International Journal of Virology and Molecular Biology

International Journal of Virology and Molecular Biology interests in all aspects of microbiology in man and animals, especially new trends and advances. It publishes general interest reviews, mini-reviews, experimental and theoretical works and computational analyses in Virology and Molecular Biology and features Wide-ranging coverage of problems related to molecular and cell biology.


Nadezda Urosevic

Editorial Board Member of International Journal of Virology and Molecular Biology

Lecturer, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Australia

Research Areas

Virology, Infection and Immunity, Molecular and Cell Biology, Neuroscience

Education

Ph.D University of Belgrade, Serbia, Yugoslavia
M.ScUniversity of Belgrade, Serbia, Yugoslavia
B.ScUniversity of Belgrade, Serbia, Yugoslavia

Experience

2008-presentAdjunct Senior Lecturer, Edith Cowan University
2008-presentAdj Research Fellow, School of Psychiatry and Clinical Neurosciences, UWA
2010Principal Investigator, The Lighthouse Laboratories, Midland, WA
2008-2009Lecturer/Lab Manager, School of Biotechnology and Biomolecular Sciences, UNSW
2006-2008Research Fellow, Psychiatry and Clinical Neurosciences, UWA
2003-2005Research Fellow, WAIMR, UWA
1991-2002Senior Research Officer, National Health and Medical Research Council (NH&MRC), Microbiology, UWA
1989-1991Research Fellow and Lecturer, Institute for Medical Research, Military Medical Academy (MMA), Belgrade, Serbia

