Journal of Microbiology Research

Journal of Microbiology Research aims to publish all the latest and outstanding research articles, reviews and letters in all areas of major importance to techniques of microbiology and applied research. It publishes high quality research and review papers on novel aspects of microbiology, including environmental, food, agricultural, medical, pharmaceutical, veterinary, soil, water and biodeterioration.

Huali Jin

Editorial Board Member of Journal of Microbiology Research

Post-doctoral Fellow, University of Illinois At Chicago, USA

Research Areas

Virology, Immunology, Vaccinology


1997-2001B.S College of Life Science and Technology, Xinjiang University, Urmuqi, China
2001-2004M.SXinjiang Key Laboratory for Bioreasources and Bioengineering, College of Life Science and Technology, Xinjiang University, Urmuqi, China
2004-2007Ph.DState Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agriculture University, Beijing, China


2007-presentPostdoctoral training, University of Illinois at Chicago, Illinois, USA, Herpes simplex virus 1 (HSV-1)infection and host innate immune responses, Herpes simplex virus 1 (HSV-1) recombinant virus vaccine, Ebola virus protein VP35 function
2004-2007China Agricultural University, Beijing China, Foot and Mouth Disease Virus (FMDV) DNA vaccine, Hepatitis B virus (HBV) DNA vaccine, New vaccine adjuvant, Vaccination against allergic diseases

Academic Achievement

Nominated as the best 100 Ph.D. thesis in China in 2009
The President Fellowship in China Agriculture University in 2005

