Research In Cancer and Tumor

International Journal of Cancer and Tumor is a peer-reviewed international journal which provides a forum for prompt communication of original and innovative research findings that have relevance to understanding the etiology of cancer and to improving the treatment and survival of patients.


Vinay Rudraraju

Research Scientist, , USA

Research Areas

Anticancer drugs, Drug delivery to brain, Drug safety and pharmacovigilance, Neuroscience

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Heterogeneous blood–tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer.PR Lockman, RK Mittapalli, KS Taskar, V Rudraraju, B Gril, KA Bohn, … Clinical cancer research 16 (23), 5664-5678
[2]  Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer.FC Thomas, K Taskar, V Rudraraju, S Goda, HR Thorsheim, JA Gaasch, … Pharmaceutical research 26 (11), 2486-2494
[3]  Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.Diane Palmieri, Paul R Lockman, Fancy C Thomas, Emily Hua, Jeanne Herring, Elizabeth Hargrave, Matthew Johnson, Natasha Flores, Yongzhen Qian, Eleazar Vega-Valle, Kunal S Taskar, Vinay Rudraraju, Rajendar K Mittapalli, Julie A Gaasch, Kaci A Bohn, Helen R Thorsheim, David J Liewehr, Sean Davis, John F Reilly, Robert Walker, Julie L Bronder, Lionel Feigenbaum, Seth M Steinberg, Kevin Camphausen, Paul S Meltzer, Victoria M Richon, Quentin R Smith, Patricia S Steeg.Clinical Cancer Research 15 (19), 6148-6157
[4]  Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.KS Taskar, V Rudraraju, RK Mittapalli, R Samala, HR Thorsheim, … Pharmaceutical research 29 (3), 770-781
[5]  Rudraraju, V., Taskar, K.S., Mittapalli, R.K., Bohn, K., Roberts, A., Thorsheim, H.R, Lockman, P.L., and Smith, Q.R: Blood-Tumor Barrier Permeability and Drug Uptake of Brain Micrometastases. Annual Meeting of the American Association of Pharmaceutical Scientists, New Orleans, Luoisiana, 2010.
[6]  Rudraraju, V., Taskar, K.S., Mittapalli, R.K., Bohn, K., Adkins, C., Lockman, P.L., Palmieri, D., Steeg, P.S. and Smith, Q.R.: Doxorubicin Distribution to Brain Metastases of Breast Cancer. Annual Meeting of the American Association of Pharmaceutical Scientists, Los Angeles, CA, 2009.
[7]  V Rudraraju, F.C.Thomas, KS Taskar, JA Gaasch, Mittapalli RK, Christopher Adkins, Kaci Bohn, Paul Lockman, Diane Palmieri, Patricia Steeg, and Quentin R. Smith “Uptake of Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, into Brain Metastases of Breast Cancer” at Annual Meeting of the American Association of Pharmaceutical Scientists, Atlanta, GA 2008.
[8]  Rudraraju V, Thomas F, Lockman PR, and Smith QR. Blood brain barrier permeability and transport of temozolomide. The American Association of Pharmaceutical Scientists, Annual Meeting. San Diego, CA. 2007.
[9]  Taskar, K.S., Goda, S., Rudraraju, V Thomas, F.C., Thorsheim, H.R. and Smith , Q.R. Role of Blood-Brain Barrier Transporters in the Brain Uptake of the Anticancer Drug, Paclitaxel. Annual Meeting of the American Association of Pharmaceutical Scientists, New Orleans, Louisiana, 2010.
[10]  Samala RK, Taskar KS, Rudraraju V, Bohn KA, Mittapalli RK, Roberts A, Thorsheim HR, Lockman PR, Smith QR “ Free drug concentration in metastatic brain tumors”. Annual Meeting of the American Association of Pharmaceutical Scientists, New Orleans, Luoisiana,2010.
[11]  Taskar, K.S., Rudraraju, V., Goda, S., Thorsheim, H.R., Mittapalli, R.K., Lockman, P.L., Palmieri, D., Steeg, P.S. and Smith, Q.R.: Blood-brain barrier permeability and active efflux transport of Paclitaxel used in the treatment of brain metastases of metastatic breast cancer. Annual Meeting of the American Association of Pharmaceutical Scientists, Los Angeles, CA, 2009.
[12]  Mittapalli RK, Bohn KA, Taskar KS, Rudraraju V, Adkins CE, Palmieri D, Steeg PS, Smith QR, Lockman PR “Tumor vascular permeability in breast cancer metastasis to brain tumor models” AAPS annual meeting 2009, Los Angeles, CA. (Abstract# R6069)