Membership

Genetics Society of Australia
Australian Society for Microbiology

Publications: Journals

[1]  Brajanovic N. (1980), The effect of adrenalin and ACTH on both free fatty acid level in serum and basal lipolysis in interscapular brown adipose tissue of rats, B.Sc. thesis in Serbian, The University of Belgrade, Belgrade, Yugoslavia.
[2]  Brajanovic N. (1982), The effect of cortisol on nuclear matrix protein phosphorylation in rat liver, M.Sc. thesis in Serbian, The University of Belgrade, Belgrade, Yugoslavia.
[3]  Sevaljevic Lj, Brajanovic N and Trajkovic D, (1982), Cortisol induced stimulation of nuclear matrix protein phosphorylation, Molecular Biology Reports, 8: 225-232.
[4]  Sevaljevic Lj and Brajanovic N, (1984), Identification of collagenase-sensitive constituents of rat liver nuclear matrix, Biochemistry International, 8: 165-170.
[5]  Holoubek V, Antoniades D, Brajanovic N, Deacon NJ, Hwu HR, Naora H and Yoshida M, (1985), Altered processing and transport of nuclear RNA during chemical carcinogenesis, in Nuclear Envelope Structure and RNA Maturation, eds Smuckler EA and Clawson GA, UCLA Symposia on Molecular and Cellular Biology, 26: 615-643.
[6]  Sevaljevic Lj, Brajanovic N, Krtolica K, Tomic M and Boskovic B, (1986), The effect of soman poisoning on the rate of RNA synthesis in vivo and in isolated nuclei, J Toxicol Clin Exp, 5: 297-305.
[7]  Brajanovic-Urosevic N, Naora H, Mills GC and Holoubek V, (1988), Nucleotide sequence of small chromatin associated RNA (Fr 3 RNA), European Journal of Biochemistry, 173: 375-376.
[8]  Urosevic, N. (1989), Primary structure of small nuclear RNA present in rat liver nonhistone chromosomal protein fraction, Ph.D. thesis in Serbian, The University of Belgrade, Belgrade, Yugoslavia.
[9]  Magic Z, Urosevic N and Dujic A, (1992) Geneticko inzenjerstvo u medicini-in Serbian (Genetic engineering in medicine), review, Vojnosanitetski Pregled, 49: 223-229.
[10]  Urosevic N, Krtolica K, Skaro-Milic A, Knezevic-Usaj S and Dujic A, (1993), Prevalence of G to T transversions among K-ras oncogene mutations in human colorectal tumors in Yugoslavia, International Journal of Cancer, 54: 249-254.
[11]  Shellam GR, Urosevic N, Sangster MY, Mansfield JP and Mackenzie JS, (1993), Characterisation of allelic forms at the retinal degeneration (rd) and-glucuronidase (Gus) loci for the mapping of the flavivirus resistance (Flv) gene on mouse chromosome 5, Mouse Genome, 91(3): 572-574.
[12]  Urosevic N, Sangster MY, Mansfield JP, Mackenzie JS and Shellam GR, (1993), Flavivirus resistance (Flvr) gene in mice: mapping studies, Arbovirus Research in Australia, 6: 130-134.
[13]  Sangster MY, Urosevic N, Mansfield JP, Mackenzie JS and Shellam GR, (1994), Mapping the Flv locus controlling resistance to flaviviruses on mouse chromosome 5, Journal of Virology, 68: 448-452.
[14]  Krtolica K, Urosevic N, Nesic D, Tukic Lj, Dimitrijevic B and Dujic A, (1994), Distinct spectrum of N-ras mutations in AML and MDS patients in Yugoslavia, Oncology Reports, 1: 619-623.
[15]  Urosevic N, Mansfield JP, Mackenzie JS and Shellam GR, (1995), Low resolution mapping around the flavivirus resistance locus (Flv) on mouse Chromosome 5, Mammalian Genome, 6: 454-458.
[16]  Urosevic N, Mann K, Hodgetts SI and Shellam GR (1997) High-resolution genetic mapping of the chromosomal region around the mouse flavivirus resistance locus (Flv). Arbovirus Research in Australia, 7: 296-299.
[17]  Urosevic N, Silvia OJ, Mansfield JP, Sangster MY, Hodgetts SI and Shellam GR (1997) Development of new flavivirus-resistant mouse strains congenic to flavivirus-susceptible C3H/HeJ mice. Arbovirus Research in Australia, 7: 300-304.
[18]  Silvia OJ, Shellam GR, Allan JE, Price P, Mackenzie JS and Urosevic N (1997) Expression of the flavivirus resistance phenotype in an in vitro cell culture system. Arbovirus Research in Australia, 7: 280-284.
[19]  Lancaster MU, Mackenzie JS and Urosevic N (1997) Expression of flaviviral non-structural proteins in a baculovirus system. Arbovirus Research in Australia, 7: 137-140.
[20]  Urosevic N, van Maanen, M, Mansfield, JP, Mackenzie, JS and Shellam, GR (1997), Molecular characterisation of virus specific RNA produced in the brains of flavivirus susceptible and resistant mice after challenge with Murray Valley encephalitis virus, Journal of General Virology, 78: 23-29.