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Huali Jin, Zhipeng Yan, Bellur Prabhakar, Zondi Feng, Yijie Ma, Dustin Verpooten, Balaji Ganesh and Bin He. The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide. Journal of General Virology. 2009, 91:352-361
[2]  Huali Jin, Yijie Ma, Bellur Prabhakar, Zondi Feng, Tibor Valyi-Nagy, Zhipeng Yan, Dustin Verpooten, Youjia Cao and Bin He. Interference of the Maturation of Dendritic cells by the γ134.5 protein of Herpes Simplex Virus 1. Journal of Virology. 2009, 83:4984-4994
[3]  Huali Jin, Chong Xiao, Shuang Geng, Yanxin Hu, Ruiping She, Yang Yu, Youmin Kang and Bin Wang. Protection from asthma due to antigen specific Tr cells induced by co-vaccination. Eur. J. Immunol. 2008. 38: 2452–2464
[4]  Huali Jin, Lin Zhao, Youmin Kang, Chong Xiao, Yanxin Hu, Ruiping She, Yang Yu, Xiaogang Du, Gan Zhao, Terry Ng, Hsien-Jue Chu, and Bin Wang. Induction of adaptive T regulatory cells that suppress the allergic response by coimmunization of DNA and protein vaccines. Journal of Immunology. 2008 180(8):5360-5372
[5]  Huali Jin, Chong Xiao, Gan Zhao, Xiaogang Du, Yang Yu, Youmin Kang and Bin Wang. Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection. J Cell Biochem. 2007 102(4):980-991
[6]  Huali Jin, Xiao Wang, Chong Xiao, Yang Yu, Youmin Kang, Xiaogang Du, Xuefeng Wei and Bin Wang. Protective immune responses against foot-and-mouth disease virus by vaccination with a DNA vaccine expressing virus-like particles. Viral Immunol. 2007, 20(3):429-440
[7]  Huali Jin, Youmin Kang, Guoxing Zheng, Qifa Xie, Chong Xiao, Xinyu Zhang, Yang Yu, Kaichun Zhu, Gan Zhao Fuchun Zhang, Aoshuang Chen and Bin Wang.Induction of active immune suppression by co-immunization with DNA-and protein-based vaccines. Virology 2005; 37:183-191
[8]  Huali Jin, Chong Xiao, Ze Chen, Youmin Kang, Yijie Ma, Kaichun Zhu, Qifa Xie, Yixian Tu, Yang Yu and Bin Wang. Induction of Th1 type response by DNA vaccinations with N, M, and E genes against SARS-CoV in mice. Biochemical and Biophysical Research Communications 2005. 328:979–986
[9]  Huali Jin, Youmin Kang, Chong Xiao, Kaichun Zhu, Yijie Ma, Qifa Xie, Junwu Ma, Qingge Xie, Cheng He, Zhansheng Yang, Zhi Sun, Xinyu Zhang, Mingyong Chen, Fuchun Zhang and Bin Wang. DNA prime followed by protein boost enhances neutralization and Th1 type immunity against FMDV. Viral Immunology 2005. 18(3):539-548
[10]  Huali Jin, Yijie Li, Zhenghai Ma, Fuchun Zhang, Qingge Xie, Dengfeng Gu and and Bin Wang. Effect of chemical adjuvants on DNA vaccination. Vaccine 2004.22:2925-2935
[11]  Wenjuan Zhang, Huali Jin, Yanxin Hu, Yang Yu, Xiaolin Li, Zheng Ding, Youmin Kang and Bin Wang. Protective response against type 1 diabetes in NOD mive after co-immunization of insulin and DNA encoding pro-insulin. Human Gene Therapy. 2009, Seq 29. Epub ahead of print
[12]  Dustin Verpooten, Zongdi Feng, Tibor Valyi-Nagy, Yijie Ma, Huali Jin, Zhipeng Yan, Youjiao Cao and Bin He. Dephosphorylation of eiF2{alpha} mediated by the{gamma}134.5 protein of herpes simplex virus 1 facilitates viral neuroinvasion. Journal of Virology. 2009, 83:12626-12630
[13]  Wenjuan Zhang, Xiaogang Du, Gan Zhao, Huali Jin, Youmin Kang, Chong Xiao, Minyu Liu and Bin Wang. Levamisole is a potential facilitator for the activation of Th1 responses of the subunit HBV vaccination. Vaccine. 2009, 27:4938-4946
[14]  Gan Zhao, Huali Jin, Jinyao Li, Baowei Su, Xiaogang Du, Youmin Kang, Xiao Wang and Bin Wang. PyNTTTTGT prototype oligonucletide IMT504, a novel effective adjuvant of the FMDV DNA vaccine. Viral Immunology, 2009, 22(2):131-138
[15]  Xiaolin Li, Huali Jin, Zhifang Wu, Simon Rayner & Bin Wang. A continuous process to extract plasmid DNA based on alkaline lysis. Nat. Protocl, Nature Protocols 2008, 3:176-180
[16]  Jinyao Li, Huali Jin, Fuchun Zhang, Xiaogang Du, Gan Zhao, Yang Yu and Bin Wang. Treatment of autoimmune ovarian disease by co-administration with mZP3 and DNA vaccine through induction of adaptive Treg cells. J Gene Medicine 2008, 10:810-820
[17]  Xiao Wang, Xinyu Zhang, Youming Kang, Huali Jin, Xiaogang Du, Gan Zhao, Yang Yu, Jinyao Li, Baowei Su, Chang Huang and Bin Wang. Interleukin-15 Enhance DNA Vaccine Elicited Mucosal and Systemic Immunity against Foot and Mouth Disease Virus. Vaccine 2008, 26:5135-5144
