American Journal of Biomedical Engineering

American Journal of Biomedical Engineering provides a forum for the publication of the latest developments in biomedical engineering, and reflects the essential multidisciplinary nature of the subject. The journal publishes in-depth critical reviews, scientific papers and technical notes.

Ming Ding

Editorial Board Member of American Journal of Biomedical Engineering

Associate Professor, University of Southern Denmark, Denmark

Research Areas

Bone Micro-CT/Nano-CT Imaging, Bone Microarchitecture/Ultrastructure, Biomechanics, Biomaterials, Tissue Engineering, Histomorphometry, Roentgen Stereometric Analysis

Education

2010DoctorMedical Science, Department of Orthopaedics, Faculty of Health Sciences, University of Aarhus, Denmark
1995-1998Ph.DMedicine, Department of Orthopaedics, Faculty of Health Sciences, University of Aarhus, Denmark
1987-1990MasterMaster of Medicine, FTC Medical College, China
1979-1984Bachelor Medicine, FTC Medical College, China

Experience

2004-presentAssociate Professor, Department of Orthopaedics & Traumatology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark
2000-2003Senior Research Scientist, Aarhus University Hospital, Denmark
1998-2000Senior Research Scientist, Aarhus University Hospital, Denmark
1994-1998Post-Doctoral, Aarhus University Hospital, Denmark
1990-1994Research fellow/Ph.D. Student, Department of Orthopaedics, Aarhus University Hospital, Denmark
1984-1987Research fellow/Ph.D. Student, Department of Orthopaedics, Aarhus University Hospital, Denmark

