American Journal of Organic Chemistry

American Journal of Organic Chemistry is an open-access, peer-reviewed journal describing the design of, synthetic approaches to, and characterization of new molecules with applications in organometallics, medicinal and heterocyclic chemistry, green chemistry, photochemistry, materials science, nanotechnology, and catalysis. Articles considered for publication include: original scientific research articles, review type articles and communications.

Anton Dolzhenko

Editorial Board Member of American Journal of Organic Chemistry

Senior Lecturer, School of Pharmacy, Curtin University, Australia

Research Areas

Organic Chemistry, Medicinal Chemistry, Structural Chemistry

Education

2000-2003PhDPerm State Pharmaceutical Academy, Perm, Russian Federation
1995-2000MSciPerm State Pharmaceutical Academy, Perm, Russian Federation

Experience

2010-presentLecturer/Senior Lecturer, School of Pharmacy, Faculty of Health Sciences, Curtin University
2004-2010Research Fellow , Department of Pharmacy, Faculty of Science, National University of Singapore, Singapor
2003-2004Lecturer, Perm State Pharmaceutical Academy, Perm, Russian Federation

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Dolzhenko, A. V.; Bai, S. Q.; Dolzhenko, A. V.; Chui, W. K. Synthesis and structure of 3,4-dihydropyrido[2',3':3,4]pyrazolo[1,5-a][1,3,5]triazin-2-amines. J. Heterocycl. Chem., 2011, doi: 10.1002/jhet.851.
[2]  Cheong, S. L.; Dolzhenko, A.V.; Paoletta, S.; Lee, E. P. R.; Kachler, S.; Federico, S.; Klotz, K.-N.; Dolzhenko, A. V.; Spalluto, G.; Moro, S.; Pastorin, G. Does the combination of optimal substitutions at the C2-, N5-and N8-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors? Bioorg. Med. Chem., 2011, 19(20), 6120-6134.
[3]  Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. Molecular and crystal structure of 7,7-dimethyl-2-pyridin-4-yl-6,7-dihydro-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine. Crystals, 2011, 1(3), 136-144.
[4]  Dolzhenko, A. V. Synthetic routes towards pyrimido[1,2-a][1,3,5]triazines. Heterocycles, 2011, 83(7), 1489-1525.
[5]  Sachdeva, N.; Dolzhenko, A. V.; Chui, W. K. Synthesis and tautomerism study of 6-benzoylmethyl-1,3,5-triazin-2,4-diamine. C. R. Chimie, 2011, 14(6), 580-587.
[6]  Dolzhenko, A. V.; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Chui, W. K. 7-(4-Fluorobenzylamino)-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine methanol disolvate. Acta Crystallogr. 2011, E67, o1183-o1184.
[7]  Dolzhenko, A. V. Synthetic routes towards thiazolo[1,3,5]triazines. Heterocycles, 2011, 83(4), 695-738.
[8]  Dolzhenko, A. V.; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Chui, W. K. 2-Phenyl-7-(4-pyridylmethylamino)-1,2,4-triazolo[1,5-a][1,3,5]triazin-5(4H)-one. Acta Crystallogr., 2011, E67(1), o85-o86.
[9]  Dolzhenko, A. V.; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Chui, W. K. 4,4-Dimethyl-3,4-dihydropyrido[2',3':3,4]pyrazolo[1,5-a][1,3,5]triazin-2-amine ethanol monosolvate. Acta Crystallogr., 2011, E67(1), o83-o84.
[10]  Sachdeva, N.; Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Chui, W. K. 4-Amino-2,8-dimethyl-6H-pyrimido[1,2-a][1,3,5]triazin-6-one. Acta Crystallogr., 2010, E66(8), o2050.
