Research In Cancer and Tumor

International Journal of Cancer and Tumor is a peer-reviewed international journal which provides a forum for prompt communication of original and innovative research findings that have relevance to understanding the etiology of cancer and to improving the treatment and survival of patients.


Narayanan Subhash

Editorial Board Member of Research In Cancer and Tumor

Research Scientist, Biophotonics Laboratory, Centre for Earth Science Studies, India

Research Areas

Biomedical Research, Plant Physiology

Education

1982Ph. D. Cochin University of Science & Technology, Subject: Laser Physics
1975M. Sc.University of Kerala, India; Subject: Physics (specialization in Electronics)

Academic Achievement

2011: Rajiv Gandhi Excellence Award by the Indian International Friendship Society (IIFS), New Delhi
1998: DAAD Fellowship Award by the DAAD Foundation, Bonn, Germany for research at University of Karlsruhe, Karlsruhe, Germany
1992-1999: Regular Associate of the International Center for Theoretical Physics, Trieste, Italy
1992: Marie Curie Award by the European Union (CEC), Brussels, Belgium for research at the Instituto di Elettronica Quantistica. Consiglio Nazionale delle Ricerche (IEQ-CNR), Firenze, Italy

Membership

Life Member of Indian Laser Association
Life Member of the Indian Chapter of the ICTP
Life Member of the Optical Society of India
Life Member of Indian Remote Sensing Society
Senior Fellow, Head and Neck Optical Diagnostic Society (HNODS), UCL, UK