Publications: Conferences/Workshops/Symposiums/Journals/Books

[1]  Ding M, Dalstra M, Danielsen CC, Kabel J, Hvid I, Linde F. Age variations in the properties of human tibial trabecular bone. J Bone Joint Surg (Br) 1997; 79-B:995-1002.
[2]  Ding M, Dalstra M, Linde F, Hvid I. Mechanical properties of the normal human cartilage-bone complex in relation to age. Clinic Biomech 1998; 13:351-358.
[3]  Ding M, Dalstra M, Linde F, Hvid I. Changes in the stiffness of the human tibial cartilage-bone complex in early-stage osteoarthrosis. Acta Orthop Scand 1998; 69:358-362.
[4]  Ding M. Ph.D. Dissertation "Age variations in the properties of human tibial trabecular bone and cartilage". Ph.D. Thesis, Aarhus University. 1999a;196-199.
[5]  Ding M, Odgaard A, Hvid I. Accuracy of cancellous bone volume fraction measured by micro-CT scanning. J Biomech 1999b; 32:323-326.
[6]  Ding M. Age variations in the properties of human tibial trabecular bone and cartilage. Acta Orthop Scand 2000a; 71: Supple 292:1-45.
[7]  Ding M, Hvid I. Quantification of age-related changes in the structure model type and trabecular thickness of human tibial cancellous. Bone 2000b; 26: 291-295.
[8]  Ding M, Danielsen CC, Hvid I. Bone density does not reflect mechanical properties in early-stage arthrosis. Acta Orthop Scand 2001; 72:181-185.
[9]  Ding M, Odgaard A, Linde F, Hvid I. Age-related variations in the microstructure of human tibial cancellous bone. J Orthop Res 2002a; 20: 81-87.
[10]  Ding M, Odgaard A, Danielsen CC, Hvid I. Mutual associations among microstructural, physical and mechanical properties of human cancellous bone. J Bone Joint Surg (Br) 2002b; 84-B:900-907.
[11]  Ding M, Odgaard A, Hvid I. Changes in the three-dimensional microstructure of human tibial cancellous bone in early osteoarthritis. J Bone Joint Surg (Br) 2003; 85(6):906-12.
[12]  Ding M, Day JS, Burr DB, Mashiba T, Hirano T, Weinans H, Sumner DR, Hvid I. Canine trabecular architecture after one year of high dose bisphosphonates. Calcif Tissue Int 2003; 72 (6): 737-744.
[13]  Ding M, Danielsen CC, Hvid I. Effects of hyaluronan on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis. Bone 2005; 36(3):489-501.
[14]  Ding M, Danielsen CC, Hvid I. Age-related three-dimensional microarchitectural adaptations of subchondral bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int 2006;78(2):113-22.
[15]  Ding M, Danielsen CC, Hvid I. The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture and mechanical properties of bone tissues in guinea pig primary osteoarthrosis. Calcif Tissue Int 2008; 82(1):77-86.
[16]  Ding M. Microarchitectural adaptations in aging and osteoarthrotic subchondral bone tissues. Acta Orthop 2010; 81: Supple 340:1-53.
[17]  Ding M, Cheng L, Bollen P, Schwarz P, Overgaard S. Glucocorticoid induced osteopenia in cancellous bone of sheep-validation of large animal model. Spine 2010;35:363-370
[18]  Ding M, Danielsen CC, Overgaard S. The effects of glucocorticoid steroid on microarchitecture, collagen, mineral and mechanical properties of sheep femur cortical bone. J Tissue Eng Regen Med 2011 Jul 13. doi: 10.1002
[19]  Day JS, Ding M, Odgaard A, Sumner DR, Hvid I, Weinans H. Parallel plate model for trabecular bone exhibits volume fraction-dependant bias. Bone 2000; 27:715-720.
[20]  Giesen EBW, Ding M, Dalstra M, Van Eijden TMGJ. Mechanical properties of cancellous bone in the human mandibular condyle are anisotropic. J Biomech 2001; 34:799-803.
[21]  Day JS, Ding M, van der Linden J, Hvid I, Sumner DR, Weinans H. A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res 2001; 19:914-918.
[22]  Veenland JF, Grashuis JL, Weinans H, Ding M, Vrooman HA. Suitability of texture features to assess changes in trabecular bone architecture. Pattern Recognition Letters 2002;23:395-403.
[23]  Giesen EBW, Ding M, Dalstra M, Van Eijden TMGJ. Letters to the editor: J Biomech 2002; 35:549-550.
[24]  Hu JH, Ding M, Søballe K, Bechtold JE, Danielsen CC, Day JS, Hvid I. Effects of short-term alendronate treatment on the three-dimensional microstructural, physical and mechanical properties of dog trabecular bone. Bone 2002; 31:591-597.
[25]  Giesen EBW, Ding M, Dalstra M, van Eijden TMGJ. Reduced mechanical load decreases the density, stiffness and strength of cancellous bone of mandibular condyle. Clinic Biomech 2003 18: 358-363.