[11]  Cheong, S. L.; Dolzhenko, A.; Kachler, S.; Paoletta, S.; Federico, S.; Cacciari, B.; Dolzhenko, A.; Klotz, K.-N.; Moro, S.; Spalluto, G.; Pastorin, G. The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition. J. Med. Chem., 2010, 53(8), 3361-3375.
[12]  Dolzhenko, A. V.; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Chui, W. K. A monoclinic polymorph of N-ethoxycarbonyl-N'-(3-phenyl-1H-1,2,4-triazol-5-yl)thiourea. Acta Crystallogr., 2010, E66(8), o1990-o1991.
[13]  Dolzhenko, A. V.; Tan, G. K.; Dolzhenko, A. V.; Koh, L. L.; Pastorin, G. 8-Methyl-2-[4-(trifluoromethyl)phenyl]-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine methanol disolvate. Acta Crystallogr., 2010, E66(7), o1835-o1836.
[14]  Bera, H.; Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Chui, W.K. 4-Carbethoxy-1-[4-(N,N-dimethylamino)benzoyl]thiosemicarbazide. Acta Crystallogr., 2010, E66(5), o1241.
[15]  Dolzhenko, A. V.; Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Pastorin, G. N'-Acetyl-5-amino-1-methyl-1H-pyrazole-4-carbohydrazonamide dihydrate. Acta Crystallogr., 2010, E66(5), o1209-o1210.
[16]  Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. N-Carbethoxy-N'-[3-(4-methylphenyl)-1H-1,2,4-triazol-5-yl]thiourea. Acta Crystallogr., 2010, E66(3), o549-o550.
[17]  Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. N-Carbethoxy-N'-(3-phenyl-1H-1,2,4-triazol-5-yl)thiourea. Acta Crystallogr., 2010, E66(2), o425.
[18]  Dolzhenko, A. V.; Pastorin, G.; Dolzhenko, A. V.; Chui, W. K. A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines. Tetrahedron Lett., 2009, 50(40), 5617-5621.
[19]  Dolzhenko, A. V.; Foo, M. C.; Tan, B. J.; Dolzhenko, A. V.; Chiu, G. N. C.; Chui, W. K. Synthesis and heterocyclizations of 3,4-dihydroquinazolin-2-yl guanidine in the search of new anticancer agents. Heterocycles, 2009, 78(7), 1761-1775.
[20]  Glushkov, V. A.; Stryapunina, O. G.; Dolzhenko, A. V.; Syropyatov, B. Ya.; Shklyaev, Y. V. Synthesis and antiaggregant and hypotensive activity of benzo-annelated azabicyclo[m.n.0]alkanes. Pharm. Chem. J., 2009, 43(5), 245-248.
[21]  Dolzhenko, A. V.; Pastorin, G.; Dolzhenko, A. V.; Chui, W. K. An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles. Tetrahedron Lett., 2009, 50(18), 2124-2128.
[22]  Dolzhenko, A. V.; Pastorin, G.; Dolzhenko, A. V.; Tan, G. K.; Koh, L. L. (4Z,6Z,12Z,14Z)-2,10-Dimethyl-2,8,10,16-tetrahydrodipyrazolo[3,4-e:3',4'-l][1,2,4,8,9,11]hexaazacyclotetradecine-4,12-diamine. Acta Crystallogr., 2009, E65(7), o1578-o1579.
[23]  Dolzhenko, A. V.; Pastorin, G.; Dolzhenko, A. V.; Tan, G. K.; Koh, L. L. 4-Hydrazino-1-methylpyrazolo[3,4-d]pyrimidine. Acta Crystallogr., 2009, E65(8), o1720-o1721.
[24]  Dolzhenko, A. V.; Sachdeva, N.; Tan, G. K.; Koh, L. L.; Chui, W. K. 2-Amino-4-(4-bromophenyl)-8-trifluoromethyl-3,4-dihydropyrimido[1,2-a][1,3,5]triazin-6(5H)-one. Acta Crystallogr., 2009, E65(4), o684.
[25]  Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. 3-Phenyl-1H-1,2,4-triazol-5-amine-5-phenyl-1H-1,2,4-triazol-3-amine (1/1). Acta Crystallogr., 2009, E65(1), o126.
[26]  Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. 3-Pyridin-2-yl-1H-1,2,4-triazol-5-amine. Acta Crystallogr., 2009, E65(1), o125.
[27]  Dolzhenko, A. V.; Pastorin, G.; Dolzhenko, A. V.; Chui, W. K. A convenient method for the synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines. Tetrahedron Lett., 2008, 49(50), 7180-7183.