Publications: Journals

[1]  Anu Baburaj, N. Subhash, C.S. Prasanth and T.N. Prakash, Laser-induced fluorescence spectral signatures of corals in Lakshadweep and Palk Bay, International J Oceans and Oceanography (In Press)
[2]  Jayaraj L Jayanthi, Narayanan Subhash, Manju Stephen, Emmanuel K Philip and Valappil T Beena, Diagnostic evaluation of the diagnostic performance of autofluorescence and diffuse reflectance in oral cancer detection: a clinical study, J. Biophotonics, 4(10), 696-706, 2011 [DOI:10.1002/jbio.201100037, 2011].
[3]  Jayanthi JL., Manju S, Philip EK, Jeemon P, Baiju KV, Beena VT and Subhash N, Diffuse reflectance spectroscopy: Diagnostic accuracy of a non-invasive screening technique for early detection of malignant changes in the oral cavity, BMJ Open 2011 [doi:10.1136/bmjopen-2011-000071].
[4]  Shiny Sara Thomas, JL Jayanthi, Narayanan Subhash, Joji Thomas, Rupananda Mallia and G.N. Aparna, Characterization of dental caries by LIF spectroscopy with 404 nm excitation, Lasers in Medical Sci., 26(3, 299-305, 2011 [DOI: 10.1007/s10103-010-0771-3].
[5]  Mallia RJ, Subhash N, Sebastian P, Kumar R, Shiny ST, Mathews A, and Madhavan J, In Vivo Temporal Evolution of ALA-Induced Normalized Fluorescence at Different Anatomical Locations of Oral Cavity: Application to Improve Cancer Diagnostic Contrast and Potential, Photodiagnosis and Photodynamic Therapy, 7(3), 162-175, 2010 [DOI:10.1016/j.pdpdt.2010.06.006].
[6]  Mallia R, Subhash N, Mathews A, Kumar R; Thomas S, Sebastian P, and Madhavan J, Clinical grading of oral mucosa by curve-fitting of corrected autofluorescence using diffuse reflectance spectra, Head & Neck, 32(6), 763-779, 2010 [DOI: 10.1002/hed .21251].
[7]  Rupananda Mallia, Narayanan Subhash, Jayaprakash Madhavan, Paul Sebastian, Rejnish Kumar, Anitha Mathews, Gigi Thomas and Jayakrishnan Radhakrishnan, Diffuse reflectance spectroscopy: An adjunct to autofluorescence spectroscopy in tongue cancer detection, Applied Spectroscopy, 64(4), 409-418, 2010 [DOI: 10.1366/000370210791114347].
[8]  Shiny Sara Thomas, Soumyakant Mohanty, JL Jayanthi, Jolly Mary Varughese, Anita Balan and Narayanan Subhash, Clinical trial for detection of dental caries using laser-induced fluorescence ratio reference standard, J. Biomedical Optics, 15(2), 027001, March/April 2010 [DOI: 10.1117/1.3365945].
[9]  Jayanthi JL, Mallia R, Shiny ST, Baiju KV, Mathews A, Kumar R, Sebastian P, Madhavan J, Aparna GN, and Subhash N, Discriminant analysis of autofluorescence spectra for classification of oral lesions in vivo, Lasers in Surgery and Medicine, 41:345-352, 2009 [DOI:10.1002/lsm.20771].
[10]  Mallia R.J., Shiny S.T., Anitha M., Rejnish Kumar R, Paul S., Jayaprakash M., and Subhash N, Oxygenated hemoglobin diffuse reflectance ratio for in vivo detection of oral precancer, J. Biomedical Optics, 13 (4), 041306-1, Jul-Aug 2008, [DOI: 10.1117/1.2952007].
[11]  Shiny S Thomas, Rupananda J Mallia, Mini Jose, and Narayanan Subhash, Investigation of in vitro dental erosion by optical techniques, Lasers in Medical Sci., 23, 319-329, 2008 [DOI: 10.1007/s10103-007-0489-z]
[12]  Mallia R.J., Shiny S.T., Anitha M., Rejnish Kumar R, Paul S., Jayaprakash M., and Subhash N., Laser-induced autofluorescence spectral ratio reference standard for early discrimination of oral cancer, Cancer, 112(7), 1503-1512, 2008 [10.1002/cncr.23324].
