8]  J. Myslivecek, S. Trojan: The importance of the prolonged postnatal period in determination of heart atrial muscarinic receptor and-adrenoceptor densities. Life Scinces 73, 25, 3289-3296, 2003
[9]  Myslivecek J., Rícny J, KoláR F., Tucek S: The effects of hydrocortisone on the rat heart muscarinic and adrenergic 1, 1 and 2 receptors, propranolol-resistant binding sites and on some consequent steps in the intracellular signalling. NS Arch. Pharmacol. 368: 366-376, 2003
[10]  Myslivecek J., Rícny J., Palkovits M., Kvetňansky R.: The Effects Of Short-Term Immobilization Stress On Muscarinic Receptors, beta-Adrenoceptors And Adenylyl Cyclase In Different Heart Regions. Annals of New York Academy of Sciences 1018: 315-322, 2004
[11]  Nováková M., Kvetňansky R., Myslivecek J.: The adaptive mechanisms of muscarinic, alpha1-adrenergic and beta-adrenergic receptors in CRH knockout mice J. Physiol. (Paris) . 2-3, p. 257-258, 2006
[12]  M. Nováková, J. Myslivecek: Identification of all 1-adrenoceptor subtypes in rat lung. Gen. Physiol. Biophys. 24: 349-353, 2005
[13]  J. Myslivecek, R. Kvetnansky: The effects of stress on muscarinic receptors. Heterologous receptor regulation: yes or not? Auton. Autacoid Pharmacol. 26: 235-251, 2006 (invited review)
[14]  J.Myslivecek, M. Nováková, M. Palkovits, O. Krizanová, R. Kvetnansky: Distribution of mRNA and binding sites of adrenoceptors and muscarinic receptors in the rat heart. Life Sci. 79: 112-120, 2006
[15]  Ballay R., Myslivecek J: Development of Autonomic Receptors and their Function in the Chick Heart and Influence of Continuous Infusion of Carbachol. Prague Medical Report 107: 1, 49–60, 2006
[16]  Benes J., Nováková M., Kvetňansky R., Myslivecek J.: Developmental Changes of Some G-protein Coupled Receptors Affected by c-fos Knock-out. Prague Medical Report 107: 1, 61–70, 2006.
[17]  M. Nováková, J. Benes, L. Kubovcáková, R. Kvetňansky, J. Myslivecek: Muscarinic receptors are affected by corticotropin releasing hormone and c-fos gene disruptions. Journal of Molecular Neuroscience 30(1-2):69-70, 2006
[18]  Vozeh, F., Myslivecek, J., Cendelín, J., Korelusová, I., Markvartová, V.: PRíspěvek k distribuci a funkci dopaminovych receptoru v mozku mutantních mysí Lurcher. Homeostasis, 44, 3, 2006
[19]  Krizanová O., Myslivecek J., Tillinger A., Jurkovicová D. and Kubovcáková L.: Adrenergic and calcium modulation of the heart in stress: from molecular biology to function. Stress 10(2):173-84. 2007
[20]  Myslivecek J., Cendelín J., Korelusová I., Kunová M., Markvartová V., Vozeh F: Changes of dopamine receptors in mice with olivocerebellar degeneration. Prague Medical Report 108: 1, 67-74, 2007.
[21]  Myslivecek J, Duysen E.G., Lockrdige O: Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice. NS Arch. Pharmacol. 376: 83-92, 2007
[22]  Myslivecek J., Nováková M., Klein M: Receptor Subtype Abundance as a Tool for Effective Intracellular Signalling. Cardiovascular & Hematological Disorders-Drug Targets 8, 1, 66-79, 2008
[23]  Zimova M, Myslivecek J, Potmesil P.: Retinoic acid attenuates the mild hyperoxic lung injury in newborn mice. Physiol Res. 57(1): 33-40, 2008
[24]  Myslivecek J., Hrabovska A.: Dopamine Receptors Regulation by Non-Dopaminergic Mechanisms; (Chapter IX) In: Dopamine Research Advances, Akiyama Watanabe Ed. pp. 193-208, Nova Publishers, Hauppauge, NY 11788, USA, 2008, ISBN: 1-60021-820-2
[25]  Myslivecek J, Klein M, Novakova M, Ricny J: The detection of non-M2 muscarinic receptor subtype in the rat heart atria and ventricles. N-S Arch Pharmacol, 378(1):103-116, 2008
[26]  Fischer V., Gabauer I., Tillinger A., Nováková M., Pecháň I., Krizanová O., Kvetňansky R., Myslivecek J.: Heart adrenoceptors gene expression and binding sites in human failing heart. Annals NY Acad Sci 1148: 400-408, 2008
[27]  O. Krizanova, T. Holotnakova, D. Jurkovicova, E. Polakova, A. Zahradnikova, L. Lacinova, R. Kvetnansky, J. Myslivecek, S. Pastorkova: Type 1 and 2 IP3 receptors respond differently to catecholamines and stress. Annals NY Acad Sci 1148: 331-337, 2008
[28]  Myslivecek J., Tillinger A., Novakova M., Kvetnansky R.: Regulation of adrenoceptors and muscarinic receptors gene expression after single and repeated stress. Annals NY Acad Sci 1148: 367-376, 2008
[29]  Tillinger A., Myslivecek J., Nováková M., Krizanová O., Kvetnansky R.:Gene expression of adrenoceptors in the heart of cold acclimated rats exposed to a novel stressor. Annals NY Acad Sci 1148: 393-399, 2008
[30]  Hrabovska A., Farar V., Li B., Bernard V., Duysen E.G., Brabec J., Lockridge O., Myslivecek J.: Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse. Chemico-Biological Interactions 183, 194–201, 2010
[31]  Novakova M., Kvetnansky R., Myslivecek J.: Sexual dimorphism in stress-induced changes in adrenergic and muscarinic receptor densities in the lung of wild type and CRH-knockout mice. Stress 13(1): 22–35, 2010