American Journal of Medicine and Medical Sciences

American Journal of Medicine and Medical Sciences aims to promote communication among clinical researchers worldwide. This journal publishes original works within the area of clinical medicine. It is academically peer-reviewed and designed for all doctors, researchers, and health workers regardless of their medical specialties, or type of employment.

Eduardo Spinedi

Editor-in-Chief of American Journal of Medicine and Medical Sciences

Head of Academic Department/Faculty, IMBICE, Argentina

Research Areas

Neuroendocrinology, Obesity, Diabetes

Education

1976Bachelor in ChemistryFacultad de Ciencias Exactas de la Universidad Nacional de La Plata
1977MS in BiochemistryFacultad de Ciencias Exactas de la Universidad Nacional de La Plata
1987Ph.D in Biochemistry Facultad de Química, Bioquímica y Farmacia de la Universidad Nacional de San Luis
1997Biochemist Specialist in Endocrinology Colegio de Bioquímicos de la Provincia de Buenos Aires
1998Biochemist Specialist in Endocrinology Asociación Bioquímica Argentina and Argentine Society of Endocrinology

Experience

1982-1983Research Fellow, Department of Physiology, University of Texas at Dallas, USA
1983-1984Visiting Scientist, National Institutes of Health (NIH-NIEHS), Research Triangle-NC, USA
1984-1989Professional Biochemist, Centro de Referencia de Radioinmunoensayo de La Plata
1988-1989Visiting Scientist, Neuroendocrine Unit, University Hospital, Geneva, Switzerland
1988-1989Assistant Professor, University Hospital, Geneva, Switzerland
1989Associate Researcher, CONICET, Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE), CIC-CONICET
1989Independent Researcher, CONICET, Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE), CIC-CONICET
1991Visiting Scientist, Neuroendocrine Unit, University Hospital, Geneva, Switzerland
1992Visiting Scientist, Neuroendocrine Unit, University Hospital, Geneva, Switzerland
1993Visiting Scientist, Division of Endocrinology & Metabolism, University Hospital, Lausanne, Switzerland
1994Visiting Scientist, Division of Endocrinology & Metabolism, University Hospital, Lausanne, Switzerland
1995Visiting Scientist, Division of Endocrinology & Metabolism, University Hospital, Lausanne, Switzerland
1996Visiting Scientist, Division of Endocrinology & Metabolism, University Hospital, Lausanne, Switzerland
1997Visiting Scientist, Division of Endocrinology & Metabolism, University Hospital, Lausanne, Switzerland
1998Visiting Scientist, Division of Endocrinology & Metabolism, University Hospital, Lausanne, Switzerland
2000Sub-Director, Instituto Multidisciplinario de Biología Celular (IMBICE), CIC-CONICET
2000-2003Interim Director, Instituto Multidisciplinario de Biología Celular (IMBICE), CIC-CONICET
2001Principal Researcher, CONICET, Laboratorio de Neuroendocrinología, Instituto Multidisciplinario de Biología Celular (IMBICE), CIC-CONICET
2004Visiting Scientist, Division of Endocrinology & Metabolism, University Hospital, Lausanne, Switzerland
2006Visiting Scientist, Division of Endocrinology & Metabolism, University Hospital, Lausanne, Switzerland
2007Distingued Visiting Professor Catedra de Bioquímica, Facultad de Medicina, Universidad Complutense de Madrid
2009Visiting Scientist,, Catedra de Bioquímica, Facultad de Medicina, Universidad Complutense de Madrid

Membership

American Endocrine Society, since 1984
International Federation of Neuroendocrinology, since 1984
Swiss Society for Endocrinology and Diabetes, since 1994
Endocrinological Society of, Argentina, since 1986
Sociedad Argentina de Endocrinología y Metabolismo, since 1991
Society for Neuroscience, between 1993-2001
International Society for NeuroImmunoModulation, since 1998