[13]  Mallia RJ, Shiny ST, Kumar R, Mathews A, Sebastian P, Madhavan J and Subhash N, Oral premalignancy detection using autofluorescence spectral ratios, Oral Oncology Suppl. 2(1):259-260, 2007.
[14]  Subhash N., Malllia J.R., Shiny S.T., Mathew A., Sebastian P and Madhavan J, Oral cancer detection using diffuse reflectance spectral ratio R540/R575 of oxygenated hemoglobin bands, J. Biomedical Optics, 11(1), 014018(1-5), Jan-Feb 2006[DOI:10.1117/1.2165184].
[15]  Subhash N., S.S. Thomas, R.J. Mallia and M. Jose, Tooth caries detection by curve fitting of laser-induced fluorescence emission: A comparative evaluation with reflectance spectroscopy, Lasers in Surgery and Medicine, 37, 320-28, 2005 [DOI: 10.1002/lsm.20229].
[16]  Subhash N., C.N. Mohanan, R. J. Mallia and V. Muralidharan, Quantification of stress adaptation by laser-induced fluorescence spectroscopy of plants exposed to engine exhaust emission and drought, Functional Plant Biology, 31, 709-719, 2004 [DOI:10.1071/FP03253].
[17]  Subhash N., Wenzel, O. and H.K. Lichtenthaler, Changes in blue-green and chlorophyll fluorescence and fluorescence ratios during senescence of green tobacco plants, Remote Sens. Environ. 69, 215-223, 1999 [DOI:10.1016/S0034-4257(99)00029-2].
[18]  Subhash N. and C.N. Mohanan, "Curve fit analysis of chlorophyll fluorescence spectra: Application to nutrient stress detection in sunflower", Remote Sens. Environ., 60, 347-356, 1997 [doi:10.1016/S0034-4257(96)00217-9].
[19]  Subhash N., P. Mazzinghi, F. Fusi, G. Agati and B. Lercari, "Analysis of laser-induced fluorescence line shape of intact leaves: Application to UV stress detection", Photochem. Photobiol., 62, 711-718, 1995 [DOI: 10.1111/j.1751-1097.1995.tb08720.x].
[20]  Subhash N. and C.N. Mohanan, "Laser-induced red chlorophyll fluorescence signatures as nutrient stress indicator in rice plants", Remote Sens. Environ., 47, 45-50, 1994 [doi:10.1016/0034-4257(94)90126-0].
[21]  Subhash N., M.K.S. Kumar, T.M.A. Rasheed, K.P.B. Moosad and K. Sathianandan, "A multipass long-path cell for absorption measurements", J. Optics, 16, 51-57, 1987.
[22]  Radhakrishnan, K. Sathianandan and N. Subhash, "Laser-induced damage to spray pyrolysis deposited transparent conducting films", J. Appl. Phys., 59, 902-904, 1986 [doi:10.1063/1.337033]
[23]  Subhash N., and K. Sathianandan, "A simple spark gap driven circuit for electro-optic Q-switches", J. Phys. E: Sci. Instrum., 17, 832-833, 1984 [doi: 10.1088/0022-3735/17/10/002].
[24]  Subhash N. and K. Sathianandan, "Thermal effects in a Nd-glass laser rod pumped in a double circular close-coupled cavity", IEEE J. Quantum Electron., QE-20, 111-116, 1984 [10.1109/JQE.1984.1072361].
[25]  Subhash N., S.C. Kartha and K. Sathianandan, "New vibrational bands in nitrogen laser emission spectra", Appl. Opt., 22, 3612-3617, 1983 [doi:10.1364/AO.22.003612].
[26]  Subhash N. and K. Sathianandan, "Laser-induced damage to transparent conducting SnO2 films at 1062 nm", J. Appl. Phys., 54, 423-424, 1983 [doi:10.1063/1.331671].
[27]  Subhash N. and K. Sathianandan, "Inexpensive timing circuit for Q-switched solid-state laser using NE555 timers", Rev. Sci. Instrum., 51, 1130-1131, 1980 [doi:10.1063/1.1136388

