International Journal of Surgical Research

International Journal of Surgical Research reports clinical investigations or fundamental research bearing directly on surgical management that will be of general interest to a broad range of surgeons and surgical researchers. It features original clinical and experimental papers, condensed reviews of new knowledge relevant to surgical research, and short technical notes serving the information needs of investigators in various fields of operative medicine.

Raffaele Cursio

Editor-in-Chief of International Journal of Surgical Research

Research Scientist, Service de Chirurgie Digestive et Transplantation Hépatique, France

Research Areas

Liver Ischemia-reperfusion Injury, Liver Regeneration, Xenotransplantation, Liver Ischemia-reperfusion Injury and Kidney Injury

Education

2002Ph.DSurgical Sciences, University of Paris XI, France

Experience

2003-presentAssistant Surgeon in General Surgery and Liver Transplantation, Archet 2 Hospital, University of Nice Sophia Antipolis, France
1999-2003Assistant Surgeon in Urology, Princesse Grace Hospital, Monaco
1993-1999Resident in General Surgery and Liver, Transplantation, Archet 2 Hospital, University of Nice Sophia Antipolis, France
1993Resident in Hepatobiliary Surgery, Liver Unit, Cardarelli Hospital, Naples, Italy
1992-1993Resident in Emergency Surgery, Cardarelli Hospital, Naples, Italy

Academic Achievement

October 2009, First class award 2009, Hospital Project for Clinical Research Centre Hospitalier Princesse Grace de Monaco, Monaco
June 1999, The 1999 Award of the French Association of Hepato-Biliary Surgery and Liver Transplantation, Journées de Printemps de l'ACHBT, Montpellier, France
March 1999, First class award, Contract of Incitation to Clinical Research, University of Nice Sophia Antipolis, France
February 1996, Prize of the Mediterranean Association for the Development of Transplantation, Marseille, France

Membership

Centre d'Enseignement et de Recherche en Chirurgie (C.E.R.C.), France
European Association of Urology
Association pour la Recherche sur les Tumeurs de la Prostate, Paris, FranceSocietà Italiana Trapianti dOrgano (SITO)
Società Italiana d’Urologia (SIU)