[26]  Giesen EBW, Ding M, Dalstra M, van Eijden TMGJ. Architectural measures of the cancellous bone of the mandibular condyle identified by principal components analysis Calcified Tissue Int 2003 73 (3): 225-231.
[27]  Kold S, Bechtold J, Ding M, Chareancholvanich K, Rahbek O, Søballe K. Compacted cancellous bone has a spring-back effect. Acta Orthop Scand 2003; 74(5):591-595.
[28]  Giesen EBW, Ding M, Dalstra M, van Eijden TMGJ. Changed morphology and mechanical properties of cancellous bone in the mandibular condyle of edentate people. J Dental Res 2004; 83(3):255-259.
[29]  Day JS, Ding M, Bednarz P, van der Linden JC, Mashiba T, Hirano T, Johnston CC, Burr DB, Hvid I, Sumner DR, Weinans H. Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties. J Orthop Res 2004; 22:465-471.
[30]  Day JS, van der Linden JC, Bank RA, Ding M, Hvid I, Sumner DR, Weinans H. Adaptation of subchondral bone in osteoarthritis. Biorheology 2004;41(3-4):359-68.
[31]  Li H, Zou X, Woo C, Ding M, Lind M, Bunger C. Instrumented Anterior Lumbar Interbody Fusion with a Bone Producing Implant Material. Spine 2005;30(8):890-6.
[32]  Kold S, Rahbek O, Toft M, Ding M, Overgaard S, Søballe K. Bone Compaction Enhances Implant Fixation in a Canine Gap Model. J Orthop Res 2005;23:824-830.
[33]  Eckardt H, Ding M, Christensen KS, Lind M, Hansen ES, Hvid I. Recombinant human Vascular Endothelial Growth Factor enhances bone formation in an experimental nonunion model. J Bone Joint Surg (Br) 2005 87-B:1434-8.
[34]  Li H, Zou X, Woo C, Ding M, Lind M, Bunger C. Experimental lumbar spine fusion with novel tantalum-coated carbon fiber implant. J Biomed Mater Res B Appl Biomater. 2007 Apr;81(1):194-200.
[35]  Abdallah BM, Ding M, Jensen C, Serakinci N, Teisner B, Dagnæs-Hansen F, Kassem M. Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone. Endocrinology. 2007 Jul;148(7):3111-21.
[36]  Hald A, Ding M, Egerod K, Hansen RR, Konradsen D, Jørgensen SG, Atalay B, Nasser A, Bjerrum OJ, Heegaard A. Differential effects of repeated low dose treatment with the cannabinoid agonist WIN 55,212-2 in experimental models of bone cancer pain and neuropathic pain. Pharmacol Biochem Behav. 2008 Nov;91(1):38-46.
[37]  Hald A, Nedergaard S, Hansen RR, Ding M, Heegaard A. Differential activation of spinal cord glial cells in murine models of neuropathic and cancer pain. Eur J Pain 2009 Feb;13(2):138-145.
[38]  CA20 Hald A, Hansen RR, Thomsen MW, Ding M, Croucher PI, Gallagher O, Ebetino FH, Kassem M, Heegaard AM. Cancer-induced bone loss and associated pain-related behavior is reduced by risedronate but not its phosphonocarboxylate analog NE-10790. Int J Cancer. 2009 Sep 1;125(5):1177-85.
[39]  Henriksen S; Babiker, H, Ding M, Overgaard S. Udvikling af kunstig knogle. I: Medicinsk Teknologi og Informatik. 2009 ; nr. 3, Juni. s. 13 (Danish)
[40]  Hald A, Rønø B, Melander MC, Ding M, Holck S, Lund LR. MMP9 is protective against lethal inflammatory mass lesions in the colon. Dis Model Mech 2011 Mar;4(2):212-27.
[41]  Henriksen S, Ding M, Vinther-Juhl M, Theilgaard N, Overgaard S. Mechanical strength of ceramic scaffolds reinforced with biopolymers is comparable to that of human bone, J Mater Sci Mater Med. 2011 May;22(5):1111-8
[42]  Hansen RR, Nielsen CK, Nasser A, Thomsen SIM, Eghorn L, Yen P, Schulenburg C, Syberg S, Ding M, Stojilkovic SS, Jorgensen NR, Heegaard AM. P2X7 receptor-deficient mice are susceptible to bone cancer pain. Pain 2011;152(8):1766-76.
[43]  Babiker H, Ding M, Sandri M, Tampieri A, Overgaard S.The effects of bone marrow aspirate, bone graft and collagen composites on fixation of titanium implants, J Biomed Mater Res B Appl Biomater, 2011, accepted for publication.
[44]  Sørensen J, Koroma K, Ding M, Wendt D, Jespersen S, Vinther Juhl M, Theilgaard N, Martin I, Overgaard S. Effects of novel polylactic acid-enhanced biphasic calcium phosphate substitute in a spine fusion model, Activation in a perfusion bioreactor, in press.
[45]  Ding M. Microarchitectural adaptations of primary osteoarthrotic subchondral bone. In: Qin L, Genant HK, Griffith J, Leung K, editors. Advanced Bioimaging technologies in assessment of the quality of bone and scaffold materials. Springer-Verlag, Berlin, 2007 p. 641-55.