American Journal of Medicine and Medical Sciences

American Journal of Medicine and Medical Sciences aims to promote communication among clinical researchers worldwide. This journal publishes original works within the area of clinical medicine. It is academically peer-reviewed and designed for all doctors, researchers, and health workers regardless of their medical specialties, or type of employment.

Lingling Xian

Research Associate, Johns Hopkins University Medical Institue, USA

Research Areas

Adult stem cell,Cancer stem cell biology (MSC,HSC,ISCs).Moleucar mechnism of  Cancer (liver cancer, leukemia). Signaling pathway-wnt, IGF, GH, TGF-B, PTH.Transcription factors- p53,NFkB,Runx1, Runx2, GATA, HMG, Sry. Epigentics.Regenerative medicine.Bone biology

Publications: Journals

[1]  Xian L, Huff CA, Resar ML. IBRUTinib: BRUTe Force against Bortezomib-Resistant Myeloma Cells. Cell Cycle. 2015;14(9):1349-50
[2]  Xian L, Wu X, Pang L, Lou M, Rosen C, Qiu T, Crane J, Frassica F, Zhang L, Pablo Rodriguez J,Jia, Yakar S,Xuan S, Efstratiadis A, Wan M, and Cao X. Matrix IGF-1 regulates bone mass by activation of mTOR in mesenchymal stem cells. Nature Medicine.2012;18(7):1095-101
[3]  Xian L, Lou M, Wu X,Yu B, Frassica F,Wan M, Pang L, Wen C, Tryggestad E, Wong J, and Cao X. Pretreatment with antioxidants prevent bone injury by improving bone marrow microenvironment for stem cells. Stem Cell Discovery.2012;2(3):100-107
[4]  Xie H, Cui Z, Wang L, Xia ZY, Hu Y, Xian L , Li CJ, Xie L, Crane J, Wan M , Zhen GH, Bian Q ,Chang WZ, Qiu T, Pickarski M, Duong L, Windle JJ, Luo XH , Liao EY, Xu Cao. PDGF-BB secreted by preosteoclasts induces CD31hiEmcnhi vessel subtype in coupling osteogenesis. Nature Medicine 2014 20:1270-1278
[5]  Williams MD, Zhang Xing, Park Jeong-Jun, Belton Am Huso T, Xian L, Siems WF, Gang DR, Resar LMS*, Reeves R*, Hill HH, Jr*. HMGA1 drives metabolomics reprogramming of intenstinal epithelium during hyperproliferation, polyposis and colorectal carcinogenesis. Analytical Bioanalytical Chem 2015; 6;14(3):1420-31
[6]  Zhang H, Xian L, Lin Z, Yang C, Zhang M, Feng W, Peng X, Chen X, Wu X. Endothelial progenitor cells as a possible component of stem cell niche to promote self-renewal of mesenchymal stem cells. Mol Cell Biochem. 2014 Dec;397(1-2):235-4
[7]  Qiu T, Xian L, Crane J, Wen C, Hilton M, Lu W, Newman P, Cao X. PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. J Bone Miner Res. 2015 Feb;30(2):309-17.
[8]  Crane JL, Zhao L, Frye JS, Xian L, Qiu T, Cao X,IGF-1 Signaling is essential for differentiation of mesenchymal stem cells for peak bone mass. Bone Research 2013;2:186-194
[9]  Yu B, Zhao X, Yang C, Crane J, Xian L, Lu W, Wan M, Cao X.Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling.J Bone Miner Res.2012;27(9):2001-14
[10]  Cao X, Wu X, Frassica D, Yu B, Pang L, Xian L, Wan M, Lei W, Armour M,et al.Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells.ProcNatlAcadSci U S A. 2011;108(4):1609-14
[11]  Tan X, Yang L, Xian L, Huang J, Di C, Gu W, Guo S, Yang L. ATP-binding cassette transporter A1 (ABCA1) promotes arsenic tolerance in human cells via reducing cellular arsenic accumulation.ClinExpPharmacol Physiol. 2014 Apr;41(4):287-94
[12]  Jiao K, Zhang M, Niu L, Yu S, Zhen G, Xian L, Yu B, Yang K, Liu P, Cao X, Wang M. Overexpressed TGF-β in subchondral bone leads to mandibular condyle degradation.J Dent Res. 2014 Feb;93(2):140-7
[13]  Xian L, Zhao J, Wang J, Fang Z, Peng B, Wang W, Ji X, Yu L..p53 promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2. MolBiol Rep. 2010;37(6):2935-40
[14]  Peng B, Cao L, Wang W, Xian L, Jiang D, Zhao J, Zhang Z, Wang X, Yu L. Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies.Mutagenesis. 2010;25(1):41-8
[15]  Zhang Y, Zhang S, Xian L, Tang J, Zhu J, Cui L, Li S, Yang L, Huang J.Expression and purification of recombinant human neuritin from Pichia pastoris and a partial analysis of its neurobiological activity in vitro.Appl Microbiol Biotechnol. 2015 Jun 6
[16]  Gao P, Zhou Y, Xian L,Li C,et al, Functional Effects of TGF-β1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma. J Immunol. 2014; 15;192(10):4560-70

Publications: Books/Book Chapters

[1]  Xian Lingling, Wu Qingfeng. Chapter 3: Basic Structure and Functions of the Eukaryotic cells (Medical Cell Biology, Text book for Chinese Medical school) Published at May 2004(The 3rd edition) by Publishing Company of Fudan University,China.