Research in Neuroscience

Research in Neuroscience is a peer-reviewed journal aims to advance our understanding of the nervous system in health and disease, thereby improving the diagnosis and treatment of neuropsychiatric and neurodegenerative disorders. It presents novel results that can be of interest to a broad spectrum of neuroscientists and that were generated by experiments guided by clearly defined aims or hypotheses.

George Panagis

Editor-in-Chief of Research in Neuroscience

Associate Professor, University of Crete, Department of Psychology, Laboratory of Behavioral Neuroscience, Greece

Research Areas

Behavioral Neuroscience, Psychopharmacology


1992-1996Ph.DUniversity of Crete


presentAssociate Professor,University of Crete
2010Visiting Professor, Charité Campus Mitte, Berlin
2004-2010Assistant Professor in Biopsychology,University of Crete
2000-2004Lecturer in Biopsychology, University of Crete
1999-2000Teaching Assistant, University of Crete
1997-1998Postdoctoral Fellow,Division of Pharmacology, Section of Neuropsychopharmacology
1995-1997Teaching Assistant, University of Crete

Academic Achievement

Scholarship, National Scholarship Foundation of Greece,1990-1991
Prize for Academic Excellence by the member of Greek parliament E. Dretakis,1992
B.Sc. with Excellence, University of Crete, Greece,1993
B.Sc. with Excellence, University of Crete, Greece. 1995
Award from the Hellenic Society for Neuroscience for the best poster presentation in the 12th Annual Meeting,1996
Award from the Hellenic Society for Neuroscience for the best poster presentation in the 17th Annual Meeting,2002


Society for Neuroscience
American Psychological Association
International Brain Research Organization (IBRO)
Federation of European Neuroscience Societies (FENS)
European Behavioural Pharmacology Society (EBPS)
Hellenic Society for Neuroscience
Hellenic Psychological Society
Hellenic Pharmacological Society

Publications: Journals

[1]  Panagis G., Miliaressis E., Anagnostakis Y. and Spyraki C. (1995) Ventral Pallidum self-stimulation: A moveable electrode mapping study, Behavioural Brain Research, 168 (2), 165-172.
[2]  Panagis G., Spyraki C. and Miliaressis E. (1995) Post-stimulation excitability of ventral pallidum self-stimulation neurons, Behavioral Neuroscience, 109 (4), 777-781.
[3]  Panagis G. and Spyraki C. (1996) Neuropharmacological evidence for the role of dopamine in ventral pallidum self-stimulation, Psychopharmacology, 123 (3), 280-288.
[4]  Nisell M., Nomikos G., Hertel P., Panagis G. and Svensson T.H. (1996) Condition-independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat, Synapse, 22, 369-381.
[5]  Panagis G., Nisell M., Nomikos G.G., Chergui K. and Svensson T.H. (1996) Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rat, Brain Research, 730, 133-142.
[6]  Panagis G., Nomikos G.G., Miliaressis E., Chergui K., Kastellakis A., Svensson T.H. and Spyraki C. (1997) Ventral Pallidum self-stimulation induces stimulus dependent increase in c-fos expression in reward related brain regions, Neuroscience, 77, 175-186.
[7]  Panagis G., Kastellakis A. and Spyraki C. (1998) Involvement of the ventral tegmental area opiate receptors in self-stimulation elicited from the ventral pallidum, Psychopharmacology, 139, 222-229.
[8]  Nomikos G.G., Hildebrand B.E., Panagis G. and Svensson T.H. (1999) Nicotine withdrawal syndrome in the rat: role of α7 nicotinic receptors in the ventral tegmental area, Neuroreport, 10, 697-702.
[9]  Hildebrand B.E., Panagis G., Svensson T.H. and Nomikos G.G. (1999) Behavioral and biochemical manifestations of mecamylamine-precipitated nicotine withdrawal: Role of nicotinic receptors in the ventral tegmental area, Neuropsychopharmacology, 21, 560-574.
[10]  Panagis G., Hildebrand B.E., Svensson T.H. and Nomikos G.G. (2000) Selective c-fos induction and decreased dopamine release in the the central nucleus of amygdala in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Synapse, 35, 15-25.
[11]  Panagis G., Kastellakis A., Spyraki C. and Nomikos GG (2000) Effects of methyllycaconitine (MLA), an alpha 7 nicotinic receptor antagonist, on nicotine-and cocaine-induced potentiation of brain stimulation reward, Psychopharmacology,149, 388-396.
[12]  Schilström, B., Fagerquist, M.V., Zhang, X., Hertel, P., Panagis, G., Nomikos, G.G. and Svensson, T.H. (2000) Putative role of presynaptic a7 nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area, Synapse, 38, 375-383.
[13]  Nomikos, G.G., Schilström, B., Hildebrand, B.E., Panagis, G., Grenhoff, J. and Svensson, T.H. (2000) Role of α7 nicotinic receptors in nicotine dependence and implications for psychiatric illness, Behavioural Brain Research, 113, 97-103.
[14]  Panagis, G. and Kastellakis, A. (2002) The effects of ventral tegmental administration of GABAA, GABAB, NMDA and AMPA receptor agonists on ventral pallidum self-stimulation, Behavioural Brain Research, 131, 115-123.
[15]  Vlachou, S., Nomikos, G.G. and Panagis, G. (2003) WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation, Behavioural Brain Research, 141, 215-222.
[16]  Antoniou, K., Papathanasiou, G., Panagis, G., Nomikos, G.G., Hyphantis, T. and Papadopoulou-Daifoti, Z. (2004) Individual responses to novelty predict qualitative differences in d-amphetamine-induced open field but not reward-related behaviors in rats, Neuroscience, 123, 613-623.
[17]  Vlachou, S., Nomikos, G.G. and Panagis G. (2005) CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat, Psychopharmacology, 179, 498-508.
[18]  Antoniou, K., Galanopoulos, A., Vlachou, S., Kourouli, T., Nahmias, V., Thermos, K., Panagis, G., Daifoti, Z., Marselos, M., Papahatjis, D. and Spyraki, C. (2005) Behavioral pharmacological properties of a novel cannabinoid 1',1'-dithiolane Δ8-THC analog, AMG-3, Behavioural Pharmacology, 16, 499-510.
[19]  Vlachou, S., Nomikos, G.G. and Panagis, G. (2006) Effects of endocannabinoid neurotransmission modulators on brain stimulation reward, Psychopharmacology, 188, 293-305.
[20]  Vlachou, S., Nomikos, G.G., Stephens, D.N. and Panagis, G. (2007) Lack of appetitive effects of Δ9-tetrahydrocannabinol in the intracranial self-stimulation and conditioned place preference procedures in rodents, Behavioural Pharmacology, 18, 311-319.
[21]  Papathanasopoulos, P., Messinis, L., Lyros, E., Kastellakis, A. and Panagis, G. (2008) Multiple Sclerosis, Cannabinoids and Cognition, The Journal of Neuropsychiatry and Clinical Neurosciences, 20, 36-51.
[22]  Vlachou, S., Stamatopoulou, F., Nomikos, G.G., & Panagis, G. (2008). Enhancement of endocannabinoid neurotransmission through CB1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine, International Journal of Neuropsychopharmacology, 11, 905-923.
[23]  Panagis, G., Vlachou, S., & Nomikos, G.G. (2008). Behavioral pharmacology of cannabinoids with a focus on preclinical models for studying reinforcing and dependence-producing properties, Current Drug Abuse Reviews, 1, 350-374.
[24]  Mavrikaki, M., Nomikos, G.G., & Panagis, G. (2009). Effects of Mood Stabilizers on Brain Reward Processes in Rats: Studies Using the Intracranial Self-Stimulation Paradigm, European Neuropsychopharmacology, 19, 205-214.
[25]  Messinis, L., Lyros, E., Andrian, V., Katsakiori, P., Panagis, G., Georgiou, V., & Papathanasopoulos, P. (2009). Neuropsychological functioning in buprenorphine maintained patients versus abstinent heroin abusers on naltrexone hydrochloride therapy, Human Psychopharmacology: Clinical and Experimental, 24, 524-531.
[26]  Fokos, S., & Panagis, G. (2010). Effects of Δ9-tetrahydrocannabinol on reward and anxiety in rats exposed to chronic unpredictable stress, Journal of Psychopharmacology, 24, 767-777.
[27]  Mavrikaki, M., Nomikos, G.G., & Panagis, G. (2010). Efficacy of the atypical antipsychotic aripiprazole in d-amphetamine-based preclinical models of mania, International Journal of Neuropsychopharmacology, 13, 541-548.
[28]  Mavrikaki, M., Markaki, E., Nomikos, G.G., & Panagis, G. (2010). Chronic WIN55,212-2 elicits sustained and conditioned increases in intracranial self-stimulation thresholds in the rat, Behavioural Brain Research, 209, 114-118.
[29]  Katsidoni, V., Apazoglou, K., & Panagis, G. (2011).Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine, Psychopharmacology, 213, 337-354.

