International Journal of Genetic Engineering

International Journal of Genetic Engineering is devoted to the rapid publication of fundamental research papers on all phases of genetic engineering. All contributions shall be rigorously refereed and selected on the basis of quality and originality of the work as well as the breadth of interest to readers.

Benoît Chénais

Editorial Board Member of International Journal of Genetic Engineering

Professor, University of Maine-Le Mans, France

Research Areas

Biochemistry, Molecular Biology, Genetics


1994Ph.DParis-XI University, Orsay
1990Master Cell physiology and biochemistry, Paris-XI University
1989Master Molecular biology and genetics, Paris-XI University


2003-2004Visiting researcher in the team of Dr. Volker Blank (McGill University, Montreal) Lady Davis Institute for Medical Research, Montreal, Canada
1994-2005Assistant professor in biochemistry, molecular biology and genetics UMR 6142 CNRS-University of Reims-Champagne Ardenne, School of Pharmacy, Reims, France

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Ladhar-Chaabouni R, Hamza-Chaffai A, Hardivillier Y, Chénais B, Denis F. Pilot study for genetic differentiation between two phenotypes of the Mediterranean population of C. glaucum and genetic discrimination between this population and others of C. glaucum and C. edule outside the Mediterranean. Marine Ecology Evol. Persp. 2010, 31, 355-363.
[2]  Blanckaert V, Ulmann L, Mimouni V, Antol J, Brancquart L, Chénais B. Docosahexaenoic acide intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231. Int. J. Oncol., 2010, 36, 737-742.
[3]  Rouault JD, Casse N, Chénais B, Hua-Van A, Filée J, Capy P. Automatic classification within families of transposable elements: application to the mariner family. Gene, 2009, 448, 227-232.
[4]  Delaurière L, Chénais B, Pradier E, Hardivillier Y, Renault S, Casse N. DNA binding specificity and cleavage activity of Pacmmar transposase. Biochemistry, 2009, 48, 7279-7286.
[5]  Delaurière L, Chénais B, Hardivillier Y, Gauvry L, Casse N. Mariner transposons as genetic tools in vertebrate cells. (Revue) Genetica, 2009, 137, 9-17.
[6]  Bounaadja L, Albert D, Chénais B, Hénault S, Zygmunt MS, Poliak S, Garin-Bastuji B. Real-time PCR for identification of Brucella spp: a comparative study of IS711, bcsp31 and per target genes. Vet. Microbiol., 2009, 137, 156-164.
[7]  Marchand J, Leignel V, Moreau B, Chénais B. Characterization and sequence analysis of manganese 1 superoxide dismutases from Brachyura (Crustacea: Decapoda): particular emphasis for hydrothermal Bythograeidae versus littoral crabs. Comp. Biochem. Physiol. Part B, 2009, 153, 191-199.
[8]  Bui QT, Casse N, Leignel V, Nicolas V, Chénais B. Widespread occurence of mariner transposons in coastal crabs. Mol. Phylogenet. Evol., 2008, 47, 1181-1189.
[9]  Leignel V, Marchand J, Moreau B, Chénais B. Metallothionein genes from hydrothermal crabs (Bythograeidae, Decapoda): Characterization, sequence analysis and comparison with coastal crabs. Comp. Biochem. Physiol., part C, 2008, 148, 6-13.
[10]  Cougnon C, Gautier C, Pilard JF, Casse N, Chénais B. Redox and ion-exchange properties in surface-tethered DNA-conducting polymers. Biosens. Bioelectron.,2008, 23, 1171-1174.
[11]  Gautier C, Esnault C, Cougnon C, Pilard JF, Casse N, Chénais B. Hybridization-induced interfacial changes detected by non-Faradaic impedimetric measurements compared to Faradaic approach. J. Electroanal. Chem., 2007, 610, 227-233.
[12]  Gautier C, Cougnon C, Pilard JF, Casse N, Chénais B. A poly(cyclopentadithiophene) matrix suitable for electrochemically controlled DNA delivery. Anal. Chem., 79, 7920-7923, 2007.
[13]  Bui QT, Delaurière L, Casse N, Nicolas V, Laulier M, Chénais B. Molecular characterization and phylogenetic position of a new mariner-like element in the coastal crab, Pachygrapsus marmoratus. Gene, 396, 248-256, 2007.
[14]  Leignel V, Cibois M, Moreau B, Chénais B. Identification of new subgroup of HSP70 in Bythograeidae (hydrothermal crabs) and Xanthidae. Gene, 396, 84-92, 2007.
[15]  Gautier C, Cougnon C, Pilard JF, Casse N, Chénais B, Laulier M. Detection and modelling of DNA hybridization by EIS measurements. Mention of a polythiophene matrix suitable for electrochemically controlled gene delivery. Biosens. Bioelectron., 22, 2025-2031, 2007.
[16]  Riou J-F, Gomez D, Mergny J-L, Guittat L, Paterski R, Chénais B, Morjani H & Trentesaux C, Régulation de la longueur des telomeres : render le telomere accessible ? (Revue) Bull. Cancer 92, 13-22, 2005.
[17]  Chénais B, Derjuga A, Massrieh W, Red-Horse K, Bellingard V, Fisher SJ & Blank V, Functional and placental expression analysis of the human NRF3 transcription factor. Mol. Endocrinol. 19, 125-137, 2005.
