American Journal of Bioinformatics Research

American Journal of Bioinformatics Research publishes all the newest and distinguished research articles, reviews and letters in all areas of bioinformatics and computational biology. Each issue contains a series of timely, in-depth written articles by leaders in the field, covering a wide range of the integration of biology with computer and information science.

Alessandro Desideri

Editorial Board Member of American Journal of Bioinformatics Research

Professor, Department of Biology University of Roma Tor Vergata, Italy

Research Areas

Biochemistry-Molecular Biology-Biophysics-Bioinformatics

Education

1982Ph. DChemistry, Leicester University ( U.K.)
1975DegreePhysics, University of Roma La Sapienza ( IT )

Experience

1995-presentFull Professor of Molecular Biology Faculty of Science, University of Rome Tor Vergata (IT)
1990-1995 Full Professor of Biochemistry Faculty of Science, University of Messina (IT)
1985-1990Associate Professor of Biochemistry Faculty of Science, University of Rome Tor Vergata (IT)
1979-1985Assistant Professor of Spectroscopy Faculty of Science, University of Calabria (IT)
1977-1979Assistant in Pysics Faculty of Science University of Calabria (IT)
1975-1976LeverHulme Fellow Dept of Chemistry Leicester University (UK)

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Di Marino D, Oteri F, Morozzo Della Rocca B, Chillemi G, Falconi M. ADP/ATP mitochondrial carrier MD simulations to shed light on the structural-dynamical events that, after an additional mutation, restore the function in a pathological single mutant. J Struct Biol. 2010 Aug 3
[2]  Coletta A, Morozzo della Rocca B, Jaisankar P, Majumder HK, Chillemi G, Sanna N, Desideri A. Assignment of UV-vis spectrum of (3,3')-diindolylmethane, a Leishmania donovani topoisomerase IB inhibitor and a candidate DNA minor groove binder. J Phys Chem A. 2010 Jul 8;114(26):7121-6.
[3]  Mancini G, D'Annessa I, Coletta A, Sanna N, Chillemi G, Desideri A. Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I-DNA complex. PLoS One. 2010 Jun 3;5(6)
[4]  Zazza C, Coletta A, Sanna N, Chillemi G, Mancini G, Desideri A. Solvent effects on the valence UV-vis absorption spectra of topotecan anticancer drug in aqueous solution at room temperature: a nanoseconds time-scale TD-DFT/MD computational study. J Phys Chem B. 2010 May 27;114(20):6770-8.
[5]  D'Angelo P, Zitolo A, Pacello F, Mancini G, Proux O, Hazemann JL, Desideri A, Battistoni A. Fe-heme structure in Cu, Zn superoxide dismutase from Haemophilus ducreyi by X-ray absorption spectroscopy. Arch Biochem Biophys. 2010 Jun 1;498(1):43-9. Epub 2010 Mar 25.
[6]  Oliveira CL, Juul S, Jørgensen HL, Knudsen B, Tordrup D, Oteri F, Falconi M, Koch J, Desideri A, Pedersen JS, Andersen FF, Knudsen BR. Structure of nanoscale truncated octahedral DNA cages: variation of single-stranded linker regions and influence on assembly yields. ACS Nano. 2010 Mar 23;4(3):1367-76.
[7]  Bruzzese F, Rocco M, Castelli S, Di Gennaro E, Desideri A, Budillon A. Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis. Mol Cancer Ther. 2009 Nov;8(11):3075-87. Epub 2009 Nov 3.
[8]  Tesauro C, Fiorani P, D'Annessa I,Chillemi G, Turchi G, Desideri A. Erybraedin C, a natural compound from the plant Bituminaria bituminosa, inhibits both the cleavage and religation activities of human topoisomerase I. Biochem J. 2010 Jan 15;425(3):531-9.
[9]  D'Annessa, Chillemi G, Desideri A. Structural-dynamical properties of the Deinococcus radiodurans topoisomerase IB in absence of DNA: correlation with the human enzyme. J Biomol Struct Dyn. 2009 Dec;27(3):307-18.
[10]  Bruzzese F, Rocco M, Castelli S, Di Gennaro E, Desideri A, Budillon A. Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis Mol Cancer Ther. 2009 Nov;8(11):3075-87. Epub 2009 Nov 3.