Publications: Books/Book Chapters

[1]  Panagis G. (1998) The biopsychology of reinforcement and addiction. Psychology, 5, 71-83. (in Greek).
[2]  Panagis G. and Kastellakis A. (1999) Drug addiction in the light of Biopsychology and Psychopharmacology: Neural mechanisms and their treatment implications. Psychology, 6, 55-71. (in Greek).
[3]  Kastellakis A. & Panagis G. (2000) Contribution of Biopsychology for society: Prospects and questions. In: J. Nestoros, V. Pesmazoglou, M. Samatas (Eds). Modern tendencies in social sciences. Athens: Tipothito. (in Greek).
[4]  Panagis, G. & Kastellakis A. (2001). Addiction as a brain disease. In A-B Rigas (Ed). Psychosocial interventions in organizations, groups and individuals. Athens: Ellinika Grammata. (in Greek).
[5]  Panagis G. (2002). Biopsychology of reinforcement: Intracranial self-stimulation studies and the role of dopamine. Psychology, 9, 92-115. (in Greek).
[6]  Panagis G. (2002). Bridging psychology and pharmacology. Psychology, 9, 396-407. (in Greek).
[7]  Panagis G. (2004). Cannabinoids, brain and behavior. Eleftherna, 1, 177-179 (in Greek).
[8]  Panagis G. (2005). Drug addiction and the brain. Hellenic Journal of Psychology, 2, 287-308 (in Greek).
[9]  Panagis G. & Kastellakis A. (2006). The endocannabinoid system: New prospects in therapeutics. Epitheorese Klinikes Farmakologias kai Farmakokinetikes, 24, 73-89 (in Greek).
[10]  Panagis G. & Dafermos M. (2008). The psyche and the brain: a historical analysis of the study of their relationship. Hellenic Journal of Psychology, 5, 324-366. (in Greek).
[11]  Panagis G. (2002) Behavioral Neuroscience: Basic principles, methods, techniques, and laboratory exercises. Athens: Paschalidis Medical Publications. (in Greek).