Publications: Conferences/Workshops/Symposiums

[1]  Subhash N., Anu Baburaj, T.N. Prakash and M.S. Syed Ismail Koya, Fluorescence spectroscopy in monitoring of reef health and composition, Proc. Nat. Conf. Coastal Processes, Resources & Mangement, Thiruvananthapuram, 5-7 Feb 2010, pp. 127131.
[2]  Anu Babu Raj, N. Subhash and T.N. Prakash, Investigation of coral stress by laser-induced fluorescence, Proc. DAE-BRNS National Laser Symposium NLS-09, BARC Mumbai, Jan 13-16, 2010, CP-12-4.
[3]  Subhash N., Autofluorescence and Diffuse reflectance spectroscopic techniques for in vivo discrimination of oral premalignancies, Proc. First World Congress on CANCER (WCC-2009), IL 41, Jan 12-14, 2009, pp.43-44.
[4]  Jayanthi, JL, Mallia RJ, Thomas SS, Baiju KV, Prasanth CS, Aparna GN, Kumar R, Sebastian P and Subhash N, "In Vivo discrimination fo oral pre-malignancy using laser-induced autofluorescence spectroscopy", Proc. 21st Kerala Science Congress, Kollam, Jan 2009, pp.520-522.
[5]  Mallia J.R., Shiny, S.T., Rejnish, K.R., Anitha, M., Paul, S., Jayaprakash, M., Gigi, T., and Subhash N.,. Photodiagnosis of oral cancer detection in vivo using diffuse reflectance spectral ratios. Proc.National Laser Symposium, Ahmedabad, Gujarat, Dec. 17-20, 2007.
[6]  Mallia JR, Shiny ST, Kumar R, Mathews A, Sebastian P, Madhavan J and Subhash N, Diagnosis of oral cavity neoplasms with fluorescence spectroscopy. Proc. Kerala Science Congress 2006, Trivandrum, January 29-31, 2006, pp.458-460.
[7]  Subhash N., J.R. Malllia, S.T. Shiny, A. Mathew, S. Paul and M. Jayaprakash, Discrimination of malignant oral cavity lesions using R540/R575 reflectance spectral ratio. Proc. International PHOTONICS 2004 Conference, BIOP-12, Kochi, 9-11 December 2004
[8]  Subhash N., F. Babani, and H.K. Lichtenthaler, Remote detection of water stress in crop plants by fluorescence imaging, Ext. Abstracts of the Second International Conference and XXVII Annual Convention of the Optical Society of India (OPTONICS 2001), pp.150-152, Aug. 27-29, 2001.
[9]  Subhash N. and Mallia JR, Changes in laser-induced chlorophyll fluorescence signatures during regeneration of kacholam and colocasia plants from water stress, Proceedings of International Geoscience and Remote Sensing Symposium, IGARSS'03, IEEE International Publication, Vol.5, pp. 3293-95, 2003 [DOI:10.1109/IGARSS.2003.1294760].
[10]  Lichtenthaler H.K., N. Subhash, O. Wenzel and J.A. Miehe, Laser-induced imaging of blue/red and blue/far-red fluorescence ratios, F440/F690 and F440/F740, as a means of early stress detection in plants, Proc. Internat. Geosci. and Remote Sens. Symp. (IGARSS'97), Singapore, Vol. IV, 1799-801, August 3-8, 1997 [DOI: 10.1109/IGARSS.1997.609078].
[11]  Subhash N. and C.N. Mohanan, Remote detection of nutrient stress in groundnut plants by deconvolution of laser-induced fluorescence spectra", Proc. Internat. Geosci. and Remote Sens. Symposium (IGARSS'95), Firenze, Italy, Vol. III, 2323-2325, 1995.
[12]  Subhash N., G. Agati, F. Fusi, P. Mazzinghi and B. Lercari, "Significance of curve fit analysis of laser induced fluorescence in vegetation remote sensing", Proc. Internat. Conf. on Lasers'93, Nevada, USA, 113-117, 1993.
[13]  Subhash N. and C.N. Mohanan, "Study of nutrient deficiencies in rice plants by laser-induced fluorescence", Proc. Fifth Kerala Science Congress, India, 340-341, 1993.
[14]  Chandrasekhar R., N. Subhash, A. Srinivasan and S. Sampath, A ground-based night airflow photometer", Proc. IMAP Workshop on ground-based experiments, Andhra University, Waltair, India, 1983.
[15]  Mohanan C.N. and N. Subhash, "Laser-induced fluorescence intensity ratio F690/F725 as a nutrient stress indicator in rice plants", Proc. National Laser Symposium, IIT, Madras, India, 318-319, 1993.
[16]  Subhash N., C.N. Mohanan and V. Raghavan, "Detection of water stress by laser induced fluorescence measurements in rice leaves", Proc. Lasers'90 Conference, San Diego, USA, p. 26, 1990

Publications: Books/Book Chapters

[1]  Subhash N., Optical spectroscopy: An emerging technology for dentistry, In: Contemporary Optics and Optoelectronics, Tata McGraw Hill, New Delhi. Eds. Sahu PP and Deb P, pp.79-81, 2007.
[2]  Subhash N., Laser induced fluorescence in remote detection of vegetation health, CESS Silver Jubilee Compendium, Eds. G.R. Ravindrakumar and N. Subhash, Published by Director, CESS, Trivandrum, Chapter 28, pp. 427-444, 2004.
[3]  Rakhesh V., Subhash N., Mohanan C.N. and Muralidharan V., Air pollution stress detection in plants by laser induced chlorophyll fluorescence, Proc. of the DAE-BRNS National Laser Symposium (Allied Publishers, New Delhi), at SCTIMST, Trivandrum, India, pp. 282-284, 2002.
[4]  Ravindrakumar G.R. and Subhash N. (Eds.), Earth system science and natural resources management, CESS Silver Jubilee Compendium, Centre for Earth Science Studies, 470p., 2004.
[5]  Rupananda Mallia and Subhash Narayanan, Photodiagnosis of Oral Malignancy-Basic, Translational and Clinical, Lap Lambert Academic Publishing GmbH, Germany, 175p, 2010.