[28]  Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. Pyrazolo[1,5-a][1,3,5]triazines (5-aza-9-deazapurines). Synthesis and biological activity. Heterocycles, 2008, 75(7), 1575-1622.
[29]  Dolzhenko, A. V.; Tan, B. J.; Dolzhenko, A. V.; Chiu, G. N. C.; Chui, W. K. Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines. J. Fluorine Chem., 2008, 129(5), 429-434.-Top 25 hottest articles in the journal (http://top25.sciencedirect.com/subject/materials-science/15/journal/journal-of-fluorine-chemistry/00221139/archive/18/)
[30]  Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. Simple synthesis of 2-amino-4-(het)aryl-4,6-dihydro-1(3)(11)H-[1,3,5]triazino[2,1-b]quinazolin-6-ones. J. Heterocycl. Chem., 2008, 45(1), 173-176.
[31]  Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Woo, S. F.; Chui, W. K. 7-Dimethylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine methanol solvate. Acta Crystallogr., 2008, E64(10), o2021.
[32]  Dolzhenko, A. V.; Chui, W. K. Synthesis and biological activity of 1,3,5-triazino[1,2-a]benzimidazol-2-amines. Pharm. Chem. J., 2007, 41(9), 470-473.
[33]  Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. Practical synthesis of regioisomeric 5(7)-amino-6,7(4,5)-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazines. Tetrahedron, 2007, 63(52), 12888-12895.
[34]  Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. Synthesis of new heterocyclic system: 1(5)H-1,5-diazacycl[3.3.2]azine-2,4-dione. Heterocycles, 2007, 71(9), 2049-2054.
[35]  Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. Synthesis of 5,7-diamino[1,2,4]triazolo[1,2-a][1,3,5]triazines via annulation of 1,3,5-triazine ring onto 3(5)-amino-1,2,4-triazoles. Heterocycles, 2007, 71(2), 429-436.
[36]  Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. Advances in chemistry and biological activity of fluorinated 1,3,5-triazines. In: Fluorine Chemistry Research Advances, Ed. I. V. Gardiner, Nova Science Publishers, NY, 2007, pp. 105-142.
[37]  Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. 5,5-Dimethyl-2-phenyl-4,5-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amine. Acta Crystallogr., 2007, E63(5), o2797.
[38]  Dolzhenko, A. V.; Tan, G. K.; Koh, L. L.; Dolzhenko, A. V.; Chui, W. K. 7,7-Dimethyl-2-phenyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amine. Acta Crystallogr., 2007, E63(5), o2796.
[39]  Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. 1,2,4-Triazolo[1,5-a][1,3,5]triazines (5-azapurines): synthesis and biological activity. Heterocycles, 2006, 68(8), 1723-1753.
[40]  Dolzhenko, A. V.; Dolzhenko, A. V.; Chui, W. K. Synthesis of ethyl 6-aryl-4-oxo-4,6-dihydro-1(12)(13)H-pyrimido[2',1':4,5][1,3,5]triazino[1,2-a]benzimidazole-3-carboxylates. J. Heterocycl. Chem., 2006, 43(6), 1513-1521.
[41]  Lee, H. Y.; Chan, L. W.; Dolzhenko, A. V.; Heng, P. W. S. Influence of viscosity and uronic acid composition of alginates on the properties of alginate films and microspheres produced by emulsification. J. Microencapsul., 2006, 23(8), 912-927.
[42]  Dolzhenko, A. V.; Chui, W. K.; Dolzhenko, A. V. Unexpected reaction of 2-hydrazinoperimidine with maleic anhydride: syntheses of (8-amino-9-oxo-9,10-dihydro-8H-imidazo[1,2-a]perimidin-10-yl)acetic acid and its azomethine derivatives. Heterocycles, 2006, 68(4), 821-828.