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Mouiel J, Gugenheim J, Toouli J, Crafa F, Cursio R, Chastanet S. Port site recurrence of cancer associated with laparoscopic diagnosis and resection: the european experience. Sem Lap Surg 1995;2:167-75.
[2]  Cursio R, Gugenheim J, Tovey M, Lasfar A, Crafa F, Michiels JF, Mouiel J. Protective properties of anti-IFNantibodies in normothermic hepatic ischemia in the rat. Transplant Proc 1996;28:73-4.
[3]  Fabiani P, Bartels M, Cursio R, Crafa F, Gugenheim J, Mouiel J. Traitement par voie coelioscopique des péritonites appendiculaires chez l'adulte. Ann Chir 1996;50:892-5 (selected in: Digest, Br J Surg 1997;84:936-9).
[4]  Militerno G, Gugenheim J, Cursio R, Hofman P, Saint-Paul MC, Damais A, Mouiel J. Prolongation of discordant heart xenograft survival after liver hemoperfusion: role of nonparenchymal liver cells. Eur Surg Res 1997;29:356-61.
[5]  Chastanet S, Cursio R, Gugenheim J, Baldini E, Chevallier A, Damais A, Charpentier B, Mouiel J. Brequinar sodium and liver hemoperfusion in xenotransplantation. Transplant Proc 1998;30:2244-5.
[6]  Zecca L, Mesonero JE, Stutz A, Poirée J-C, Giudicelli J, Cursio R, Gloor SM, Semenza G. Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sits; the role of the pancreas in Pro-LPH maturation. FEBS Lett 1998;435:225-8.
[7]  Cursio R, Gugenheim J, Panaia-Ferrari P, Lasfar A, Tovey M, Chastanet S, Ferré C, Saint-Paul MC, Mouiel J. Improvement of rat normothermic liver ischemia/reperfusion by muramyl dipeptide. J Surg Res 1998;80:339-44.
[8]  Cursio R, Gugenheim J, Ricci JE, Crenesse D, Rostagno P, Maulon L, Saint-Paul MC, Ferrua B, Auberger P. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inibition of liver apoptosis. FASEB J 1999;13:253-61.
[9]  Cursio R, Gugenheim J, Mouiel J, Saint-Paul MC, Ragusa L, Bronzino E, Canino V. Biocompatibility of suture materials used in colonic surgery: experimental study in the rat. Minerva Chir 1999;54:49-55.
[10]  Cursio R, Gugenheim J, Panaia-Ferrari P, Lasfar A, Tovey M, Chastanet S, Ferré C, Saint-Paul MC, Crenesse D, Mouiel J. Modulation of kupffer cell activity by muramyl dipeptide ameliorates normothermic liver ischemia/reperfusion in rats. Transplant Proc 1999;31:2146-7.
[11]  Astarcioglu I, Cursio R, Reynes M, Gugenheim J. Increased risk of antibody-mediated rejection of reduced-size liver allografts. J Surg Res 1999;87:258-62.
[12]  Crenesse D, Gugenheim J, Hornoy J, Tornieri K, Laurens M, Cambien B, Lenegrate G, Cursio R, De Souza G, Auberger P, Heurteaux C, Rossi B. Protein kinase activation by warm and cold hypoxia-reoxigenation in primary-cultured rat hepatocytes-JNK(1)/SAPK(1) involvement in apoptosis. Hepatology 2000;32:1029-36.
[13]  Cursio R, Gugenheim J, Ricci JE, Crenesse D, Rostagno P, Maulon L, Saint-Paul MC, Ferrua B, Mouiel J, Auberger P. Caspase inhibition protects from liver injury following ischemia and reperfusion in rats. Transpl Int 2000;13(suppl.1):S568-72.
[14]  Crenesse D, Schmid-Alliana A, Laurens, Cursio R, Gugenheim J. JNK(1)/SAPK(1) involvement in hypoxia-reoxigenation-induced apoptosis in rat hepatocytes. Transplant Proc 2001;33:260-1.
[15]  Cursio R. Ischemia-Reperfusion. Press Med 2001;30:29-30.
[16]  Cursio R, Choquenet C, Brunner Ph. Successful transarterial embolization of idiopathic renal arteriovenous fistula. Minerva Chir 2001;56:321-3.
[17]  Cursio R, Mari B, Saint-Paul M-C, Rostagno Ph, Louis K, Dive V, Gugenheim J, Auberger P. Matrix metalloproteinases inhibition decreases liver ischemia/reperfusion injury in rats. FASEB J Nov 14,2001 (online fj.01-0279fje).
