Research In Cancer and Tumor

International Journal of Cancer and Tumor is a peer-reviewed international journal which provides a forum for prompt communication of original and innovative research findings that have relevance to understanding the etiology of cancer and to improving the treatment and survival of patients.

Tao Shen

Post-doctoral Fellow, University of Oklahoma Health Sciences Center, USA

Research Areas

Cancer immunotherapy, Oncogenesis, Cell cycle regulation, Cell signaling, Protein kinases and phosphatases

Education

2008-2013PhDLouisiana State University Health Sciences Center,Shreveport, LA
1992-1996BSEast China University of Science and Technology, Shanghai, China

Publications: Journals

[1]  Fan C, Chen L, Huang Q, Shen T, Welsh EA, Teer JK, Cai J, Cress WD, Wu J (2015) Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma. Br J Cancer. 2015 Nov 10. doi: 10.1038/bjc.2015.378.
[2]  Zhou H, Shen T, Luo Y, Liu L, Huang S (2014) Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway. Oncotarget. 5(20):10140-50.
[3]  Shen T, Huang S (2012) The Role of Cdc25A in the regulation of cell proliferation and apaptosis. Anticancer Agents Med Chem. 12:631-639.
[4]  Chen W, Liu L, Luo Y, Odaka Y, Awate S, Zhou H, Shen T, Zheng S, Lu Y, Huang S (2012) Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells. Cancer Prev Res (Phila). 5: 778-787.
[5]  Luo Y, Liu L, Rogers D, Su W, Odaka Y, Zhou H, Chen W, Shen T, Alexander JS, Huang S (2012) Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression. Neoplasia. 14:228-237.
[6]  Han X, Xu B, Beevers CS, Odaka Y, Chen L, Liu L, Luo Y, Zhou H, Chen W, Shen T, Huang S (2012) Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells. Carcinogenesis. 33:868-875.
[7]  Luo Y, Chen W, Zhou H, Liu L, Shen T, Alexander JS, Zheng S, Lu Y, Huang S. (2011) Cryptotanshinone inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3/ERK and small GTPase pathways. Cancer Prev Res (Phila). 4:2083-2091.
[8]  Xu B, Chen S, Luo Y, Chen Z, Liu L, Zhou H, Chen W, Shen T, Han X, Chen L, Huang S (2011) Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PLoS One. 6: e19052.
[9]  Luo Y, Zhou H, Liu L, Shen T, Chen W, Xu B, Han X, Alexander JS, Alam A, Huang S (2011) The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway. Oncogene. 30:2098-2107.
[10]  Zhou H, Shen T, Luo Y, Liu L, Chen W, Xu B, Han X, Rivera CA, Huang S (2010) The antitumor activity of the fungicide ciclopirox. Int J Cancer 127:2467-2477.
[11]  Liu L, Luo Y, Chen L, Shen T, Xu B, Chen W, Zhou H, Han X, Huang S (2010) Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol Chem. 285:38362-38373.

Publications: Conferences/Workshops/Symposiums

[1]  Shen T, Zhou H, Huang S (2013) The anticancer mechanisms of ciclopirox olamine The 104th Annual Meeting of American Association for Cancer Research, Washington, DC, April 6-10, 2013.
[2]  Shen T, Zhou H, Huang S (2012) Ciclopirox olamine downregulates Cdc25A expression in tumor cells. The 103rd Annual Meeting of American Association for Cancer Research, Chicago, IL, March 31-April 4, 2012
[3]  Shen T, Zhou H, Huang S (2011) Molecular mechanisms by which ciclopirox inhibits proliferation and induces apoptosis of tumor cells. The 105th Annual Meeting of American Society for Biochemistry and Molecular Biology, Washington, DC, April 9-15, 2011.