American Journal of Organic Chemistry

American Journal of Organic Chemistry is an open-access, peer-reviewed journal describing the design of, synthetic approaches to, and characterization of new molecules with applications in organometallics, medicinal and heterocyclic chemistry, green chemistry, photochemistry, materials science, nanotechnology, and catalysis. Articles considered for publication include: original scientific research articles, review type articles and communications.

Silvana Raic-Malic

Editorial Board Member of American Journal of Organic Chemistry

Associate Professor, Faculty of Chemical Engineering and Technology, Croatia

Research Areas

Development of New Compounds for Application in Medicinal Chemistry, Synthetic Organic Chemistry

Education

1998Ph.DOrganic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Croatia
1996MasterOrganic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Croatia

Experience

2009-presentVice dean of Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, Zagreb
2007-2009Head of Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, Zagreb
2007-presentAssociate Professor, Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Croatia
2004-2007Assistant Professor, Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Croatia
1998-2004Senior Assistant, Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Croatia
1996Assistant, Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Croatia

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  M. Martić, L. Pernot, Y. Westermaier, R. Perozzo, T. Gazivoda Kraljević, S. Krištafor, S. Raić-Malić, L. Scapozza, S. Ametamey, Synthesis, Crystal Structure, and In Vitro Biological Evaluation of C-6 Pyrimidine Derivatives: New Lead Structures For Monitoring Gene Expression In Vivo, Nucleosides, Nucleotides & Nucleic Acids, 30(4) (2011) accepted for publication.
[2]  U. Müller, M. Martić, T. Gazivoda-Kraljević, S. Krištafor, C. Ranadheera, A. Müller, M. Born, S. D. Krämer, S. Raić-Malić, S. M. Ametamey, Synthesis and Evaluation of a C-6 Alkylated Pyrimidine Derivative for In Vivo Imaging of HSV1-TK Gene Expression, Nuc. Med. & Biol. (2011) accepted for publication.
[3]  S. Krištafor, I. Novaković, T. Gazivoda Kraljević, S. Kraljević Pavelić, P. Lučin, Y. Westermaier, L. Scapozza, S. M. Ametamey, Silvana Raić-Malić, A New N-methyl Thymine Derivative Comprising Dihydroxyisobutenyl Unit as Ligand for Thymidine Kinase of Herpes Simplex Virus Type 1 (HSV-1 TK), Bioorg. Med. Chem. Lett. 21 (2011) 6161-6165.
[4]  T. Gazivoda Kraljević, M. Petrović, S. Krištafor, D. Makuc, J. Plavec, S. M. Ametamey S. Raić-Malić*, Methoxymethyl (MOM) for Nitrogen Protection of Pyrimidines Bearing C-6 Acyclic Side-Chain, Molecules 16 (2011) 5113-5129.
[5]  S. Krištafor, A. Meščić, M. Cetina, S. Korunda, D. Makuc, J. Plavec, S. Raić-Malić*, Synthesis, Structural and Conformational Studies of Z-and E-Isomers of Fluorinated C-6 Isobutenyl N-Methyl Thymine Derivatives, J. Fluor. Chem. 132 (2011) 573-578.
[6]  S. Krištafor, T. Gazivoda Kraljević, S. M. Ametamey, M. Cetina, I. Ratkaj, R. Tandara Haček, S. Kraljević Pavelić, S. Raić-Malić, Syntheses and Antitumor Evaluation of C(6) Isobutyl and Isobutenyl Substituted Pyrimidines and Dihydropyrrolo[1, 2-c]pyrimidin-1, 3-diones, Chem. & Biodiver. 8 (2011) 1455-1469.
