Advances in Analytical Chemistry

Advances in Analytical Chemistry is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of analytical chemistry. The journal publishes features and news articles about major advances, trends, and challenges in analytical chemistry. These articles include peer-reviewed features written by researchers and news stories that discuss novel analytical concepts and instruments.

Samuel Akapo

Editorial Board Member of Advances in Analytical Chemistry

Research Scientist, Teva Parenteral Medicines, Inc., USA

Research Areas

Analytical Method Development and Validation including HPLC, GC, GC/MS, FTIR, UV, etc., and Regulatory Compliance for the Pharmaceutical and Allied Industry

Education

Ph.DChemistry, University of London (Birkbeck College), London, U.K.
M.ScIndustrial Chemistry, University of Benin, Benin City, Nigeria
B.ScChemistry, University of Lagos, Lagos, Nigeria

Experience

2009-presentTeva Parenteral Medicines, Inc., Irvine, CA,Senior Manager, Product Analytical Science
2005-2008DEY LABORATORIES, NAPA, CA,Manager/Associate Director
2002-2005DEY LABORATORIES, NAPA, CA,Senior/Principal Scientist
1997-2000Analyze INC.,Chandler,Az,Consulting Chemist
1996-1997Nasa Ames Research Center, Moffett Field, Ca,Research Scientist
1994-1996Nasa Ames Research Center, Moffett Field, Ca,Postdoctoral Research Associate
1989-1994Ogun State University, Ago-Iwoye, Nigeria,Associate Professor

Academic Achievement

2005 President's, and 2007 Innovation Awards, Dey LP
NRC-NASA Postdoctoral Research Award, 1994
British Commonwealth Scholarship, 1986
Provost's/Deans Award, University of Lagos, 1982

Membership

Member, American Chemical Society
Member, American Association of Pharmaceutical Scientists
Member, Parenteral Drug Association
Chartered Chemist, Royal Society of Chemistry, UK