[43]  Dolzhenko, A. V.; Chui, W. K.; Dolzhenko, A. V. Microwave-assisted synthesis of s-triazino[2,1-b][1,3]-benzoxazoles, s-triazino[2,1-b][1,3]benzothiazoles and s-triazino[1,2-a]benzimidazoles. Synthesis, 2006, (4), 597-602.
[44]  Dolzhenko, A. V.; Chui, W. K. Synthesis of 2-amino-s-triazino[1,2-a]benzimidazoles as potential antifolates from 2-guanidino-and 2-guanidino-5-methylbenzimidazoles. J. Heterocycl. Chem., 2006, 43(1), 95-100.
[45]  Dolzhenko, A. V.; Kolotova, N. V.; Kotegov, V. P.; Syropyatov, B. Ya.; Vasilyuk, M. V.; Rudakova, G. V.; Novikova, V. V.; Feshin, V. P. Synthesis and biological activity of substituted tetrachlorophthalic acid monoamides. Pharm. Chem. J., 2005, 39(8), 409-412.
[46]  Dolzhenko, A. V.; Chui, W. K.; Dolzhenko, A. V.; Chan, L. W. Synthesis and biological activity of fluorinated 2-amino-4-aryl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazoles. J. Fluorine Chem., 2005, 126(5), 759-763.
[47]  Dolzhenko, A. V.; Chui, W. K. A synthesis of a novel heterocyclic system: 2H-furo[3,2-b][1,4]benzothiazin-2-one. Heterocycles, 2004, 63(11), 2623-2626.
[48]  Dolzhenko, A. V.; Kolotova, N. V.; Kozminykh, V. O.; Chui, W.-K.; Heng, P. W. S.; Khrustalev, V.N. Synthesis and structural studies of (2-oxo-2,3-dihydroimidazo[1,2-a]pyridine-3-yl)acetic acids. Heterocycles. 2004, 63(1), 55-62.
[49]  Dolzhenko, A. V.; Syropyatov, B. Ya.; Koz'minykh, V. O.; Kolotova, N. V.; Zakhmatov, A. V.; Borodin, A. Yu. Substituted amides and hydrazides of dicarboxylic acids. Part 18. Synthesis and hypertensive activity of 3(6)-methyl-2-pyridylamides of some dicarboxylic acids. Pharm. Chem. J., 2003, 37(8), 407-408.
[50]  Dolzhenko, A. V.; Koz'minykh, V. O.; Kolotova, N. V.; Burdi, N. Z.; Kotegov, V. P.; Novoselova, G. N.; Syropyatov, B. Ya. Substituted amides and hydrazides of dicarboxylic acids. Part 17. Synthesis and antibacterial and anticonvulsant activity of some amides and acylhydrazides of phthalic acid. Pharm. Chem. J., 2003, 37(7), 342-344.
[51]  Dolzhenko, A. V.; Kotegov, V. P.; Godina, A. T.; Syropyatov, B. Ya.; Kolotova, N. V.; Koz'minykh, V. O. Hypoglycemic activity of substituted amides and hydrazides of succinic acid. Eksp. Klin. Farmakol., 2003, 66(3), 36-38; (in Russian) Chem. Abst. 139:358010.
[52]  Dolzhenko, A. V.; Koz'minykh, V. O.; Kolotova, N. V.; Syropyatov, B. Ya.; Novoselova, G. N. Substituted amides and hydrazides of dicarboxylic acids. Part 16. Synthesis and antibacterial activity of some amides and acylhydrazides of succinic acid. Pharm. Chem. J., 2003, 37(5), 229-231.
[53]  Dolzhenko, A. V.; Kolotova, N. V.; Koz'minykh, V. O.; Syropyatov, B. Ya.; Kotegov, V. P.; Godina, A. T.; Rudakova, G. V. Substituted amides and hydrazides of dicarboxylic acids. Part 15. Synthesis and hypoglycemic activity of some amides and acylhydrazides of tetrachlorophthalic acid. Pharm. Chem. J., 2003, 37(4), 186-188.
[54]  Dolzhenko, A. V.; Kolotova, N. V.; Koz'minykh, V. O.; Vasilyuk, M. V.; Kotegov, V. P.; Novoselova, G. N.; Syropyatov, B. Ya.; Vakhrin, M. I. Substituted amides and hydrazides of dicarboxylic acids. Part 14. Synthesis and antimicrobial and antiinflammatory activity of 4-antipyrylamides, 2-thiazolylamides, and 1-triazolylamides of some dicarboxylic acids. Pharm. Chem. J., 2003, 37(3), 149-151.
[55]  Shklyaev, Yu. V.; Glushkov, V. A.; Syropyatov, B. Ya.; Dolzhenko, A. V.; Grigor'ev, N. B.; Danilov, A. V.; Granik, V. G. Antihypertensive and antiaggregatory activity of derivatives of oximes of the isoquinoline series. Vopr. Biol. Med. Farm. Khim., 2003, (1), 50-53; (in Russian) Chem. Abst. 140:111252.