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Moreno G, Perello M, Camihort G, Luna G, Console G, Gaillard RC, Spinedi E. Impact of transient correction of increased adrenocortical activity in hypothalamo-damaged, hyperadipose female rats. International Journal of Obesity 30:73-82
[2]   Franca LR, Suescun MO, Miranda JR, Giovambattista A, Perello M, Spinedi E, Calandra RS. Testis structure and function in a non-genetic hyperadipose rat model at prepubertal and adult ages. Endocrinology 147:15561563
[3]   Perello M, Chacon F, Cardinali DP, Esquifino AI, Spinedi E. Effect of social isolation on 24-h pattern of stress hormones and leptin in rats. Life Sciences 78:1857-1862
[4]   Giovambattista A, Piermaria J, Suescun MO, Calandra RS, Gaillard RC, Spinedi E. Direct effect of ghrelin on leptin production by cultured rat white adipocytes. Obesity Research 14:19-27
[5]   Spinedi E, Voirol MJ, Verdumo C, Giacominni M, Pralong F, Gaillard RC. Hypothalamic ghrelin treatment modulates NPY-but not CRH-ergic activity in adrenalectomized rats subjected to food restriction: evidence of a novel hypothalamic ghrelin effect. Endocrine 29:477-484
[6]   Perello M, Castrogiovanni D, Giovambattista A, Gaillard RC, Spinedi E. Impairment in insulin sensitivity after early androgenization in the post-pubertal female rat.Life Sciences 80: 1792-1798
[7]   Ghrelin Gene-Related Peptides Modulate Rat White Adiposity. Giovambattista A, Gaillard RC, Spinedi E. Vitamins and Hormones 77: 171-207
[8]   Effect of aging on 24-hour pattern of stress hormones and leptin in rats. Cano P, Cardinali DP, Spinedi E, Esquifino AI. Life Sciences 83: 142-148
[9]   Neuroendocrine, Metabolic, and Immune Functions during the Acute Phase Response of Inflammatory Stress in Monosodium L-Glutamate-Damaged, Hyperadipose Male Rat. Castrogiovanni D, Gaillard RC, Giovambattista A, Spinedi E. Neuroendocrinology 88: 227-234
[10]   Efecto de esteroides sexuales sobre la función endocrina adipocitaria e insulinosensibilidad periferica.Giovambattista A, Castrogiovami D, Spinedi E.Revista Argentina de Endocrinología y Metabolismo 45: 149-161
[11]  Prolonged but Not Short Negative Energy Condition Restored Corticoadrenal Leptin Sensitivity in the Hypothalamic Obese Rat.Perello M, Castrogiovanni D, Giovambattista A, Gaillard RC, Spinedi E. Neuroendocrinology 89: 276-287
[12]   Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats. Alzamendi A, Giovambattista A, Raschia A, Madrid V, Gaillard RC, Rebolledo O, Gagliardino JJ, Spinedi E.Endocrine 35: 227-232
[13]   Parametrial adipose tissue and metabolic dysfunctions induced by fructose rich diet in normal and neonatal-androgenized adult female rats. Alzamendi1A, Castrogiovanni D, Ortega HH, Gaillard RC, Giovambattista A, Spinedi E.Obesity (Silver Spring) 18: 441-448
[14]   Analysis of Angiotensin II-and ACTH-Driven Mineralocorticoid Functions and Omental Adiposity in a Non-Genetic, Hyperadipose Female Rat Phenotype. Perelló M, Cónsole G, Gaillard RC and Spinedi E Endocrine 37: 497-506
[15]   Increased male offspring's risk of metabolic-neuroendocrine dysfunction and overweight after fructose rich diet intake by the lactating mother Alzamendi A, Castrogiovanni D, Gaillard RC, Spinedi E, Giovambattista A Endocrinology 151:4214-4223.
[16]   Hypothalamic Obesity: A pivotal role of endogenous glucocorticoid. Spinedi E, Giovambattista A, Gaillard RC In: Glucocorticoids Effects, Action Mechanisms, and Therapeutic Uses. A.C. Pelt (ed). Nova Science Publishers, Inc. New York, USA. 1-22 (ISBN: 978-1-61728-758-9; eBook & Hardcoverbook)
[17]   Modulatory Role of Ovarian Function on Neuro-Immuno-Endocrine Axis Activity. Perello M, Giovambattista A, Castrogiovanni D, Gaillard RC, Spinedi E. NeuroImmunoModulation 18:19-27
[18]   In Vitro functionality of isolated embryonic hypothalamic vasopressin-ergic and oxytocin-ergic neurons: modulatory effects of brain-derived neurotrophic factor and angiotensin IIMoreno G, Piermaria J, Gaillard RC, Spinedi E Endocrine 39:83-88
[19]   Enhanced pro-inflammatory cytokine response to bacterial lipopolysaccharide in the adult male rat, after either neonatal or pre-pubertal ablation of biological testosterone activity Ongaro L, Castrogiovanni D, Giovambattista A, Gaillard RC, Spinedi E NeuroImmunoModulation, in press