[21]  Lancaster MU, Hodgetts SI, Mackenzie JS and Urosevic N (1998), Characterisation of viral defective RNA produced during persistent infection of Vero cells with Murray Valley encaphalitis virus, Journal of Virology, 72: 2474-2482.
[22]  Shellam, G.R., Sangster, M.Y. and Urosevic, N. (1998), Genetic control of host resistance to flavivirus diseases, In Genetic resistance to animal diseases, Office International Des Epizooties Scientific & Technical Review, 17 (1): 231-248.
[23]  Andreyev, H.J.N., Norman, A.R., Cunningham, D., Oates, J.R., Clarke, P.A. and collaborative group of authors from 13 countries including N. Urosevic and K. Krtolica representing Yugoslavia (1998) Kirsten ras mutations in patients with colorectal cancer: the multicentre 'RASCAL' study, Journal of National Cancer Institute, 90 (9): 675-684.
[24]  Urosevic, N., Silvia, O.J., Mansfield, JP, Sangster MY, Hodgetts SI and Shellam GR (1999) Development and characterisation of new flavivirus resistant mouse strains bearing Flvr-like and Flvmr alleles from wild or wild-derived mice, J. Gen. Virology, 80: 897-906.
[25]  Silvia O.J. and Urosevic N. (1999) Variations in LPS responsiveness among different mouse substrains of C3H lineage and their congenic derivative sublines, Immunogenetics, 50: 354-357.
[26]  Urosevic N., Silvia O.J. and Shellam G.R. (2000) Host natural resistance to flaviviruses controlled by Flv, Research Advances in Virology, 1: 79-89.
[27]  Silvia O.J., Shellam G.R. and Urosevic N. (2001), Innate resistance to flavivirus infection in mice controlled by Flv is nitric oxide-independent, J General Virology, 82: 603-607.
[28]  Andreyev HJN, AR Norman, D Cunningham……..and N Urosevic (2001) Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study, British J. Cancer, 85: 692-696.
[29]  Urosevic N. and Shellam G.R. (2002), Host genetic resistance to Japanese encephalitis group viruses, Current Topics in Microbiology and Immunology, 267: 153-170.
[30]  N. Trutic, Z. Magic, N. Urosevic and K. Krtolica (2002) Acute-phase protein gene expression in rat liver following whole body X-irradiation or partial hepatectomy, Comp. Biochem. Physiol. Part C, 133: 461-470.
[31]  HJN Andreyev, R Benamouzig, M Beranek, D Cunningham, W Giaretti, AFPM de Goeij, BJ Iacopetta, E Jullian, K Krtolica, JQ Lee, N Lees, F Al-Mulla, O Muller, AR Norman, M Pauly, V Pricolo, A Russo, C Troungos, N Urosevic, ST Wang, R Ward, (2003) Mutant K-ras2 in serum, Gut, 52: 912-916.
[32]  Urosevic N (2003) Is flavivirus resistance interferon type I-independent? Special Feature on Evasion of Immune System by Flaviviruses, Immunol. Cell Biol. J. 81: 224-229.
[33]  Silvia OJ, Pantelic L, Mackenzie JS, Shellam GR, Papadimitriou J and Urosevic N. (2004) Virus spread, tissue inflammation and antiviral response in brains of flavivirus susceptible and resistant mice acutely infected with Murray Valley encephalitis virus, Archives of Virology, 149(3): 447-464.
[34]  Stoddart CW, Martin-Iverson MT, Jablensky A and Urosevic N (2004) A novel mouse Chr5 locus Diht controls dopamine-induced hypothermia. Mammalian Genome, 15: 901-913.
[35]  Pantelic L, Sivakumaran H and Urosevic N (2005) Differential induction of antiviral effects against West Nile virus in primary mouse macrophages derived from flavivirus susceptible and congenic resistant mice by interferon type I and poly IC. Journal of Virology, 79(3): 1753-1764.
[36]  Pantelic L and Urosevic N (2005) Are macrophages involved in antibody-mediated enhancement of West Nile virus infection in mice? Arbovirus Research in Australia, 9: 290-297.
[37]  Shueb RH, Pantelic L and Urosevic N (2005) A delayed morbidity in genetically resistant mice triggered by some flaviviruses. Arbovirus Research in Australia, 9: 344-351.
[38]  N. Urosevic & L. Pantelic, RNA Interference-The Role of siRNAs as Alternative Antiviral Agents, In: International Proceedings: XXIV World Congress of Pathology and Laboratory Medicine, 2007, pp 261-268, editor Lai-Meng Looi, published by MEDIMOND, Bologna, Italy. (ISBN-978-88-7587-378-3).
[39]  Urosevic N and Martins RN (2008) Infection and Alzheimer's disease-the apoE ε4 connection and lipid metabolism, Journal of Alzheimer's Disease, Special Issue "Chronic inflammation and Amyloidogenesis in Alzheimer's Disease: The Emerging Role of Infection", 13 (4): 421-435.
[40]  Shueb H, Papadimitriou J. and Urosevic N. (2011) Fatal persistence of West Nile virus subtype Kunjin in the brains of flavivirus resistant mice. Virus Research, 155: 455-461.