[56]  Dolzhenko, A. V.; Kolotova, N. V.; Koz'minykh, V. O.; Syropyatov, B. Ya.; Kotegov, V. P.; Godina, A. T.; Rudakova, G. V. Substituted amides and hydrazides of dicarboxylic acids. Part 13. Synthesis and hypoglycemic activity of some substituted amides and acylhydrazides of phthalic acid. Pharm. Chem. J., 2003, 37(1), 19-21.
[57]  Dolzhenko, A. V.; Kolotova, N. V.; Kozminykh, V. O.; Syropyatov, B. Ya.; Kotegov, V. P.; Godina, A. T. Hypoglycemic effect of several substituted amides and acylhydrazides of succinic acid. Pharmazie, 2002, 57(11), 776-778.
[58]  Mikhailovskii, A. G.; Syropyatov, B. Ya.; Dolzhenko, A. V.; Vakhrin, M. I. Synthesis and study of the antiaggregant and hypotensive properties of N-benzyl-3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline derivatives. Pharm. Chem. J., 2002, 36(7), 374-376.
[59]  Mikhailovskii, A. G.; Dolzhenko, A. V.; Syropyatov, B. Ya.; Shklyaev, Yu. V.; Vakhrin, M. I. Chloromethyl and aryloxymethyl 3,4-dihydroisoquinoline derivatives: synthesis and study of antiaggregant and antihypoxant properties. Pharm. Chem. J., 2002, 36(6), 288-291.
[60]  Dolzhenko, A. V.; Kolotova, N. V.; Koz'minykh, V. O.; Syropyatov, B. Ya.; Kotegov, V. P.; Godina, A. T. Substituted amides and hydrazides of dicarboxylic acids. Part 12. Synthesis and hypoglycemic and hypertensive activity of some pyridylamides and acylhydrazides of maleic and citraconic acid. Pharm. Chem. J., 2002, 36(4), 174-176.
[61]  Dolzhenko, A. V.; Kolotova, N. V.; Koz'minykh, V. O.; Syropyatov, B. Ya. Substituted amides and hydrazides of dicarboxylic acids. Part 11. Synthesis and pharmacological activity of a series of pyridylamides of dicarboxylic acids. Pharm. Chem. J., 2002, 36(3), 125-127.
[62]  Dolzhenko, A. V.; Kolotova, N. V.; Koz'minykh, V. O.; Syropyatov, B. Ya.; Kotegov, V. P.; Godina, A. T. Subsituted amides and hydrazides of dicarboxylic acids. Part 10. Synthesis and pharmacological activity of substituted amides and hydrazides of succinic acid. Pharm. Chem. J., 2002, 36(2), 58-60.
[63]  Kolotova, N. V.; Koz'minykh, V. O.; Dolzhenko, A. V.; Koz'minykh, E. N.; Kotegov, V. P.; Godina, A. T.; Syropyatov, B. Ya.; Novoselova, G. N. Substituted amides and hydrazides of dicarboxylic acids. Part 9. Pharmacological activity of the products of interaction of 2-aminopyridines and 2-aminopyrimidine with dicarboxylic acid anhydrides. Pharm. Chem. J., 2001, 35(3), 146-150.
[64]  Kolotova, N. V.; Dolzhenko, A. V.; Koz'minykh, V. O.; Kotegov, V. P.; Godina, A. T. Substituted amides and hydrazides of 1,4-dicarboxylic acids. Part 8. Synthesis and hypoglycemic activity of substituted succinic acid amides and hydrazides. Pharm. Chem. J., 1999, 33(12), 635-637.
[65]  Mikhailovskii, A. G.; Bubnov, Yu. N.; Syropyatov, B. Ya.; Dolzhenko, A. V.; Timofeeva, Yu. P. Synthesis and study of antiaggregatory and hypotensive activity of 3,3-dialkylisoquinoline azomethines and their derivatives. Pharm. Chem. J., 1999, 33(3), 128-131.
[66]  Mikhailovskii, A. G.; Syropyatov, B. Ya.; Shklyaev, V. S.; Timofeeva, Yu. P.; Dolzhenko, A. V. Synthesis and study of antiaggregative and hypotensive activity of condensed isoquinoline derivatives. Pharm. Chem. J., 1998, 32(8), 419-421.