[7]  T. Gazivoda Kraljević, S. Krištafor, L. Šuman, M. Kralj, S. M. Ametamey, M. Cetina*, S. Raić-Malić*, Synthesis, X-ray Crystal Structure Study and Antitumoral Evaluations of 5, 6-Disubstituted Pyrimidine Derivatives, Bioorg. Med. Chem. 18 (2010) 2704-2712.
[8]  S. Krištafor, T. Gazivoda Kraljević, D. Makuc, J. Plavec, L. Šuman, M. Kralj, S. Raić-Malić*, Synthesis, Structural Studies and Antitumoral Evaluation of C-6 Alkyl and Alkenyl Side Chain Pyrimidine Derivatives, Molecules 14 (2009) 4866-4879.
[9]  S. Krištafor, T. Gazivoda, M. Cetina, S. Raić-Malić*, Synthesis and Structural Characterization of the C-6 Fluoroalkylated Pyrimidine Derivatives. J. Mol. Struct., 923 (2009) 19-23.
[10]  T. Gazivoda, S. Raić-Malić, V. Krištafor, D. Makuc, J. Plavec, S. Kraljević-Pavelić, K. Pavelić, L. Naesens, G. Andrei, R. Snoeck, J. Balzarini, M. Mintas, Synthesis, Cytostatic and Anti-HIV Evaluations of the New Unsaturated Acyclic C-5 Pyrimidine Nucleoside Analogues, Bioorg. Med. Chem. 16 (2008) 5624-5634.
[11]  T. Gazivoda, S. Raić-Malić, A. Hergold-Brundić, M. Cetina, Synthesis and Structural Characterization of the 5-(2-Haloethyl)Pyrimidines-Hydrogen-Bonded chains in a-(1-Carbamyliminomethylene)-y-Butyrolactone, Molecules 13 (2008) 2786-2795.
[12]  T. Gazivoda, S. Krištafor, M. Cetina, A. Nagl, S. Raić-Malić*, Synthesis and structural studies of C-5 aryl and C-6 alkyl substituted pyrimidine derivatives, Struct. Chem. 19 (2008) 441-449.
[13]  T. Gazivoda, M. Šokčević, M. Kralj, L. Šuman, K. Pavelić, E. De Clercq, G. Andrei, R. Snoeck, J. Balzarini, M. Mintas, S. Raić-Malić*, Synthesis, Antiviral and Cytostatic Evaluations of the New C-5 Substituted Pyrimidine and Furo[2, 3-d]pyrimidine 4, 5-Didehydro-L-ascorbic Acid Derivatives, J. Med. Chem. 50 (2007) 4105-4112.
[14]  S. Prekupec, D. Makuc, J. Plavec, L. Šuman, M. Kralj, K. Pavelić, J. Balzarini, E. De Clercq, M. Mintas, S. Raić-Malić*, Novel C-6 Fluorinated Acyclic Side Chain Pyrimidine Derivatives: Synthesis, H-1 and C-13 NMR Conformational Studies, and Antiviral and Cytostatic Evaluations, J. Med. Chem. 50 (2007) 3037-3045.
[15]  T. Gazivoda, S. Raić-Malić, M. Marjanović, M. Kralj, K. Pavelić, J. Balzarini, E. De Clercq, M. Mintas, The Novel C-5 Aryl, Alkenyl and Alkynyl Substituted Uracil Derivatives of L-Ascorbic Acid: Synthesis, Cytostatic and Antiviral Activity Evaluations, Bioorg. Med. Chem. 15 (2007) 749-758.
[16]  T. Gazivoda, K. Wittine, I. Lovrić, D. Makuc, J. Plavec, M. Cetina, D. Mrvoš-Sermek, L. Šuman, M. Kralj, K. Pavelić, M. Mintas, S. Raić-Malić*, Synthesis, Structural Studies and Cytostatic Evaluation of 5, 6-di-O-Modified L-Ascorbic Acid Derivatives, Carbohydr. Res. 341 (2006) 433-442.
[17]  Z. Rajić, B. Zorc, S. Raić-Malić, K. Ester, M. Kralj, K. Pavelić, J. Balzarini, E. De Clercq, M. Mintas, Hydantoin derivatives of L-and D-amino acids: synthesis, antiviral and antitumoral activity evaluations, Molecules 11 (2006) 837-848.
[18]  V. Krištafor, S. Raić-Malić, M. Cetina, M. Kralj, L. Šuman, K. Pavelić, J. Balzarini, Jan, E. De Clercq, M. Mintas, Synthesis, X-ray Crystal Structural Study, Antiviral and Cytostatic Evaluations of the Novel Unsaturated Acyclic and Epoxide Nucleoside Analogues, Bioorg. Med. Chem. 14 (2006) 8126-8138.