[18]  Cursio R, Mari B, Saint-Paul M-C, Rostagno Ph, Louis K, Dive V, Gugenheim J, Auberger P. Rat liver injury after normothermic ischemia is prevented by a phosphinic matrix metalloproteinase inhibitor. FASEB J 2002;16:93-95.
[19]  Crenesse D, Tornieri K, Laurens M, Heurteaux C, Cursio R, Gugenheim J, Schimd-Alliana A. Diltiazem reduces apoptosis in rat hepatocytes subjected to warm hypoxia reoxygenation. Pharmacology 2002;65:87-95.
[20]  Cursio R, Choquenet C. Laparoscopic tumorectomy of renal carcinoma recurred in remaining kidney. Minerva Chir 2002;57:507-8.
[21]  Cursio R, Choquenet C. Iatrogenic bladder stone formation on adsorbable suture 3-years after radical prostatectomy. Minerva Urol Nefrol 2002;54:127-8.
[22]  Foligne B, Senegas-Balas F, Cursio R, Cayuela C, Antoine J-M, Rolf-Petersen N, Balas D. Consequences of adrenalectomy on small intestine trophic parameters in aged rats contrast with young ones: evidence of a defective adaptation by aging and lack of corticoids. Dig Dis Sci 2003;48:1147-58.
[23]  Crenesse D, Laurens M, Herteaux C, Cursio R, Saint-Paul MC, Schmid-Alliana A, Gugenheim J. Rat liver ischemia-reperfusion-induced apoptosis and necrosis are decreased by FK506 pretreatment. Eur J Pharmacol 2003;473:177-184.
[24]  Cursio R. Surgical research and technology: new therapeutic approaches in liver transplantation. Chirurgia 2004;17:5-9.
[25]  Cursio R. Filippa N, Miele C, Colosetti P, Auberger P, Van Obberghen E, Gugenheim J. Fas ligand expression following normothermic liver ischemia-reperfusion. J Surg Res 2005;125:30-6.
[26]  Cursio R. Filippa N, Miele C, Van Obberghen E, Gugenheim J. Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury. Br J Surg 2006;93:752-61.
[27]  Cursio R. Miele C, Filippa N, Van Obberghen E, Gugenheim J. Alterations in protein tyrosine kinase pathways in rat liver following normothermic ischemia-reperfusion. Transplant Proc 2006;38:3362-65.
[28]  El-Ghoneimi A, Cursio R, Schmid-Alliana A, Tovey M, Rossi B, Gugenheim J. Pentoxifylline inhibits liver expression of tumor necrosis factor alpha mRNA following normothermic ischemia-reperfusion. HPB 2007;9:112-119.
[29]  Bini R, Cursio R, Belhacene N, Giudicelli J, Ferruà B, Olivero G, Auberger P, Mari B, Gugenheim J, Cotogni P. Effect of caspase inhibition on thymic apoptosis in hemorrhagic shock. J Invest Surg 2007;20:97-103.
[30]  El-Ghoneimi A, Cursio R, Schmid-Alliana A, Tovey M, Rossi B, Gugenheim J. Inhibition of tumor necrosis factor alpha gene transcription by pentoxifylline reduces normothermic liver ischemia-reperfusion injury in rats. Transplant Proc 2007;39:1761-4.
[31]  Cursio R, Defamie V, Le Brigand K, Moreilhon C, Saint-Paul M-C, Laurens M, Crenesse D, Cardinaud B, Auberger P, Gugenheim J, Barbry P, Mari B. Gene expression profiling of human liver transplants identifies an early transcriptional signature associated with initial poor graft function. Am J Transplant 2008;8:1221-36.
[32]  Cursio R, Colosetti P, Auberger P, Gugenheim J. Liver apoptosis following normothermic ischemia-reperfusion: in vivo evaluation of caspase activity by Flivo assay. Transplant Proc 2008;40:2038-41.
[33]  Cursio R, Miele C, Filippa N, Van Obberghen E, Gugenheim J. Liver HIF-1 alpha induction precedes apoptosis apoptosis following normothermic ischemia-reperfusion. Transplant Proc 2008;40:2042-5.
[34]  Baldini E, Cursio R, De Sousa G, Margara A, Honiger J, Saint-Paul MC, Bayer P, Raimondi V, Rahmani R, Mouiel J, Gugenheim J. Peritoneal implantation of cryopreserved encapsulated porcine hepatocytes in rats without immunosuppression: viability and function. Transplant Proc 2008;40:2049-52.
