American Journal of Medicine and Medical Sciences

American Journal of Medicine and Medical Sciences aims to promote communication among clinical researchers worldwide. This journal publishes original works within the area of clinical medicine. It is academically peer-reviewed and designed for all doctors, researchers, and health workers regardless of their medical specialties, or type of employment.

Lei Zhang

Editorial Board Member of American Journal of Medicine and Medical Sciences

Research Scientist, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, USA

Research Areas

Cancer Diagnostics/Biomarker Research


2005Ph.DMicrobiology and Molecular Biology, University of Bremen, Germany
2001M.ScDevelopmental Biology and Molecular Genetics, Shandong Normal University, China
1998B.ScBiology, Shandong Normal University, China


2010-presentPrinciple Investigator, Cancer Diagnostics/Biomarker Research (TRDRP,CBCRP), Division of Oral Biology and Medicine, School of Dentistry, Universityof California, Los Angeles, USA
2008Assistant Researcher (Research Faculty). Division of Oral Biology andMedicine, School of Dentistry, University of California, Los Angeles, USA
2007-2008Postdoctoral Researcher, Molecular Diagnostics. Division of Oral Biology andMedicine, School of Dentistry, University of California, Los Angeles, USA
2006-2007Research Scholar. Clinical Microbial Diagnostics. Department of BiologicalSciences, School of Dental Medicine, Case Western Reserve University, USA
2001-2006Staff Scientist. Design and application of oligonucleotide microarray. Centre ofApplied Gene Sensor Technology, Max Planck Institute; & Faculty of Biologyand Chemistry, University of Bremen, Germany

Academic Achievement

2010 California Breast Cancer Research Program Symposium Innovation Award
2010 California Breast Cancer Research Program Symposium Best Poster Award
2010 Tobacco-Related Disease Research Program New Investigator Award
2010 California Breast Cancer Research Program Innovative, Exploratory & Developmental Awards


Steering committee, Lung Cancer Early Detection Initiative Input Meeting
Oral Session Chairman, Salivary Diagnostics, 39th Annual Meeting of the AADR
Member, American Association for Cancer Research
Member, International/American Association for Dental Research
Member, American Association for the Advancement of Science (AAAS)
Keynote speaker, European Concerted Action Research Action Final Report Conference

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Yan, X., Elashoff, D., Akin, D., Santiago, S., Zhang, L.* (Corresponding Author). Gene expression profiles in saliva of lung adenocarcinomas of smokers and nonsmokers. Journal of Molecular Biomarkers & Diagnosis. 2011, accepted.
[2]  Farrell, J.J.*, Zhang, L. (Co-first Author), Zhou, H., Chia, D., Elashoff, D., Paster, B.J. et al.. Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut. 2011, in press.
[3]  Lee, Y., Zhou, H., Reiss, J.K., Yan, X., Zhang, L., et al.. Direct saliva transcriptome analysis. Clinical Chemistry. 2011, in press.
[4]  Zhang, L.* (Corresponding Author), Xiao, H., Karlan, S., Zhou, H., Gross, J., et al.. Discovery and Preclinical Validation of Salivary Transcriptomic and Proteomic Biomarkers for the Non-Invasive Detection of Breast Cancer. PLoS ONE. 2010; 5(12): e15573.
[5]  Zhang, L., Farrell, J.J., Zhou, H., Elashoff, D., Akin, D., et al.. Salivary Transcriptomic Biomarkers for Detection of Resectable Pancreatic Cancer. Gastroenterology, 2010; 138: 949-957.
[6]  Brinkmann, O., Zhang, L., Giannobile, W., Wong, D.T.. Salivary biomarkers for periodontal disease diagnostics. Expert Opinion on Medical Diagnostics. 2011; 5(1), 25-35.
[7]  Hu, S., Gao, K., Pollard, R., Arellano, M., Zhou, H., Zhang, L., et al.. Preclinical validation of salivary biomarkers for primary Sj√∂gren's syndrome. Arthritis Care & Research. 2010; 62(11):1633-8.
[8]  Wei, F., Patel, P., Liao, W., Chaudhry, K., Zhang, L., et al.. Electrochemical Sensor for Multiplex Biomarkers Detection. Clinical Cancer Research, 2009; 15(13): 4446-52.
[9]  Gao, K., Zhou, H., Zhang, L., Lee, J. W., Zhou, Q., et al.. Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer. PLoS One, 2009; 4(6):e5875.
[10]  Zhang, L., Xiao, H., Wong, D. T. 2009. Salivary Biomarkers for Clinical Applications. Molecular Diagnosis & Therapy, 2009; 13(4):245-59.
[11]  Zhang, L., Henson, B., Camargo, P.M., Wong, D.T. 2009. The clinical value of salivary biomarkers for periodontal disease. Periodontology 2000, 2009; 51:25-37.
[12]  Farrell, J.J., Zhang, L., Sugimoto, Zhou, H., Elashoff, D., Gao, K., Paster, B. Wong, D.T. 2009. Multiple salivary biomarkers for pancreatic cancer detection. Gastroenterology, 136(1), 964.
[13]  Zhang, L., Jiang, J., Arellano, M., Zhang, L., Yan, X., Wong, D.T., Hu, S. 2008. Quantification of Serum Proteins of Metastatic Oral Cancer Patients Using LC-MS/MS and iTRAQ Labeling. The Open Proteomics Journal, 1, 72-78.
[14]  Han, Y., Zhang L., Chung, P., Kirchner L., Buhimschi, I., Buhimschi, C. 2007. Evidence of uncultivated bacteria as etiologic agents of intra-amniotic infection and inflammation leading to preterm birth (PTB). American Journal of Obstetrics and Gynecology, 197(6): 66.
[15]  Han, Y., Ikegami, A., Chung, P., Zhang, L., Zhou, Y. and Deng, C. 2007. Use of sonoporation for fluorescent dextran delivery and one-step doublecrossover mutant construction in Fusobacterium nucleatum. Applied and Environmental Microbiology, 73(11):3677-83.
[16]  Zhang, L., Hurek, T., Reinhold-Hurek, B. 2007. A nifH-based oligonucleotide microarray for functional diagnostics of nitrogen-fixing microorganisms. Microbial Ecology, 24(11):1385-91.
[17]  Zhang, L., Hurek, T., Reinhold-Hurek, B. 2005. Position of the fluorescent label is a crucial factor determining signal intensity in microarray hybridizations. Nucleic Acids Research, 33: e166.
[18]  Zhang, L., X. L. Ma, Q. Zhang, C. L. Ma, P. P. Wang, Y. F. Sun, Y. X. Zhao, and H. Zhang. 2001. Expressed sequence tags from a NaCl-treated Suaeda salsa cDNA library. Gene, 267:193-200.