[11]  Fiorani P, Tesauro C, Mancini G, Chillemi G, D'Annessa I, Graziani G, Tentori L, Muzi A, Desideri A. Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant. Nucleic Acids Res. 2009 Sep 18. [Epub ahead of print]
[12]  Falconi M, Oteri F, Chillemi G, Andersen FF, Tordrup D, Oliveira CL, Pedersen JS, Knudsen BR, Desideri A Deciphering the Structural Properties That Confer Stability to a DNA Nanocage. ACS Nano. 2009 Jun 22.
[13]  Castelli S, Campagna A, Vassallo O, Tesauro C, Fiorani P, Tagliatesta P, Oteri F, Falconi M, Majumder HK, Desideri A Conjugated eicosapentaenoic acid inhibits human topoisomerase IB with a mechanism different from camptothecin. Arch Biochem Biophys. 2009 Jun 15;486(2):103-10. Epub 2009 May 4.
[14]  Sanna N, Chillemi G, Gontrani L, Grandi A, Mancini G, Castelli S, Zagotto G, Zazza C, Barone V, Desideri A UV-vis spectra of the anticancer camptothecin family drugs in aqueous solution: specific spectroscopic signatures unraveled by a combined computational and experimental study. J Phys Chem B. 2009 Apr 23;113(16):5369-75.
[15]  Ammendola S, Lembo A, Battistoni A, Tagliatesta P, Ghisalberti C, Desideri A 10-undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong antimicrobial activity through a mechanism that limits iron availability. FEMS Microbiol Lett. 2009 May;294(1):61-7. Epub 2009 Mar 18.
[16]  Biocca S, Falconi M, Filesi I, Baldini F, Vecchione L, Mango R, Romeo F, Federici G, Desideri A, Novelli G Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity. PLoS One. 2009;4(2):e4648. Epub 2009 Feb 27.
[17]  Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-Mattioli M, Sonenberg N, Achsel T, Bagni C. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 2008 Sep 19;134(6):1042-54.
[18]  Losasso C, Cretaio E, Fiorani P, D'Annessa I, Chillemi G, Benedetti P. Free in PMC A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance. Nucleic Acids Res. 2008 Oct;36(17):5635-44.
[19]  Chillemi G, D'Annessa I, Fiorani P, Losasso C, Benedetti P, Desideri A. Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations. Nucleic Acids Res. 2008 Oct;36(17):5645-51.
[20]  Conte C, Gambardella S, Bulli C, Rinaldi F, Di Marino D, Falconi M, Bramanti P, Desideri A, Novelli G. Screening of EDA1 gene in X-linked anhidrotic ectodermal dysplasia using DHPLC: identification of 14 novel mutations in Italian patients. Genet Test. 2008 Sep;12(3):437-42.
[21]  Falconi M, Oteri F, Eliseo T, Cicero DO, Desideri A. MD simulations of papillomavirus DNA-E2 protein complexes hints at a protein structural code for DNA deformation. Biophys J. 2008 Aug;95(3):1108-17.
[22]  Lauria G, Sanchez P, Della Rocca BM, Pierri CL, Polizio F, Stipani I, Desideri A. Structural-dynamical properties of the transmembrane segment VI of the mitochondrial oxoglutarate carrier studied by site directed spin-labeling. Mol Membr Biol. 2008 Apr;25(3):236-44.
[23]  Chillemi G, D'Annessa I, Fiorani P, Losasso C, Benedetti P, Desideri A. Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations. Nucleic Acids Res. 2008 Oct;36(17):5645-51.
[24]  Conte C, Gambardella S, Bulli C, Rinaldi F, Di Marino D, Falconi M, Bramanti P, Desideri A, Novelli G. Screening of EDA1 gene in X-linked anhidrotic ectodermal dysplasia using DHPLC: identification of 14 novel mutations in Italian patients. Genet Test. 2008 Sep;12(3):437-42.
[25]  Falconi M, Oteri F, Eliseo T, Cicero DO, Desideri A. MD simulations of papillomavirus DNA-E2 protein complexes hints at a protein structural code for DNA deformation. Biophys J. 2008 Aug;95(3):1108-17.