[19]  A. Johayem, S. Raić-Malić, K. Lazzati, P. Schubiger, L. Scapozza, S. Ametamey, Synthesis and Characterization of a C(6) Nucleoside Analogue for the in vivo Imaging of the Gene Expression of Herpes Simplex Virus Type 1 Thymidine Kinase (HSV1 TK), Chem. & Biodiver. 3 (2006) 274-283.
[20]  T. Gazivoda, M. Plevnik, J. Plavec, S. Kraljević, M. Kralj, K. Pavelić, J. Balzarini, E. De Clercq, M. Mintas, S. Raić-Malić*, The Novel Pyrimidine and Purine Derivatives of L-ascorbic Acid: Synthesis, One-and Two-Dimensional 1H and 13C NMR Study, Cytostatic and Antiviral Evaluation, Bioorg. Med. Chem. 13 (2005) 131-139.
[21]  N. Opačić, M. Barbarić, B. Zorc, M. Cetina, A. Nagl, D. Frković, M. Kralj, K. Pavelić, J. Balzarini, G. Andrei, E. De Clerq, S. Raić-Malić and M. Mintas, The Novel L-and D-Amino Acid Derivatives of Hydroxyurea and Hydantoins: Synthesis, X-Ray Crystal Structure Study, Cytostatic and Antiviral Evaluations, J. Med. Chem. 48 (2005) 475-482.
[22]  M. Cetina, A. Nagl, S. Prekupec, S. Raić-Malić, M. Mintas, Hydrogen bonding and C-H...p interactions in 7-hydroxy-3-methoxy-4-methylpiperido[1, 2-c]pyrimidine-1-one, Acta Cryst. C 61 (2005) 158-160.
[23]  S. Prekupec, B. Kalokira, M. Grdiša, K. Pavelić, E. De Clercq, M. Mintas, S. Raić-Malić*, Synthesis and Comparative Cytostatic Activity of the Novel N-7 Acyclic Purine Nucleoside Analogues with Natural N-9 Regioisomers, Heterocycles 65 (2005) 787-796.
[24]  N. Opačić, B. Zorc, M. Cetina, D. Mrvoš-Sermek, S. Raić-Malić, M. Mintas, Synthesis and X-Ray Crystal Structure Study of the Hydroxyurea and Hydantoin Derivatives of L-Valine, J. Pept. Res. 66 (2005) 85-93.
[25]  S. Prekupec, J. Plavec, M. Cetina, S. Kraljević, M. Kralj, K. Pavelić, E. De Clercq, G. Andrei, S. Raić-Malić, M. Mintas, The Novel 5-Methyl 6-Acyclic Chain Substituted Pyrimidine Derivatives: Synthesis, 1H and 13C NMR Conformational Analysis, Antiviral and Cytostatic Evaluations, Antivir. Chem. Chemother. 16 (2005) 327-338
[26]  K. Wittine, T. Gazivoda, M. Markuš, D. Mrvoš-Sermek, A. Hergold-Brundić, M. Cetina, D. Žiher, V. Gabelica, M. Mintas, S. Raić-Malić*, Crystal Structures, Circular Dichroism Spectra and Relative Configurations of Some L-Ascorbic Acid Derivatives, J. Mol. Struct. 687 (2004) 101-106.
[27]  S. Raić-Malić, L. Tomašković, D. Mrvoš-Sermek, B. Prugovečki, M. Cetina, M. Grdiša, K. Pavelić, A. Mannschreck, J. Balzarini, E. De Clercq, M. Mintas, Spirobipyridopyrans, Spirobinaphthopyrans, Indolinospiropyridopyrans, Indolinospironaphthopyrans and Indolinospironaphtho-1, 4-oxazines: Synthesis, Study of X-Ray Crystal Structure and Antitumor Activities, Bioorg. Med. Chem. 12 (2004) 1037-1045.
[28]  S. Raić-Malić*, A. Johayem, S. M. Ametamey, S. Batinac, E. De Clercq, G. Folkers, L. Scapozza, Synthesis, 18F-radiolabelling and biological evaluations of C-6 alkylated pyrimidine nucleoside analogues, Nucleosides, Nucleotides & Nucleic Acids 23 (2004) 1707-1721.
[29]  S. Batinac, D. Mrvoš Sermek, M. Cetina, K. Pavelić, M. Mintas, S. Raić-Malić*, Synthesis of the novel bicyclic oxepinopyrimidine and fluorinated pyrrolidopyrimidines, Heterocycles 63 (2004) 2523-2536.
[30]  S. Prekupec, D. Svedružić, T. Gazivoda, D. Mrvoš-Sermek, A. Nagl, M. Grdiša, K. Pavelić, J. Balzarini, E. De Clercq, G. Folkers, L. Scapozza, M. Mintas, S. Raić-Malić*, Synthesis and Biological Evaluation of Iodinated and Fluorinated 9-(2-Hydroxypropyl) and 9-(2-Hydroxyethoxy)methyl Purine Nucleoside Analogues, J. Med. Chem. 46 (2003) 5763-5772.