Publications: Conferences/Workshops/Symposiums

[1]  Sevaljevic Lj, Brajanovic N, Trajkovic D and Krtolica K, (1981), Cortisol-induced phosphorylation of rat liver nuclear matrix proteins in in vitro system, 14th FEBS Meeting, Edinburgh, UK.
[2]  Sevaljevic Lj and Brajanovic N, (1983), Two major nuclear matrix proteins are collagenase-sensitive and enriched in glycine and proline, 5th Balkan Biochem Biophys Days, Thessaloniki, Greece.
[3]  Holoubek V, Brajanovic N and Antoniades D, (1985), Transcripts of repeat RNA released from the nuclei during hepatocarcinogenesis, 76th Annual Meeting Amer Assoc Canc Res, Houston, Tx, USA.
[4]  Urosevic N and Holoubek V, (1987), A model of base-paired interactions between Fr 3 RNA and U1A, U2 and U5 snRNAs, 18th FEBS Meeting, Ljubljana, Yugoslavia.
[5]  Krtolica K, Urosevic N, Nesic D, Tukic Lj, Magic Z, Dimitrijevic B and Dujic A, (1990), Detection of ras gene mutations in human leukemias, 6th Meeting of Haematologists and Transfusiologists of Yugoslavia, Zagreb, Yugoslavia.
[6]  Urosevic N, Krtolica K, Nesic D, Tukic Lj, Magic Z, Dimitrijevic B and Dujic A, (1990), Use of PCR in detection of activated ras oncogenes in clinical specimens, 27th Cancerologists' Week, Belgrade, Yugoslavia.
[7]  Urosevic N, Sangster MY, Mansfield JP, Mackenzie JS and Shellam GR, (1993), Mapping a mouse gene controlling resistance to flaviviruses, 1993-Annual Scientific Meeting of the Australian Society for Microbiology, Perth, WA, Australia.
[8]  Krtolica K, Urosevic N, Nesic D, Tukic Lj, Magic Z and Dimitrijevic B, (1994), Oncogene activation in patients with myeloid disorders, 1st Congress of Geneticists of Serbia, Vrnjacka Spa, Serbia, Yugoslavia.
[9]  Knezevic-Usaj S, Krtolica K, Urosevic N, Radojkovic M, Skaro-Milic A, Bogdanovic Z and Cerovic S, (1994), Correlation between quantitative nuclear morphology, K-ras oncogene mutations and the expression of epithelial HLA-DR determinant in colorectal carcinomas, 1994-Annual Meeting of Gastroenterologists of Serbia, Mt. Zlatibor, Serbia, Yugoslavia.
[10]  Urosevic N, van Maanen M, Mansfield JP, Mackenzie JS and Shellam GR, (1994), Studies on Murray Valley encephalitis virus (MVE) RNAs produced in either flavivirus-resistant or flavivirus-susceptible mouse strains, 2nd International Meeting on Hepatitis C and Related Viruses, San Diego, CA, USA.
[11]  Silvia OJ, Mansfield JP, Shellam GR, Mackenzie JS, Papadimitriou JM and Urosevic N, (1994) Studies on flavivirus infection in congenic C3H/HeJ and C3H/RV mice, 1994-Annual Scientific Meeting of the Australian Society for Microbiology, Melbourne, Vic, Australia.
[12]  Urosevic N, Mansfield JP, Mackenzie JS and Shellam GR (1995) Low resolution mapping around a mouse flavivirus resistance locus, Flv, using microsatellites, 17th Annual Conference on the Organisation and Expression of the Genome, Lorne, Vic, Australia.
[13]  Silvia OJ, Mansfield JP, Lancaster MU, Shellam GR, Papadimitriou JM and Urosevic N (1995) The spread of Murray Valley encephalitis virus throughout the brains of flavivirus susceptible and resistant mice. Microbiology Australia 16(4): GP30.
[14]  Lancaster MU, Silvia OJ, Coelen RJ, Mackenzie JS and Urosevic N (1995) Characterisation of RNA species during persistent infection of Vero cells with Murray Valley encephalitis virus. Microbiology Australia 16(4): GP32.
[15]  Knezevic-Usaj S, Cerovic S, Rabrenovic Lj, Petrovic M, Urosevic N, Lipkovski J, Krtolica K and Milosavljevic I (1995) Prognostic markers of colorectal carcinomas: NORs, infiltration of dendritic cells and presence of point mutation in the K-ras ocogene, International Gastro-Surgical Club, 6th Joint Meeting of Surgeons and Gastroenterologists, Bangkok, Thailand.
[16]  Knezevic-Usaj S, Krtolica K, Urosevic N, Panisic M, Radojkovic M, Cuk V, Bogdanovic Z, Cerovic S and Markovic-Lipkovski J. (1995) Epithelial Expression of HLA-DR and mutation of K-ras oncogene in colorectal carcinoma, Xvth European Congress of Pathology, Copenhagen, Denmark.