[35]  Cursio R, Miele C, Filippa N, Colosetti P, Auberger P, Van Obberghen E, Gugenheim J. Tyrosine phosphorylation of insulin receptor substrates during ischemia/reperfusion-induced apoptosis in rat liver. Langenbecks Arch Surg 2009;394:123-31.
[36]  Baldini E, Cursio R, De Sousa G, Margara A, Honiger J, Saint-Paul MC, Bayer P, Raimondi V, Rahmani R, Mouiel J, Gugenheim J. Cryopreserved porcine hepatocytes: expression and induction of cytochrome P450, isoform CYP2E1. Transplant Proc 2009;41:1367-69.
[37]  Cursio R, Colosetti P, Saint-Paul M-C, Pagnotta S, Gounon P,Iannelli A, Auberger P, Gugenheim J. Induction of different types of cell death after normothermic liver ischemia-reperfusion. Transplant Proc 2010 ;42 :3977-3980.
[38]  Cursio R, Auberger P, Gugenheim J. Inhibition of apoptosis: a new therapeutic approach to prevent liver ischemia/reperfusion lesions? Gastroenterol Clin Biol 2000;24:607-8.
[39]  Cursio R. Caspase inhibition in liver transplantation: from basic research to clinical studies. HPB 2010;12:1-3.
[40]  Mouiel J, Crafa F, Iovine L, Cursio R, Baqué P. Risque oncologique en laparoscopie. In: Jean Mouiel, Actualités Digestives Médico-Chirurgicales, XVIe Série, ed. Masson 1995, pp. 50-6.
[41]  Mouiel J, Crafa F, Cursio R, Stubinski R, Gugenheim J. Oncological risk in laparoscopic surgery. In: Greene F, Rosin D (eds), Minimal Access Surgical Oncology, Radcliffe Medical Press, Oxford, New York 1995, pp. 167-82.
[42]  Mouiel J, Crafa F, Cursio R, Gugenheim J. Oncological risks in laparoscopic surgery. In: Gasless Laparoscopy in General surgery and Gynecology: Diagnostic and Therapeutic Procedures. Paolucci V., Schaeff B., editors, New York, Thieme, 1996, pp. 24-9.
[43]  Crafa F, Baqué P, Fabiani P, Cursio R, Migliori G, Chastanet S, Mouiel J. Polypes colo-rectaux : rendez-vous laparoscopique. In: Jean Mouiel, Actualités Digestives Médico-Chirurgicales, XVIIe Série, ed. Masson, 1996, pp. 37-41.
[44]  Mouiel J, Gugenheim J, Crafa F, Cursio R, Iovine L, Chastanet S. Rôle de la laparoscopie dans le cancer du pancréas. In: Jean Mouiel, Actualités Digestives Médico-Chirurgicales, XVIIe Série, ed. Masson, 1996, pp. 120-6.
[45]  Cursio R, Auberger P, Gugenheim J. Inhibition of apoptosis: a new therapeutic approach to prevent liver ischemia/reperfusion lesions? Gastroenterol Clin Biol 2000;24:607-8.
[46]  Cursio R, Filippa N, Miele C, Gugenheim J, Van Obberghen E. The role of PKB in anti-apoptotic signals during normothermic liver ischemia/reperfusion injury in rats. In: Proceedings of the 38th Congress of the European Society for Surgical Research. Ed. Monduzzi, Bologna, Italy, 2003, pp. 95-103.
[47]  Cursio R, Bini R, Belhacene N, Giudicelli B, Ferruà B, Olivero G, Auberger P, Mari B, Gugenheim J. Caspase inhibitor Z-VAD-FMK failed to protect rats from sublethal hemorrhagic shock. In: Proceedings of the 38th Congress of the European Society for Surgical Research. Ed. Monduzzi, Bologna, Italy, 2003, pp. 87-94.
[48]  Cursio R, Filippa N, Miele C, Van Obberghen E, Gugenheim J. Role of FAS Ligand in normothermic liver ischemia/reperfusion injury in rats. In: Proceedings of the 39th Congress of the European Society for Surgical Research. Ed. Monduzzi, Bologna, Italy, 2004, pp.145-55.
[49]  Cursio R, Bini R, Olivero G, Cotogni P, Castagna E, Gugenheim J. Pharmacological modulation of NF-kappa B an HSP70 in a rat hemorrhagic shock model. In: Proceedings of the 39th Congress of the European Society for Surgical Research. Ed. Monduzzi, Bologna, Italy, 2004, pp. 187-99.
[50]  Cursio R. Autophagy and liver ischemia-reperfusion injury. In Autophagy: Principles, Regulation and Role in Diseases, Nova Publisher, New York, USA (in press).