[26]  Lauria G, Sanchez P, Della Rocca BM, Pierri CL, Polizio F, Stipani I, Desideri A. Structural-dynamical properties of the transmembrane segment VI of the mitochondrial oxoglutarate carrier studied by site directed spin-labeling. Mol Membr Biol. 2008 Apr;25(3):236-44.
[27]  Falconi M, Biocca S, Novelli G, Desideri A. Molecular dynamics simulation of human LOX-1 provides an explanation for the lack of OxLDL binding to the Trp150Ala mutant. BMC Struct Biol. 2007 Nov 7;7:73.
[28]  Chillemi G, Fiorani P, Bruselles A, Castelli S, Campagna A, Sarra O, Tesauro C, Fiorentini M, Vassallo O, D'Annessa I, Santoleri S, Desideri A. Role of flexibility and long range communication on the function of human topoisomerase I. Ital J Biochem. 2007 Jun;56(2):110-4.
[29]  Biancolella M, Valentini A, Minella D, Vecchione L, D'Amico F, Chillemi G, Gravina P, Bueno S, Prosperini G, Desideri A, Federici G, Bernardini S, Novelli G. Effects of dutasteride on the expression of genes related to androgen metabolism and related pathway in human prostate cancer cell lines. Invest New Drugs. 2007 Oct;25(5):491-7.
[30]  Chillemi G, Bruselles A, Fiorani P, Bueno S, Desideri A. The open state of human topoisomerase I as probed by molecular dynamics simulation. Nucleic Acids Res. 2007;35(9):3032-8.
[31]  Falconi M, Santolamazza A, Eliseo T, de Prat-Gay G, Cicero DO, Desideri A. Molecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation. FEBS J. 2007 May;274(9):2385-95.
[32]  Valentini A, Biancolella M, Amati F, Gravina P, Miano R, Chillemi G, Farcomeni A, Bueno S, Vespasiani G, Desideri A, Federici G, Novelli G, Bernardini S. Valproic acid induces neuroendocrine differentiation and UGT2B7 up-regulation in human prostate carcinoma cell line. Drug Metab Dispos. 2007 Jun;35(6):968-72.
[33]  Amati F., Biancolella M., Farcomeni A., Giallonardi S., Bueno S., Minella D., Secchione L., Chillemi G., Desideri A., Novelli G. Dynamic changes in gene expression profiles of 22q11 and related orthologous genes during mouse development. Gene 2007, 391, 91-102.
[34]  Valentini A, Biancolella M, Amati F, Gravina P, Miano R, Chillemi G, Farcomeni A, Bueno S, Vespasiani G, Desideri A, Federici G, Novelli G, Bernardini S. Valproic acid induces neuroendocrine differentiation and UGT2B7 up-regulation in human prostate carcinoma cell line. Drug Metab Dispos. 2007, 35, 968-972.
[35]  Chillemi G, Bruselles A, Fiorani P, Bueno S, Desideri A. The open state of human topoisomerase I as probed by molecular dynamics simulation. Nucleic Acids Res. 2007, 3, 3032-3040.
[36]  Falconi M, Santolamazza A, Eliseo T, de Prat-Gay G, Cicero DO, Desideri A. Molecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation. FEBS J. 2007, 274, 2385-2395.
[37]  Chillemi G, Fiorani P, Bruselles A, Castelli S, Campagna A, Sarra O, Tesauro C, Fiorentini M, Vassallo O, D'Annessa I, Santoleri S, Desideri A. Role of flexibility and long range communication on the function of human topoisomerase I. Ital. J. Biochem. 2007, 56, 110-114.
[38]  Cicero D.O., Falconi M., Candi E., Mele S., Cadot S., Di Venere A., Rufini S., Melino G., Desideri A. NMR structure of the p63 SAM domain and dynamics properties of G534V and T537P pathological mutants, identified in the AEC syndrome. Cell Biochemistry and Biophysics 2006, 44, 475-489.
[39]  De Domenico I., Lania A., Bonaccorsi M.C., di Patti B., Battistoni A., Musci G., Desideri A. Purification and characterization of recombinant Caulobacter crescentus Cu,Zn superoxide dismutase. Biochimica et Biophysica Acta 2006, 1764, 105-109.
[40]  Falconi M., Chillemi G., Di Marino D., DAnnessa I., Morozzo Della Rocca B., Palmieri L., Desideri A. Structural dynamics of the Mitochondrial ADP/ATP carrier Revealed by Molecular Dynamics Simulation Studies. Proteins: Structure, Function, and Bioinformatics 2006, 65:681-691.