[17]  Silvia OJ, Mansfield JP, Shellam GR, Mackenzie JS, Papadimitriou JM and Urosevic N (1996) Detection and location of Murray Valley encephalitis virus in the brains of resistant and susceptible congenic mice. 7 Arbovirus Research in Australia. Surfers Paradise, Queensland.
[18]  Silvia OJ, Papadimitriou JM, Shellam GR, Allan JE and Urosevic N (1996) The effect of flavivirus infection on the accumulation of CD4+ and CD8+ T cells in the brains of susceptible and resistant mice. First Congress, Federation of Immunological Societies of Asia-Oceania. Adelaide, p101.
[19]  Urosevic N, Hodgetts SI, Mann K, Lyons P and Shellam GR (1997) High resolution genetic mapping and mouse YAC library screening for the markers closely linked to the flavivirus resistance locus (Flv), 44th Annual Conference of the Genetics Society of Australia, Perth.
[20]  Urosevic N. (1997) The use of reverse genetics to search for a gene controlling resistance to flaviviruses (Flv) in mice (Invited Speaker), The First Symposium on Molecular Genetics, Mutagenesis and Genotoxicology, Serbian Society of Geneticists, Mt Zlatibor, Serbia.
[21]  Urosevic N., Silvia O.J, Zareh P., Lyons P.A. and Shellam G.R. (1999), Innate resistance to flavivirus infection in a mouse model, XI International Congress of Virology, Sydney.
[22]  Pantelic L. and Urosevic N. (2001), The effect of various treatments on the infectibility of macrophage cultures derived from flavivirus susceptible and resistant mice, P3.35. ASM Annual Scientific Meeting, Perth.
[23]  Stoddart C., Martin-Iverson M. and Urosevic N. (2001), Linkage between resistance to neurotropic flaviviruses and dopaminergic effects in the mouse brain, P4.24. ASM Annual Scientific Meeting, Perth.
[24]  Urosevic N., Pantelic L. and Shellam G.R. (2001), Is flavivirus resistance controlled by more than one genetic locus? PP16.2. ASM Annual Scientific Meeting, Perth.
[25]  Urosevic N., Shueb H., Pantelic Lj., Shellam G.R. and Papadimitriou J. (2002) Vulnerability of flavivirus resistant mouse strains to delayed encephalitis caused by the low doses of low virulent viruses, Euresco Conferences, Neuroendocrine-Immune Interactions, San Feliu de Guixols, Spain.
[26]  Pantelic L., G.R. Shellam and N. Urosevic (2002) Type I interferon effects on virus resistance in peritoneal macrophages derived from flavivirus susceptible and resistant mice. 32nd Annual Scientific Meeting of the Australasian Society for Immunology, Brisbane, QLD.
[27]  Urosevic N, Pantelic L and Sivakumaran H. (2003) Selective induction of antiviral state in macrophages from flavivirus susceptible and resistant mice-a step closer to solving the susceptibility/resistance puzzle, Workshop on Viral Immunology 2, 33rd Annual Scientific Meeting of the Australasian Society for Immunology, Perth, WA.
[28]  Pantelic L and Urosevic N (2003) Involvement of macrophages in pathogenesis of West Nile (WN) virus encephalitis", Poster Session 2, 33rd Annual Scientific Meeting of the Australasian Society for Immunology, Perth, WA.
[29]  Pantelic L and Urosevic N (2004) A primary macrophage model-a simple approach to study the effect of antiviral agents as well as host susceptibility to flavivirus West Nile, Invited talk-Urosevic presenting author, World Conference on Magic Bullets (Paul Ehrlich), Nurnberg, Germany.
[30]  Shueb RH and Urosevic N (2005) T cells involvement in the pathogenesis of Kunjin virus infection in flavivirus resistant mice. ASI Workshop, Perth.
[31]  C.W. Stoddart, N. Urosevic, M.T. Martin-Iverson. (2005) D1-like and D2-like dopamine receptor interactions differ among behaviours. Society for Neuroscience Annual Meeting, Washington, DC, Nov 12-16.
[32]  Urosevic N (2007) RNA Interference-The role of siRNAs as alternative therapeutic agents, 24th World Congress of Pathology and Laboratory Medicine, Kuala Lumpur, Invited Talk
[33]  Urosevic N (2008) Principal parallels between Interferon type I-and small inhibitory (si)RNA-based therapies. EHRLICH II, 2nd World Conference on Magic Bullets, Nürnberg, Germany
[34]  Shueb RH and Urosevic N (2009) Differential role of T cells during Kunjin virus and Murray Valley Encephalitis virus infection in flavivirus-resistant mice. 4th Asian Dengue Research Network Meeting, Singapore.