[13]  Kunal Taskar, Vinay Rudraraju, Satyanarayana Goda, Helen Thorsheim, Mittapalli RK, Paul Lockman, Diane Palmieri, Patricia Steeg, Quentin Smith “Blood-brain barrier permeability and active efflux transport of Paclitaxel used in the treatment of brain metastases of metastatic breast cancer” AAPS annual meeting 2009, Los Angeles, CA. (Abstract# R6143)
[14]  KS Taskar, V Rudraraju, H Thorsheim, JA Gaasch, Mittapalli RK, PR Lockman, P Steeg, D Palmieri, JW Polli, SX Castellino, SD Rubin, QR Smith “Distribution of Dual Tyrosine Kinase Inhibitor Lapatinib in Brain Metastases of Breast Cancer” at AAPS, Atlanta 2008.
[15]  Rudraraju, V., Taskar, K., Mittapalli, R., Bohn, K., Gaasch, J., Palmieri, D., Steeg, P., Lockman, P., and Smith, Q.R.: Blood-tumor barrier permeability and drug uptake in an experimental model of brain metastases of breast cancer. Annual Meeting of the American Association for Cancer Research, San Diego, CA, 2008.
[16]  Bohn KA, Mittapalli RK, Taskar KS, Rudraraju V, Adkins CE, Palmieri D, Steeg PS, Smith QR, Lockman PR “ Heterogeneity of permeability in a pre-clinical model of brain metastases of breast cancer does not correlate with vascular density, HIF-1α expression or tumor survival” AACR annual meeting 2010, Washington DC (Abstract# 2373)
[17]  Brunilde Gril, Lockman PR, Bohn KA, Adkins CA, Mittapalli RK, Taskar KS, Vinay R, Palmieri D, Smith QR, Steeg P, “ Vascular Density in a Brain Metastasis of Breast Cancer Mice Model” AACR, Denver, 2009 (Abstract# 3171)
[18]  Quentin.R.Smith, V.Rudraraju, KS Taskar, JA Gaasch, Mittapalli RK, KA Bohn, D. Palmieri, P. Lockman and P.Steeg “ Anticancer Drug uptake and distribution in MDA-MB-231BR brain metastases of breast cancer” Era of Hope, DOD Breast Cancer Research Programme, Baltimore 2008.
[19]  PR Lockman, KA Bohn, Mittapalli RK, R Vinay, KS Taskar, JA Gaasch, D Palmieri, QR Smith & P Steeg “ Blood-Tumor Barrier Permeability and Vascularity In a Model of Brain Metastasis of Breast Cancer” Era of Hope, DOD breast Cancer Research Programme, Baltimore 2008.
[20]  Mittapalli RK, KA Bohn, JM Egbert, VK Manda, V Rudraraju, KS Taskar, JA Gaasch, QR Smith and PR Lockman “Permeability Measurements At Blood-Brain and Blood-Tumor Barrier Using Different Molecular Weight Fluorescent markers” at Society For Neuroscience, Washington DC 2008.
[21]  K.S.Taskar, Mittapalli RK, V.Rudraraju, J.A. Gaasch, J.M. Egbert, K.A. Bohn, F.C.Thomas, P.R. Lockman & Q.R. Smith “Improved Left Ventricle Intracardiac Injection Method For Developing A Metastatic Tumor Model.” at Society for Neuroscience Annual Meeting 2007, San Diego, CA
[22]  KA Bohn, Mittapalli RK, KS Taskar, V Rudraraju, CE Adkins, QR Smith, PR Lockman “ Microvascular Density in a murine model of Brain Metastasis of Breast Cancer” at Society for Neuroscience, Washington DC 2008.
[23]  Taskar, K.S., Thomas, F.C., Goda, S., Rudraraju, V., Thorsheim, H.R. and Smith, Q.R.: Blood-brain barrier permeability and active efflux transport of drugs used in the treatment of metastatic breast cancer. 8th Cerebral Vascular Biology International Conference, Sendai, Japan, 2009. (Outstanding presentation award)
[24]  Mittapalli RK, Taskar KS, Rudraraju V, Bohn KA, Chris AE, Palmieri D, Steeg PS, Smith QR, Lockman PR “Experimental Brain Metastasis of Breast Cancer Demonstrates Heterogenous Permeability Where Lesion Size Does not Correlate to Increase Permeability” Gordon Research Conference 2010, New London, NH
[25]  Lockman PR, Mittapalli RK, Bohn KA, Adkins CE, KS Taskar, V Rudraraju, JA Gaasch, D Palmieri, P Steeg, QR Smith “ Development of quantitative fluorescent microscopy methodology to determine the vascular permeability of metastatic and implanted tumor” Gordon Research Conference 2008. Tilton, NH
[26]  Quentin.R.Smith, V.Rudraraju, KS Taskar, Mittapalli RK, D. Palmieri, P. Steeg, S. D. Rubin, J. W. Polli, S. X. Castellino, P. Lockman “ Lapatinib Distribution in Brain Metastases of Breast Cancer Following oral Dosing in Mice” at Breast Cancer Symposium, Washington DC 2008.
[27]  Mittapalli RK, Taskar KS, Rudraraju V, Bohn KA, Chris AE, Palmieri D, Steeg PS, Smith QR, Lockman PR “Brain Metastases have Heterogeneous Permeability which Correlates with Chemotherapeutic Failure” at National Graduate Student Research Festival, NIH, Bethesda, MD, Oct 2010