[41]  Gambardella S, Biancolella M, D'Apice M.R., Amati F, Sangiuolo F, Farcomeni A, Chillemi G, Bueno S, Desideri A., Novelli G. Gene expression profile study in CFTR mutated bronchial cell lines. Clin. Exp. Med. 2006, 6, 157-65.
[42]  Fiorani P., Chillemi G., Lo sasso C., Castell S., Desideri A. The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant. Nucleic Acids Research 2006, 34, 18, 5093-5100.
[43]  Maragliano L., Falconi M., Sergi A., Cioni P., Castelli S., Lania A., Stroppolo M.E., Strambini G., Ferrario M., Desideri A. Experimental and simulative dissociation of dimeric Cu,Zn superoxide dismutase doubly mutated at intersubunitsurface. Biophys. Journal 2005, 88,2875-82
[44]  Chillemi G., Fiorani P., Castelli S., Bruselles A., Benedtti P., Desideri A. Effect on DNA relaxation of the single Thr718Ala mutation in human topoisomerase I: a functional and molecular dynamics study. Nucleic AcidResearch 2005, 33, 3339-3350.
[45]  Morozzo della Rocca B., Miniero D.V., Tasco G., Dolce V., Falconi M., Ludovico A., Cappello A.R., Sanchez P., Stipani I., Casadio R., Desideri A., Palmieri F. Substrate-induced conformational changes of the mitochondrial oxoglutarate carrier: a spectroscopic and molecular modelling study. Molecular Membrane Biology 2005, 22, 1-10.
[46]  D.Angelo P., Pacello F., Mancini G., Proux O., Hazemann J.L., Desideri A., Battistoni A. X-ray absorption investigation of a unique protein domain able to bind both copper(I) and copper(II) at adjacent sites of the N terminus of haemophilus ducreyi Cu,Zn superoxide dismutase. Biochemistry 2005, 44, 13144-13150.
[47]  Sanna N., Chillemi G., Grandi A., Castelli S., Desideri A., Barone V. New hints on the pH-driven tautomeric equilibria of the topotecan anticancer drug in aqueous solutions from an integrated spectroscopic and quantum-mechanical approach. Journal Am.Chem. Soc. 2005, 127, 154, 29-36.
[48]  Sennato S., Bordi F., Cametti C., Coluzza C., Desideri A., Rufini G. Evidence of domain formation in cardiolipin-glycerophospholipid mixed monolayers. A thermodynamic and AFM study. Journal Physical Chemistry2005, 109, 15950-15957.
[49]  Desideri A., Cavallari M., Falconi M., Ferrario M. Molecular Dynamics Simulations of the Trp Repressor-DNA complex and the AV77 Mutan. Computer Physics Communication 20t. 05, 169: 130-134.
[50]  Falconi M., Melino G., Desideri A. Molecular dynamics simulation of the C-terminal sterile α-motif domain of p73α: evidences of a dynamical relationship between helices 3 and 5. Biochemical Biophysical Research Communication 2004, 316, 1037-1042
[51]  Chillemi G., Bruselles A., Redinbo M., Desideri A. Role of the linker domain and the 203-214 N-terminal residue in the human topoisomerase I DNA complex dynamics. Biophysical Journal 2004, 87, 4087-9
[52]  Garofoli S., Falconi M., Desideri A. Thermophilicity of wild type and mutant cold shock proteins by molecular dynamics simulation. Journal Biomolecular Structure & Dynamics 2004, 21, 771-780.0
[53]  Bottini M., Divenere A., Tautz L., Desideri A., Lugli P., Avigliano L., Rosato N. Structural stability of azurin encapsulated in Sol-Gel glasses: a fluorimetric study. Journal of Sol-Gel Science and Technology 2004, 30, 205-214.
[54]  Chillemi G., Fiorani P., Benedetti P., Desideri A. Protein concerted motions in the DNA-human topoisomerase I complex. Nucleic Acids Research 2003, 5, 1525-1535.
[55]  Cioni P., Pesce A., Morozzo della Rocca B., Castelli S., Falconi M., Parrili L., Bolognesi M., Strambini G., Desideri A. Active-site copper and zinc ions modulate the quaternary structure of prokaryotic Cu,Zn superoxide dismutase. Journal of Molecular Biology 2003, 326, 1351-1360.