[18]  Laquerriere P, Michel J, Balossier G & Chénais B, Light elements quantification in stimulated cells cryosections studied by electron probe microanalysis. Micron 33, 597-603, 2002.
[19]  Richard D, Morjani H & Chénais B, Free radical production and labile iron pool decrease triggered by subtoxic concentration of aclarubicin in human leukemia cell lines. Leukemia Res. 26, 925-929, 2002.
[20]  Richard D, Hollender P & Chénais B, Involvement of reactive oxygen species in aclarubicin-induced differentiation and invasiveness of HL-60 leukemia cells. Int. J. Oncol. 21, 393-400, 2002.
[21]  Richard D, Hollender P & Chénais B, Butyric acid increases invasiveness of HL-60 leukemia cells: role of reactive oxygen species. FEBS Lett. 518, 158-163, 2002.
[22]  Chénais B, Morjani H & Drapier JC, Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool. J. Neurochem. 81, 615-623, 2002.
[23]  Chénais B, Andriollo M, Guiraud P, Belhoussine R & Jeannesson P, Oxidative stress involvement in chemically-induced differentiation of K562 cells. Free Radic. Biol. Med., 28, 18-27, 2000.
[24]  Chénais B, Molle I & Jeannesson P, Inhibitory effect of nitric oxide on chemically-induced differentiation of human leukemic K562 cells. Biochem. Pharmacol., 58, 773-778, 1999.
[25]  Chénais B, Requirement of GATA-1 and p45 NF-E2 expression in butyric acid-induced erythroid differentiation. Biochem. Biophys. Res. Commun. 253, 883-886, 1998.
[26]  Chénais B, Molle I, Trentesaux C & Jeannesson P, Time-course of butyric acid-induced differentiation in human K562 leukemic cell line: rapid increase in-globin, porphobilinogen deaminase and NF-E2 mRNA levels. Leukemia 11, 1575-1579, 1997.
[27]  Jeannesson P, Lahlil R, Chénais B, Devy L, Gillet R, Aries A, Morceau F & Trentesaux C, Anthracyclines as tumor cell differentiating agents: effects on the regulation of erythroid gene expression. (Revue) Leuk. Lymphoma 26: 575-587, 1997.
[28]  Morceau F, Chénais B, Gillet R, Jardillier JC, Jeannesson P & Trentesaux C, Transcriptional and posttranscriptional regulation of erythroid gene expression in anthracycline-induced differentiation of human erythroleukemic cells. Cell Growth Differ. 7, 1023-1029, 1996.
[29]  Akarid K, Chénais B, Chau F, Sinet M, Desforges B & Gougerot-Pocidalo MA, Absence of involvement of nitric oxide in LP-BM5-induced immunodeficiency syndrome. FEMS Immunol. Med. Microbiol. 15, 169-176, 1996.
[30]  Morceau F, Aries A, Lahlil R, Chénais B, Devy L, Doubeikovskaia Z, Doubeikovski A, Jardillier JC, Trentesaux C & Jeannesson P, Molecular mechanisms of anthracyclines-mediated differentiation of human erythroleukemic cells. (Revue) in Challenges of Modern Medicine, vol. 10, Differentiation Therapy (Waxman, S. Ed.), Ares-Serono Symposia Publications, pp. 477-481, 1995.
[31]  Chénais B & Tenu JP, Involvement of nitric oxide synthase in antiproliferative activity of macrophages: induction of the enzyme requires two different kinds of signal acting synergistically. (Revue) Int. J. Immunopharmacol. 16, 401-406, 1994.
[32]  Chénais B, Bobé P, Lemaire G & Tenu JP, Inhibition of nitric oxide synthase by antioxydant molecules: transcriptional and post-transcriptional regulation. in Biology of Nitric Oxide Part 4, Enzymology, Biochemistry and Immunology (Moncada, S., Feelish, M., Busse, R., and Higgs, E.A. Eds) Portland Press, London UK, pp. 81-83, 1994.
[33]  Lemaire G, Chénais B, Lepoivre M & Petit JF, Protein-tyrosine kinase inhibitors block the induction of nitric oxide synthase in macrophages. in Biology of Nitric Oxide Part 4, Enzymology, Biochemistry and Immunology (Moncada, S., Feelish, M., Busse, R., and Higgs, E.A. Eds) Portland Press Proceedings, London UK, pp. 348-351, 1994.
[34]  Chénais B, Yapo A, Lepoivre M & Tenu JP, N-hydroxy-L-arginine, a reactional intermediate in nitric oxide biosynthesis, induces cytostasis in human and murine tumor cells. Biochem. Biophys. Res. Commun. 196, 1558-1565, 1993.
[35]  Tenu, JP, Yapo A, Chénais B & Lepoivre M, Release of Ng-hydroxy-L-arginine by stimulated EMT-6 adenocarcinoma cells. in Biology of Nitric Oxide (Moncada, S., Marletta, M.A., Hibbs, J.B., and Higgs, E.A. Eds) Portland Press, London UK, pp. 58-61, 1992.
[36]  Chénais B, Yapo A, Lepoivre M & Tenu JP, High-performance liquid chromatographic analysis of the unusual pathway of oxidation, of L-arginine to citrulline and nitric oxide in mammalian cells. J. Chromatogr. A, 539, 433-441, 1991.
[37]  Lepoivre M, Chénais B, Yapo A, Lemaire G, Thelander L & Tenu JP, Alterations of ribonucleotide reductase activity following induction of the nitrite generating pathway in adenocarcinoma cells. J. Biol. Chem., 265, 14143-14149, 1990.