[18]  Xiao Wang, Huali Jin, Xiaogang Du, Chun Cai, Yang Yu, Gan Zhao, Baowei Su, Shan Huang, Yanxin Hu, Dongmei Luo, Ruiping She, Xinsong Luo, Xianfang Zeng, Xinyuan Yi and Bin Wang. The protective efficacy aganist Schistosoma japonicum infection by immunization with DNA vaccine and levamisole as adjuvant in mice. Vaccine 2008, 26:1832-1845
[19]  Baowei Su, Junpeng Wang, Xiao Wang, Huali Jin, Gan Zhao, Zheng Ding, Youmin Kang and Bin Wang. The effects of IL-6 and TNF-alpha as molecular adjuvants on immune responses to FMDV and maturation of dendritic cells by DNA vaccination. Vaccine, 2008, 26: 5111-5122
[20]  Yang Yu, Huali Jin, Ze Chen, Qingling Yu, Yijie Ma, Chong Xiao, Xiaolin Sun and Bin Wang. Children vaccines do not induce the cross-reactivity against SARS-CoV. J. Clin. Pathol. 2007, 60:208-211
[21]  Youmin Kang, Huali Jin, Guoxing Zheng, Xiaogang Du, Chong Xiao, Xiaoying Zhang, Shuang Geng, Xiaolin, Li, Aoshuang Chen and Bin Wang. Co-Inoculation of DNA and Protein Vaccines Induces Antigen Specific T Cell Suppression. BBRC 2007, 353:1034-1039
[22]  Kaichun Zhu, Huali Jin, Chong Xiao, Zhonghuai He, Qinghong Zhu and Bin Wang. A continuous thermal lysis for the large-scale preparation of plasmid DNA. Nat. Protocl, 2007, 1:3088-3093
[23]  Xiaogang Du, Guoxing Zheng, Huali Jin, Youmin Kang, Junpeng Wang, Chong Xiao, Shuo Zhang, Mingyu Liu, Lin Zhao, Aoshuang Chen and Bin Wang. Effect of the Co-stimulatory molecules, 4-1BBL, OX40L and CD70, as adjuvants on the cellular and memory responses on HBsAg DNA vaccination. J. Gene Medicine, 2007; 9: 136–146
[24]  Jiangmei Yin, Huali Jin, Fu Yang, Zen Ding, Chang Huang, Qinghong Zhu and Bin Wang. Synergistic effects of the adjuvants IFN-gamma and levamisole on DNA vaccination against the infection of Newcastle disease virus. Viral Immunol. 2007, 20:288-299
[25]  Xiaolin Li, Huali Jin, Zhifang Wu, Simon Rayner, Jiangmei Yin, Yang Yu, Wenjuan Zhang, Zhonghuai He, Chen Wang and Bin Wang. An automated process extracts plasmid DNA by alkaline lysis. Appl Microl and Biotech 2007, 75:1217-1223
[26]  Chong Xiao, Huali Jin, Yanxin Hu, Junpeng Wang, Xiaogang Du, Youmin Kang, Yu Yang, Ruiping She and Bin Wang. Enhanced protective efficacy and reduced viral load of foot-and-mouth disease DNA vaccine with co-stimulatory molecules as the molecular adjuvants. Antiviral Research 2007, 76:11-22
[27]  Xiang Li, Bin Wang, Huali Jin, Jiang Wei, Tian Jiesheng, Guan Feng and Yin Li. Bacterial Magnetic Particles (BMPs)-PEI as a novel non-viral vector for efficient gene delivery in vitro and in vivo. J Gene Medicine 2007 9: 679–690
[28]  Yanxin Hu, Huali Jin, Xiaogang Du, Chong Xiao, Dongmei Luo, Bin Wang, and Ruiping She. Effects of Chronic Heat Stress on Immune Responses of the Foot-and-mouth Disease (FMD) DNA Vaccination. DNA & Cell Biology, 2007, 26(8):619-626
[29]  Jinyao Li, Huali Jin, Ailian Zhang, Yijie Li, Bin Wang and Fuchun Zhang. Enhanced contraceptive response by co-immunization of DNA and protein vaccines encoding the mouse zona pellucida 3 with minimal oophoritis in mouse ovary. J Gene Med. 2007, 9:1095-1103
[30]  Ping Tai, Junpeng Wang, Huali Jin, Xiaoming Song, Jun Yan, Youmin Kang, Lin Zhao, Xiaojin An, Xiaogang Du, Xiufen Chen, Guoliang Xia and Bin Wang. Estrogen is a potential mediator to convert activated CD4+CD25-T cells into CD4+CD25+ regulatory T cells. J. Cell. Physol. 2008, 214:456-464
[31]  Ailiang Zhang, Huali Jin, Fuchun Zhang, Zhenghai Ma, Yixian Tu, Zhihui Ren, Xinyu Zhang, Kaichun Zhu and Bin Wang. Effects of multiple copies of CpG on DNA vaccination. DNA and Cell Biology, 2005, 24: (5)292-298
[32]  Kaichun Zhu, Huali Jin, Yijie Ma, Zhihui Ren, Chong Xiao, Zhonghuai He, Fuchun Zhang, Qinghong Zhu and Bin Wang. A continuous thermal lysis for large-scale preparation of plasmid DNA. J. Biotechnology, 2005 118:457-464
[33]  Youmin Kang, Huali Jin, Qifa Xie, Jiangmei Yin, Yang Yu, Chong Xiao, Xiaoying Zhang and Bin Wang. Effect of Levamisole as an Adjuvant on Inactivated Viral Vaccine. Vaccine, 2005, 23:5543-5550
[34]  Jiangmei Yin, Huali Jin, Qifa Xie, Youmin Kang, Chong Xiao, Lin zhao, Xiaolin Li, Zheng Ding and Bin Wang. Effect of LMS+ adjuvant on inactivated LaSota vaccine. Viral Immunology 2006, 19(3): 525-535
[35]  Lin Zhao, Huali Jin, Chong Xiao, Steve Chu, Terry Ng, Ruiping She, Yanxin Hu and Bin Wang. A Rodent Model for Flea Allergy Dermatitis Induced By Flea Antigen. Vet. Immun. Immunopath. 2006, 114:285–296