[56]  Morozzo della Rocca B., Lauria G., Venerini F., Desideri A., Palmieri L., Polizio F., Capobinco L., Stipani V., Cappello A.R., Palmieri F. The mitochondrial oxoglutarate carrier: structural and dynamical properties of transmembrane segment IV studied by site-directed spin labeling. Biochemistry 2003, 42,5493-99
[57]  Fiorani P., Bruselles A., Falconi M., Chillemi G., Desideri A., Benedetti P. Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I. Journal of Biological Chemistry 2003, 278(44):43268-75.
[58]  Orsale M., Melino S., Contessa G.M., Torre V., Andreotti G., Motta A., Paci M., Desideri A., Cicero D.O. Two distinct calcium-calmodulin interactions with N-terminal regions of the olfactory and rod cyclic nucleotide-gated channels characterized by NMR spectroscopy. FEBS Letters 2003, 548(1-3):11-6.
[59]  Falconi M., Brunelli M., Pesce A., Ferrario M., Bolognesi M., Desideri A. Static and dynamic water molecules in Cu,Zn superoxide dismutase. Proteins: Structure, Function and Genetics 2003, 51(4):607-15.
[60]  Falconi M., Altobelli G., Iovino M.C., Politi V., Desideri A. Molecular dynamics simulation of matrix metalloproteinase 2: fluctuations and time evolution of recognition pockets. Journal Computer-Aided Molecular Design 2003, 17(12):837-48.
[61]  Sergi A., Ciccotti G., falconi m., Desideri A., Ferrario M. Effective binding force calculation in a dimeric protein by molecular dynamics simulation. Journal of chemical physics, (2002) 116, 6329-6338.
[62]  Falconi M., Parrilli L., Battistoni A., Desideri A. Protein flexibility in monomeric Cu,Zn superoxide dismutase detected by molecular dynamics simulation and limited proteolysis Proteins: structure, function and genetics, (2002) 47, 513-520.
[63]  Militello V., Leone M., Cupane A., Santucci R., Desideri A. Local dynamics properties of the heme pocket in native and solvent-induced iolten-globule state of cytochrome C. Biophys. Chem. (2002) 97, 121-128
[64]  Castrignanò T., Chillemi G., Varani G., Desideri A. Molecular dynamics simulation of the rna complex of a double stranded rna-dinding domain reveals dynamic features of the intermolecular interface and its hydration. Biophysical j. 2002, 83, 3542-3552
[65]  Falconi M., Cambria M.T., Cambria A., Desideri A. Structure and stability of the insulin dimer investigated by molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics 2001, 18, 761-762.
[66]  Iovino M., Falconi M., Marcellini A., Desideri A. Molecular dynamics simulation of the antimicrobial salivary peptide histatin-5 in water and in trifluoroethanol. Journal Peptide Research 2001, 58, 45-55.
[67]  Falconi M., Stroppolo M.E., Cioni P., Sergi A., Ferrario M., Desideri A. Dynamics-function correlation in Photobacterium leiognathi superoxide dismutase: a spectroscopic and molecular dynamics simulation study. Biophysical Journal 2001, 80 2556-2567.
[68]  Stroppolo M.E., Pesce A., Dorazio M., Oneill P., Bordo D., Rosano C., Milani M., Battistoni A., Bolognesi M., Desideri A. Single mutation at the subunit interface modulate copper reactivity in Photobacterium leiognathi Cu,Zn superoxide dismutase. Journal of Molecular Biology 2001, 308, 555-563.
[69]  Chillemi G., Castrignanò T., Desideri A. Structure and hydration of the DNA-human topoisomerase I covalent complex. Biophysical Journal 2001, 81, 490-500.
[70]  Pacello F., Langford P.R., Kroll J.S., Indiani C., Smulevich G., Rotilio G., Battistoni A., Desideri A. A novel heme protein: the Cu,Zn superoxide dismutase from Haemophilus ducreyi. Journal of Biological Chemistry 2001, 276, 30326-30334.
[71]  Iovino M., Falconi M., Petruzzelli R., Desideri A. Role of the helix capping in the stability of the mouse prion (180-213) segment: investigation through molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics 2001, 19, 237-246.