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Akapo SO, Syed S, Mamangun A, Skinner W. Chromatographic and spectral analysis of two main extractable compounds present in aqueous extracts of laminated aluminum foil used for protecting LDPE-filled drug vials. Intl. J. Anal. Chem. (2009). DOI: 10.1155/2009/6933210.
[2]  Akapo, S., Gupta, J., Martinez, E. and Roach, M. In vitro deposition properties of nebulized formoterol fumarate: effect of nebulization time, airflow, volume of fill, and nebulizer type. Curr. Med. Res. Opin. 25(4): 807-819 (2009).
[3]  Akapo, S., McCrea, C., Gupta, J., Roach, M., and Skinner W. Chiral HPLC analysis of formoterol stereoisomers and thermodynamic study of their interconversion in aqueous pharmaceutical formulations. J. Pharm. Biomed. Anal. 49(3): 632-637 (2009).
[4]  Akapo, S., Gupta, J., Matinez, E., McCrea C., Ye, L., Roach, M. The compatibility and aerosol characteristics of formoterol fumarate mixed with other nebulizing solutions. Ann. Pharmacother. 42(10): 1416-1424 (2008).
[5]  Akapo, S.O., McCrea, C.M. SPME-GC determination of potential volatile organic leachables in aqueous based pharmaceutical formulations packaged in overwrapped LDPE vials. J. Pharm. Biomed. Anal. 47: 526-534 (2008).
[6]  Akapo, S.O. Wegner, M., Mamangun, A., Krishnakumar, C., Asif, M., Dussex, J-C. Optimization and validation of a gas chromatographic method for analysis of (RS,SR)-diastereoisomeric impurity in formoterol fumarate. J. Chromatogr. A 1045: 211-216 (2004).
[7]  Akapo, S.O., Asif, M. Validation of RP-HPLC method for the assay of formoterol and its related substances in formoterol fumarate dihydrate drug substance. J. Biomed. Pharm. Anal. 33: 935-945 (2003).
[8]  Jarand, C.W., Akapo, S.O., Swenson, L.J., Kelman, B.J. Diisocyanate emission from a paint product: A preliminary analysis. Appl. Occup. Env. Hyg. 17(7): 491-494 (2002).
[9]  Akapo, S.O., Dimandja, J.-M.D., Kojiro, D.R., Valentin, J.R., Carle, G.C. Gas chromatography in space-A review. J. Chromatogr. A 843: 147-162 (1999).
[10]  Akapo, S.O., Fatunmbi, H.O. The performance of mixed horizontally polymerized phases versus conventional C18 silica columns for reversed-phase HPLC. LC.GC 17(4): 334-344 (1999).
[11]  Akapo, S.O., Matyska, M.T., Pesek, J.J. Retention characteristics and selected applications of cyclic siloxane-based octadecylsilyl bonded phases in reversed-phase high performance liquid chromatography. J. Chromatogr. A 773: 53-63 (1997).
[12]  Akapo, S.O. Evaluation of transition metal complexes of aminopropylsilyl dithiooxamide bonded phases for gas chromatography. Anal. Chimica Acta 341: 35-42 (1997).
[13]  Akapo, S.O., Simpson, C.F. Influence of temperature and mobile phase composition on retention properties of oligomeric bonded phases in reversed-phase liquid chromatography (RPLC). Chromatographia 44: 135-144 (1997).
[14]  Akapo, S.O. Retention behavior of C1-C4 hydrocarbons on copper (II) complexes of cyano-and mercaptopropyl bonded phases. Anal. Commun. 33: 311-313 (1996).
[15]  Akapo, S.O., Dimandja, J.-M.D., Matyska, M.T., Pesek, J.J. Improvement of gas chromatographic performance of cyclic siloxane bonded phases by incorporation of n-alkyl groups. Anal. Chem. 68: 1954-1959 (1996).
[16]  Akapo, S.O., Dimandja, J.-M.D., Matyska, M.T., Pesek, J.J. Synthesis of chemically bonded squalene(ane) phases for micropacked gas chromatographic separation of low-molecular-weight hydrocarbons in extraterrestrial atmospheres. Chromatographia 42: 141-146 (1996).
[17]  Akapo, S.O., Dimandja, J.-M.D., Matyska, M.T., Pesek, J.J. Spectroscopic and chromatographic evaluation of cyclic siloxane bonded phases for microcolumn gas chromatography of lower hydrocarbons. J. Microcol. Sep. 8: 189-200 (1996).
[18]  Akapo, S.O. Separation of light hydrocarbons on micropacked bidentate alkylsilane silica columns by gas chromatography. J. Chromatogr. Sci. 34: 130-138 (1996).
[19]  Akapo, S.O. Characterization of micropacked alkyl-bonded silica columns for gas chromatographic analyses of light hydrocarbons in planetary atmospheres. J. Chromatogr. A 709: 291-301 (1995).
[20]  Akapo, S.O., Simpson, C.F. Synthesis of stationary phases for reversed-phase HPLC: Comparison of the fluidized bed technique with the organic solvent process. J. Chromatogr. Sci. 32: 86-92 (1994).
[21]  Sosanwo, O., Ogunsanwo, B.M., Akapo, S.O. Studies on black soap part II: Isolation and analysis of wash-active-substance (WAS) from the black soap (ose dudu). Nigerian J. Sci. 28: 217-221 (1994).
[22]  Akapo, S.O., Olowu, R.O. Preliminary investigation of mineral elements in selected Nigerian breads and bakers' flours. Nigerian Food J. 10: 16-22 (1992).
[23]  Akapo, S.O., Simpson, C.F. Structural investigation of oligomeric n-octylsilyl reversed phases. J. Chromatogr. 557: 515-522 (1991).
[24]  Okegbile, E.O., Aina, K.M., Soboyejo, A.N., Akapo, S.O. Studies on lipid content and fatty acid composition of Dialium guineense Wild (velvet tamarind) seed. Bioscience Res. Commun. 3: 103-109 (1991).
[25]  Akapo, S.O., Scott, R.P.W., Simpson, C.F. The production of stable, uniform reversed phases for liquid chromatography by oligomeric synthesis. J. Liq. Chromatogr. 14: 217-236 (1991).
[26]  Akapo, S.O., Simpson, C.F. Preparation, structure and chromatographic properties of different silica-based octylsilyl bonded phases. J. Chromatogr. Sci. 28: 186-193 (1990).
[27]  Akapo, S.O., Simpson, C.F. Influence of mobile phase additives on the retention behaviour of polar solutes on oligomeric n-octylsilyl reversed phases. Anal. Proceedings 26: 394-397 (1989).
[28]  Akapo, S.O., Alexandra Furst, Khong, T.M., Simpson, C.F. Chromatographic evaluation of oligomeric C8 reversed phases for use in high-performance liquid chromatography. J. Chromatogr. 471: 283-296 (1989).
[29]  Akapo, S.O., Alexandra Furst, Khong, T.M., Simpson, C.F. Effect of carbon load on the chromatographic performance of n-octylsilyl reversed phases in LC. Anal. Proceedings 26: 61-64 (1989).
[30]  Akapo, S.O. Khong, T.M., Simpson, C.F., Toussaint, B., Yates, J.G. A novel method for determining the particle density of porous aeratable powders. Powder Technol. 58: 237-242 (1989).
[31]  Odlyha, M., Akapo, S.O., Simpson, C.F. DSC study of chemically modified porous silica powders. Thermochimica Acta 134: 457-461 (1988).