Basic Sciences of Medicine

Basic Sciences of Medicine is a peer reviewed international basic medical sciences journal, which is aimed to promote research and information in basic medical sciences. It can improve health, health care and health education, internationally by elevating the quality of medical care, disease prevention, and research.

Fazal Shirazi

Post-doctoral Fellow, THE UNIV OF TEXAS M.D ANDERSON CANCER CENTER, USA

Research Areas

FUNGAL MORPHOGENESIS AND PATHOGENESIS, APOPTOSIS AND DRUG DISCOVERY, METABOLIC SYNDROME

Education

2007-2011PHDPUNE UNIVERSITY, INDIA
1999-2001MSGURUGHASIDAS UNIVERSITY, BILASPUR, INDIA
1996-1999BSGURUGHASIDAS UNIVERSITY, BILASPUR, INDIA

Experience

2012-presentPost Doctoral Fellow, Infectious Diseases, UT MD Anderson Cancer Center, Houston, TX, USA. I am working on apoptosis of Zygomycete fungus and Candida by manipulating various stress pathways to increase efficacy of antifungal drugs. I am also studying effect of metabolic syndrome (obesity and hyperglycemia) on mucormycosis in invertebrate model of Drosophila melanogaster.
2007-2010CSIR Senior Research Fellow, Biochemical Science Division, National Chemical Laboratory, Pune, India. I worked on “Biochemical and molecular characterization of programmed cell death in dimorphic fungus Benjaminiella poitrasii’’.
2004-2007Project assistant, Biochemical Science Division, National Chemical Laboratory, Pune on a CSIR funded project “Development of Novel Fungicides”.
2002-2004Biotechnologist trainee , Institute of In-vitro Fertilization, Mumbai, India.

Membership

Association of Microbiology of India
American Association of Microbiology

Publications: Journals

[1]  Shingate B.B, Hazra B.G, Salunke D.B, Pore V.S, Shirazi F, Deshpande M.V (2013) Synthesis and antimicrobial activity of novel oxysterols from lanosterol. Tetrahedron 69:11153-11163.
[2]  Barbu E.M, Shirazi F, McGrath DM, Albert N, Sidman R.L, Pasqualini R, Arap W, Kontoyiannis D.P (2013) An antimicrobial peptidomimetic induces mucorales cell death through mitochondria-mediated apoptosis. PLOS ONE 8 (10): e76981.
[3]  Shirazi F, Kontoyiannis D.P (2013) The calcineurin pathway inhibitor tacrolimus enhances the in vitro activity of azoles against mucorales via apoptosis. Eukaryot Cell 12:1225-1234.
[4]  Shirazi F, Pontikos M.A, Walsh T.J, Albert N.D, Lewis R.E, Kontoyiannis D.P (2013) Hyperthermia sensitizes Rhizopus oryzae to posaconazole and itraconazole action through apoptosis. Antimicrob Agents Chemother 57 (9): 4360-4368.
[5]  Shirazi F, Kontoyiannis D.P (2013) Mitochondrial respiratory pathways inhibition in Rhizopus oryzae potentiates activity of posaconazole and itraconazole via apoptosis. PLOS ONE 8:e63393.
[6]  Shingate B.B, Hazra B.G, Salunke D.B, Pore V.S, Shirazi F, Deshpande M.V (2011) Synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with vinyl side chain. Chem Biol Interface 1:198-208.
[7]  Shingate B.B, Hazra B.G, Salunke D.B, Pore V.S, Shirazi F, Deshpande M.V (2011) Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain. Eur J Med Chem 46:3681-3689.
[8]  Chaudhary P.M, Chavan S.R, Shirazi F, Razdan M, Nimkar P, Maybhate S.P, Likhite A.P, Gonnade R, Hazara B.G, Deshpande M.V, Deshpande S.R (2009) Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors. Bioorg Med Chem 17:2433-2440.
[9]  Vatmurge N.S, Hazra B.G, Pore V.S, Shirazi F, Deshpande M.V, Kadreppa S, Chattopadhyay S, Gonnade R.G (2008) Synthesis and biological evaluation of bile acid dimers linked with 1,2,3-triazole and bis-β-lactam. Org Biomol Chem 6:3823-3830.
[10]  Gholap A.R, Toti K.S, Shirazi F, Deshpande M.V, Srinivasan K.V (2008) Efficient synthesis of antifungal pyrimidines via palladium catalyzed Suzuki/ Sonogashira cross-coupling reaction from Biginelli 3,4-dihydropyrimidin- 2(1H)-ones. Tetrahedron 64:10214-10223.
[11]  Bavikar S.N, Salunke D.B, Hazra B.G, Pore V.S, Dodd R.H, Thierry J, Shirazi F, Deshpande M.V, Kadreppa S, Chattopadhyay S (2008) Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: Impending synergistic agents. Bioorg Med Chem Lett 18:5512-5517.
[12]  Vatmurge N.S, Hazra B.G, Pore V.S, Shirazi F, Chavan P.S, Deshpande M.V (2007) Synthesis and antimicrobial activity of β-lactam–bile acid conjugates linked via triazole. Bioorg Med Chem 18:2043-2047
[13]  Gholap A. R, Toti K. S, Shirazi F, Kumari R, Bhat M. K, Deshpande M.V, Srinivasana K.V(2007) Synthesis and evaluation of antifungal properties of a series of the novel 2-amino -5-oxo-4-phenyl-5, 6,7,8- tetrahydroquinoline- 3-carbonitrile and its analogues. Bioorg Med Chem 15:6705-6715.
[14]  Shirazi F, Kulkarni M, Deshpande M.V (2007) A rapid and sensitive method for screening of chitinase inhibitors using Ostazin Brilliant Red labeled chitin as a substrate for chitinase estimation. Lett Appl Microbiol 44:660-665.