[72]  Cioni P., Stroppolo M.E., Desideri A., Strambini G.B. Dynamic features of the subunit inerface of Cu,Zn superoxide dismutase as probed by tryptophan phosphorescence. Archives of Biochemistry and Biophysics 2001, 391, 111-118.
[73]  Sinibaldi F., Fiorucci L., Mei G., Ferri T., Desideri A., Ascoli f., Santucci R. Cytochrome c reconstituted from two peptide fragments displays native-like redox properties. European Biochemical Journal 2001, 268, 4537-4543
[74]  Bongiovanni C., Ferri T., Poscia A., Varalli M., Santucci R., Desideri A. An electrochemical multienzymatic biosensor for determination of cholesterol. Bioelectrochemistry 2001, 54, 17-22.
[75]  Bordo D., Pesce A., Bolognesi M., Stroppolo M.E., Falconi M., Desideri A. Copper-zinc superoxide dismutase in prokaryotes and eukaryotes. Handbook of metalloproteins-Messerschmidt A., Huber R., Poulos T. Wieghardt K., Wiley J. and son eds. 2001, 1284-1300.
[76]  Stroppolo M.E., Falconi M., Caccuri A.M., Desideri A. Superefficient enzymes. Cellular and Molecular Life Sciences 2001, 58, 1451-1460.
[77]  Iovino M., Desideri A. Structural dynamics investigations of proteins by EPR spectroscopy and MD simulations. Spectroscopic techniques in biophysics-Giacometti G.M. and Giacometti G. eds, ios press, 2001 261-269
[78]  Falconi M., Stroppolo M.E., Cioni P., Sergi A., Desideri A., Ferrario M. Dynamics-function correlation in Cu,Zn superoxide dismutase: a spectroscopic and molecular dynamics simulation study. Biophysical Journal 2001, 80, 2556-2567.
[79]  Falconi M., Desideri A., Rufini S. Membrane perturbing activity of viperidae myotoxins: an electrostatic surface potential aproach to a puzzling problem. Journal of Molecular Recognition 2000, 13, 14-19.
[80]  Falconi M., Venerini F., Desideri A. Dependence of the mechanical intersubunit communication of a dimeric protein to specific mutation as revealed by molecular dynamics simulation. Journal of Molecular Liquids 2000, 84, 29-37.
[81]  Luise A., Falconi M., Desideri A. Molecular dynamics simulation of solvated azurin: correlation between surface solvent accessibility and water residence times. Proteins: Structure, Function and Genetics 2000, 39, 56-67.
[82]  Stroppolo M.E., Malvezzi-Campeggi F., Mei G., Rosato N., Desideri A. Role of the tertiary and quaternary structures in the stability of dimeric copper,zinc superoxide dismutases. Archives of Biochemistry and Biophysics 2000, 377, 215-218.
[83]  Dorazio M., Battistoni A., Stroppolo M.E., Desideri A. Single mutation induces a metal dependent subunit association in dimeric Cu,Zn superoxide dismutase. Biochem. Biophys. Res. Comm. 2000, 272, 81-83.
[84]  Santucci R., Fiorucci L., Sinibaldi F., Polizio F., Desideri A., Ascoli F. The heme-containing N-fragment (residues 1-56) cytochrome c is a bis-histidine functional system. Archives of Biochemistry and Biophysics 2000, 379, 331-336.
[85]  Castrignanò T., Chillemi G., Desideri A. Structure and hydration of BamHI DNA recognition site: a molecular dynamics investigation. Biophysical Journal 2000, 79, 1263-1272.
[86]  Pesce A., Battistoni A., Stroppolo M.E., Polizio F., Desideri A., Nardini M., Kroll J.S., Langford P.R., Oneill P., Sette M., Bolognesi M. Functional and crystallographic characterization of Salmonella typhymurium Cu,Zn superoxide dismutase coded by the sodCI virulence gene. Journal of Molecular Biology 2000, 302, 465-478.
[87]  Santucci R., Bongiovanni C., Mei G., Ferri T., Polizio F., Desideri A. Anion size modulates the structure of the A state of cytochrome c. Biochemistry 2000, 39, 12632-12638
[88]  Stroppolo M. E., Pesce A., Falconi M., Oneill P., Bolognesi M., Desideri A. Single mutation at the intersubunit interface confers extra efficiency to Cu,Zn superoxide dismutase. FEBS Letters 2000, 24080, 1-4