[31]  P. Pospišil, B. D. Pilger, S. Marveggio, P. Schelling, C. Wurth, L. Scapozza, G. Folkers, M. Pongračić, M. Mintas, S. Raić-Malić, Synthesis, Kinetics and Molecular Docking of Novel 9-Hydroxypropyl Purine Nucleoside Analogues as Ligands of Herpesviral Thymidine Kinases, Helv. Chim. Acta 85 (2002) 3237-3250.
[32]  S. Raić-Malić*, D. Svedružić, T. Gazivoda, A. Marunović, A. Hergold-Brundić, A. Nagl, J. Balzarini, E. De Clercq, M. Mintas, Synthesis and Biological Activities of Novel Pyrimidine Derivatives of 4, 5-Didehydro-5, 6-dideoxy-L-Ascorbic Acid, J. Med. Chem. 43 (2000) 4806-4811.
[33]  S. Raić-Malić*, A. Hergold-Brundić, A. Nagl, M. Grdiša, K. Pavelić, E. De Clercq, M. Mintas, Novel Pyrimidine and Purine Derivatives of L-Ascorbic Acid: Synthesis and Biological Evaluation, J. Med. Chem. 42 (1999) 2673-2678.
[34]  S. Raić-Malić*, M. Grdiša, K. Pavelić, M. Mintas, Synthesis and biological evaluation of the novel purine and pyrimidine nucleoside analogues containing 2, 3-epoxypropyl, 3-amino-2-hydroxypropyl or 2, 3-epoxypropyl ether moiety, Eur. J. Med. Chem. 34 (1999) 405-413.
[35]  S. Raić-Malić, D. Vikić-Topić, M. Mintas, NMR Characterization of the novel purine and pyrimidine nucleoside analogues with 2, 3-epoxypropyl, 3-amino-2-hydroxypropyl moiety, Spectroscopy Letters 32 (1999) 649-660.
[36]  S. Raić, M. Mintas, A. Danilovski, M. Vinković, M. Pongračić, J. Plavec, D. Vikić-Topić, Acyclic Purine Nucleoside Analogues: Computational and NMR Studies of Conformational Behaviour, J. Mol. Structure 410-411 (1997) 31-33.
[37]  S. Raić, M. Pongračić, M. Mintas, IR Evidences for N-9 and N-7 Regioisomers of the Acyclic Purine Nucleoside Analogues, Spectroscopy Letters 30 (1997) 999-1011.
[38]  M. Pongračić, S. Raić, D. Vikić-Topić, M. Mintas, Acyclic Analogues of Purine Nucleosides with Dimethylaminoethyl and Dimethylaminoethoxyalkyl Side Chains: Preparation, One and Two Dimensional 1H and 13C NMR Studies, Croat. Chem. Acta 70 (1997) 1047-1062.
[39]  S. Raić, M. Pongračić, J. Vorkapić-Furač, D. Vikić-Topić, A. Hergold-Brundić, A. Nagl, M. Mintas, The Novel 6-(N-Pyrrolyl)purine Acyclic Nucleosides: 1H and 13C NMR X-Ray Structural Study, Nucleosides & Nucleotides 15 (1996) 937-960.
[40]  S. Raić, J. Vorkapić-Furač, A. Hergold-Brundić, A. Nagl, M. Mintas, A. Mannschreck: Merocyanine Isomers of Spiro[indolino-indolopyrans]: 1H and 13C NMR and X-Ray Crystal Structure Study, Croat. Chem. Acta 69 (1996) 987-996.
[41]  S. Raić, M. Pongračić, J. Vorkapić-Furač, D. Vikić-Topić, A. Hergold-Brundić, A. Nagl, M. Mintas, New Acyclic Purine Nucleoside Analogues Containing Exocyclic Pyrrolo Moiety: Synthetic, NMR and X-Ray Crystal Structure Study, Croat. Chem. Acta 69 (1996) 967-986.
[42]  S. Raić, M. Pongračić, J. Vorkapić-Furač, D. Vikić-Topić, M. Mintas, Acyclic Analogues of Purine Nucleosides: One-and Two-Dimensional 1H and 13C NMR Evidences for N-9 and N-7 Regioisomers, Spectroscopy Letters 29 (1996) 1141-1155.
[43]  Mladen Mintas, Silvana Raić-Malić, Nenad Raos, "Principles of Drug Design", Zagreb, Hinus, 2000, book written in croatian.
[44]  Nenad Raos, Silvana Raić-Malić, Mladen Mintas, "Stereochemistry of Drugs: Pharmacophores and Receptors", Školska knjiga, 2005, book written in croatian.
[45]  Mladen Mintas, Silvana Raić-Malić, "Medicinal Chemistry", Medicinska naklada, Zagreb, 2009, book written in croatian.